Reality in the Name of God, or, Divine Insistence: An Essay on Creation, Infinity, and the Ontological Implications of Kabbalah

What should philosophical theology look like after the critique of Onto-theology, after Phenomenology, and in the age of Speculative Realism? What does Kabbalah have to say to Philosophy? Since Kant and especially since Husserl, philosophy has only permitted itself to speak about how one relates to God in terms of the intentionality of consciousness and not of how God is in himself. This meant that one could only ever speak to God as an addressed and yearned-for holy Thou, but not to God as infinite creator of all. In this book-length essay, the author argues that reality itself is made up of the Holy Name of God. Drawing upon the set-theoretical ontology of Alain Badiou, the computational theory of Stephen Wolfram, the physics of Frank Tipler, the psychoanalytical theory of Jacques Lacan, and the genius of Georg Cantor, the author works to demonstrate that the universe is a computer processing the divine Name and that all existence is made of information (the bit). As a result of this ontic pan-computationalism, it is shown that the future resurrection of the dead can take place and how it may in fact occur. Along the way, the book also offers compelling critiques of several significant theories of reality, including the phenomenological theologies of Emmanuel Levinas and Jean-Luc Marion, Process Theology, and Object-Oriented Ontology

Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies

Recently identified broadly neutralizing antibodies (bNAbs) that potently neutralize most HIV-1 strains are key to potential antibody-based therapeutic approaches to combat HIV/AIDS in the absence of an effective vaccine. Increasing bNAb potencies and resistance to common routes of HIV-1 escape through mutation would facilitate their use as therapeutics. We previously used structure-based design to create the bNAb NIH45-46G54W, which exhibits superior potency and/or breadth compared with other bNAbs. We report new, more effective NIH45-46^(G54W) variants designed using analyses of the NIH45-46–gp120 complex structure and sequences of NIH45-46^(G54W)–resistant HIV-1 strains. One variant, 45-46m2, neutralizes 96% of HIV-1 strains in a cross-clade panel and viruses isolated from an HIV-infected individual that are resistant to all other known bNAbs, making it the single most broad and potent anti–HIV-1 antibody to date. A description of its mechanism is presented based on a 45-46m2–gp120 crystal structure. A second variant, 45-46m7, designed to thwart HIV-1 resistance to NIH45-46G54W arising from mutations in a gp120 consensus sequence, targets a common route of HIV-1 escape. In combination, 45-46m2 and 45-46m7 reduce the possible routes for the evolution of fit viral escape mutants in HIV-1_(YU-2)–infected humanized mice, with viremic control exhibited when a third antibody, 10–1074, was added to the combination

Measuring the predictability of life outcomes with a scientific mass collaboration.

How predictable are life trajectories? We investigated this question with a scientific mass collaboration using the common task method; 160 teams built predictive models for six life outcomes using data from the Fragile Families and Child Wellbeing Study, a high-quality birth cohort study. Despite using a rich dataset and applying machine-learning methods optimized for prediction, the best predictions were not very accurate and were only slightly better than those from a simple benchmark model. Within each outcome, prediction error was strongly associated with the family being predicted and weakly associated with the technique used to generate the prediction. Overall, these results suggest practical limits to the predictability of life outcomes in some settings and illustrate the value of mass collaborations in the social sciences

G-quadruplex organic frameworks

Two-dimensional covalent organic frameworks often π stack into crystalline solids that allow precise spatial positioning of molecular building blocks. Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-assembly of naphthalene diimide and perylene diimide electron acceptors end-capped with two guanine electron donors into crystalline G-quadruplex-based organic frameworks, wherein the electron donors and acceptors form ordered, segregated π-stacked arrays. Time-resolved optical and electron paramagnetic resonance spectroscopies show that photogenerated holes and electrons in the frameworks have long lifetimes and display recombination kinetics typical of dissociated charge carriers. Moreover, the reduced acceptors form polarons in which the electron is shared over several molecules. The G-quadruplex frameworks also demonstrate potential as cathode materials in Li-ion batteries because of the favourable electron- and Li-ion-transporting capacity provided by the ordered rylene diimide arrays and G-quadruplex structures, respectively

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Peer reviewe

Divine Name Verification: An Essay on Anti-Darwinism, Intelligent Design, and the Computational Nature of Reality

In this book, Noah Horwitz argues that the age of Darwinism is ending. Building on the ontological insights of his first book Reality in the Name of God in order to intervene into the intelligent design versus evolution debate, Horwitz argues in favor of intelligent design by attempting to demonstrate the essentially computational nature of reality. In doing so, Horwitz draws on the work of many of today’s key computational theorists (e.g., Wolfram, Chaitin, Friedkin, Lloyd, Schmidhuber, etc.) and articulates and defends a computational definition of life, and in the process lays out key criticisms of Darwinism. He does so in part by incorporating the insights of the Lamarckian theories of Lynn Margulis and Maximo Sandin. The possible criticisms of a computationalist view from both a developmental perspective (e.g., Lewontin, Jablonka, West-Eberhard, etc.) and chaos theory (e.g., Brian Goodwin) are addressed. In doing so, Horwitz engages critically with the work of intelligent design theorists like William Dembksi. At the same time, he attempts to define the nature of the Speculative Realist turn in contemporary Continental Philosophy and articulates criticisms of leading figures and movements associated with it, such as Object-Oriented Ontology, Quentin Meillassoux, and Ray Brassier. Ultimately, Horwitz attempts to show that rather than heading towards heat death, existence itself will find its own apotheosis at the Omega Point. However, that final glorification is only possible given that all of reality is compressible into the divine name itself

Reality in the Name of God, or, Divine Insistence: An Essay on Creation, Infinity, and the Ontological Implications of Kabbalah

What should philosophical theology look like after the critique of Onto-theology, after Phenomenology, and in the age of Speculative Realism? What does Kabbalah have to say to Philosophy? Since Kant and especially since Husserl, philosophy has only permitted itself to speak about how one relates to God in terms of the intentionality of consciousness and not of how God is in himself. This meant that one could only ever speak to God as an addressed and yearned-for holy Thou, but not to God as infinite creator of all. In this book-length essay, the author argues that reality itself is made up of the Holy Name of God. Drawing upon the set-theoretical ontology of Alain Badiou, the computational theory of Stephen Wolfram, the physics of Frank Tipler, the psychoanalytical theory of Jacques Lacan, and the genius of Georg Cantor, the author works to demonstrate that the universe is a computer processing the divine Name and that all existence is made of information (the bit). As a result of this ontic pan-computationalism, it is shown that the future resurrection of the dead can take place and how it may in fact occur. Along the way, the book also offers compelling critiques of several significant theories of reality, including the phenomenological theologies of Emmanuel Levinas and Jean-Luc Marion, Process Theology, and Object-Oriented Ontology

Divine Name Verification: An Essay on Anti-Darwinism, Intelligent Design, and the Computational Nature of Reality

In this book, Noah Horwitz argues that the age of Darwinism is ending. Building on the ontological insights of his first book Reality in the Name of God in order to intervene into the intelligent design versus evolution debate, Horwitz argues in favor of intelligent design by attempting to demonstrate the essentially computational nature of reality. In doing so, Horwitz draws on the work of many of today’s key computational theorists (e.g., Wolfram, Chaitin, Friedkin, Lloyd, Schmidhuber, etc.) and articulates and defends a computational definition of life, and in the process lays out key criticisms of Darwinism. He does so in part by incorporating the insights of the Lamarckian theories of Lynn Margulis and Maximo Sandin. The possible criticisms of a computationalist view from both a developmental perspective (e.g., Lewontin, Jablonka, West-Eberhard, etc.) and chaos theory (e.g., Brian Goodwin) are addressed. In doing so, Horwitz engages critically with the work of intelligent design theorists like William Dembksi. At the same time, he attempts to define the nature of the Speculative Realist turn in contemporary Continental Philosophy and articulates criticisms of leading figures and movements associated with it, such as Object-Oriented Ontology, Quentin Meillassoux, and Ray Brassier. Ultimately, Horwitz attempts to show that rather than heading towards heat death, existence itself will find its own apotheosis at the Omega Point. However, that final glorification is only possible given that all of reality is compressible into the divine name itself