2,733 research outputs found
Evaluation of the possibility of obtaining welded joints of plates from Al-Mg-Mn aluminum alloys, strengthened by the introduction of TiB2 particles
In the work, the possibility of obtaining strong welded joints of aluminum alloys modified with particles is demonstrated. For research, strengthened aluminum alloys of the Al-Mg-Mn system with the introduction of TiB2 particles were obtained. TiB2 particles in specially prepared Al-TiB master alloys obtained by self-propagating high-temperature synthesis were introduced ex situ into the melt according to an original technique using ultrasonic treatment. Plates from the studied cast alloys were butt-welded by one-sided welded joints of various depths. To obtain welded joints, the method of electron beam welding was used. Mechanical properties of the studied alloys and their welded joints under tension were studied. It was shown that the introduction of particles resulted in a change in the internal structure of the alloys, characterized by the formation of compact dendritic structures and a decrease in the average grain size from 155 to 95 ”m. The change in the internal structure due to the introduction of particles led to an increase in the tensile strength of the obtained alloys from 163 to 204 MPa. It was found that the obtained joints have sufficient relative strength values. Relative strength values reach 0.9 of the nominal strength of materials already at the ratio of the welded joint depth to the thickness of the welded plates, equal to 0.6 for the initial alloy and in the range of 0.67â0.8 for strengthened alloys
Phase composition, structure and properties of the spark plasma sintered ceramics obtained from the Al12Mg17-B-Si powder mixtures
In this work, composite materials were obtained by spark plasma sintering of an Al12Mg17-B-Si powder mixture. The structure, phase composition, and mechanical properties of the obtained composites were studied. It was found that various compounds based on B12 icosahedrons, such as AlB12, B4Si, and B6Si, are formed during spark plasma sintering. Based on the SEM images and results of XRD analysis of the obtained specimens, a probable scheme for the formation of the phase composition of composite materials during spark plasma sintering was proposed. An increase in the Al12Mg17-B powder content in the initial mixture from 30 to 70 wt% leads to an increase in hardness from 16.55 to 21.24 GPa and a decrease in the friction coefficient and wear rate from 0.56 to 0.32 and 13.60 to 5.60 10â5 mmâ3/(N/m), respectively
Study of influence of aluminum nitride nanoparticles on the structure, phase composition and mechanical properties of AZ91 alloy
In this work, magnesium-based composites were obtained by shock-wave compaction of a powder mixture of Mg-5 wt.% AlN at a shock-wave pressure of 2 GPa. Their microstructure was investigated and the phase composition was determined, from which it follows that the nanoparticles retain their phase composition and are uniformly distributed in the magnesium matrix. The materials obtained by shock-wave compaction were used as master alloys for the production of magnesium alloys by die casting. The amount of aluminum nitride nanoparticles in the AZ91 magnesium alloy was 0.5 wt.%. Studies of the microstructure of the magnesium alloys showed a decrease in the average grain size of the magnesium matrix from 610 to 420 m. Studies of mechanical properties have shown that the introduction of aluminum nitride nanoparticles increases the yield strength from 55 to 119 MPa, the tensile strength from 122 to 171 MPa and the plasticity from 4 to 6.5%, respectively. The effect of nanoparticles on the fracture behavior of the magnesium alloy under tension was determine
Pro-neural transcription factors as cancer markers.
BACKGROUND: The aberrant transcription in cancer of genes normally associated with embryonic tissue differentiation at various organ sites may be a hallmark of tumour progression. For example, neuroendocrine differentiation is found more commonly in cancers destined to progress, including prostate and lung. We sought to identify proteins which are involved in neuroendocrine differentiation and differentially expressed in aggressive/metastatic tumours. RESULTS: Expression arrays were used to identify up-regulated transcripts in a neuroendocrine (NE) transgenic mouse model of prostate cancer. Amongst these were several genes normally expressed in neural tissues, including the pro-neural transcription factors Ascl1 and Hes6. Using quantitative RT-PCR and immuno-histochemistry we showed that these same genes were highly expressed in castrate resistant, metastatic LNCaP cell-lines. Finally we performed a meta-analysis on expression array datasets from human clinical material. The expression of these pro-neural transcripts effectively segregates metastatic from localised prostate cancer and benign tissue as well as sub-clustering a variety of other human cancers. CONCLUSION: By focussing on transcription factors known to drive normal tissue development and comparing expression signatures for normal and malignant mouse tissues we have identified two transcription factors, Ascl1 and Hes6, which appear effective markers for an aggressive phenotype in all prostate models and tissues examined. We suggest that the aberrant initiation of differentiation programs may confer a selective advantage on cells in all contexts and this approach to identify biomarkers therefore has the potential to uncover proteins equally applicable to pre-clinical and clinical cancer biology.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are
ĐĐœĐ°Đ»ĐžĐ· ĐșĐ»ŃŃĐ”ĐČŃŃ ĐœĐ°ĐżŃĐ°ĐČĐ»Đ”ĐœĐžĐč ĐœĐžĐ·ĐșĐŸŃглДŃĐŸĐŽĐœĐŸĐč ŃŃĐ°ĐœŃŃĐŸŃĐŒĐ°ŃОО ŃĐșĐŸĐœĐŸĐŒĐžĐșĐž ĐĐŸŃĐșĐČŃ ĐœĐ° пДŃĐžĐŸĐŽ ĐŽĐŸ 2035 ĐłĐŸĐŽĐ°
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ŃĐ”ĐżĐ»ĐŸĐČŃŃ
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, Đ° ŃĐ°ĐșжД ĐČ ŃŃĐ”ŃĐ” ŃĐ°ĐșŃĐž, ĐșĐ°ŃŃĐ”ŃĐžĐœĐłĐ°, ĐŽĐŸŃŃĐ°ĐČĐșĐž, ĐșĐŸĐŒĐŒĐ”ŃŃĐ”ŃĐșĐžŃ
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ŃŃŃĐ”ĐșŃĐžĐČĐœŃŃ
ĐłĐ”ĐœĐ”ŃĐžŃŃŃŃĐžŃ
ĐŒĐŸŃĐœĐŸŃŃĐ”Đč Đž Đ·Đ°ĐșŃĐżĐșĐ° ĐœĐ”ĐŽĐŸŃŃĐ°ŃŃĐžŃ
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ĐłĐŸŃĐŸĐŽŃĐșĐžŃ
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ĐŃĐžĐœŃŃОД ŃДЎДŃĐ°Đ»ŃĐœĐŸĐč ĐĄŃŃĐ°ŃДгОО ŃĐŸŃОалŃĐœĐŸ-ŃĐșĐŸĐœĐŸĐŒĐžŃĐ”ŃĐșĐŸĐłĐŸ ŃĐ°Đ·ĐČĐžŃĐžŃ Đ ĐŸŃŃĐžĐčŃĐșĐŸĐč ЀДЎДŃĐ°ŃОО Ń ĐœĐžĐ·ĐșĐžĐŒ ŃŃĐŸĐČĐœĐ”ĐŒ ĐČŃбŃĐŸŃĐŸĐČ ĐżĐ°ŃĐœĐžĐșĐŸĐČŃŃ
ĐłĐ°Đ·ĐŸĐČ ĐŽĐŸ 2050 ĐłĐŸĐŽĐ° ĐŸĐżŃДЎДлŃĐ”Ń ĐœĐ”ĐŸĐ±Ń
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Đž ĐœĐ°ĐžĐ±ĐŸĐ»Đ”Đ” ŃŃŃĐ”ĐșŃĐžĐČĐœŃŃ
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ŃĐŒĐžŃŃĐžĐč паŃĐœĐžĐșĐŸĐČŃŃ
ĐłĐ°Đ·ĐŸĐČ, ĐŸĐ±ŃŃĐ»ĐŸĐČĐ»Đ”ĐœĐœŃŃ
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ĐłĐŸŃĐŸĐŽŃĐșĐžŃ
ĐżŃĐŸĐłŃĐ°ĐŒĐŒ, ŃŃ
Đ”ĐŒ ŃĐ°Đ·ĐČĐžŃĐžŃ Đž ĐžĐœĐČĐ”ŃŃĐžŃĐžĐŸĐœĐœŃŃ
ĐżŃĐŸĐ”ĐșŃĐŸĐČ. РДзŃĐ»ŃŃĐ°ŃŃ Đž ĐČŃĐČĐŸĐŽŃ ŃŃĐ°ŃŃĐž ĐŒĐŸĐłŃŃ Đ±ŃŃŃ ĐżĐŸĐ»Đ”Đ·ĐœŃ ĐżŃĐž ŃĐ°Đ·ŃĐ°Đ±ĐŸŃĐșĐ” ĐŽĐŸĐșŃĐŒĐ”ĐœŃĐŸĐČ ŃŃŃĐ°ŃДгОŃĐ”ŃĐșĐŸĐłĐŸ ĐżĐ»Đ°ĐœĐžŃĐŸĐČĐ°ĐœĐžŃ ĐłĐŸŃĐŸĐŽĐ° ĐĐŸŃĐșĐČŃ
Differential branching fraction and angular analysis of the decay B0âKâ0ÎŒ+ÎŒâ
The angular distribution and differential branching fraction of the decay B 0â K â0 ÎŒ + ÎŒ â are studied using a data sample, collected by the LHCb experiment in pp collisions at sâ=7 TeV, corresponding to an integrated luminosity of 1.0 fbâ1. Several angular observables are measured in bins of the dimuon invariant mass squared, q 2. A first measurement of the zero-crossing point of the forward-backward asymmetry of the dimuon system is also presented. The zero-crossing point is measured to be q20=4.9±0.9GeV2/c4 , where the uncertainty is the sum of statistical and systematic uncertainties. The results are consistent with the Standard Model predictions
Opposite-side flavour tagging of B mesons at the LHCb experiment
The calibration and performance of the oppositeside
flavour tagging algorithms used for the measurements
of time-dependent asymmetries at the LHCb experiment
are described. The algorithms have been developed using
simulated events and optimized and calibrated with
B
+ âJ/ÏK
+, B0 âJ/ÏK
â0 and B0 âD
ââ
Ό
+
ΜΌ decay
modes with 0.37 fbâ1 of data collected in pp collisions
at
â
s = 7 TeV during the 2011 physics run. The oppositeside
tagging power is determined in the B
+ â J/ÏK
+
channel to be (2.10 ± 0.08 ± 0.24) %, where the first uncertainty
is statistical and the second is systematic
Measurement of the branching fraction
The branching fraction is measured in a data sample
corresponding to 0.41 of integrated luminosity collected with the LHCb
detector at the LHC. This channel is sensitive to the penguin contributions
affecting the sin2 measurement from The
time-integrated branching fraction is measured to be . This is the most precise measurement to
date
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