Multi-RAT enhanced Private Wireless Networks with Intent-Based Network Management Automation

Private wireless networks have become essential enablers for network use cases in enterprises. Emerging enterprise applications push private networks to be more complex in terms of operation and management. However, current private network managers are contending with the challenge of finding a strategy for a network solution that adequately fulfils the service Key Performance Indicators (KPIs) for the growing innovative applications, which are increasingly uplink hungry. They also confront the need to optimise the management of networks without the cost implications associated with hiring onsite experts. In addressing these two key challenges, we demonstrate a multi-connectivity framework that utilises multi-radio access technologies, namely 5GNR, WiFi-6, and LiFi, to enhance private 5G network capacity with intent-based network automation in a museum. Our framework employs MP-TCP link aggregation strategy that combines multiple network connections to ensure a minimum throughput capacity to meet the maximum uplink requirement for a smart tourism pilot use case.As a management enabler, we simplify network service deployment by using an intent-based platform with a Natural Language Processing (NLP) interface. Integrating multi-connectivity and intent-based networking in a private 5G network provides significant advantages for advancing future-generation wireless private networks in research and innovation

The UK Programmable Fixed and Mobile Internet Infrastructure:Overview, capabilities and use cases deployment

Leading state-of-the-art research facilities at the Universities of Edinburgh (UoE), Bristol (UoB), Lancaster (UoLan), King's College London (KCL) and Digital Catapult (DCAT) are interconnected through a dedicated JISC/JANET network infrastructure. Using Software Defined Networking (SDN) and Network Function Virtualisation (NFV) technologies, these distributed test-beds are integrated using a multi-domain NFV Orchestrator. This paper introduces a novel specialist distributed test-bed developed for facilitating the increasingly large and complex experimentation of future Internet system architectures, technologies, services and applications between the geographically dispersed laboratories across the UK. The aim is to enable students, researchers and enterprises to interconnect with and carry out remote experiments using these test-beds. Each one contributes a range of key capabilities for Internet research including optical networks, optical wireless and radio frequency communications, Internet of Things (IoT), SDN, NFV, as well as cloud computing technologies and services

Kaempferol: A potential agent in the prevention of colorectal cancer

Abstract Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and mortality rate and its incidence is considerably increasing annually due to the change in the dietary habit and lifestyle of the world population. Although conventional therapeutic options, such as surgery, chemo‐ and radiotherapy have profound impacts on the treatment of CRC, dietary therapeutic agents, particularly natural products have been regarded as the safest alternatives for the treatment of CRC. Kaempferol (KMP), a naturally derived flavonol, has been shown to reduce the production of reactive oxygen species (ROS), such as superoxide ions, hydroxyl radicals, and reactive nitrogen species (RNS), especially peroxynitrite. Furthermore, this flavonol inhibits xanthine oxidase (XO) activity and increases the activities of catalase, heme oxygenase‐1 (HO), and superoxide dismutase (SOD) in a wide range of cancer and non‐cancer cells. Based on several studies, KMP is also a hopeful anticancer which carries out its anticancer action via suppression of angiogenesis, stimulation of apoptosis, and cell cycle arrest. Due to various applications of KMP as an anticancer flavonol, this review article aims to highlight the current knowledge regarding the role of KMP in CRC

N1-Methylnicotinamide : Is It Time to Consider as a Dietary Supplement for Athletes?

Exercise is considered to be a "medicine" due to its modulatory roles in metabolic disorders such as diabetes and obesity. The intensity and duration of exercise determine the mechanism of energy production by various tissues of the body, especially by muscles, in which the requirement for adenosine triphosphate (ATP) increases by as much as 100-fold. Naturally, athletes try to improve their exercise performance by dietary supplementation with, e.g., vitamins, metabolites, and amino acids. MNAM, as a vitamin B3 metabolite, reduces serum levels and liver contents of triglycerides, and cholesterol and induces lipolysis. It stimulates gluconeogenesis and prohibits liver cholesterol and fatty acid synthesis through the expression of sirtuin1 (SIRT1). It seems that MNAM is not responsible for the actions of NNMT in the adipose tissues as MNAM inhibits the activity of NNMT in the adipose tissue and acts like inhibitors of its activity. NNMT-MNAM axis is more activated in the muscles of participants who were undergoing the high-volume-low-intensity exercise and caloric restriction. Therefore, MNAM could be an important myokine during exercise and fasting where it provides the required energy for muscles through the induction of lipolysis and gluconeogenesis in the liver and adipose tissues, respectively. Increased levels of MNAM in exercise and fasting led us to propose that the consumption of MNAM during training especially endurance training could boost exercise capacity and improves performance. Therefore, in this review, we shed light on the potential of MNAM as a dietary supplement in sports medicine