Posttraumatic stress disorders in the Nanai after pollution of the Amur River: ethnocultural analysis

13301甲第4000号博士（医学）金沢大学博士論文本文Full 以下に掲載：Environ Health Prev Med 18(6) pp.485-493 2013. Springer Japan. 共著者：Natalia Korshunova, Hironobu Katsuyama, Masashi Demura, Hideji Tanii, Midori Katsuyama, Sri Ratna Rahayu, Nikolay Anatoljevich Bogdanov, Lyudmila Vasilyevna Solokhina, Kiyofumi Saijo

Dissecting selective signatures and candidate genes in grandparent lines subject to high selection pressure for broiler production and in a local Russian chicken breed of Ushanka

Breeding improvements and quantitative trait genetics are essential to the advancement of broiler production. The impact of artificial selection on genomic architecture and the genetic markers sought remains a key area of research. Here, we used whole-genome resequencing data to analyze the genomic architecture, diversity, and selective sweeps in Cornish White (CRW) and Plymouth Rock White (PRW) transboundary breeds selected for meat production and, comparatively, in an aboriginal Russian breed of Ushanka (USH). Reads were aligned to the reference genome bGalGal1.mat.broiler.GRCg7b and filtered to remove PCR duplicates and low-quality reads using BWA-MEM2 and bcftools software; 12,563,892 SNPs were produced for subsequent analyses. Compared to CRW and PRW, USH had a lower diversity and a higher genetic distinctiveness. Selective sweep regions and corresponding candidate genes were examined based on ZFST, hapFLK, and ROH assessment procedures. Twenty-seven prioritized chicken genes and the functional projection from human homologs suggest their importance for selection signals in the studied breeds. These genes have a functional relationship with such trait categories as body weight, muscles, fat metabolism and deposition, reproduction, etc., mainly aligned with the QTLs in the sweep regions. This information is pivotal for further executing genomic selection to enhance phenotypic traits

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

State of the climate in 2018

In 2018, the dominant greenhouse gases released into Earth’s atmosphere—carbon dioxide, methane, and nitrous oxide—continued their increase. The annual global average carbon dioxide concentration at Earth’s surface was 407.4 ± 0.1 ppm, the highest in the modern instrumental record and in ice core records dating back 800 000 years. Combined, greenhouse gases and several halogenated gases contribute just over 3 W m−2 to radiative forcing and represent a nearly 43% increase since 1990. Carbon dioxide is responsible for about 65% of this radiative forcing. With a weak La Niña in early 2018 transitioning to a weak El Niño by the year’s end, the global surface (land and ocean) temperature was the fourth highest on record, with only 2015 through 2017 being warmer. Several European countries reported record high annual temperatures. There were also more high, and fewer low, temperature extremes than in nearly all of the 68-year extremes record. Madagascar recorded a record daily temperature of 40.5°C in Morondava in March, while South Korea set its record high of 41.0°C in August in Hongcheon. Nawabshah, Pakistan, recorded its highest temperature of 50.2°C, which may be a new daily world record for April. Globally, the annual lower troposphere temperature was third to seventh highest, depending on the dataset analyzed. The lower stratospheric temperature was approximately fifth lowest. The 2018 Arctic land surface temperature was 1.2°C above the 1981–2010 average, tying for third highest in the 118-year record, following 2016 and 2017. June’s Arctic snow cover extent was almost half of what it was 35 years ago. Across Greenland, however, regional summer temperatures were generally below or near average. Additionally, a satellite survey of 47 glaciers in Greenland indicated a net increase in area for the first time since records began in 1999. Increasing permafrost temperatures were reported at most observation sites in the Arctic, with the overall increase of 0.1°–0.2°C between 2017 and 2018 being comparable to the highest rate of warming ever observed in the region. On 17 March, Arctic sea ice extent marked the second smallest annual maximum in the 38-year record, larger than only 2017. The minimum extent in 2018 was reached on 19 September and again on 23 September, tying 2008 and 2010 for the sixth lowest extent on record. The 23 September date tied 1997 as the latest sea ice minimum date on record. First-year ice now dominates the ice cover, comprising 77% of the March 2018 ice pack compared to 55% during the 1980s. Because thinner, younger ice is more vulnerable to melting out in summer, this shift in sea ice age has contributed to the decreasing trend in minimum ice extent. Regionally, Bering Sea ice extent was at record lows for almost the entire 2017/18 ice season. For the Antarctic continent as a whole, 2018 was warmer than average. On the highest points of the Antarctic Plateau, the automatic weather station Relay (74°S) broke or tied six monthly temperature records throughout the year, with August breaking its record by nearly 8°C. However, cool conditions in the western Bellingshausen Sea and Amundsen Sea sector contributed to a low melt season overall for 2017/18. High SSTs contributed to low summer sea ice extent in the Ross and Weddell Seas in 2018, underpinning the second lowest Antarctic summer minimum sea ice extent on record. Despite conducive conditions for its formation, the ozone hole at its maximum extent in September was near the 2000–18 mean, likely due to an ongoing slow decline in stratospheric chlorine monoxide concentration. Across the oceans, globally averaged SST decreased slightly since the record El Niño year of 2016 but was still far above the climatological mean. On average, SST is increasing at a rate of 0.10° ± 0.01°C decade−1 since 1950. The warming appeared largest in the tropical Indian Ocean and smallest in the North Pacific. The deeper ocean continues to warm year after year. For the seventh consecutive year, global annual mean sea level became the highest in the 26-year record, rising to 81 mm above the 1993 average. As anticipated in a warming climate, the hydrological cycle over the ocean is accelerating: dry regions are becoming drier and wet regions rainier. Closer to the equator, 95 named tropical storms were observed during 2018, well above the 1981–2010 average of 82. Eleven tropical cyclones reached Saffir–Simpson scale Category 5 intensity. North Atlantic Major Hurricane Michael’s landfall intensity of 140 kt was the fourth strongest for any continental U.S. hurricane landfall in the 168-year record. Michael caused more than 30 fatalities and $25 billion (U.S. dollars) in damages. In the western North Pacific, Super Typhoon Mangkhut led to 160 fatalities and$6 billion (U.S. dollars) in damages across the Philippines, Hong Kong, Macau, mainland China, Guam, and the Northern Mariana Islands. Tropical Storm Son-Tinh was responsible for 170 fatalities in Vietnam and Laos. Nearly all the islands of Micronesia experienced at least moderate impacts from various tropical cyclones. Across land, many areas around the globe received copious precipitation, notable at different time scales. Rodrigues and Réunion Island near southern Africa each reported their third wettest year on record. In Hawaii, 1262 mm precipitation at Waipā Gardens (Kauai) on 14–15 April set a new U.S. record for 24-h precipitation. In Brazil, the city of Belo Horizonte received nearly 75 mm of rain in just 20 minutes, nearly half its monthly average. Globally, fire activity during 2018 was the lowest since the start of the record in 1997, with a combined burned area of about 500 million hectares. This reinforced the long-term downward trend in fire emissions driven by changes in land use in frequently burning savannas. However, wildfires burned 3.5 million hectares across the United States, well above the 2000–10 average of 2.7 million hectares. Combined, U.S. wildfire damages for the 2017 and 2018 wildfire seasons exceeded $40 billion (U.S. dollars)

The role of energy audit in energy management system

The relevance of the discussed issue is caused by the need to achieve the strategic state and society goal to increase the gross domestic product (GDP) in a few times and reduce its power consumption. It will allow Russia to join the ranks of developed countries, and not to be their raw materials appendage. This problem can only be solved by converting the Russian economy on energy saving technologies and improving the energy efficiency of fuel and energy resources, since the economic development by increasing oil and gas production has exhausted itself, and makes no significant GDP growth. The main aim of the study is to show the importance of an energy audit for effective management of energy saving at all stages of energy production, transmission, transformation, distribution and consumption. The methods used in the study: analysis of fulfillment of energy saving laws and regulations and problems preventing one of the wealthiest countries in the world in reserves and production of fuel and energy resources to join the ranks of highly developed countries. The results. The authors examined the contents of the main functions of energy management: planning, organization, motivation and control, as well as the types and content of an energy audit. It is shown that only with the help of in-depth energy audit, forming a bank of objective data about the energy flows, it is possible to realize the functions of energy management; calculate fuel and energy balances of equipment, company, region, country, allowing reliable and continuous supply of fuel and energy resources of the enterprise and regions. Critical analysis of the energy balance allows setting the objective rates of fuel and energy resources consumption, extraction and production, assessing possible energy saving potential in the implementation of various energy saving activities, and making a real energy saving program. Thus, the study concluded that it is impossible to manage effectively the energy efficiency in the country and to reduce the energy intensity of GDP without a comprehensive reliable energy audit in the production and consumption of energy resources, as well as without using all levers of power management

The role of energy audit in energy management system

The relevance of the discussed issue is caused by the need to achieve the strategic state and society goal to increase the gross domestic product (GDP) in a few times and reduce its power consumption. It will allow Russia to join the ranks of developed countries, and not to be their raw materials appendage. This problem can only be solved by converting the Russian economy on energy saving technologies and improving the energy efficiency of fuel and energy resources, since the economic development by increasing oil and gas production has exhausted itself, and makes no significant GDP growth. The main aim of the study is to show the importance of an energy audit for effective management of energy saving at all stages of energy production, transmission, transformation, distribution and consumption. The methods used in the study: analysis of fulfillment of energy saving laws and regulations and problems preventing one of the wealthiest countries in the world in reserves and production of fuel and energy resources to join the ranks of highly developed countries. The results. The authors examined the contents of the main functions of energy management: planning, organization, motivation and control, as well as the types and content of an energy audit. It is shown that only with the help of in-depth energy audit, forming a bank of objective data about the energy flows, it is possible to realize the functions of energy management; calculate fuel and energy balances of equipment, company, region, country, allowing reliable and continuous supply of fuel and energy resources of the enterprise and regions. Critical analysis of the energy balance allows setting the objective rates of fuel and energy resources consumption, extraction and production, assessing possible energy saving potential in the implementation of various energy saving activities, and making a real energy saving program. Thus, the study concluded that it is impossible to manage effectively the energy efficiency in the country and to reduce the energy intensity of GDP without a comprehensive reliable energy audit in the production and consumption of energy resources, as well as without using all levers of power management

Fermentation of an oat drink enriched with sunflower root inulin

The use of secondary raw materials to obtain useful products is a relevant direction of research. So sunflower root remains in large quantities after harvesting sunflower. For example, in 2021, after harvesting sunflower, about 67 million tons of dry organic residues of this plant remained in the fields. The possibility to use sunflower roots for inulin production is interesting, so earlier sunflower roots were examined for the presence of inulin in it. Studies have shown that up to 10% of inulin can be found in sunflower roots. Inulin is a dietary fiber and a prebiotic and has a beneficial effect on the microbiome of the gastrointestinal tract. The development of fermented oat drinks will provide a combination of the functional properties of probiotic cultures with the prebiotic properties of inulin from sunflower root. In this article, two technological schemes for the production of a functional oat drink containing inulin extract from sunflower root are investigated. For the fermentation of the drink, lactic acid bacteria of the species Lactobacillus acidophilus were chosen. Several variants of beverage formulations were investigated. The dynamics of changes in the content of inulin during fermentation for 24 hours is presented

Development of Novel Tetrapyrrole Structure Photosensitizers for Cancer Photodynamic Therapy

The effectiveness of photodynamic therapy (PDT) is based on the triad effects of photosensitizer (PS), molecular oxygen and visible light on malignant tumors. Such complex induces a multifactorial manner including reactive-oxygen-species-mediated damage and the killing of cells, vasculature damage of the tumor, and activation of the organism immunity. The effectiveness of PDT depends on the properties of photosensitizing drugs, their selectivity, enhanced photoproduction of reactive particles, absorption in the near infrared spectrum, and drug delivery strategies. Photosensitizers of the tetrapyrrole structure (porphyrins) are widely used in PDT because of their unique diagnostic and therapeutic functions. Nevertheless, the clinical use of the first-generation PS (sodium porfimer and hematoporphyrins) revealed difficulties, such as long-term skin photosensitivity, insufficient penetration into deep-seated tumors and incorrect localization to it. The second generation is based on different approaches of the synthesis and conjugation of porphyrin PS with biomolecules, which made it possible to approach the targeted PDT of tumors. Despite the fact that the development of the second-generation PS started about 30 years ago, these technologies are still in demand and are in intensive development, especially in the direction of improving the process of optimization split linkers responsive to input. Bioconjugation and encapsulation by targeting molecules are among the main strategies for developing of the PS synthesis. A targeted drug delivery system with the effect of increased permeability and retention by tumor cells is one of the ultimate goals of the synthesis of second-generation PS. This review presents porphyrin PS of various generations, discusses factors affecting cellular biodistribution and uptake, and indicates their role as diagnostic and therapeutic (theranostic) agents. New complexes based on porphyrin PS for photoimmunotherapy are presented, where specific antibodies are used that are chemically bound to PS, absorbing light from the near infrared part of the spectrum. Additionally, a two-photon photodynamic approach using third-generation photosensitizers for the treatment of tumors is discussed, which indicates the prospects for the further development of a promising method antitumor PDT