FORTRAN program for calculating compressible laminar and turbulent boundary layers in arbitrary pressure gradients

FORTRAN program for calculating compressible laminar and turbulent boundary layers in arbitrary pressure gradient

FORTRAN program for computing coordinates of circular arc single and tandem turbomachinery blade sections on a plane

FORTRAN program for computing coordinates of circular arc single and tandem turbomachinery blade sections on plan

The politics of self-help: The Rockefeller Foundation, philanthropy and the 'long' Green Revolution

While scholars of contemporary philanthropy have observed a concerted interest in the promotion of ‘self-help,’ little has been said about the political history of this investment and its significance in determining both domestic and international development priorities. We locate this modern conceptualisation of self-help in early twentieth-century philanthropic practice that sought to ‘gift’ to individuals and communities the precious habit of self-reliance and social autonomy. The Rockefeller Foundation promoted rural development projects that deliberately sought to ‘emancipate’ the tradition-bound peasant, transforming him or her into a productive, enterprising subject. We begin by documenting their early agricultural extension work, which attempted to spark agrarian change in the US South through the inculcation of modern habits and aspirations among farmers and their families. These agrarian schemes illustrate the newfound faith that ‘rural up-lift’ could only be sustained if farming communities were trained to ‘help themselves’ by investing physically and psychologically in the process of modernisation. We then locate subsequent attempts to incentivise and accelerate international agricultural development within the broader geopolitical imperatives of the Green Revolution and the Cold War. While US technical assistance undoubtedly sought to prevent political upheaval in the Third World, we argue that Rockefeller-led modernisation projects, based on insights gleaned from behavioural economics, championed a model of human capital – and the idea of ‘revolution within’ – in order to contain the threat of ‘revolution without’. Approaching agricultural development through this problematisation of the farmer reveals the ‘long history’ of the Green Revolution – unfolding from the domestic to the international and from the late nineteenth century to the present – as well as the continuing role of philanthropy in forging a new global order.A Philip Leverhulme Prize as well as Cambridge Humanities Research Grant awarded to Nally helped to support this research.This is the author accepted manuscript. The final version is available from Elsevier at http://dx.doi.org/10.1016/j.polgeo.2015.04.00

Vegetative States: Potatoes, Affordances, and Survival Ecologies

The potato has been critical to plant-human assemblages both in South America and in Europe. A study of the capacities, or affordances of this plant within diverse political economies highlights its mutability in some circumstances and vulnerability in others. The contrasts are stark. In South America, peasant agriculture took the potato across a large and diverse ecumene allowing its elaboration into many varieties and sustaining extensive state systems that taxed its production. Spanish colonialism repurposed the plant as the calorific basis for concentrations of coerced labor at silver mines. Back in Europe it was initially the resistance of the potato to state violence that encouraged peasants to turn over their fields to tuberous plant that ‘concealed’ its food underground. But its calorific productivity per acre again saw it repurposed as peasants were converted to proletarians, allowed to subsist on only the smallest plots while working for landlords on larger estates

Against food security: On forms of care and fields of violence

This paper addresses recent changes to the policy landscape on global food security. It argues that a new consensus is emerging on how to tackle (or more hubristically ‘end’) global hunger and spur agricultural development. The consensus I speak of is evident in recent briefings by the World Economic Forum (especially its ‘New Vision for Agriculture’), the ‘New Alliance for Food Security and Nutrition,’ initiated by the G-8 (now G-7), the Grow Africa network, the US government’s ‘Feed the Future’ programme, the philanthropy-led, Alliance for Green Revolution in Africa, not to mention the many flagship reports emanating from the International Financial Institutions as well key statements from global food retailers and leading agribusinesses. The paper argues that this ‘new vision’ for global agriculture is deeply problematic. Indeed the projected ‘solutions’ – in so far as they aim to radically transform agricultural life, especially in Africa – may well cause more harm than good. To put this argument more forcefully: what today is commonly called ‘food security’ is perhaps better seen as a way of subjugating the poor under the pretence of doing them good.I wish to acknowledge the generous support provided by a Philip Leverhulme Prize which enabled me to complete the research presented in this paper.This is the author accepted manuscript. The final version is available from Taylor & Francis via http://dx.doi.org/10.1080/13600826.2016.115870

“When You Move You Have Fun”: Perceived Barriers, and Facilitators of Physical Activity From a Child's Perspective

In Northern Ireland (NI), many children do not meet the recommended levels of physical activity (PA). To reduce the prevalence of physical inactivity and associated health conditions, it is important to understand the influences on children's PA, which in turn has the potential to inform future intervention design. The purpose of this formative study was to examine the current views, barriers, facilitators, experiences, and perceptions of children in relation to PA in the classroom, school, and home environments, and to assess the acceptability of components for a school-based intervention. Write and draw tasks and semi-structured focus groups (n = 10) were conducted with 50 children aged 7–9 years (22 boys, 28 girls) from six primary schools. Focus groups were recorded, transcribed, and analyzed thematically. Pen profiles were constructed from the transcripts in a deductive manner and represent key emergent themes. Results indicated that children's perception and knowledge of PA was mainly structured and sport-based, while some referred to fun, play and health. Fun, social support and outdoor activity were identified as key facilitators. Barriers included parental restrictions, lack of time and space in the different environments. The acceptability of intervention components was examined, children recognized the potential benefits of additional movement in the classroom, but opinions differed on the sit-to-stand desks. Findings contribute to a more detailed understanding of children's perceptions of context specific PA, the barriers they face, in addition to factors that support them to lead a physically active lifestyle, which may inform future PA promotion strategies

The identification of informative genes from multiple datasets with increasing complexity

Background In microarray data analysis, factors such as data quality, biological variation, and the increasingly multi-layered nature of more complex biological systems complicates the modelling of regulatory networks that can represent and capture the interactions among genes. We believe that the use of multiple datasets derived from related biological systems leads to more robust models. Therefore, we developed a novel framework for modelling regulatory networks that involves training and evaluation on independent datasets. Our approach includes the following steps: (1) ordering the datasets based on their level of noise and informativeness; (2) selection of a Bayesian classifier with an appropriate level of complexity by evaluation of predictive performance on independent data sets; (3) comparing the different gene selections and the influence of increasing the model complexity; (4) functional analysis of the informative genes. Results In this paper, we identify the most appropriate model complexity using cross-validation and independent test set validation for predicting gene expression in three published datasets related to myogenesis and muscle differentiation. Furthermore, we demonstrate that models trained on simpler datasets can be used to identify interactions among genes and select the most informative. We also show that these models can explain the myogenesis-related genes (genes of interest) significantly better than others (P < 0.004) since the improvement in their rankings is much more pronounced. Finally, after further evaluating our results on synthetic datasets, we show that our approach outperforms a concordance method by Lai et al. in identifying informative genes from multiple datasets with increasing complexity whilst additionally modelling the interaction between genes. Conclusions We show that Bayesian networks derived from simpler controlled systems have better performance than those trained on datasets from more complex biological systems. Further, we present that highly predictive and consistent genes, from the pool of differentially expressed genes, across independent datasets are more likely to be fundamentally involved in the biological process under study. We conclude that networks trained on simpler controlled systems, such as in vitro experiments, can be used to model and capture interactions among genes in more complex datasets, such as in vivo experiments, where these interactions would otherwise be concealed by a multitude of other ongoing events

Surgical experience and identification of errors in laparoscopic cholecystectomy.

BACKGROUND: Surgical errors are acts or omissions resulting in negative consequences and/or increased operating time. This study describes surgeon-reported errors in laparoscopic cholecystectomy. METHODS: Intraoperative videos were uploaded and annotated on Touch SurgeryTM Enterprise. Participants evaluated videos for severity using a 10-point intraoperative cholecystitis grading score, and errors using Observational Clinical Human Reliability Assessment, which includes skill, consequence, and mechanism classifications. RESULTS: Nine videos were assessed by 8 participants (3 junior (specialist trainee (ST) 3-5), 2 senior trainees (ST6-8), and 3 consultants). Participants identified 550 errors. Positive relationships were seen between total operating time and error count (r2 = 0.284, P < 0.001), intraoperative grade score and error count (r2 = 0.578, P = 0.001), and intraoperative grade score and total operating time (r2 = 0.157, P < 0.001). Error counts differed significantly across intraoperative phases (H(6) = 47.06, P < 0.001), most frequently at dissection of the hepatocystic triangle (total 282; median 33.5 (i.q.r. 23.5-47.8, range 15-63)), ligation/division of cystic structures (total 124; median 13.5 (i.q.r. 12-19.3, range 10-26)), and gallbladder dissection (total 117; median 14.5 (i.q.r. 10.3-18.8, range 6-26)). There were no significant differences in error counts between juniors, seniors, and consultants (H(2) = 0.03, P = 0.987). Errors were classified differently. For dissection of the hepatocystic triangle, thermal injuries (50 in total) were frequently classified as executional, consequential errors; trainees classified thermal injuries as step done with excessive force, speed, depth, distance, time or rotation (29 out of 50), whereas consultants classified them as incorrect orientation (6 out of 50). For ligation/division of cystic structures, inappropriate clipping (60 errors in total), procedural errors were reported by junior trainees (6 out of 60), but not consultants. For gallbladder dissection, inappropriate dissection (20 errors in total) was reported in incorrect planes by consultants and seniors (6 out of 20), but not by juniors. Poor economy of movement (11 errors in total) was reported more by consultants (8 out of 11) than trainees (3 out of 11). CONCLUSION: This study suggests that surgical experience influences error interpretation, but the benefits for surgical training are currently unclear

Identification of gut bacteria such as Lactobacillus johnsonii that disseminate to systemic tissues of wild type and MyD88-/- mice

In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways. Nevertheless, some gut taxa have been reported to disseminate to systemic tissues. However, the extent to which this normally occurs during homeostasis in healthy organisms is still unknown. In this study, we recovered viable gut bacteria from systemic tissues of healthy wild type (WT) and MyD8