A New Equation of State Formulation for Argon Covering the Fluid Region for Temperatures From the Melting Line to 2300 K at Pressures up to 50 000 MPa

A new equation of state for argon has been developed in view to extend the range of validity of the equation of state previously proposed by Tegeler et al. (1999) and to obtain a better physical description of the experimental thermodynamic data for the whole fluid region (single-phase and coexistence states). As proposed by Tegeler et al., this equation is also based on a functional form of the residual part of the reduced Helmholtz free energy. However in this work, the fundamental equation for the Helmholtz free energy has been derived from the measured quantities CV(rho,T) and P(rho,T). The empirical description of the isochoric heat capacity CV is based on an original empirical description containing explicitly the metastable states. The new formulation is valid for the whole fluid region from the melting line to 2300 K and for pressures up to 50 000 MPa. It also predicts existence of a maximum of the isochoric heat capacity CV along isochors as experimentally observed in several other fluids

Hydrodynamic parameters of air-bubble stimulated underwater spark discharges

Considerable amount of research work has been focused on investigation and optimization of strong acoustic waves generated by spark discharges in water. There are several methods to achieve and to stimulate underwater spark breakdowns, including free-discharges, wire-guided and gas-bubble stimulated discharges. In the present work, air bubbles are injected into water in order to achieve spark discharges in relatively long inter-electrode gaps. This paper reports on hydrodynamic and acoustic characteristics of spark discharges stimulated by air bubbles and presents the functional relationships between the hydrodynamic and electrical parameters of such discharges, including breakdown voltage, spark plasma resistance and energy available in the discharge. A hydrodynamic analytical model has been developed and used to calculate the acoustic efficiency of the underwater spark discharges

Impulsive breakdown in water : optimisation of energy delivery for high acoustic output

The high voltage impulsive breakdown process in water is complex, with the nature of the impulsive breakdown depending upon the magnitude, polarity and rise time of the HV impulses, the water conductivity, and the electrode topology. In the case of μs and sub-μs high voltage impulses of sufficient magnitude, the breakdown develops through the formation of plasma streamers in the water. When the first streamer crosses the entire inter-electrode gap, the energy released in the breakdown channel transforms this channel into a gas/vapor cavity, which pulsates and radiates acoustic impulse(s). Optimisation of the hydrodynamic (period of cavity oscillation) and acoustic (peak magnitude of the acoustic impulse(s)) parameters is required for practical applications of these underwater spark discharges. The present paper analyses the functional behavior of the period of cavity oscillation and the peak magnitude of the acoustic impulse for spark discharges generated by self-triggered underwater discharges (free discharges), spark discharges triggered by air bubbles injected into the inter-electrode gap, and wire-guided discharges. The advantages and limitations of these methods of generation of underwater acoustic impulses by spark discharges are discussed

Improving the Price of Anarchy for Selfish Routing via Coordination Mechanisms

We reconsider the well-studied Selfish Routing game with affine latency functions. The Price of Anarchy for this class of games takes maximum value 4/3; this maximum is attained already for a simple network of two parallel links, known as Pigou's network. We improve upon the value 4/3 by means of Coordination Mechanisms. We increase the latency functions of the edges in the network, i.e., if $\ell_e(x)$ is the latency function of an edge $e$, we replace it by $\hat{\ell}_e(x)$ with $\ell_e(x) \le \hat{\ell}_e(x)$ for all $x$. Then an adversary fixes a demand rate as input. The engineered Price of Anarchy of the mechanism is defined as the worst-case ratio of the Nash social cost in the modified network over the optimal social cost in the original network. Formally, if \CM(r) denotes the cost of the worst Nash flow in the modified network for rate $r$ and \Copt(r) denotes the cost of the optimal flow in the original network for the same rate then [\ePoA = \max_{r \ge 0} \frac{\CM(r)}{\Copt(r)}.] We first exhibit a simple coordination mechanism that achieves for any network of parallel links an engineered Price of Anarchy strictly less than 4/3. For the case of two parallel links our basic mechanism gives 5/4 = 1.25. Then, for the case of two parallel links, we describe an optimal mechanism; its engineered Price of Anarchy lies between 1.191 and 1.192.Comment: 17 pages, 2 figures, preliminary version appeared at ESA 201

Atomic and molecular spectra emitted by normal liquid ⁴He excited by corona discharge

The liquid ⁴He at fixed temperature 4.2 K and different pressures up to 8 MPa was excited by corona discharge of both negative and positive polarity. Emission of He I atomic lines and He₂ molecular bands are observed. In negative corona the lines spectra show a distinct blue-shift and line-broadening, which becomes stronger with the pressure increasing. The rotational structure of molecular bands is resolved at pressures (0.1–0.2) MPa. The blue shift of the Q-branch maximum at different pressures was observed. Rotational temperature of 900 K has been estimated for the d³Σ⁺u-b³Πg molecular band. A positive corona was realized on a point anode for fewer radii of the electrode and larger voltage than in the negative corona. Electric currents in both negative and positive corona differ weakly. Spectral analysis of the radiation from the positive corona shows qualitative differences of spectral features of these discharges. The spectra observed in the positive corona have marked nonsymmetric shape. The asymmetric atomic and molecular spectra show an increased intensity of their long-length (red) wings

A Bayesian method for evaluating and discovering disease loci associations

Background: A genome-wide association study (GWAS) typically involves examining representative SNPs in individuals from some population. A GWAS data set can concern a million SNPs and may soon concern billions. Researchers investigate the association of each SNP individually with a disease, and it is becoming increasingly commonplace to also analyze multi-SNP associations. Techniques for handling so many hypotheses include the Bonferroni correction and recently developed Bayesian methods. These methods can encounter problems. Most importantly, they are not applicable to a complex multi-locus hypothesis which has several competing hypotheses rather than only a null hypothesis. A method that computes the posterior probability of complex hypotheses is a pressing need. Methodology/Findings: We introduce the Bayesian network posterior probability (BNPP) method which addresses the difficulties. The method represents the relationship between a disease and SNPs using a directed acyclic graph (DAG) model, and computes the likelihood of such models using a Bayesian network scoring criterion. The posterior probability of a hypothesis is computed based on the likelihoods of all competing hypotheses. The BNPP can not only be used to evaluate a hypothesis that has previously been discovered or suspected, but also to discover new disease loci associations. The results of experiments using simulated and real data sets are presented. Our results concerning simulated data sets indicate that the BNPP exhibits both better evaluation and discovery performance than does a p-value based method. For the real data sets, previous findings in the literature are confirmed and additional findings are found. Conclusions/Significance: We conclude that the BNPP resolves a pressing problem by providing a way to compute the posterior probability of complex multi-locus hypotheses. A researcher can use the BNPP to determine the expected utility of investigating a hypothesis further. Furthermore, we conclude that the BNPP is a promising method for discovering disease loci associations. © 2011 Jiang et al

Acoustic impulses generated by air-bubble stimulated underwater spark discharges

Considerable research efforts have been expended in investigating and optimising the emission of acoustic pressure impulses by high power spark discharges in water. Several methods are typically used to generate transient underwater spark discharges, including breakdown of water by stressing electrode(s) with HV impulses, initiation of spark discharges with thin metallic wires placed between opposite electrodes and by injecting gas bubbles into the inter-electrode gap. This paper is aimed at the investigation of the acoustic, hydrodynamic and electrical characteristics of underwater spark discharges initiated by injected air-bubbles. At a constant applied voltage, the injection of air bubbles allows the inter-electrode gap to be increased thus producing stronger acoustic impulses. This paper reports on the impact of injected air bubbles on the characteristics of transient underwater plasma discharges and on the functional relationships between hydrodynamic and electrical parameters of such discharges, including breakdown voltage, plasma resistance, energy delivered into the plasma cavity and the period of gas/plasma cavity oscillation. An analytical model which relates the acoustic efficiency, plasma resistance and energy available in discharge has been developed which can be used for the optimisation and tailoring of underwater plasma-acoustic sources

Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones

BACKGROUND: Studies suggest that the related proteins nucleoplasmin and nucleophosmin (also called B23, NO38 or numatrin) are nuclear chaperones that mediate the assembly of nucleosomes and ribosomes, respectively, and that these activities are accomplished through the binding of basic proteins via their acidic domains. Recently discovered and less well characterized members of this family of acidic phosphoproteins include mouse nucleophosmin/nucleoplasmin 3 (Npm3) and Xenopus NO29. Here we report the cloning and initial characterization of the human ortholog of Npm3. RESULTS: Human genomic and cDNA clones of NPM3 were isolated and sequenced. NPM3 lies 5.5 kb upstream of FGF8 and thus maps to chromosome 10q24-26. In addition to amino acid similarities, NPM3 shares many physical characteristics with the nucleophosmin/nucleoplasmin family, including an acidic domain, multiple potential phosphorylation sites and a putative nuclear localization signal. Comparative analyses of 14 members of this family from various metazoans suggest that Xenopus NO29 is a candidate ortholog of human and mouse NPM3, and they further group both proteins closer with the nucleoplasmins than with the nucleophosmins. Northern blot analysis revealed that NPM3 was strongly expressed in all 16 human tissues examined, with especially robust expression in pancreas and testis; lung displayed the lowest level of expression. An analysis of subcellular fractions of NIH3T3 cells expressing epitope-tagged NPM3 revealed that NPM3 protein was localized solely in the nucleus. CONCLUSIONS: Human NPM3 is an abundant and widely expressed protein with primarily nuclear localization. These biological activities, together with its physical relationship to the chaparones nucleoplasmin and nucleophosmin, are consistent with the proposed function of NPM3 as a molecular chaperone functioning in the nucleus

Online k-server routing problems

In an online k-server routing problem, a crew of k servers has to visit points in a metric space as they arrive in real time. Possible objective functions include minimizing the makespan (k-Traveling Salesman Problem) and minimizing the sum of completion times (k-Traveling Repairman Problem). We give competitive algorithms, resource augmentation results and lower bounds for k-server routing problems in a wide class of metric spaces. In some cases the competitive ratio is dramatically better than that of the corresponding single server problem. Namely, we give a 1+O((log¿k)/k)-competitive algorithm for the k-Traveling Salesman Problem and the k-Traveling Repairman Problem when the underlying metric space is the real line. We also prove that a similar result cannot hold for the Euclidean plane