18 research outputs found
Palaeomagnetism of Late Miocene to Quaternary volcanics from the eastern segment of the Trans-Mexican Volcanic Belt
A systematic palaeomagnetic study in the eastern part of the Trans-Mexican Volcanic Belt includes 39 Miocene,
Pliocene and Quaternary volcanic rocks in the southeastern Mexico Basin (Sierra Nevada and Sierra de RıŽo FrıŽo),
the Altiplano area, and the Palma Sola Massif. A total of 430 samples have been selectively demagnetized using
mostly alternating field demagnetizing methods, supplemented by thermal analyses. Most characteristic remanences
are carried by low-Ti titanomagnetites, with occasional titanohematites or slightly maghemitized low-Ti titanomagnetites,
of similar direction. Seven sites were discarded because they presented intermediate directions, hydrothermal
alteration or were remagnetized by lightning strikes. The mean directions of 32 sites, together with 24 sites from
Sierra de las Cruces in the western Mexico basin, indicate rocks older than 2 Ma are rotated some 10° counterclockwise
with respect to Quaternary rocks, whereas there is no rotational difference between Miocene and Pliocene rocks.
Statistical analyses between different regrouped populations confirm that the rotational pattern is due to the age of
the volcanics rocks but not to their spatial distribution. The Quaternary mean direction from the three Mexico Basin
ranges is consistent with the geographical reference pole. In contrast, the Pliocene mean direction from volcanic rocks
of the Altiplano area and the Sierra de Las Cruces is slightly rotated some 10° westwards with respect to the reference
direction from North America. No significant rotations have been observed in the eastern TMVB (from the western
Mexico Basin to the border of the Altiplano), between late Miocene and late Pliocene times. It suggests that a very
small, counterclockwise vertical-axis rotation may have been taken place in this segment of the TMVB between late
Pliocene and Quaternary times. Comparisons of these results with a summary of the available palaeomagnetic data
in the area indicate that the previously reported Quaternary rotations are of questionable reliability, and that the
large counterclockwise rotations, reported in Cretaceous to Miocene rocks, probably took place before the late
Miocene. These new palaeomagnetic data support the idea that the eastern TMVB since the late Miocene, has been
a zone of extension with a little, left-lateral shear component
Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study
Background
In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new âTrigger Toolâ represents a sensitive predictor of adverse events in general surgery.
Methods
An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described âTrigger Toolâ based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis.
Results
The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The âTrigger Toolâ had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the âTrigger Toolâ.
Conclusions
The âTrigger Toolâ has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Relación de los centros educativos de enseñanza secundaria con el entorno en Iberoamérica
La presente aportaciĂłn recoge la visiĂłn de 46 especialistas de trece paĂses iberoamericanos sobre las formas de entender y promover la relaciĂłn de los centros educativos con el entorno. Situados en la enseñanza secundaria (y en la franja de edad de 15 a 18 años), se trata de delimitar la manera cĂłmo se conecta la vida interna y la vida externa del centro educativo, presentando los modelos que se utilizan, las estrategias de intervenciĂłn y las experiencias mĂĄs significativas en cada uno de los paĂses. Las aportaciones no buscan tanto revisar la vinculaciĂłn de los centros educativos entre sĂ como de analizar fundamentalmente las vinculaciones con la comunidad y las organizaciones que acoge (asociaciones, empresas, organizaciones gubernamentales o no gubernamentales significativas,âŠ). Al respecto, una parte de los escritos recogen experiencias y estrategias que concretan la relaciĂłn que estudiamos. Esperamos sea asĂ un apoyo para los estudiosos de la temĂĄtica, pero tambiĂ©n aporte contenidos que ayuden a los directivos a mejorar su gestiĂłn de las relaciones externas. La orientaciĂłn de los escritos al anĂĄlisis organizativo y a la funciĂłn de los directivos como promotores de las relaciĂłn con la comunidad tiene que ver con las finalidades y objetivos de la RedAGE; tambiĂ©n con el convencimiento por parte de los que escriben que la ordenaciĂłn que se haga del contexto de intervenciĂłn y la actuaciĂłn de los directivos es fundamental para obtener y mantener las respuestas mĂĄs idĂłneas a las exigencias del medio socio-cultural-econĂłmico. Su realizaciĂłn se vincula al encuentro de especialistas de la RedAGE realizado en el mes de marzo de 2013 en La Paz. AllĂ, los representantes de las organizaciones miembro presentaron y debatieron, durante el mismo, documentos sobre la temĂĄtica de la vinculaciĂłn escuela y entorno, en sus respectivos paĂses, que constituyen la base sobre la que se han realizado las aportaciones definitivas que recoge el presente texto. Se cubre asĂ y de nuevo un propĂłsito fundamental de la Red AGE, como es el de fomentar el intercambio de experiencias, la promociĂłn del conocimiento sobre administraciĂłn y gestiĂłn educativa y la reflexiĂłn sobre la prĂĄctica de la gestiĂłn. La finalidad Ășltima es la de mejorar el funcionamiento de los centros educativos (y, a travĂ©s de ellos, de los sistemas educativos), procurando sean de calidad y un instrumento para el cambio profesional y social
Precariedad, exclusiĂłn social y diversidad funcional (discapacidad): lĂłgicas y efectos subjetivos del sufrimiento social contemporĂĄneo (II). InnovaciĂłn docente en FilosofĂa
El PIMCD "Precariedad, exclusiĂłn social y diversidad funcional (discapacidad): lĂłgicas y efectos subjetivos del sufrimiento social contemporĂĄneo (II). InnovaciĂłn docente en FilosofĂa" se ocupa de conceptos generalmente eludidos por la tradiciĂłn teĂłrica (contando como nĂșcleos aglutinantes los de la precariedad laboral, la exclusiĂłn social y diversidad funcional o discapacidad), cuyo anĂĄlisis propicia nuevas prĂĄcticas en la enseñanza universitaria de filosofĂa, adoptando como meta principal el aprendizaje centrado en el estudiantado, el diseño de nuevas herramientas de enseñanza y el fomento de una universidad inclusiva. El proyecto cuenta con 26 docentes de la UCM y otros 28 docentes de otras 17 universidades españolas (UV, UNED, UGR, UNIZAR, UAH, UC3M, UCA, UNIOVI, ULL, EHU/UPV, UA, UAM, Deusto, IFS/CSIC, UCJC, URJC y Univ. Pontificia de Comillas), que permitirĂĄn dotar a las actividades programadas de un alcance idĂłneo para consolidar la adquisiciĂłn de competencias argumentativas y dialĂ©cticas por parte de lxs estudiantes implicados en el marco de los seminarios previstos. Se integrarĂĄn en el PIMCD, aparte de PDI, al menos 26 estudiantes de mĂĄster y doctorado de la Facultad de FilosofĂa, a lxs que acompañarĂĄn durante el desarrollo del PIMCD 4 Alumni de la Facultad de FilosofĂa de la UCM, actualmente investigadores post-doc y profesorxs de IES, cuya experiencia serĂĄ beneficiosa para su introducciĂłn en la investigaciĂłn. Asimismo, el equipo cuenta con el apoyo de varixs profesorxs asociadxs, que en algunos casos son tambiĂ©n profesores de IES. Varixs docentes externos a la UCM participantes en el PIMCD poseen una dilatada experiencia en la coordinaciĂłn de proyectos de innovaciĂłn de otras universidades, lo que redundarĂĄ en beneficio de las actividades a desarrollar. La coordinadora y otrxs miembros del PIMCD pertenecen a la Red de InnovaciĂłn Docente en Filosofia (RIEF), puesta en marcha desde la Universitat de ValĂšncia (http://rief.blogs.uv.es/encuentros-de-la-rief/), a la que mantendremos informada de las actividades realizadas en el proyecto. Asimismo, lxs 6 miembros del PAS permitirĂĄn difundir debidamente las actividades realizadas en el PIMCD entre lxs estudiantes Erasmus IN del curso 2019/20 en la Facultad de FilosofĂa, de la misma manera que orientar en las tareas de maquetaciĂłn y ediciĂłn que puedan ser necesarias de cara a la publicaciĂłn de lxs resultados del PIMCD y en las tareas de pesquisa bibliogrĂĄfica necesarias para el desarrollo de los objetivos propuestos. Han manifestado su interĂ©s en los resultados derivados del PIMCD editoriales especializadas en la difusiĂłn de investigaciones predoctorales como Ăpeiron y CTK E-Books
VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad
Acta de congresoLa conmemoraciĂłn de los cien años de la Reforma Universitaria de 1918 se presentĂł como una ocasiĂłn propicia para debatir el rol de la historia, la teorĂa y la crĂtica en la formaciĂłn y en la prĂĄctica profesional de diseñadores, arquitectos y urbanistas.
En ese marco el VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad constituyĂł un espacio de intercambio y reflexiĂłn cuya realizaciĂłn ha sido posible gracias a la colaboraciĂłn entre Facultades de Arquitectura, Urbanismo y Diseño de la Universidad Nacional y la Facultad de Arquitectura de la Universidad CatĂłlica de CĂłrdoba, contando ademĂĄs con la activa participaciĂłn de mayorĂa de las Facultades, Centros e Institutos de Historia de la Arquitectura del paĂs y la regiĂłn.
Orientado en su convocatoria tanto a docentes como a estudiantes de Arquitectura y Diseño Industrial de todos los niveles de la FAUD-UNC promovió el debate de ideas a partir de experiencias concretas en instancias tales como mesas temåticas de caråcter interdisciplinario, que adoptaron la modalidad de presentación de ponencias, entre otras actividades.
En el ĂĄmbito de VIII Encuentro, desarrollado en la sede Ciudad Universitaria de CĂłrdoba, se desplegaron numerosas posiciones sobre la enseñanza, la investigaciĂłn y la formaciĂłn en historia, teorĂa y crĂtica del diseño, la arquitectura y la ciudad; sumĂĄndose el aporte realizado a travĂ©s de sus respectivas conferencias de Ana Clarisa AgĂŒero, Bibiana Cicutti, Fernando Aliata y Alberto Petrina. El conjunto de ponencias que se publican en este Repositorio de la UNC son el resultado de dos intensas jornadas de exposiciones, cuyos contenidos han posibilitado actualizar viejos dilemas y promover nuevos debates.
El evento recibiĂł el apoyo de las autoridades de la FAUD-UNC, en especial de la SecretarĂa de InvestigaciĂłn y de la Biblioteca de nuestra casa, como asĂ tambiĂ©n de la Facultad de Arquitectura de la UCC; va para todos ellos un especial agradecimiento
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
New insights into the antiviral activity of nordihydroguaiaretic acid: Inhibition of dengue virus serotype 1 replication
Background: Dengue virus (DENV) is considered one of the most important pathogens in the world causing 390 million infections each year. Currently, the development of vaccines against DENV presents some shortcomings and there is no antiviral therapy available for its infection. An important challenge is that both treatments and vaccines must be effective against all four DENV serotypes. Nordihydroguaiaretic acid (NDGA), isolated from Larrea divaricata Cav. (Zygophyllaceae) has shown a significant inhibitory effect on a broad spectrum of viruses, including DENV serotypes 2 and 4. Purpose: We evaluated the in vitro virucidal and antiviral activity of NDGA on DENV serotype 1 (DENV1), including the study of its mechanism of action, to provide more evidence on its antiviral activity. Methods: The viability of viral particles was quantified by the plaque-forming unit reduction method. NDGA effects on DENV1 genome and viral proteins were evaluated by qPCR and immunofluorescence, respectively. Lysosomotropic activity was assayed using acridine orange and neutral red dyes. Results: NDGA showed in vitro virucidal and antiviral activity against DENV1. The antiviral effect would be effective within the first 2 h after viral internalization, when the uncoating process takes place. In addition, we determined by qPCR that NDGA decreases the amount of intracellular RNA of DENV1 and, by immunofluorescence, the number of cells infected. These results indicate that the antiviral effect of NDGA would have an intracellular mechanism of action, which is consistent with its ability to be incorporated into host cells. Considering the inhibitory activity of NDGA on the cellular lipid metabolism, we compared the antiviral effect of two inhibitors acting on two different pathways of this type of metabolism: 1) resveratrol that inhibits the sterol regulatory element of binding proteins, and 2) caffeic acid that inhibits the 5-lipoxygenase (5-LOX) enzyme. Only caffeic acid produced an inhibitory effect on DENV1 infection. We studied the lysosomotropic activity of NDGA on host cells and found, for the first time, that this compound inhibited the acidification of cell vesicles which would prevent DENV1 uncoating process. Conclusion: The present work contributes to the knowledge of NDGA activity on DENV. We describe its activity on DENV1, a serotype different to those that have been already reported. Moreover, we provide evidence on which stage/s of the viral replication cycle NDGA exerts its effects. We suggest that the mechanism of action of NDGA on DENV1 is related to its lysosomotropic effect, which inhibits the viral uncoating process.Fil: Martinez, Florencia. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; Argentina. Universidad CatĂłlica de CĂłrdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad JosĂ© Sanchez Labrador S. J. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad JosĂ© Sanchez Labrador S. J.; ArgentinaFil: Ghietto, LucĂa MarĂa. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; ArgentinaFil: Lingua, Giuliana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; ArgentinaFil: Mugas, MarĂa Laura. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto Multidisciplinario de BiologĂa Vegetal. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas FĂsicas y Naturales. Instituto Multidisciplinario de BiologĂa Vegetal; ArgentinaFil: Aguilar, Juan Javier. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; ArgentinaFil: Gil, Pedro Ignacio. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; ArgentinaFil: Pisano, MarĂa BelĂ©n. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; ArgentinaFil: Marioni, Juliana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto Multidisciplinario de BiologĂa Vegetal. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas FĂsicas y Naturales. Instituto Multidisciplinario de BiologĂa Vegetal; ArgentinaFil: Paglini, Maria Gabriela. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de InvestigaciĂłn MĂ©dica Mercedes y MartĂn Ferreyra. Universidad Nacional de CĂłrdoba. Instituto de InvestigaciĂłn MĂ©dica Mercedes y MartĂn Ferreyra; ArgentinaFil: Contigiani de Minio, Marta Silvia. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; ArgentinaFil: NĂșñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto Multidisciplinario de BiologĂa Vegetal. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas FĂsicas y Naturales. Instituto Multidisciplinario de BiologĂa Vegetal; ArgentinaFil: Konigheim, Brenda Salome. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; Argentin