McMullin On-Farm Flood Capture and Recharge Project: Hydrologic and Hydraulic Analyses (H&H), final report

Approval of a Hydrologic and Hydraulic Analyses (H&H) by California Department of Water Resources (DWR) is a pre-requisite for projects being funded through DWR’s Flood Corridor Program. The H&H needs to show early in the project schedule in analysis acceptable to DWR that the project will produce the anticipated flood risk reduction benefits. A Benefit:Cost (B/C) ratio provides a metric for comparing benefits from a project in relation to DWR costs for the project. In our analysis, we calculated a B/C of 1.86 for Phase 1, the diversion of 150 cubic feet per second (cfs) from the Kings River onto the project during flood flow conditions between December and May, and of 1.98 for Phase 2/3, the diversion of 500 cfs from the Kings River onto the project during the same conditions. We provide background on the project and the area that will be affected by the project (the study area), summarize our methods, and present our findings. Two large hydrologic issues face the Kings Basin: severe and chronic overdraft of about 0.16M ac-ft annually, and flood risks along the Kings River and the downstream San Joaquin River. Since 1983, downstream communities along the Kings and San Joaquin Rivers have suffered over $1B in flood damages (2013$). To help mitigate these two issues, this project proposes diverting and capturing Kings River floodwater at the James Bypass onto agricultural lands adjacent to the Kings River for conjunctive use purposes (e.g. recharge, in lieu recharge, irrigation). This project is planned in three phases: Phase 1 (Ph1) will divert 150 cubic feet per second (cfs) onto agricultural fields from December through May and 100 cfs from June through September. Fifty-five hundred acres are planned for enrollment in Ph1 with 375 acres under flood easements; 1,125 acres managed under dual purpose of accepting flood flows and being managed for farming; and the remaining acreage receiving flood flows when available for in lieu recharge. Phases 2 and 3 (Ph 2/3) together will expand enrollment to 16,000 acres with expected equivalent ratios for flood easements, dual purpose and farming. Ph2/3 is planned to have a 500 cfs flood diversion and capture capacity. We assessed hydrologic and hydraulics conditions and economics for these planned phases following the scope of work defined in Task Order 1 between Kings River Conservation District (KRCD) and Tetra Tech

Efficacy of TAGteach Interventions: Comparing the Effects of Verbal and Audible Feedback on Skill Acquisition of Volleyball Skills

TAGteach® (based on principles of teaching with acoustical guidance) is an emerging behavioral coaching strategy that utilizes verbal instructions, visual models, and audible feedback to promote skill acquisition of a variety of skills (e.g., sports, activities of daily living, and occupational skills). Extending the findings of previous research, the current study compared the effects of audible feedback (inherent in TAGteach and verbal feedback on the skill acquisition of two volleyball skills. Five female adolescents participated in the study. Results indicated that, for all participants, implementation of TAGteach procedures (regardless of the topography of feedback), produced increases in task analysis steps performed correctly, and those increases maintained for up to two weeks. Results further indicate that performance inconsistently generalized to the natural setting (i.e., inclusion of a volleyball). Results are discussed in terms of crucial components of TAGteach and the analysis of efficient behavioral instruction. Keywords: TAGteach, sports, behavioral instruction, feedbac

Difficulties of Identifying Design Discharges

Abstract A study of three locations in a 16-km reach of the lower Verde River in Arizona demonstrates the problem of identifying generalized design flows in the arid and semiarid regions of the southwestern US, where flow regimes are highly variable and often non-continuous, where coarse bed material is supplied locally by steep ephemeral-flow tributaries, and where channel morphologies are forced by large, infrequent floods, canyon walls, tributary fans and alluvial terraces. At the three sites, channel slopes vary from 0.0027 to 0.0041, and the median size of the surface bed materials ranges from 81 to 145 mm. Hydraulic analysis (HEC-RAS) showed that, depending on the definition used, the bankfull discharge at the three sites ranges from 450 to 1,900 cms (1.7-to 8-yr RI), the critical discharge ( = 1) for bed-material mobilization ranges from 398 to 811 cms (1.6-to 3.8-yr RI), and significant sediment transport ( > 1.5) occurs at flows between 989 and 1,740 cms (4-to 8-yr RI). At any given flow above the critical discharge at one location, bed material can be immobile, in transport, or being deposited at any of the other two locations. Selection of flows for engineering design or restoration purposes in rivers with similar conditions is, therefore, highly constrained by local conditions, and site-specific geomorphic, hydraulic and sediment-transport analyses are required rather than generalized relations based on assumed relations between bankfull discharge, flood frequency, and effective discharge

Afterword: three letters

The essays consider issues of affect and emotion in terms of three early English letters - by Chaucer, the Paston family, and Henry VIII - in order to consider issues of the personal and the literary. It also comments on the volume of essays as a whole, and consider the field of the history of emotions and affect studies

Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V‑Type Activator Possessing Fatty Acid Specificity

Regulation of lipoxygenase (LOX) activity is of great interest due to the involvement of the various LOX isoforms in the inflammatory process and hence many diseases. The bulk of investigations have centered around the discovery and design of inhibitors. However, the emerging understanding of the role of h15-LOX-1 in the resolution of inflammation provides a rationale for the development of activators as well. Bicyclic pyrazolines are known bioactive molecules that have been shown to display antibiotic and anti-inflammatory activities. In the current work, we reevaluated a previously discovered bicyclic pyrazoline h15-LOX-1 activator, PKUMDL_MH_1001 (written as 1 for this publication), and determined that it is inactive against other human LOX isozymes, h5-LOX, h12-LOX, and h15-LOX-2. Analytical characterization of 1 obtained in the final synthesis step identified it as a mixture of cis- and trans-diastereomers: cis-1 (12%) and trans-1 (88%); and kinetic analysis indicated similar potency between the two. Using compound 1 as the cis-trans mixture, h15-LOX-1 catalysis with arachidonic acid (AA) (AC50 = 7.8 +/- 1 μM, A max = 240%) and linoleic acid (AC50 = 5.3 +/- 0.7 μM, A max = 98%) was activated, but not with docosahexaenoic acid (DHA) or mono-oxylipins. Steady-state kinetics demonstrate V-type activation for 1, with a β value of 2.2 +/- 0.4 and an K x of 16 +/- 1 μM. Finally, it is demonstrated that the mechanism of activation for 1 is likely not due to decreasing substrate inhibition, as was postulated previously. 1 also did not affect the activity of the h15-LOX-1 selective inhibitor, ML351, nor did 1 affect the activity of allosteric effectors, such as 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12S-HETE) and 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-HpDHA). These data confirm that 1 binds to a distinct activation binding site, as previously postulated. Future work should be aimed at the development of selective activators that are capable of activating h15-LOX-1 catalysis with DHA, thus enhancing the production of DHA-derived pro-resolution biomolecules

Three-Year Outcomes in Recipients of Mismatched Unrelated Bone Marrow Donor Transplants Using Post-Transplantation Cyclophosphamide: Follow-Up from a National Marrow Donor Program-Sponsored Prospective Clinical Trial.

The use of post-transplantation cyclophosphamide (PTCy) as graft-versus-host disease (GVHD) prophylaxis has resulted in reductions in GVHD and improved outcomes in allogeneic hematopoietic cell transplantation (HCT) using HLA-mismatched related donors. We report the 3-year outcomes of the first multicenter prospective clinical trial using PTCy in the setting of mismatched unrelated donor (MMUD) bone marrow HCT. The study enrolled 80 patients, treated with either myeloablative conditioning (MAC; n = 40) or reduced-intensity conditioning (RIC; n = 40), with the primary endpoint of 1-year overall survival (OS). The median follow-up for this study was 34 months (range, 12 to 46 months) in the RIC group and 36 months (range, 18 to 49 months) in the MAC group. Three-year OS and nonrelapse mortality were 70% and 15%, respectively, in the RIC group and 62% and 10% in the MAC group. No GVHD was reported after 1 year. The incidence of relapse was 29% in the RIC group and 51% in the MAC group. OS did not differ based on HLA match grade (63% in the 7/8 strata and 71% in the 4 to 6/8 strata). These encouraging outcomes, which were sustained for 3 years post-HCT, support the continued exploration of MMUD HCT using a PTCy platform. Important future areas to address include relapse reduction and furthering our understanding of optimal donor selection based on HLA and non-HLA factors