2,358 research outputs found
A Reanalysis of theUltraviolet Extinction from Interstellar Dust in the Large Magellanic Cloud
We have reanalyzed the Large Magellanic Cloud's (LMC) ultraviolet (UV)
extinction using data from the IUE final archive. Our new analysis takes
advantage of the improved signal--to--noise of the IUE NEWSIPS reduction, the
exclusion of stars with very low reddening, the careful selection of well
matched comparison stars, and an analysis of the effects of Galactic foreground
dust. Differences between the average extinction curves of the 30 Dor region
and the rest of the LMC are reduced compared to previous studies. We find that
there is a group of stars with very weak 2175 Ang. bumps that lie in or near
the region occupied by the supergiant shell, LMC 2, on the southeast side of 30
Dor. The average extinction curves inside and outside LMC 2 show a very
significant difference in 2175 Ang. bump strength, but their far--UV
extinctions are similar. While it is unclear whether or not the extinction
outside the LMC 2 region can be fit with the relation of Cardelli, Clayton and
Mathis (CCM), sightlines near LMC 2 cannot be fit with CCM due to their weak
2175 Ang. bumps. While the extinction properties seen in the LMC lie within the
range of properties seen in the Galaxy, the correlations of UV extinction
properties with environment seen in the Galaxy do not appear to hold in the
LMC.Comment: 29 pages, 10 figures, to be published in Ap
Development of ERAU VOLTRON Hybrid-Electric Powerplant
The energy density of todayâs batteries is not high enough for electric powered aircraft to achieve an operationally viable range plus FAA stipulated reserve flight times. Hybrid-electric power generation systems may be able to bridge the gap, providing a way for these aircraft to fly distances not possible with batteries alone. There is a recognition that gasoline-electric hybrid systems can deliver specific energy and specific power that are higher than any currently available battery system.
Embry-Riddle Aeronautical Universityâs (ERAUâs) Eagle Flight Research Center (EFRC) is building a 70+ kW hybrid-electric power generation system using a rotary engine and Permanent Magnet Synchronous Machine (PMSM) & Inverter. The rotary engine will be directly coupled to the PMSM which will generate electrical energy to power multi-rotor eVTOL vehicles. These results will be achieved by utilizing advanced control systems implemented on a National Instruments Compact RIO.
Past research conducted at the EFRC demonstrated the ability to design and operate a hybrid-electric powerplant. The VOLTRON project will attempt to create a system with an even higher specific energy but with the compact size and high power characteristics of a rotary engine and eventually alternative fuel flexibility
Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9
We examined complement-dependent cytotoxicity (CDC) by hexamer formation-enhanced CD20 mAb Hx-7D8 of patient-derived chronic lymphocytic leukemia (CLL) cells that are relatively resistant to CDC. CDC was analyzed in normal human serum (NHS) and serum from an individual genetically deficient for C9. Hx-7D8 was able to kill up to 80% of CLL cells in complete absence of C9. We conclude that the narrow C5b-8 pores formed without C9 are sufficient for CDC due to efficient antibody-mediated hexamer formation. In the absence of C9, we observed transient intracellular increases of Ca2 + during CDC (as assessed with FLUO-4) that were extended in time. This suggests that small C5b-8 pores allow Ca2 + to enter the cell, while dissipation of the fluorescent signal accompanying cell disintegration is delayed. The Ca2 + signal is retained concomitantly with TOPRO-3 (viability dye) staining, thereby confirming that Ca2 + influx represents the most proximate mediator of cell death by CDC
Dreaming of drams: Authenticity in Scottish whisky tourism as an expression of unresolved Habermasian rationalities
In this paper, the production of whisky tourism at both independently owned and corporately owned distilleries in Scotland is explored by focusing on four examples (Arran, Glengoyne, Glenturret and Bruichladdich). In particular, claims of authenticity and Scottishness of Scottish whiskies through commercial materials, case studies, website-forum discussions and 'independent' writing about such whisky are analysed. It is argued that the globalisation and commodification of whisky and whisky tourism, and the communicative backlash to these trends typified by the search for authenticity, is representative of a Habermasian struggle between two irreconcilable rationalities. This paper will demonstrate that the meaning and purpose of leisure can be understood through such explorations of the tension between the instrumentality of commodification and the freedom of individuals to locate their own leisure lives in the lifeworld that remains. © 2011 Taylor & Francis
Mental health care for irregular migrants in Europe: Barriers and how they are overcome
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited
Evaluation of a short RNA within Prostate Cancer Gene 3 in the predictive role for future cancer using non-malignant prostate biopsies.
BACKGROUND: Prostate Cancer 3 (PCA3) is a long non-coding RNA (ncRNA) upregulated in prostate cancer (PCa). We recently identified a short ncRNA expressed from intron 1 of PCA3. Here we test the ability of this ncRNA to predict the presence of cancer in men with a biopsy without PCa. METHODS: We selected men whose initial biopsy did not identify PCa and selected matched cohorts whose subsequent biopsies revealed PCa or benign tissue. We extracted RNA from the initial biopsy and measured PCA3-shRNA2, PCA3 and PSA (qRT-PCR). RESULTS: We identified 116 men with and 94 men without an eventual diagnosis of PCa in 2-5 biopsies (mean 26 months), collected from 2002-2008. The cohorts were similar for age, PSA and surveillance period. We detected PSA and PCA3-shRNA2 RNA in all samples, and PCA3 RNA in 90% of biopsies. The expression of PCA3 and PCA3-shRNA2 were correlated (Pearson's r = 0.37, p<0.01). There was upregulation of PCA3 (2.1-fold, t-test p = 0.02) and PCA3-shRNA2 (1.5-fold) in men with PCa on subsequent biopsy, although this was not significant for the latter RNA (p = 0.2). PCA3 was associated with the future detection of PCa (C-index 0.61, p = 0.01). This was not the case for PCA3-shRNA2 (C-index 0.55, p = 0.2). CONCLUSIONS: PCA3 and PCA3-shRNA2 expression are detectable in historic biopsies and their expression is correlated suggesting co-expression. PCA3 expression was upregulated in men with PCa diagnosed at a future date, the same did not hold for PCA3-shRNA2. Futures studies should explore expression in urine and look at a time course between biopsy and PCa detection
Heavy quarkonium: progress, puzzles, and opportunities
A golden age for heavy quarkonium physics dawned a decade ago, initiated by
the confluence of exciting advances in quantum chromodynamics (QCD) and an
explosion of related experimental activity. The early years of this period were
chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in
2004, which presented a comprehensive review of the status of the field at that
time and provided specific recommendations for further progress. However, the
broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles
could only be partially anticipated. Since the release of the YR, the BESII
program concluded only to give birth to BESIII; the -factories and CLEO-c
flourished; quarkonium production and polarization measurements at HERA and the
Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the
deconfinement regime. All these experiments leave legacies of quality,
precision, and unsolved mysteries for quarkonium physics, and therefore beg for
continuing investigations. The plethora of newly-found quarkonium-like states
unleashed a flood of theoretical investigations into new forms of matter such
as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the
spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b},
and b\bar{c} bound states have been shown to validate some theoretical
approaches to QCD and highlight lack of quantitative success for others. The
intriguing details of quarkonium suppression in heavy-ion collisions that have
emerged from RHIC have elevated the importance of separating hot- and
cold-nuclear-matter effects in quark-gluon plasma studies. This review
systematically addresses all these matters and concludes by prioritizing
directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K.
Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D.
Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A.
Petrov, P. Robbe, A. Vair
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