Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors

Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence. Conversely, THC also has potentially therapeutic effects, including analgesia, muscle relaxation, and neuroprotection. However, the mechanisms that dissociate these responses are still not known. Using mice lacking the serotonin receptor 5-HT2A, we revealed that the analgesic and amnesic effects of THC are independent of each other: while amnesia induced by THC disappears in the mutant mice, THC can still promote analgesia in these animals. In subsequent molecular studies, we showed that in specific brain regions involved in memory formation, the receptors for THC and the 5-HT2A receptors work together by physically interacting with each other. Experimentally interfering with this interaction prevented the memory deficits induced by THC, but not its analgesic properties. Our results highlight a novel mechanism by which the beneficial analgesic properties of THC can be dissociated from its cognitive side effects

COVID-19 in hospitalized HIV-positive and HIV-negative patients: A matched study

Objectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization.This work was supported by the Instituto de Salud Carlos III (ISCII) (grant no. COV20/00108) and the Spanish AIDS Research Network (RD16/0025), which is included in the Spanish I+D+I Plan and is co- funded by ISCIII- Subdirección General de Evaluación and European Funding for Regional Development (FEDER)S

Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes

Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico = picolinate) (4), [(η 6-p-cym)RuCl(dap)] + (p-cym = p-cymene) (5), and [(η 6-p-cym)RuCl(imidazole-CO 2H)(PPh 3)] + (6), were synthesized by using a solid-phase approach. Conjugates 3-5 readily underwent hydrolysis and DNA binding, whereas conjugate 6 was inert to ligand substitution. NMR spectroscopy and molecular dynamics calculations showed that conjugate formation does not perturb the overall peptide structure. Only 6 exhibited antiproliferative activity in human tumor cells (IC 50 = 63 ± 2 μ in MCF-7 cells and IC 50 = 26 ± 3 μ in DU-145 cells) with active participation of somatostatin receptors in cellular uptake. Similar cytotoxic activity was found in a normal cell line (IC 50 = 45 ± 2.6 μ in CHO cells), which can be attributed to a similar level of expression of somatostatin subtype-2 receptor. These studies provide new insights into the effect of receptor-binding peptide conjugation on the activity of metal-based anticancer drugs, and demonstrate the potential of such hybrid compounds to target tumor cells specifically. © 2012 American Chemical Society

Photonic sensor systems for the identification of hydrocarbons and crude oils in static and flow conditions

Identification of hydrocarbons and crude oils is typically carried out with samples that, taken from natural sources or refineries, must be brought to the laboratory for their analysis with rather sophisticated instruments. Alternatively, “in situ” procedures have been also developed for this purpose. In this work, we propose the use of a series of several sensor systems based on photonic transducers in the form of chips for the identification and classification of crude oils and hydrocarbons through the determination of their refractive index in the visible and absorption in the near infrared regions of the electromagnetic spectrum. Two of the photonic transducers rely on modifications of a Bragg microcavity and they monitor the changes in visible light interference phenomena that occur in response to the variation of the refractive index of oils. The third one, in the form of a dielectric mirror, monitors the near infrared absorption of crude oils and hydrocarbons through the recording of a transflectance spectrum. The capacity of these transducers for crude oil identification is proved by the analysis of a series of oils and distilled fractions that have been properly identified and classified as a function of their density and partition of long hydrocarbon chains. The three photonic transducers are operated with optical fibers and can be used in static and dynamic modes, this latter under conditions that are especially well-suited for “insitu” analysis of oil streams in real facilities. The proved resistance of the chips to high pressure and temperature conditions supports their suitability to withstand harsh working environments as those existing in extraction wells.Peer reviewe

Assessment of Platelet REACtivity After Transcatheter Aortic Valve Replacement: The REAC-TAVI Trial

OBJECTIVES: The REAC-TAVI (Assessment of platelet REACtivity after Transcatheter Aortic Valve Implantation) trial enrolled patients with aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) pre-treated with aspirin + clopidogrel, aimed to compare the efficacy of clopidogrel and ticagrelor in suppressing high platelet reactivity (HPR) after TAVI. BACKGROUND: Current recommendations support short-term use of aspirin + clopidogrel for patients with severe AS undergoing TAVR despite the lack of compelling evidence. METHODS: This was a prospective, randomized, multicenter investigation. Platelet reactivity was measured at 6 different time points with the VerifyNow assay (Accriva Diagnostics, San Diego, California). HPR was defined as (P2Y12 reaction units (PRU) ≥208. Patients with HPR before TAVR were randomized to either aspirin + ticagrelor or aspirin + clopidogrel for 3 months. Patients without HPR continued with aspirin + clopidogrel (registry cohort). The primary endpoint was non-HPR status (PRU <208) in ≥70% of patients treated with ticagrelor at 90 days post-TAVR. RESULTS: A total of 68 patients were included. Of these, 48 (71%) had HPR (PRU 273 ± 09) and were randomized to aspirin + ticagrelor (n = 24, PRU 277 ± 08) or continued with aspirin + clopidogrel (n = 24, PRU 269 ± 49). The remaining 20 patients (29%) without HPR (PRU 133 ± 12) were included in the registry. Overall, platelet reactivity across all the study time points after TAVR was lower in patients randomized to ticagrelor compared with those treated with clopidogrel, including those enrolled in the registry (p < 0.001). The primary endpoint was achieved in 100% of patients with ticagrelor compared with 21% with clopidogrel (p < 0.001). Interestingly, 33% of clopidogrel responder patients at baseline developed HPR status during the first month after TAVR. CONCLUSIONS: HPR to clopidogrel is present in a considerable number of patients with AS undergoing TAVR. Ticagrelor achieves a better and faster effect, providing sustained suppression of HPR to these patients. (Platelet Reactivity After TAVI: A Multicenter Pilot Study [REAC-TAVI]; NCT02224066)

Development of a New largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies.

The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long hindered due to certain particularities of these proteinaceous pathogens. Difficulties related to their purification from brain homogenates of disease-affected animals were resolved almost a decade ago by the development of in vitro recombinant prion propagation systems giving rise to highly infectious recombinant prions. However, lack of knowledge about the molecular mechanisms of the misfolding event and the complexity of systems such as the Protein Misfolding Cyclic Amplification (PMCA), have limited generating the large amounts of homogeneous recombinant prion preparations required for high-resolution techniques such as solid state Nuclear Magnetic Resonance (ssNMR) imaging. Herein, we present a novel recombinant prion propagation system based on PMCA that substitutes sonication with shaking thereby allowing the production of unprecedented amounts of multi-labeled, infectious recombinant prions. The use of specific cofactors, such as dextran sulfate, limit the structural heterogeneity of the in vitro propagated prions and makes possible, for the first time, the generation of infectious and likely homogeneous samples in sufficient quantities for studies with high-resolution structural techniques as demonstrated by the preliminary ssNMR spectrum presented here. Overall, we consider that this new method named Protein Misfolding Shaking Amplification (PMSA), opens new avenues to finally elucidate the three-dimensional structure of infectious prions

Revista de Vertebrados de la Estación Biológica de Doñana

Contribución al estudio de la bermejuela Rutilus arcasi, Steindachner, 1866 de la cuenca del Júcar (Osteichthyes: Cyprinidae)II. Edad y crecimientoSobre la taxonomía de Barbus comiza Steindachner, 1865 (Ostariophysi: Cyprinidae)Fenología de una comunidad de anfibios asociada a cursos fluviales temporales.Nueva especie para la ciencia de Anolis (Lacertilia: Iguanidae) de Cuba pertenecient eal complejo argillaceusSegregación ecológica en una comunidad de ofidios.El Aguila Imperial (Aquila adalberti): dispersión de los jóvenes, estructura de edades y mortalidaSobre diferencias individuales en la alimentación de Tyto albaInfluencia de las condiciones ambientales sobre la organización de la comunidad de aves invernantes en un bosque subalpino mediterráneoVariaciones en la agregación y distribución de la cabra montés (Capra pyrenaica Schinz,1838) detectadas con un muestreo de excrementosAlimentación del conejo (Oryctolagus cuniculus L. 1758) en Doñana. SO, EspañaSobre la distribución de Barbus meridionales Risso, 1826 (Ostariophysi: Cyprinidae) en la Península IbéricaSobre la distribución de Barbus meridionales Risso, 1826 (Ostariophysi: Cyprinidae) en la Península IbéricaNueva cita de Barbus microcephalus Almaça (Pisces, Cyprinidae) en España.Revisión taxonómica y distribución de Cobitis maroccana Pellegrin, 1929 (Osteichthyes, Cobitidae)Datos sobre una población de Lacerta viviparaSobre la presencia de Emys orbicularis en la provincia de León.Algunas observaciones sobre la captura de quirópteros por Falco subbuteo y Falco tinunculusNyctalus leisleri (Kuhk, 1818) (Mammalia: Chiroptera). Una nueva especie para las islas CanariaNuevos datos acerca de la distribución del topillo campesino Microtus arvalis, PALLAS 1778, en la Península IbéricaPeer reviewe

Productivity trends and collaboration patterns: A diachronic study in the eating disorders field

[EN] Objective The present study seeks to extend previous bibliometric studies on eating disorders (EDs) by including a time-dependent analysis of the growth and evolution of multi-author collaborations and their correlation with ED publication trends from 1980 to 2014 (35 years). Methods Using standardized practices, we searched Web of Science (WoS) Core Collection (WoSCC) (indexes: Science Citation Index-Expanded [SCIE], & Social Science Citation Index [SSCI]) and Scopus (areas: Health Sciences, Life Sciences, & Social Sciences and Humanities) to identify a large sample of articles related to EDs. We then submitted our sample of articles to bibliometric and graph theory analyses to identify co-authorship and social network patterns. Results We present a large number of detailed findings, including a clear pattern of scientific growth measured as number of publications per five-year period or quinquennium (Q), a tremendous increase in the number of authors attracted by the ED subject, and a very high and steady growth in collaborative work. Conclusions We inferred that the noted publication growth was likely driven by the noted increase in the number of new authors per Q. Social network analyses suggested that collaborations within ED follow patters of interaction that are similar to well established and recognized disciplines, as indicated by the presence of a ¿giant cluster¿, high cluster density, and the replication of the ¿small world¿ phenomenon¿the principle that we are all linked by short chains of acquaintances.This work was performed with a subsidy from Universidad Catolica de Valencia "San Vicente Martir" to resarch group INDOTEI: Evaluacion de la Ciencia, for the years 2016-2017. This work is benefited from Spanish Government assistance through Government Delegation for the National Drugs Plan of the Ministry of Health, Social Services and Equality (project 2016/028); and National R+D+I (projects: CS02012-39632-C02-01 and CS02015-65594-C2-2-R) and 2015-Networks of Excellence Call (project CS02015-71867-REDT) of the Ministry of Economy and Competitiveness.Valderrama Zurian, JC.; Aguilar-Moya, R.; Cepeda-Benito, A.; Melero-Fuentes, D.; Navarro-Moreno, MÁ.; Gandía-Balaguer, A.; Aleixandre-Benavent, R. (2017). Productivity trends and collaboration patterns: A diachronic study in the eating disorders field. PLoS ONE. 12(8):1-17. https://doi.org/10.1371/journal.pone.0182760S117128McClelland, J., Bozhilova, N., Campbell, I., & Schmidt, U. (2013). A Systematic Review of the Effects of Neuromodulation on Eating and Body Weight: Evidence from Human and Animal Studies. 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The Validity and Clinical Utility of Binge Eating Disorder. FOCUS, 12(4), 489-505. doi:10.1176/appi.focus.120412Theander, S. S. (2002). Literature on eating disorders during 40 Years: increasing number of papers, emergence of bulimia nervosa. European Eating Disorders Review, 10(6), 386-398. doi:10.1002/erv.495Clinton, D. (2010). Towards an ecology of eating disorders: Creating sustainability through the integration of scientific research and clinical practice. European Eating Disorders Review, 18(1), 1-9. doi:10.1002/erv.986Soh, N. L.-W., & Walter, G. (2013). Publications on cross-cultural aspects of eating disorders. Journal of Eating Disorders, 1(1). doi:10.1186/2050-2974-1-4Wuchty, S., Jones, B. F., & Uzzi, B. (2007). The Increasing Dominance of Teams in Production of Knowledge. Science, 316(5827), 1036-1039. doi:10.1126/science.1136099Kumar, S. (2015). Co-authorship networks: a review of the literature. Aslib Journal of Information Management, 67(1), 55-73. doi:10.1108/ajim-09-2014-0116Barabási, A. ., Jeong, H., Néda, Z., Ravasz, E., Schubert, A., & Vicsek, T. (2002). Evolution of the social network of scientific collaborations. Physica A: Statistical Mechanics and its Applications, 311(3-4), 590-614. doi:10.1016/s0378-4371(02)00736-7Newman, M. E. J. (2004). Coauthorship networks and patterns of scientific collaboration. Proceedings of the National Academy of Sciences, 101(Supplement 1), 5200-5205. doi:10.1073/pnas.0307545100Aleixandre-Benavent, R., & Alonso-Arroyo, A. (2011). Indicadores bibliométricos, patología del aparato respiratorio y reducción del consumo de tabaco. Revista de Patología Respiratoria, 14(1), 1-3. doi:10.1016/s1576-9895(11)70095-9Pino-Díaz, J., Jiménez-Contreras, E., Ruíz-Baños, R., & Bailón-Moreno, R. (2011). Evaluación de redes tecnocientíficas: la red española sobre Áreas Protegidas, según la Web of Science. Revista española de Documentación Científica, 34(3), 301-333. doi:10.3989/redc.2011.3.804Valderrama-Zurián, J.-C., Aguilar-Moya, R., Melero-Fuentes, D., & Aleixandre-Benavent, R. (2015). A systematic analysis of duplicate records in Scopus. Journal of Informetrics, 9(3), 570-576. doi:10.1016/j.joi.2015.05.002Guardiola-Wanden-Berghe, R., Sanz-Valero, J., & Wanden-Berghe, C. (2012). Medical subject headings versus American Psychological Association Index Terms: indexing eating disorders. Scientometrics, 94(1), 305-311. doi:10.1007/s11192-012-0866-7Soh, N., Walter, G., Touyz, S., Russell, J., Malhi, G. S., & Hunt, G. E. (2012). Food for thought: Comparison of citations received from articles appearing in specialized eating disorder journals versus general psychiatry journals. International Journal of Eating Disorders, 45(8), 990-994. doi:10.1002/eat.22036Theander, S. S. (2004). Trends in the literature on eating disorders over 36 years(1965-2000): terminology, interpretation and treatment. European Eating Disorders Review, 12(1), 4-17. doi:10.1002/erv.559Kawamura, M., Thomas, C. D. L., Tsurumoto, A., Sasahara, H., & Kawaguchi, Y. (2000). Lotka’s law and productivity index of authors in a scientific journal. Journal of Oral Science, 42(2), 75-78. doi:10.2334/josnusd.42.75Lawani SM. Quality, collaboration and citations in cancer research: A bibliometric study. PhD thesis. Florida State University, Tallahassee. 1980.Watts, D. J., & Strogatz, S. H. (1998). Collective dynamics of ‘small-world’ networks. Nature, 393(6684), 440-442. doi:10.1038/30918Jacomy, M., Venturini, T., Heymann, S., & Bastian, M. (2014). ForceAtlas2, a Continuous Graph Layout Algorithm for Handy Network Visualization Designed for the Gephi Software. PLoS ONE, 9(6), e98679. doi:10.1371/journal.pone.0098679Pike, K. M., & Dunne, P. E. (2015). The rise of eating disorders in Asia: a review. Journal of Eating Disorders, 3(1). doi:10.1186/s40337-015-0070-2El Ghoch, M., Soave, F., Calugi, S., & Dalle Grave, R. (2013). Eating Disorders, Physical Fitness and Sport Performance: A Systematic Review. Nutrients, 5(12), 5140-5160. doi:10.3390/nu5125140Jones, A. W. (2007). The distribution of forensic journals, reflections on authorship practices, peer-review and role of the impact factor. Forensic Science International, 165(2-3), 115-128. doi:10.1016/j.forsciint.2006.05.013Baker, T., Hatsukami, D., Lerman, C., O’Malley, S., Shields, A., & Fiore, M. (2003). Transdisciplinary science applied to the evaluation of treatments for tobacco use. Nicotine & Tobacco Research, 5(6), 89-99. doi:10.1080/14622200310001625564González-Alcaide, G., Melero-Fuentes, D., Aleixandre-Benavent, R., & Valderrama-Zurián, J.-C. (2013). Productivity and Collaboration in Scientific Publications on Criminology. Journal of Criminal Justice Education, 24(1), 15-37. doi:10.1080/10511253.2012.664153López-Muñoz, F., Alamo, C., Rubio, G., García-García, P., Martín-Agueda, B., & Cuenca, E. (2003). Bibliometric analysis of biomedical publications on SSRI during 1980-2000. Depression and Anxiety, 18(2), 95-103. doi:10.1002/da.10121González-Alcaide, G., Aleixandre-Benavent, R., Navarro-Molina, C., & Valderrama-Zurián, J. C. (2008). Coauthorship networks and institutional collaboration patterns in reproductive biology. Fertility and Sterility, 90(4), 941-956. doi:10.1016/j.fertnstert.2007.07.1378González-Alcaide, G., Park, J., Huamaní, C., Belinchón, I., & Ramos, J. M. (2015). Evolution of Cooperation Patterns in Psoriasis Research: Co-Authorship Network Analysis of Papers in Medline (1942–2013). PLOS ONE, 10(12), e0144837. doi:10.1371/journal.pone.0144837Bordons, M., & Ángeles Zulueta, M. (2002). La interdisciplinariedad en los grupos españoles de investigación en el área cardiovascular. Revista Española de Cardiología, 55(9), 900-912. doi:10.1016/s0300-8932(02)76728-6Chan, H. F., Önder, A. S., & Torgler, B. (2015). The first cut is the deepest: repeated interactions of coauthorship and academic productivity in Nobel laureate teams. Scientometrics, 106(2), 509-524. doi:10.1007/s11192-015-1796-yBordons, M., Aparicio, J., González-Albo, B., & Díaz-Faes, A. A. (2015). The relationship between the research performance of scientists and their position in co-authorship networks in three fields. Journal of Informetrics, 9(1), 135-144. doi:10.1016/j.joi.2014.12.001Newman, M. E. J. (2001). The structure of scientific collaboration networks. Proceedings of the National Academy of Sciences, 98(2), 404-409. doi:10.1073/pnas.98.2.404Fatt, C. K., Ujum, E. A., & Ratnavelu, K. (2010). The structure of collaboration in the Journal of Finance. Scientometrics, 85(3), 849-860. doi:10.1007/s11192-010-0254-0Kretschmer, H. (2004). Author productivity and geodesic distance in bibliographic co-authorship networks, and visibility on the Web. Scientometrics, 60(3), 409-420. doi:10.1023/b:scie.0000034383.86665.22Yan, E., Ding, Y., & Zhu, Q. (2009). Mapping library and information science in China: a coauthorship network analysis. Scientometrics, 83(1), 115-131. doi:10.1007/s11192-009-0027-9Yin, L., Kretschmer, H., Hanneman, R. A., & Liu, Z. (2006). Connection and stratification in research collaboration: An analysis of the COLLNET network. Information Processing & Management, 42(6), 1599-1613. doi:10.1016/j.ipm.2006.03.021Lambiotte, R., & Panzarasa, P. (2009). Communities, knowledge creation, and information diffusion. Journal of Informetrics, 3(3), 180-190. doi:10.1016/j.joi.2009.03.007Leydesdorff, L. (2012). World shares of publications of the USA, EU-27, and China compared and predicted using the new Web of Science interface versus Scopus. 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Lo glocal y el turismo. Nuevos paradigmas de interpretación.

El estudio del turismo se realiza desde múltiples escalas y enfoques, este libro aborda muchos temas que es necesario discutir desde diversas perspectivas; es el caso de la reflexión sobre la propia disciplina y sus conceptos, así como los asuntos específicos referidos al impacto territorial, los tipos de turismo, las cuestiones ambientales, el tema de la pobreza, la competitividad, las políticas públicas, el papel de las universidades, las áreas naturales protegidas, la sustentabilidad, la cultura, el desarrollo, la seguridad, todos temas centrales documentados y expuestos con originalidad y dominio del asunto. Lo multiescalar es básico para la comprensión del sistema turístico, sistema formado de procesos globales, regionales y locales. El eje de discusión del libro es lo glocal, esa interacción entre lo nacional y local con lo global