Inter-correlations between laboratory Inter-correlations between laboratory and field-based tests of muscle contractile power

International Journal of Exercise Science 9(5): 635-645, 2016. Muscle contractile properties have previously been distinguished by fiber typing muscle samples obtained from needle biopsy; however due to conflicting evidence regarding sampling bias and the related need for multiple biopsies, it is not certain if these results are a reliable reflection of whole muscle fiber type expression. Inter-correlations between laboratory and field-based measures of muscle contractile power were used to determine which assessments best discriminate between participants of varying sprint performance, and indirectly reveal potential for power vs. endurance exercise performance. Healthy active male (n=32) and female (n=17) participants were recruited from the Central West region of New South Wales. Isometric rate of force development (RFD) and isokinetic torque were assessed at different velocities. A counter movement jump (CMJ) test was implemented to assess concentric and eccentric RFD. A modified Wingate test was used to assess peak power expressed as Watts using a stationary start to the onset of decreased cadence. A 20m sprint was used as a field-based measurement of exercise performance, recording split times at 2m, 10m and 20m, and interval times from 2-10m, 2-20m, and 10-20m. Over 85% (r2=0.851) of 10-20m sprint running performance variance was significantly accounted for by a multiple regression model consisting of peak Watts per kilogram body mass during the modified Wingate (pkWkg), sex, and peak concentric rate of force development (pkcRFDkg). Results indicate a highly significant and predictive relationship between performance measures assessed by the modified Wingate test and sprint running performance in both males and females. Laboratory power tests alone seem sensitive enough to ascertain suitability for power vs. endurance performance potential

The Organic Food Premium: A Local Assessment in the UK

The present study combines stated and revealed preferences in order to estimate the hypothetical bias of a sample of organic food consumers from Canterbury in the UK. It uses contingent valuation and hedonic pricing to compare stated and revealed preferences and employs the Almost Ideal Demand System to estimate the elasticity of organic products. The results show that the average price premium is fairly large (approximately 10%). They also demonstrate, crucially, that the size of this estimate is encouragingly similar whether a willingness-to-pay or hedonic pricing method is used. The estimated elasticity of organic products is on average above one, suggesting an elastic response to pricing policy in the present sample. Desirable next steps and potential policy applications for future research are also discussed

Chronic kidney disease in public renal practices in Queensland, Australia, 2011–2018

Aim: To describe adults with (non-dialysis) chronic kidney disease (CKD) in nine public renal practice sites in the Australian state of Queensland. Methods: 7,060 persons were recruited to a CKD Registry in May 2011 and until start of kidney replacement therapy (KRT), death without KRT or June 2018, for a median period of 3.4 years. Results: The cohort comprised 7,060 persons, 52% males, with a median age of 68 yr; 85% had CKD stages 3A to 5, 45.4% were diabetic, 24.6% had diabetic nephropathy, and 51.7% were obese. Younger persons mostly had glomerulonephritis or genetic renal disease, while older persons mostly had diabetic nephropathy, renovascular disease and multiple diagnoses. Proportions of specific renal diagnoses varied >2-fold across sites. Over the first year, eGFR fell in 24% but was stable or improved in 76%. Over follow up, 10% started KRT, at a median age of 62 yr, most with CKD stages 4 and 5 at consent, while 18.8% died without KRT, at a median age of 80 yr. Indigenous people were younger at consent and more often had diabetes and diabetic kidney disease and had higher incidence rates of KRT. Conclusion: The spectrum of characteristics in CKD patients in renal practices is much broader than represented by the minority who ultimately start KRT. Variation in CKD by causes, age, site and Indigenous status, the prevalence of obesity, relative stability of kidney function in many persons over the short term, and differences between those who KRT and die without KRT are all important to explore

The faint young Sun problem

For more than four decades, scientists have been trying to find an answer to one of the most fundamental questions in paleoclimatology, the `faint young Sun problem'. For the early Earth, models of stellar evolution predict a solar energy input to the climate system which is about 25% lower than today. This would result in a completely frozen world over the first two billion years in the history of our planet, if all other parameters controlling Earth's climate had been the same. Yet there is ample evidence for the presence of liquid surface water and even life in the Archean (3.8 to 2.5 billion years before present), so some effect (or effects) must have been compensating for the faint young Sun. A wide range of possible solutions have been suggested and explored during the last four decades, with most studies focusing on higher concentrations of atmospheric greenhouse gases like carbon dioxide, methane or ammonia. All of these solutions present considerable difficulties, however, so the faint young Sun problem cannot be regarded as solved. Here I review research on the subject, including the latest suggestions for solutions of the faint young Sun problem and recent geochemical constraints on the composition of Earth's early atmosphere. Furthermore, I will outline the most promising directions for future research. In particular I would argue that both improved geochemical constraints on the state of the Archean climate system and numerical experiments with state-of-the-art climate models are required to finally assess what kept the oceans on the Archean Earth from freezing over completely.Comment: 32 pages, 8 figures. Invited review paper accepted for publication in Reviews of Geophysic

Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States

Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators. A within-person differential loading and analysis strategy reduces heterogeneity for changes in muscle mass by ∼40% and uses a genome-wide transcriptome method that models each mRNA from coding exons and 3′ and 5′ untranslated regions (UTRs). Our strategy detects ∼3–4 times more regulated genes than similarly sized studies, including substantial UTR-selective regulation undetected by other methods. We discover a core of 141 genes correlated to muscle growth, which we validate from newly analyzed independent samples (n = 100). Further validating these identified genes via RNAi in primary muscle cells, we demonstrate that members of the core genes were regulators of protein synthesis. Using proteome-constrained networks and pathway analysis reveals notable relationships with the molecular characteristics of human muscle aging and insulin sensitivity, as well as potential drug therapies

Global application of an unoccupied aerial vehicle photogrammetry protocol for predicting aboveground biomass in non‐forest ecosystems

P. 1-15Non-forest ecosystems, dominated by shrubs, grasses and herbaceous plants, provide ecosystem services including carbon sequestration and forage for grazing, and are highly sensitive to climatic changes. Yet these ecosystems are poorly represented in remotely sensed biomass products and are undersampled by in situ monitoring. Current global change threats emphasize the need for new tools to capture biomass change in non-forest ecosystems at appropriate scales. Here we developed and deployed a new protocol for photogrammetric height using unoccupied aerial vehicle (UAV) images to test its capability for delivering standardized measurements of biomass across a globally distributed field experiment. We assessed whether canopy height inferred from UAV photogrammetry allows the prediction of aboveground biomass (AGB) across low-stature plant species by conducting 38 photogrammetric surveys over 741 harvested plots to sample 50 species. We found mean canopy height was strongly predictive of AGB across species, with a median adjusted R2 of 0.87 (ranging from 0.46 to 0.99) and median prediction error from leave-one-out cross-validation of 3.9%. Biomass per-unit-of-height was similar within but different among, plant functional types. We found that photogrammetric reconstructions of canopy height were sensitive to wind speed but not sun elevation during surveys. We demonstrated that our photogrammetric approach produced generalizable measurements across growth forms and environmental settings and yielded accuracies as good as those obtained from in situ approaches. We demonstrate that using a standardized approach for UAV photogrammetry can deliver accurate AGB estimates across a wide range of dynamic and heterogeneous ecosystems. Many academic and land management institutions have the technical capacity to deploy these approaches over extents of 1–10 ha−1. Photogrammetric approaches could provide much-needed information required to calibrate and validate the vegetation models and satellite-derived biomass products that are essential to understand vulnerable and understudied non-forested ecosystems around the globe.S