153 research outputs found
Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio)
With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing. Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo. Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally. Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue. Furthermore, the differences in α-mannan and β-1,3-glucans chain lengths of each YCW fraction affected their capacity to be recognised by different PRRs. As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs. Together these findings demonstrate the importance of characterising the molecular and biochemical properties of YCW fractions when assessing and concluding their immune potential. Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds
Local stability of self-gravitating fluid disks made of two components in relative motion
Context. We consider a simple self-gravitating disk, made of two fluid
components characterized by different effective thermal speeds and interacting
with one another only through gravity; two-component models of this type have
often been considered in order to estimate the impact of the cold interstellar
medium on gravitational instabilities in star-dominated galaxy disks.
Aims. This simple model allows us to produce a unified description of
instabilities in non-viscous self-gravitating disks, some originating from
Jeans collapse, and others from the relative motion between the two components.
In particular, the model suggests that the small streaming velocity between the
two components associated with the so-called asymmetric drift may be the origin
of instability for suitable non-axisymmetric perturbations.
Methods. The result is obtained by examining the properties of a local,
linear dispersion relation for tightly wound density waves in such
two-component model. The parameters characterizing the equilibrium model and
the related dispersion relation allow us to recover as natural limits the
cases, known in the literature, in which the relative drift between the two
components is ignored.
Results. Dynamically, the instability is similar to (although gentler than)
that known to affect counter-rotating disks. However, in contrast to the
instability induced by counter-rotation, which is a relatively rare phenomenon,
the mechanism discussed in this paper is likely to be rather common in nature.
Conclusions. We briefly indicate some consequences of the instability on the
evolution of galaxy disks and possible applications to other astrophysical
systems, in particular to protostellar disks and accretion disks.Comment: 9 pages, 5 figures, Astronomy & Astrophysics, in pres
Near-island biological hotspots in barren ocean basins
Phytoplankton production drives marine ecosystem trophic-structure and global fisheries yields. Phytoplankton biomass is particularly influential near coral reef islands and atolls that span the oligotrophic tropical oceans. The paradoxical enhancement in phytoplankton near an island-reef ecosystem—Island Mass Effect (IME)—was first documented 60 years ago, yet much remains unknown about the prevalence and drivers of this ecologically important phenomenon. Here we provide the first basin-scale investigation of IME. We show that IME is a near-ubiquitous feature among a majority (91%) of coral reef ecosystems surveyed, creating near-island ‘hotspots' of phytoplankton biomass throughout the upper water column. Variations in IME strength are governed by geomorphic type (atoll vs island), bathymetric slope, reef area and local human impacts (for example, human-derived nutrient input). These ocean oases increase nearshore phytoplankton biomass by up to 86% over oceanic conditions, providing basal energetic resources to higher trophic levels that support subsistence-based human populations
Recommended from our members
Internal Tides and Turbulence along the 3000-m Isobath of the Hawaiian Ridge
Full-depth velocity and density profiles taken along the 3000-m isobath characterize the semidiurnal
internal tide and bottom-intensified turbulence along the Hawaiian Ridge. Observations reveal baroclinic
energy fluxes of 21 ± 5 kW m⁻¹ radiating from French Frigate Shoals, 17 ± 2.5 kW m⁻¹ from Kauai
Channel west of Oahu, and 13 ± 3.5 kW m⁻¹ from west of Nihoa Island. Weaker fluxes of 1–4 ± 2 kWm⁻¹
radiate from the region near Necker Island and east of Nihoa Island. Observed off-ridge energy fluxes
generally agree to within a factor of 2 with those produced by a tidally forced numerical model. Average
turbulent diapycnal diffusivity K is (0.5–1) x 10⁻⁴ m² s⁻¹ above 2000 m, increasing exponentially to 20 x 10⁻⁴ m² s⁻¹ near the bottom. Microstructure values agree well with those inferred from a finescale internal
wave-based parameterization. A linear relationship between the vertically integrated energy flux and vertically
integrated turbulent dissipation rate implies that dissipative length scales for the radiating internal
tide exceed 1000 km
Forcing factors affecting sea level changes at the coast
We review the characteristics of sea level variability at the coast focussing on how it differs from the variability in the nearby deep ocean. Sea level variability occurs on all timescales, with processes at higher frequencies tending to have a larger magnitude at the coast due to resonance and other dynamics. In the case of some processes, such as the tides, the presence of the coast and the shallow waters of the shelves results in the processes being considerably more complex than offshore. However, ‘coastal variability’ should not always be considered as ‘short spatial scale variability’ but can be the result of signals transmitted along the coast from 1000s km away. Fortunately, thanks to tide gauges being necessarily located at the coast, many aspects of coastal sea level variability can be claimed to be better understood than those in the deep ocean. Nevertheless, certain aspects of coastal variability remain under-researched, including how changes in some processes (e.g., wave setup, river runoff) may have contributed to the historical mean sea level records obtained from tide gauges which are now used routinely in large-scale climate research
The state of the Martian climate
60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes
In Silico Reconstitution of Actin-Based Symmetry Breaking and Motility
Computational modeling and experimentation in a model system for actin-based force generation explain how actin networks initiate and maintain directional movement
Seasonal-to-interannual prediction of North American coastal marine ecosystems: forecast methods, mechanisms of predictability, and priority developments
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Jacox, M. G., Alexander, M. A., Siedlecki, S., Chen, K., Kwon, Y., Brodie, S., Ortiz, I., Tommasi, D., Widlansky, M. J., Barrie, D., Capotondi, A., Cheng, W., Di Lorenzo, E., Edwards, C., Fiechter, J., Fratantoni, P., Hazen, E. L., Hermann, A. J., Kumar, A., Miller, A. J., Pirhalla, D., Buil, M. P., Ray, S., Sheridan, S. C., Subramanian, A., Thompson, P., Thorne, L., Annamalai, H., Aydin, K., Bograd, S. J., Griffis, R. B., Kearney, K., Kim, H., Mariotti, A., Merrifield, M., & Rykaczewski, R. Seasonal-to-interannual prediction of North American coastal marine ecosystems: forecast methods, mechanisms of predictability, and priority developments. Progress in Oceanography, 183, (2020): 102307, doi:10.1016/j.pocean.2020.102307.Marine ecosystem forecasting is an area of active research and rapid development. Promise has been shown for skillful prediction of physical, biogeochemical, and ecological variables on a range of timescales, suggesting potential for forecasts to aid in the management of living marine resources and coastal communities. However, the mechanisms underlying forecast skill in marine ecosystems are often poorly understood, and many forecasts, especially for biological variables, rely on empirical statistical relationships developed from historical observations. Here, we review statistical and dynamical marine ecosystem forecasting methods and highlight examples of their application along U.S. coastlines for seasonal-to-interannual (1–24 month) prediction of properties ranging from coastal sea level to marine top predator distributions. We then describe known mechanisms governing marine ecosystem predictability and how they have been used in forecasts to date. These mechanisms include physical atmospheric and oceanic processes, biogeochemical and ecological responses to physical forcing, and intrinsic characteristics of species themselves. In reviewing the state of the knowledge on forecasting techniques and mechanisms underlying marine ecosystem predictability, we aim to facilitate forecast development and uptake by (i) identifying methods and processes that can be exploited for development of skillful regional forecasts, (ii) informing priorities for forecast development and verification, and (iii) improving understanding of conditional forecast skill (i.e., a priori knowledge of whether a forecast is likely to be skillful). While we focus primarily on coastal marine ecosystems surrounding North America (and the U.S. in particular), we detail forecast methods, physical and biological mechanisms, and priority developments that are globally relevant.This study was supported by the NOAA Climate Program Office’s Modeling, Analysis, Predictions, and Projections (MAPP) program through grants NA17OAR4310108, NA17OAR4310112, NA17OAR4310111, NA17OAR4310110, NA17OAR4310109, NA17OAR4310104, NA17OAR4310106, and NA17OAR4310113. This paper is a product of the NOAA/MAPP Marine Prediction Task Force
- …