Households\u27 Preferences and Willingness to Pay for Hydrological Services in Veracruz, Mexico

Payments for Ecosystem Services (PES) are transfer payments from governing bodies, households, firms, or non-governmental organizations to incentivize natural resource owners and managers to carry out environmental conservation efforts that promote the provision of ecosystem services. PES programs targeting reduction of deforestation have gained popularity due to the extensive ecosystem services of forests including carbon storage, wildlife habitat, biodiversity, and the provision of hydrological services (HS), the ecosystem services that provide benefits such as water quality improvement, water damage mitigation, and non-use value. There is evidence in the literature that PES programs, while theoretically beneficial, face issues with long-term financial sustainability (Nava-Lopez et al., 2018). An increase in financing can be achieved through the introduction of a fee in the water bill of water users. However, these fees are often chosen arbitrarily without any rigorous assessment of households’ willingness-to-pay (WTP) for HS provided upstream (i.e., by forest landowners upstream from the cities) and little is known about the preferences of these households. This paper aims to estimate the value consumers have for HS through the use of a choice experiment (CE). The use of a CE allows us to elicit the preferences of the consumers of HS with respect to both the cost and the attributes of the PES program. We choose the state of Veracruz to conduct the CE because it is one of the most intensely deforested states that also struggles with both water quality and water damage issues. (Nava-Lopez et al., 2018). We developed and administered an in-person, tablet-based CE in October 2018 which used five attributes to describe the hypothetical Payments for Hydrological Services (PHS) program: Water Quality, Water Regulation Services, Eligible Land, Program Administration, and Fee. We obtained a sample of 777 observations, split between representative samples of Xalapa and Coatepec, the two cities of the state that have experience with hydrological PES programs. Water Quality and Water Regulation Services are the two attributes thought to be the main benefits that consumers would be interested in. Eligible Land has a policy implication because local governments are interested in increasing the eligibility to include shade-grown coffee. Program Administration will allow us to estimate whether consumer’s support for such PES program depends on the type of institution managing it. Fee is a variable with options 5, 20, 40, and 80 MXN per month, the amount added to household’s water bill to pay for the program. In this thesis, we construct conditional logit and mixed logit models to analyze discrete choice data. The results show that for the four non-monetary attributes, the utility function parameters of the coefficients are positive, showing respondents propensity for an improved program. The sign of the Fee coefficient is negative, showing consumers demand for lower prices. Further, the coefficients of Water Quality and Water Regulation Service are higher than those for Eligible Land and Program Administration, showing that respondents care more about improved results than the organizational structure of program delivery. A key difference between Coatepec and Xalapa is the Eligible Land variable. It is significant for Coatepec while insignificantly different from zero in Xalapa. With Coatepec being more of an agricultural small-town and Xalapa being a larger city, it intuitively makes sense that Xalapa would not care about the land enrolled in the program, and Coatepec would. Both cities do care about the Program Administration variable, with Coatepec having a coefficient twice the magnitude of the coefficient Xalapa. Our research has shown that the downstream water users in an area serve as a viable option for substantially extending the financial base of a PHS program. Evaluating the total economic value of ecosystem services and revising the level payments to landowners are two of the key policy improvements that are recommended in the future in order to make PES programs in Mexico more effective and efficient (Lara-Pulido, 2018). Our results also highlight the need to take local perceptions as well as income inequality into consideration in the design and promotion of PHS programs

The Effect of target speed and verbal instruction on NPC measures in a young, healthy, and active population

Purpose: Evaluate the effect of target speed and verbal instruction on near point of convergence (NPC) measurements in a young, healthy, and active population. Methods: NPC was measured in 20 individuals with three target speeds and two sets of verbal instruction. The target speeds used were 1 cm/s, 3 cm/s, 5 cm/s, and participant self-paced. The verbal instruction given was either to indicate when the target became “double” or “blurry”. Results: Paired-samples t-tests revealed significant differences between 5 cm/s (5.44 ± 2.01) and 1 cm/s (6.72 ± 2.39, p = .003), 3 cm/s (6.10 ± 2.36, p = .030) and self-paced (6.63 ± 2.26, p = .005). A significant difference (p < .001) was also found between the “double” (6.72 ± 2.39) and “blurry” (10.82 ± 3.08) conditions Conclusion: For young, healthy and active individuals, target speed and verbal instruction matter when measuring NPC

Kurrburra the Boonwurrung 'wirrirrap' and bard (1797-1849)-a man of high degree

Kurrburra (aka Mr Ruffy) (1797-1849), Aboriginal wirrirrap (doctor, healer, bard), sage counsellor of his people, consultant with koalas, and heroic slayer of a feared orangutan-like cryptid that lived in the ranges north of Western Port, is believed to have been born in 1797, and was a member of the Yawen djirra clan, the eastern-most group of the Boonwurrung People whose Country stretched from Wirribi-yaluk (Werribee River) to Wammun (Wilsons Promontory) in Victoria. His moiety was Bunjil and in the early 1840s he had 2 wives: Kurundum (1819-?) and Bowyeup (1823-?), and 2 children, whose names are not known. Kurrburra's traditional Aboriginal name is the Boonwurrung word for the iconic marsupial Phascolarctos cinereus, more commonly known as the koala

Koalas – agents for change : a case study from regional Victoria

We investigated the success of the Koala Conservation and Education Program conducted in Ballarat, Victoria, Australia from 2000-2009 by interviewing 28 individuals, from various stakeholder groups involved in the project. Transcripts were analysed using grounded theory to identify common themes, keywords and phrases. We conclude that the chosen ‘flagship’ species, the koala, was crucial for the success of the project which culminated in the adoption of the Koala Plan of Management and habitat overlays into the City of Ballarat’s planning scheme. Local people were concerned about the koala based on its conservation status nationally and globally rather than because of its local or Victorian status. We conclude that the concept of 'flagship' species in the case of the koala, is more a global than a local construct

Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia

<p>Abstract</p> <p>Background</p> <p>Evidence of genetic association between the NRG1 (Neuregulin-1) gene and schizophrenia is now well-documented. Furthermore, several recent reports suggest association between schizophrenia and single-nucleotide polymorphisms (SNPs) in ERBB4, one of the receptors for Neuregulin-1. In this study, we have extended the previously published associations by investigating the involvement of all eight genes from the ERBB and NRG families for association with schizophrenia.</p> <p>Methods</p> <p>Eight genes from the ERBB and NRG families were tested for association to schizophrenia using a collection of 396 cases and 1,342 blood bank controls ascertained from Aberdeen, UK. A total of 365 SNPs were tested. Association testing of both alleles and genotypes was carried out using the fast Fisher's Exact Test (FET). To understand better the nature of the associations, all pairs of SNPs separated by ≥ 0.5 cM with at least nominal evidence of association (<it>P </it>< 0.10) were tested for evidence of pairwise interaction by logistic regression analysis.</p> <p>Results</p> <p>42 out of 365 tested SNPs in the eight genes from the ERBB and NRG gene families were significantly associated with schizophrenia (<it>P </it>< 0.05). Associated SNPs were located in ERBB4 and NRG1, confirming earlier reports. However, novel associations were also seen in NRG2, NRG3 and EGFR. In pairwise interaction tests, clear evidence of gene-gene interaction was detected for NRG1-NRG2, NRG1-NRG3 and EGFR-NRG2, and suggestive evidence was also seen for ERBB4-NRG1, ERBB4-NRG2, ERBB4-NRG3 and ERBB4-ERBB2. Evidence of intragenic interaction was seen for SNPs in ERBB4.</p> <p>Conclusion</p> <p>These new findings suggest that observed associations between NRG1 and schizophrenia may be mediated through functional interaction not just with ERBB4, but with other members of the NRG and ERBB families. There is evidence that genetic interaction among these loci may increase susceptibility to schizophrenia.</p

Multiple Interventions for Diabetic Foot Ulcer Treatment Trial (MIDFUT): study protocol for a randomised controlled trial.

INTRODUCTION: Diabetes affects more than 425 million people worldwide with a lifetime risk of diabetic foot ulcer (DFU) of up to 25%. Management includes wound debridement, wound dressings, offloading, treatment of infection and ischaemia, optimising glycaemic control; use of advanced adjuvant therapies is limited by high cost and lack of robust evidence. METHODS AND ANALYSIS: A multicentre, seamless phase II/III, open, parallel group, multi-arm multi-stage randomised controlled trial in patients with a hard-to-heal DFU, with blinded outcome assessment. A maximum of 447 participants will be randomised (245 participants in phase II and 202 participants in phase III). The phase II primary objective will determine the efficacy of treatment strategies including hydrosurgical debridement ± decellularised dermal allograft, or the combination with negative pressure wound therapy, as an adjunct to treatment as usual (TAU), compared with TAU alone, with patients randomised in a 1:1:1:2 allocation. The outcome is achieving at least 50% reduction in index ulcer area at 4 weeks post randomisation.The phase III primary objective will determine whether one treatment strategy, continued from phase II, reduces time to healing of the index ulcer compared with TAU alone, with participants randomised in a 1:1 allocation. Secondary objectives will compare healing status of the index ulcer, infection rate, reulceration, quality of life, cost-effectiveness and incidence of adverse events over 52 weeks post randomisation. Phase II and phase III primary endpoint analysis will be conducted using a mixed-effects logistic regression model and Cox proportional hazards regression, respectively. A within-trial economic evaluation will be undertaken; the primary economic analysis will be a cost-utility analysis presenting ICERs for each treatment strategy in rank order of effectiveness, with effects expressed as quality-adjusted life years.The trial has predefined progression criteria for the selection of one treatment strategy into phase III based on efficacy, safety and costs at 4 weeks. ETHICS AND DISSEMINATION: Ethics approval has been granted by the National Research Ethics Service (NRES) Committee Yorkshire and The Humber - Bradford Leeds Research Ethics Committee; approved 26 April 2017; (REC reference: 17/YH/0055). There is planned publication of a monograph in National Institute for Health Research journals and main trial results and associated papers in high-impact peer-reviewed journals. TRIAL REGISTRATION NUMBER: ISRCTN64926597; registered on 6 June 2017

Patients with Surgical Wounds Healing by Secondary Intention: A Prospective, Cohort Study

Background: Surgical wounds healing by secondary intention can be difficult and costly to manage and are profoundly under researched. This prospective inception, cohort study aimed to derive a better understanding of surgical wounds healing by secondary intention and to facilitate the design of future research investigating effective treatments. Objectives: To investigate the clinical characteristics of patients with surgical wounds healing by secondary intention and the surgeries that preceded their wounds; to clearly delineate the clinical outcomes of these patients, specifically focusing on time to wound healing and its determinants; to explore the types of treatments for surgical wounds healing by secondary intention; and to assess the impact surgical wounds healing by secondary intention have on patients’ quality of life. Design: Prospective, inception cohort study. Setting: Acute and community settings in eight sites across two large centres in the United Kingdom (Hull and Leeds, UK). Methods: Patients with a surgical wounds healing by secondary intention (an open wound, < 3 weeks’ duration, resulting from surgery), were recruited and followed up for at least 12 months. Key outcome events included: time to healing; treatment type; infection; hospital re-admission and further procedures; health-related quality of life and pain. Results: In total, 393 patients were recruited. Common co-morbidities were cardiovascular disease (38%), diabetes (26%) and peripheral vascular disease (14.5%). Baseline median SWHSI area was 6 cm2 (range 0.01-1200). Abdominal (n=132), foot (n=59), leg (n=58) and peri-anal (n=34) wounds were common. The majority of wounds (236, 60.1%) were intentionally left open following surgery; the remainder were mostly dehisced wounds. Healing was observed in 320 (81.4%) wounds with a median time to healing of 86 days (95% CI: 75-130). Factors associated with delayed healing included wound infection at any point and baseline wound area above the median. Health-related quality of life scores were low at baseline but improved with time and healing. Conclusions: This is the first inception cohort study in patients with surgical wounds healing by secondary intention. Patient characteristics have been clearly defined, with prolonged healing times and adverse events being common impacting on patient’s health-related quality of life. Areas for, and factors crucial to the design of, future research have been identified. Key Words: Surgical wounds, secondary intention, inception cohort, characteristics, clinical outcomes, treatments, quality of life

Sustainable intensification – “oxymoron” or “third-way”? A systematic review

Sustainable Intensification (SI) is a term that has been advanced to capture a concept that some consider as the ‘third paradigm’ for global agricultural development. However, the term has become subject to intense debates as well as scepticism and confusion regarding its meaning and the characteristics of production systems that could indicate SI (defined as “indicators”). This has resulted in a proliferation of literature. We have conducted a systematic review of a sample of this literature analysing the most commonly suggested indicators of SI in order to investigate the extent to which the critiques of SI are valid in their viewpoints that SI is an oxymoron, underpinned by a productivist agenda, and to identify the critical issues in the development of a comprehensive and unambiguous set of SI indicators. From 633 articles identified by a search of relevant databases, a sample of 75 articles were selected and analysed using the NVIVO™ software. The results were organised according to a Socio-Ecological Systems (SES) framework comprising seven sub-systems or components − resource system, resource units, governance system, resource users, interactions, outcomes, and environment. A total of 218 indicators (both positive and negative) were identified. Most of these indicators focused on the ‘outcomes’ of agricultural systems with the majority being related to agricultural production. Few indicators were identified as relating to the economic and societal dimensions of food systems. Whilst this potentially suggested a productivist bias in the current interpretation of SI it was difficult to draw a black and white conclusion, since for the other system components, the majority of the indicators suggested appeared to take a more holistic point-of-view and emphasised both productivity and sustainability of agricultural systems. Our analysis suggests that a key reason why SI may be viewed with scepticism is a lack of specificity and elucidation of the rationale, scale, and farm type for which SI is proposed. Moreover, a number of the indicators were so loosely defined that the interventions they imply could be enacted without due consideration of the social impacts of their adoption. We conclude that there is need to develop SI indicators according to specific farming types and scales and also with more consideration of the social and political dimensions of food systems in order to promote a constructive dialogue around the concept of SI to take place. Unless the concept of SI is described and measured in such a holistic and inclusive manner, it is unlikely to be accepted as a valid descriptor of sought-after agricultural practices by players in the Third Sector

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, loci within the MHC determine susceptibility remains unclear. Here, in several large type 1 diabetes data sets, we analyse a combined total of 1,729 polymorphisms, and apply statistical methods - recursive partitioning and regression - to pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A (risk ratios >1.5; Pcombined = 2.01 × 10-19 and 2.35 × 10-13, respectively) in addition to the established associations of the MHC class II genes. Other loci with smaller and/or rarer effects might also be involved, but to find these, future searches must take into account both the HLA class II and class I genes and use even larger samples. Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes. ©2007 Nature Publishing Group

Towards a muon collider

A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work