Assessing the RELAPS-3D Heat Conduction Enclosure Model

Three heat conduction problems that have exact solutions are modeled with RELAP5-3D using the conduction enclosure model. These comparisons are designed to be used in the RELAP5-3D development assessment scheduled to be completed in 2009. It is shown that with proper input choices and adequate model detail the exact solutions can be matched. In addition, this analysis identified an error and the required correction in the cylindrical and spherical heat conductor models in RELAP5-3D which will be corrected in a future version of RELAP5-3D

Advanced Caution and Warning System, Final Report - 2011

The work described in this report is a continuation of the ACAWS work funded in fiscal year (FY) 2010 under the Exploration Technology Development Program (ETDP), Integrated Systems Health Management (ISHM) project. In FY 2010, we developed requirements for an ACAWS system and vetted the requirements with potential users via a concept demonstration system. In FY 2011, we developed a working prototype of aspects of that concept, with placeholders for technologies to be fully developed in future phases of the project. The objective is to develop general capability to assist operators with system health monitoring and failure diagnosis. Moreover, ACAWS was integrated with the Discrete Controls (DC) task of the Autonomous Systems and Avionics (ASA) project. The primary objective of DC is to demonstrate an electronic and interactive procedure display environment and multiple levels of automation (automatic execution by computer, execution by computer if the operator consents, and manual execution by the operator)

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc