On the optimality of Treasury bond auctions : the Spanish case

Se analizan las subastas del Tesoro español tanto desde una perspectiva teorica como empirica. En el analisis teorico se presenta un modelo con objeto de estudiar si las subastas de bonos españoles maximizan los ingresos para el vendedor. En el analisis empirico se contrastan las predicciones del modelo teorico y se examinan los determinantes del 'descuento' (diferencial entre el precio del mercado secundario y el de la subasta). (ad

Optimalidad de las subastas de bonos : el caso español

Artículo de revistaEste articulo es un resumen del Documento de Trabajo N. 9905, del Servicio de Estudios del Banco de España. El objetivo es analizar si el tipo de subastas de bonos del Estado utilizado por el Tesoro español maximiza los ingresos esperados por este. Para ello se desarrolla un modelo teorico muy simplificado que recoge las dos peculiaridades mas destacadas de la subasta de bonos española : el mecanismo utilizado y la incertidumbre sobre la cantidad que se va a emitir. Se lleva a cabo un analisis empirico de dichas subastas para el periodo enero 1993 - agosto 1997, a fin de examinar el tamaño, la significatividad y los determinantes del descuento de la subasta. (igg

Las competencias TIC en los estudiantes universitarios de primer ingreso

El continuo desarrollo de la Sociedad del Conocimiento obliga a que las instituciones de educación superior deban preparar a sus profesionales con cada vez mayores competencias en el uso de las TIC aplicadas a diferentes campos de las Ciencias. En este sentido, y para poder adaptar los objetivos de aprendizaje de las asignaturas relacionas con las TIC a las reales necesidades de los estudiantes, es fundamental contar con un diagnóstico inicial de estas competencias de los estudiantes cuando llegan a la universidad. Así, el objetivo del presente trabajo fue investigar las percepciones que tienen los estudiantes que ingresan a la Facultad de Ciencias de la Educación, de la Universidad Nacional de Chimborazo en Ecuador, sobre el manejo de sus competencias TIC. Para esto se diseñó un estudio no experimental de alcance descriptivo, aplicando la técnica de la encuesta con un instrumento previamente diseñado y validado en la Universidad Metropolitana de Ciencias de la Educación de Chile. Los resultados muestran ciertas preferencias de uso de algunas herramientas y recursos web 2.0 tanto para trabajo colaborativo, almacenamiento en la nube, para tomar notas, entre otras. Así como, su auto-percepción sobre el manejo de algunas herramientas tecnológicas

Gender differences on healthcare accessibility and outcomes of a electronic inter-clinician consultation program at the cardiology department in a Galician Health Area

Aims To assess the longer-term results (hospital admissions and mortality) in women versus men referred to a cardiology department from primary care using an e-consultation in our outpatient care programme. Methods We selected 61,306 patients (30,312 women and 30,994 men) who visited the cardiology service at least once between 2010 and 2021: 69.1% (19,997 women and 20,462 men) were attended in e-consultation (from 2013 to 2021) and 30.9% (8920 women and 9136 men) in in-person consultations (from 2010 to 2012) without gender differences in the proportion of patients attended in each period. Using an interrupted time series regression model, we analysed the impact of incorporating e-consultation into the healthcare model and evaluated the elapsed time to cardiology care, heart failure (HF), cardiovascular (CV), and all-cause hospital admissions and mortality during the one-year after cardiology consultation. Results The introduction of e-consultation substantially decreased waiting times to cardiology care; during the in-person consultation period, the mean delay for cardiology care was 57.9 (24.8) days in men and 55.8 (22.8) days in women. During the e-consultation period, the waiting time to cardiology care was markedly reduced to 9.41 (4.02) days in men and 9.46 (4.18) in women. After e-consultation implantation, there was a significant reduction in the 1-year rate of hospital admissions and mortality, both in women and men iRR [IC 95%]: 0.95 [0.93–0.96] for HF, 0.90 [0.89–0.91] for CV and 0.70 [0.69–0.71] for all-cause hospitalization; and 0.93 [0.92–0.95] for HF, 0.86 [0.86–0.87] for CV and 0.88 [0.87–0.89] for all-cause mortality in women; and 0.91 [0.89–0.92] for HF, 0.90 [0.89–0.91] for CV and 0.72 [0.71–0.73] for all-cause hospitalization; and 0.96 [0.93–0.97] for HF, 0.87 [95% CI: 0.86–0.87] for CV and 0.87 [0.86–0.87] for all-cause mortality, in men. Conclusion Compared with the in-person consultation period, an outpatient care programme that includes an e-consultation significantly reduced waiting time to cardiology care and was safe, with a lower rate of hospital admissions and mortality in the first year, without significative gender differencesS

The aetiology of paediatric inflammatory vulvovaginitis

5 p.Vulvovaginitis is the most common gynaecological problem in prepubertal girls and clear-cut data on the microbial aetiology of moderate to severe infections are lacking. Many microorganisms have been reported in several studies, but frequently the paediatrician does not know the pathogenic significance of an isolate reported in vaginal specimens of girls with vulvovaginitis. A multicentre study was performed, selecting 74 girls aged 2 to 12 years old with a clinical picture of vulvovaginitis and inflammatory cells on Gram stain. All the specimens were cultured following standard microbiological techniques and the paediatricians completed a questionnaire to highlight risk factors after interviewing the parents or tutors. The data were compared with those obtained in a control group of 11 girls without vulvovaginitis attending a clinic. Streptococcus pyogenesand Haemophilus spp.were isolated in 47 and 12 cases, respectively. Upper respiratory infection in the previous month ( P<0.001) and vulvovaginitis in the previous year ( P<0.05) were identified as significant risk factors. Foreign bodies, sexual abuse, poor hygiene and bad socioeconomic situation were not identified as risk factors for the infection

Bone mineral density, bone remodeling and osteoprotegerin in patients with acute coronary syndrome

Producción CientíficaThe objective of this study was to evaluate the relationship between coronary disease and osteoporosis and determine the effect of osteoprotegerin (OPG) on bone remodeling and bone mineral density (BMD) in a group of patients with acute coronary syndrome. Eightythree patients (52 males and 31 women) with acute coronary syndrome (75 patients with acute myocardial infarction and 8 with unstable angina) with an average age of 61±10 years were studied. Levels of osteocalcin, urinarydeoxypyridinoline, OPG and the receptor activator of nuclear factor-κB ligand (RANKL) were determined during the hospital stay. Femoral neck, trochanter and lumbar spine densitometry was carried out using a DXA densitometer. Thirty percent of patients presented osteoporosis (39% of females and 26% of males). Osteoporotic patients were older and had a lower weight and height and elevated serum levels of osteocalcin (3.6±2.25 2.63 versus ±1.55, p=0.05). Levels of OPG and RANKL were similar in both groups and showed no relationship with BMD. In conclusion, no relationship was observed between the OPG/RANKL system and BMD in these patients

The impact of inter-clinician electronic consultation in patients diagnosed with atrial fibrillation in primary care

Background An early diagnosis and early initiation of oral anticoagulants (OAC) are main determinants for outcomes in patients with atrial fibrillation (AF). Inter-clinician electronic consultations (e-consultations) program for the general practitioner referrals to cardiologist may improve health care access by reducing the elapsed time for cardiology care. Objective To evaluate the effect of a reduced elapsed time to care after a inter-clinician e-consultations program implementation (2013–2019) in comparison with previous in-person consultation (2010–2012) in the outpatient health care management in a Cardiology Department. Methodology We included 10,488 patients with AF from 1 January 2010, to 31 December 2019. Until 2012, all patients attended an in-person consultation (2010–2012). In 2013, we instituted an e-consult program (2013–2019) for all primary care referrals to cardiologists that preceded patient's in-person consultation when considered. The shared electronic patient dossier (EPD) was available between GP and cardiologist, and any change in therapy advice from cardiologist was directly implemented in this EPD. Results During the e-consultation period (2013–2019) were referred 6627 patients by GPs to cardiology versus 3861 during the in-person consultation (2010–2012). The e-consultation implementation was associated with a reduction in the elapsed time to anticoagulation prescription (177.6 ± 8.9 vs. 22.5 ± 8.1 days, p < .001), and an increase of OAC use (61% [95% IC: 19.6%–102.4%], p < .001). The e-consult program implementation was associated with a reduction in the 1-year CV mortality (.48 [95% CI: .30–.75]) and all-cause mortality (.42 [95% CI: .29–.62]). The OAC reduces the stroke mortality (.15 [95% CI: .06–.39]) and CV mortality (.43 [95% CI: .29–.62]) and all-cause mortality (.23 [95% CI: .17–.31]). Conclusion A shared EPD-based inter-clinician e-consultation program significantly reduced the elapsed time for cardiology consultation and initiation of OAC. The implementation of this program was associated with a lower risk of stroke and cardiovascular/all-cause mortalityS

Valor pronóstico de los anticuerpos anti-Chlamydia pneumoniae en la cardiopatía isquémica

Producción CientíficaSe ha relacionado la enfermedad arterial coronaria con infección por Chlamydia pneumoniae, pero existen pocos estudios que valoren la presencia de anticuerpos frente a este microorganismo y el pronóstico de los pacientes con cardiopatía isquémica. El objetivo de nuestro estudio fue valorar el impacto de la positividad de anticuerpos anti-Chlamydia pneumoniae en la morbimortalidad asociada a la cardiopatía isquémica

TOR complex 1 regulates the yeast plasma membrane proton pump and pH and potassium homeostasis

[EN] We have identified in yeast a connection between two master regulators of cell growth: a biochemical connection involving the TORC1 protein kinase (which activates protein synthesis, nutrient uptake, and anabolism) and a biophysical connection involving the plasma membrane proton-pumping H+ -ATPase Pma1 (which drives nutrient and K+ uptake and regulates pH homeostasis). Raising the temperature to nonpermissive values in a TOR thermosensitive mutant decreases Pma1 activity. Rapamycin, a TORC1 inhibitor, inhibits Pma1 dependent on its receptor Fpr1 and on the protein phosphatase Sit4, a TORC1 effector. Mutation of either Sit4 or Tco89, a nonessential subunit of TORC1, decreases proton efflux, K+ uptake, intracellular pH, cell growth, and tolerance to weak organic acids. Tco89 does not affect Pma1 activity but activates K+ transport.We thank Prof. Michael N. Hall (Basel) for strains SH100 and SH221, and Prof. Joaquin Arino (Barcelona) for strain BY4741 and its null mutant derivatives fpr1 Delta 0, sit4 Delta 0, and tco89 Delta 0. We also thank Prof. Francisco Portillo (Madrid) for the antibody against the double phosphorylation of Ser911 Thr912 in Pma1. This work was funded by grant PROME-TEOII/2014/041 from Generalitat Valenciana (Valencia, Spain).Mahmoud, S.; Planes Ferrer, MD.; Cabedo López, M.; Trujillo, C.; Rienzo, A.; Caballero Molada, M.; Sharma, SC.... (2017). TOR complex 1 regulates the yeast plasma membrane proton pump and pH and potassium homeostasis. FEBS Letters. 591(13):1993-2002. https://doi.org/10.1002/1873-3468.12673S199320025911

Synthesis and characterization of a Bio-MOF based on mixed adeninate/tricarboxylate ligands and zinc ions

Artículo científicoIn this work, we present a new metal organic framework Zn7(Ad)4(BTC)4(DMF)O·4DMA·3DMF·4H2O which was synthesized under hydrothermal conditions with adenine and trimesic acid (BTC) linkers. The structure was determined by single-crystal (XRD) and the compound was further characterized by Scanning electron microscopy (SEM), infrared spectroscopy (IR), and thermogravimetric analysis. The 3D anionic framework includes adenine present in two-different coordination modes, with dimethylammonium balancing the framework charg