Stepwise drying of Lake Turkana at the end of the African Humid Period: a forced regression modulated by solar activity variations?

Although the timing of the termination of the African Humid Period (AHP) is now relatively well estab- lished, the modes and controlling factors of this drying are still debated. Here, through a geomorphological approach, we characterize the regression of Lake Turkana at the end of the AHP. We show that lake level fall during this period was not continuous but rather stepwise and consisted of five episodes of rapid lake level fall separated by episodes marked by slower rates of lake level fall. Whereas the overall regres- sive trend reflects a decrease in regional precipitations linked to the gradual reduction in Northern Hemisphere summer in- solation, itself controlled by orbital precession, we focus dis- cussion on the origin of the five periods of accelerated lake level fall. We propose that these periods are due to temporary reductions in rainfall across the Lake Turkana area associ- ated with repeated westward displacement of the Congo Air Boundary (CAB) during solar activity minima

A new species of hippopotamine (Cetartiodactyla, Hippopotamidae) from the late Miocene Baynunah Formation, Abu Dhabi, United Arab Emirates

The discovery of new hippopotamid material from the late Miocene Baynunah Formation (Abu Dhabi, United Arab Emirates) has prompted the revision of the existing material of this as yet unnamed fossil taxon. The Baynunah hippopotamid appears to be distinct from all other contemporary and later species in having a relatively more elongate symphysis, a feature similar to the earlier (and more primitive) Kenyapotamus. Yet, the Baynunah hippopotamid presents a dentition typical of the Hippopotaminae. It is therefore a distinct species attributed to the later subfamily, described and named in this contribution. This species provides further evidence for a ca. 8 Ma evolutionary event (termed “Hippopotamine Event”) that initiated the spread and ecological significance of the Hippopotaminae into wet habitats across Africa and Eurasia. The morphological affinities of the new species from Abu Dhabi suggest that the Arabian Peninsula was not a dispersal route from Africa toward southern Asia for the Hippopotamidae at ca. 7.5 Ma to 6.5 Ma

The Lake CHAd Deep DRILLing project (CHADRILL) – targeting ~10 million years of environmental and climate change in Africa

At present, Lake Chad ( ∼ 13◦0 N, ∼ 14◦ E) is a shallow freshwater lake located in the Sahel/Sahara region of central northern Africa. The lake is primarily fed by the Chari–Logone river system draining a ∼ 600 000 km2 watershed in tropical Africa. Discharge is strongly controlled by the annual passage of the intertropical convergence zone (ITCZ) and monsoon circulation leading to a peak in rainfall during boreal summer. During recent decades, a large number of studies have been carried out in the Lake Chad Basin (LCB). They have mostly focused on a patchwork of exposed lake sediments and outcrops once inhabited by early hominids. A dataset generated from a 673 m long geotechnical borehole drilled in 1973, along with outcrop and seismic reflection studies, reveal several hundred metres of Miocene–Pleistocene lacustrine deposits. CHADRILL aims to recover a sedimentary core spanning the Miocene–Pleistocene sediment succession of Lake Chad through deep drilling. This record will provide significant insights into the modulation of orbitally forced changes in northern African hydroclimate under different climate boundary conditions such as high CO2 and absence of Northern Hemisphere ice sheets. These investigations will also help unravel both the age and the origin of the lake and its current desert surrounding. The LCB is very rich in early hominid fossils (Australopithecus bahrelghazali; Sahelanthropus tchadensis) of Late Miocene age. Thus, retrieving a sediment core from this basin will provide the most continuous climatic and environmental record with which to compare hominid migrations across northern Africa and has major implications for understanding human evolution. Furthermore, due to its dramatic and episodically changing water levels and associated depositional modes, Lake Chad’s sediments resemble maybe an analogue for lake systems that were once present on Mars. Consequently, the study of the subsurface biosphere contained in these sediments has the potential to shed light on microbial biodiversity present in this type of depositional environment. We propose to drill a total of ∼ 1800 m of poorly to semi-consolidated lacustrine, fluvial, and eolian sediments down to bedrock at a single on-shore site close to the shoreline of present-day Lake Chad. We propose to locate our drilling operations on-shore close to the site where the geotechnical Bol borehole (13◦280 N, 14◦440 E) was drilled in 1973. This is for two main reasons: (1) nowhere else in the Chad Basin do we have such detailed information about the lithologies to be drilled; and (2) the Bol site is close to the depocentre of the Chad Basin and therefore likely to provide the stratigraphically most continuous sequence

Apolipoprotein E mediates evasion from hepatitis C virus−neutralizing antibodies

Background & Aims Efforts to develop an effective vaccine against hepatitis C virus (HCV) have been hindered by the propensity of the virus to evade host immune responses. HCV particles in serum and in cell culture associate with lipoproteins, which contribute to viral entry. Lipoprotein association has also been proposed to mediate viral evasion of the humoral immune response, though the mechanisms are poorly defined. Methods We used small interfering RNAs to reduce levels of apolipoprotein E (apoE) in cell culture−derived HCV−producing Huh7.5-derived hepatoma cells and confirmed its depletion by immunoblot analyses of purified viral particles. Before infection of naïve hepatoma cells, we exposed cell culture−derived HCV strains of different genotypes, subtypes, and variants to serum and polyclonal and monoclonal antibodies isolated from patients with chronic HCV infection. We analyzed the interaction of apoE with viral envelope glycoprotein E2 and HCV virions by immunoprecipitation. Results Through loss-of-function studies on patient-derived HCV variants of several genotypes and subtypes, we found that the HCV particle apoE allows the virus to avoid neutralization by patient-derived antibodies. Functional studies with human monoclonal antiviral antibodies showed that conformational epitopes of envelope glycoprotein E2 domains B and C were exposed after depletion of apoE. The level and conformation of virion-associated apoE affected the ability of the virus to escape neutralization by antibodies. Conclusions In cell-infection studies, we found that HCV-associated apoE helps the virus avoid neutralization by antibodies against HCV isolated from chronically infected patients. This method of immune evasion poses a challenge for the development of HCV vaccines

A UBVI and uvbyCaHbeta Analysis of the Intermediate-Age Open Cluster, NGC 5822

NGC 5822 is a richly populated, moderately nearby, intermediate-age open cluster covering an area larger than the full moon on the sky. A CCD survey of the cluster on the UBVI and uvbyCaHbeta systems shows that the cluster is superposed upon a heavily reddened field of background stars with E(B-V) > 0.35 mag, while the cluster has small and uniform reddening at E(b-y) = 0.075 +/- 0.008 mag or E(B-V) = 0.103 +/- 0.011 mag, based upon 48 and 61 probable A and F dwarf single-star members, respectively. The errors quoted include both internal photometric precision and external photometric uncertainties. The metallicity derived from 61 probable single F-star members is [Fe/H] = -0.058 +/- 0.027 (sem) from m_1 and 0.010 +/- 0.020 (sem) from hk, for a weighted average of [Fe/H] = -0.019 +/- 0.023, where the errors refer to the internal errors from the photometry alone. With reddening and metallicity fixed, the cluster age and apparent distance modulus are obtained through a comparison to appropriate isochrones in both VI and BV, producing 0.9 +/- 0.1 Gyr and 9.85 +/- 0.15, respectively. The giant branch remains dominated by two distinct clumps of stars, though the brighter clump seems a better match to the core-He-burning phase while the fainter clump straddles the first-ascent red giant branch. Four potential new clump members have been identified, equally split between the two groups. Reanalysis of the UBV two-color data extending well down the main sequence shows it to be optimally matched by reddening near E(B-V) = 0.10 rather than the older value of 0.15, leading to [Fe/H] between -0.16 and 0.00 from the ultraviolet excess of the unevolved dwarfs. The impact of the lower reddening and younger age of the cluster on previous analyses of the cluster is discussed.Comment: 20 figures and 5 tables (portions of data tables 3 and 5 only

"Freshwater killer whales": beaching behavior of an alien fish to hunt land birds

The behavioral strategies developed by predators to capture and kill their prey are fascinating, notably for predators that forage for prey at, or beyond, the boundaries of their ecosystem. We report here the occurrence of a beaching behavior used by an alien and large-bodied freshwater predatory fish (Silurus glanis) to capture birds on land (i.e. pigeons, Columbia livia). Among a total of 45 beaching behaviors observed and filmed, 28% were successful in bird capture. Stable isotope analyses (δ¹³C and δ¹⁵N) of predators and their putative prey revealed a highly variable dietary contribution of land birds among individuals. Since this extreme behavior has not been reported in the native range of the species, our results suggest that some individuals in introduced predator populations may adapt their behavior to forage on novel prey in new environments, leading to behavioral and trophic specialization to actively cross the water-land interface

Current density inhomogeneity throughout the thickness of superconducting films and its effect on their irreversible magnetic properties

We calculate the distribution of the current density $j$ in superconducting films along the direction of an external field applied perpendicular to the film plane. Our analysis reveals that in the presence of bulk pinning $j$ is inhomogeneous on a length scale of order the inter vortex distance. This inhomogeneity is significantly enhanced in the presence of surface pinning. We introduce new critical state model, which takes into account the current density variations throughout the film thickness, and show how these variations give rise to the experimentally observed thickness dependence of $$ and magnetic relaxation rate.Comment: RevTex, 9 PS figures. To appear in Phys. Rev.

The formation of disc galaxies in a LCDM universe

We study the formation of disc galaxies in a fully cosmological framework using adaptive mesh refinement simulations. We perform an extensive parameter study of the main subgrid processes that control how gas is converted into stars and the coupled effect of supernovae feedback. We argue that previous attempts to form disc galaxies have been unsuccessful because of the universal adoption of strong feedback combined with high star formation efficiencies. Unless extreme amounts of energy are injected into the interstellar medium during supernovae events, these star formation parameters result in bulge dominated S0/Sa galaxies as star formation is too efficient at z~3. We show that a low efficiency of star-formation more closely models the subparsec physical processes, especially at high redshift. We highlight the successful formation of extended disc galaxies with scale lengths r_d=4-5 kpc, flat rotation curves and bulge to disc ratios of B/D~1/4. Not only do we resolve the formation of a Milky Way-like spiral galaxy, we also observe the secular evolution of the disc as it forms a pseudo-bulge. The disc properties agree well with observations and are compatible with the photometric and baryonic Tully-Fisher relations, the Kennicutt-Schmidt relation and the observed angular momentum content of spiral galaxies. We conclude that underlying small-scale star formation physics plays a larger role than previously considered in simulations of galaxy formation.Comment: Published in MNRA

Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.

Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore, virus production is dependent on hepatic very-low-density lipoprotein (VLDL) assembly, and circulating virions are physically associated with lipoproteins in complexes termed lipoviral particles. Evidence has indicated several functional roles for the formation of these complexes, including co-opting of lipoprotein receptors for attachment and entry, concealing epitopes to facilitate immune escape, and hijacking host factors for HCV maturation and secretion. Here, we review the evidence surrounding pathogenesis of the hepatitis C infection regarding lipoprotein engagement, cholesterol and triglyceride regulation, and the molecular mechanisms underlying these effects

Flavour compounds in tomato fruits: identification of loci and potential pathways affecting volatile composition

The unique flavour of a tomato fruit is the sum of a complex interaction among sugars, acids, and a large set of volatile compounds. While it is generally acknowledged that the flavour of commercially produced tomatoes is inferior, the biochemical and genetic complexity of the trait has made breeding for improved flavour extremely difficult. The volatiles, in particular, present a major challenge for flavour improvement, being generated from a diverse set of lipid, amino acid, and carotenoid precursors. Very few genes controlling their biosynthesis have been identified. New quantitative trait loci (QTLs) that affect the volatile emissions of red-ripe fruits are described here. A population of introgression lines derived from a cross between the cultivated tomato Solanum lycopersicum and its wild relative, S. habrochaites, was characterized over multiple seasons and locations. A total of 30 QTLs affecting the emission of one or more volatiles were mapped. The data from this mapping project, combined with previously collected data on an IL population derived from a cross between S. lycopersicum and S. pennellii populations, were used to construct a correlational database. A metabolite tree derived from these data provides new insights into the pathways for the synthesis of several of these volatiles. One QTL is a novel locus affecting fruit carotenoid content on chromosome 2. Volatile emissions from this and other lines indicate that the linear and cyclic apocarotenoid volatiles are probably derived from separate carotenoid pools