Complement Activation in Patients With Probable Systemic Lupus Erythematosus and Ability to Predict Progression to American College of Rheumatology-Classified Systemic Lupus Erythematosus.

ObjectiveTo evaluate the frequency of cell-bound complement activation products (CB-CAPs) as a marker of complement activation in patients with suspected systemic lupus erythematosus (SLE) and the usefulness of this biomarker as a predictor of the evolution of probable SLE into SLE as classified by the American College of Rheumatology (ACR) criteria.MethodsPatients in whom SLE was suspected by lupus experts and who fulfilled 3 ACR classification criteria for SLE (probable SLE) were enrolled, along with patients with established SLE as classified by both the ACR and the Systemic Lupus International Collaborating Clinics (SLICC) criteria, patients with primary Sjögren's syndrome (SS), and patients with other rheumatic diseases. Individual CB-CAPs were measured by flow cytometry, and positivity rates were compared to those of commonly assessed biomarkers, including serum complement proteins (C3 and C4) and autoantibodies. The frequency of a positive multianalyte assay panel (MAP), which includes CB-CAPs, was also evaluated. Probable SLE cases were followed up prospectively.ResultsThe 92 patients with probable SLE were diagnosed more recently than the 53 patients with established SLE, and their use of antirheumatic medications was lower. At the enrollment visit, more patients with probable SLE were positive for CB-CAPs (28%) or MAP (40%) than had low complement levels (9%) (P = 0.0001 for each). In probable SLE, MAP scores of >0.8 at enrollment predicted fulfillment of a fourth ACR criterion within 18 months (hazard ratio 3.11, P < 0.01).ConclusionComplement activation occurs in some patients with probable SLE and can be detected with higher frequency by evaluating CB-CAPs and MAP than by assessing traditional serum complement protein levels. A MAP score above 0.8 predicts transition to classifiable SLE according to ACR criteria

Estimating photometric redshifts with artificial neural networks

A new approach to estimating photometric redshifts - using Artificial Neural Networks (ANNs) - is investigated. Unlike the standard template-fitting photometric redshift technique, a large spectroscopically-identified training set is required but, where one is available, ANNs produce photometric redshift accuracies at least as good as and often better than the template-fitting method. The Bayesian priors on the underlying redshift distribution are automatically taken into account. Furthermore, inputs other than galaxy colours - such as morphology, angular size and surface brightness - may be easily incorporated, and their utility assessed. Different ANN architectures are tested on a semi-analytic model galaxy catalogue and the results are compared with the template-fitting method. Finally the method is tested on a sample of ~ 20000 galaxies from the Sloan Digital Sky Survey. The r.m.s. redshift error in the range z < 0.35 is ~ 0.021.Comment: Submitted to MNRAS, 9 pages, 9 figures, substantial improvements to paper structur

The not-so-massive black hole in the microquasar GRS1915+105

We present a new dynamical study of the black hole X-ray transient GRS1915+105 making use of near-infrared spectroscopy obtained with X-shooter at the VLT. We detect a large number of donor star absorption features across a wide range of wavelengths spanning the H and K bands. Our 24 epochs covering a baseline of over 1 year permit us to determine a new binary ephemeris including a refined orbital period of P=33.85 +/- 0.16 d. The donor star radial velocity curves deliver a significantly improved determination of the donor semi-amplitude which is both accurate (K_2=126 +/- 1 km/s) and robust against choice of donor star template and spectral features used. We furthermore constrain the donor star's rotational broadening to vsini=21 +/-4 km/s, delivering a binary mass ratio of q=0.042 +/- 0.024. If we combine these new constraints with distance and inclination estimates derived from modelling the radio emission, a black hole mass of M_BH=10.1 +/- 0.6 M_sun is inferred, paired with an evolved mass donor of M_2=0.47 +/- 0.27 M_sun. Our analysis suggests a more typical black hole mass for GRS1915+105 rather than the unusually high values derived in the pioneering dynamical study by Greiner et al. (2001). Our data demonstrate that high-resolution infrared spectroscopy of obscured accreting binaries can deliver dynamical mass determinations with a precision on par with optical studies

Dark Matter in the Universe: Evidence, Candidates and Searches

Contribution from the students of the 4th CERNCLAF School of High-Energy Physics who participated in the Discussion Session addressing the issues of dark matter in the Universe

A planetary companion around the K giant eps Corona Borealis

Aims. Our aim is to search for and study the origin of the low-amplitude and long-periodic radial velocity (RV) variations in K giants. Methods. We present high-resolution RV measurements of K2 giant epsilon CrB from February 2005 to January 2012 using the fiber-fed Bohyunsan Observatory Echelle Spectrograph (BOES) at the Bohyunsan Optical Astronomy Observatory (BOAO). Results. We find that the RV measurements for epsilon CrB exhibit a periodic variation of 417.9 +/- 0.5 days with a semi-amplitude of 129.4 +/- 2.0 m/s. There is no correlation between RV measurements and chromospheric activity in the Ca II H region, the Hipparcos photometry, or bisector velocity span. Conclusions. Keplerian motion is the most likely explanation, with the RV variations arising from an orbital motion. Assuming a possible stellar mass of 1.7 +/- 0.1 M_Sun for epsilon CrB, we obtain a minimum mass for the planetary companion of 6.7 +/- 0.3 M_Jup with an orbital semi-major axis of 1.3 AU and eccentricity of 0.11. We also discuss the implications of our observations for stellar metallicity versus planet occurrence rate and stellar mass versus planetary mass relations.Comment: 5 pages, 7 figures, 3 tables, accepted for publisation in Astronomy & Astrophysic

The immune cell landscape in kidneys of patients with lupus nephritis.

Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control subjects using single-cell RNA sequencing. Our analysis revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid cells, T cells, natural killer cells and B cells that demonstrated both pro-inflammatory responses and inflammation-resolving responses. We found evidence of local activation of B cells correlated with an age-associated B-cell signature and evidence of progressive stages of monocyte differentiation within the kidney. A clear interferon response was observed in most cells. Two chemokine receptors, CXCR4 and CX3CR1, were broadly expressed, implying a potentially central role in cell trafficking. Gene expression of immune cells in urine and kidney was highly correlated, which would suggest that urine might serve as a surrogate for kidney biopsies

Charged kaon lifetime at KLOE

Preliminary result on the charged kaon lifetime, obtained by the KLOE experiment operating at DA$\Phi$NE, the Frascati $\phi$-factory, is presentedComment: 3 pages, 3 figures, to appear in the proceedings of 42nd Rencontres de Moriond on Electroweak Interactions and Unified Theories, La Thuile, Aosta Valley, Italy, 10-17 Mar 200

A global fit to determine the pseudoscalar mixing angle and the gluonium content of the eta' meson

We update the values of the eta-eta' mixing angle and of the eta' gluonium content by fitting our measurement R_phi = BR(phi to eta' gamma)/ BR(phi to eta gamma) together with several vector meson radiative decays to pseudoscalars (V to P gamma), pseudoscalar mesons radiative decays to vectors (P to V gamma) and the eta' to gamma gamma, pi^0 to gamma gamma widths. From the fit we extract a gluonium fraction of Z^2_G = 0.12 +- 0.04, the pseudoscalar mixing angle psi_P = (40.4 +- 0.6) degree and the phi-omega mixing angle psi_V = (3.32 +- 0.09) degree. Z^2_G and psi_P are fairly consistent with those previously published. We also evaluate the impact on the eta' gluonium content determination of future experimental improvements of the eta' branching ratios and decay width.Comment: 13 pages, 7 figures to submit to JHE

Discovery of a weak magnetic field in the photosphere of the single giant Pollux

Aims: We observe the nearby, weakly-active single giant, Pollux, in order to directly study and infer the nature of its magnetic field. Methods: We used the new generation spectropolarimeters ESPaDOnS and NARVAL to observe and detect circular polarization within the photospheric absorption lines of Pollux. Our observations span 18 months from 2007-2009. We treated the spectropolarimetric data using the Least-Squares Deconvolution method to create high signal-to-noise ratio mean Stokes V profiles. We also measured the classical activity indicator S-index for the Ca H&K lines, and the stellar radial velocity (RV). Results: We have unambiguously detected a weak Stokes V signal in the spectral lines of Pollux, and measured the related surface-averaged longitudinal magnetic field Bl. The longitudinal field averaged over the span of the observations is below one gauss. Our data suggest variations of the longitudinal magnetic field, but no significant variation of the S-index. We observe variations of RV which are qualitatively consistent with the published ephemeris for a proposed exoplanet orbiting Pollux. The observed variations of Bl appear to mimic those of RV, but additional data for this relationship to be established. Using evolutionary models including the effects of rotation, we derive the mass of Pollux and we discuss its evolutionary status and the origin of its magnetic field. Conclusions: This work presents the first direct detection of the magnetic field of Pollux, and demonstrates that ESPaDOnS and NARVAL are capable of obtaining sub-G measurements of the surface-averaged longitudinal magnetic field of giant stars, and of directly studying the relationships between magnetic activity, stellar evolution and planet hosting of these stars.Comment: 8 pages, 6 figures, accepted for publication in Astronomy and Astrophysic

Measurement of the K_L \to \pi\mu\nu form factor parameters with the KLOE detector

Using 328 pb^{-1}of data collected at DAFNE corresponding to $\sim$ 1.8 million $K_L\to \pi\mu\nu$ decays, we have measured the $K_{\mu 3}$ form factor parameters. The structure of the $K-\pi$ vector-current provides information about the dynamics of the strong interaction; its knowledge is necessary for evaluation of the phase-space integral required for measuring the CKM matrix element $V_{us}$ and for testing lepton universality in kaon decays. Using a new parametrization for the vector and scalar form factors, we find $\lambda_+$=\pt(25.7\pm 0.6),-3, and $\lambda_0$=\pt(14.0\pm 2.1),-3,. Our result for $\lambda_0$, together with recent lattice calculations of $f_\pi$, $f_K$ and $f(0)$, satisfies the Callan-Trieman relatio