The encoding of model-based control signals in rat anterior cingulate cortex

The anterior cingulate cortex (ACC) has been implicated in a wide variety of behaviours. Yet, a comprehensive theory of the ACC function is lacking. A promising theory is that ACC uses information from past experience to create predictive mental models that guide future response selection – that is the ACC is a model-based controller. This thesis tests the key hypotheses supporting this theory in two separate tasks. The results of the first experiment show that ACC tracks a rat’s state with high spatiotemporal resolution during a binary-choice task. The results of the second task demonstrate that ACC neurons encode several abstract features of a task, including information about the block structure of the task. Together the results suggests that the schema in the ACC is to reconfigure in order to reflect abstract rules of the task, which is essential for optimizing future response selection

Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements.

The anterior cingulate cortex (ACC) encodes information supporting mnemonic and cognitive processes. We show here that a rat's position can be decoded with high spatiotemporal resolution from ACC activity. ACC neurons encoded the current state of the animal and task, except for brief excursions that sometimes occurred at target feeders. During excursions, the decoded position became more similar to a remote target feeder than the rat's physical position. Excursions recruited activation of neurons encoding choice and reward, and the likelihood of excursions at a feeder was inversely correlated with feeder preference. These data suggest that the excursion phenomenon was related to evaluating real or fictive choice outcomes, particularly after disfavoured reinforcements. We propose that the multiplexing of position with choice-related information forms a mental model isomorphic with the task space, which can be mentally navigated via excursions to recall multimodal information about the utility of remote locations

Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements

The anterior cingulate cortex (ACC) encodes information supporting mnemonic and cognitive processes. We show here that a rat’s position can be decoded with high spatiotemporal resolution from ACC activity. ACC neurons encoded the current state of the animal and task, except for brief excursions that sometimes occurred at target feeders. During excursions, the decoded position became more similar to a remote target feeder than the rat’s physical position. Excursions recruited activation of neurons encoding choice and reward, and the likelihood of excursions at a feeder was inversely correlated with feeder preference. These data suggest that the excursion phenomenon was related to evaluating real or fictive choice outcomes, particularly after disfavoured reinforcements. We propose that the multiplexing of position with choice-related information forms a mental model isomorphic with the task space, which can be mentally navigated via excursions to recall multimodal information about the utility of remote locations