Determinants of Nutritional Differences in Mediterranean Rural Spain, 1840-1965 Birth Cohorts: A Comparison between Irrigated and Dry Farming Agriculture

Anthropometric studies have given much attention to the impact of industrialization and urbanization on the biological standards of living of urban populations. Instead, we know less about the evolution of height and the disparities within the rural world and how they have changed during the modern economic growth process. This article analyzes the evolution and the determining factors that would explain the inequality of the biological welfare of a group of rural populations in Mediterranean Spain. Using a database of the heights of military conscripts (N = 146, 041) of the study area, a comparison is made of the biological well-being of the cohorts born between 1840 and 1965 in different rural environments (irrigated vs. dry farming). The results show that the recruits residing in irrigated areas were taller than those in dry farming areas and that the nutritional differences were greater among the latter. The advantage of the heights in irrigated areas widened with the development of commercial agriculture at the end of the nineteenth century and, although it began to reduce from the early decades of the twentieth century, the anthropometric gap persisted throughout the period analyzed. The data also suggest that the distribution of income was also more unequal in the dry farming areas, where the diet was less varied and rich than in the irrigated areas. This situation could be largely explained by the existence of low productivity agriculture in these dry farming areas, among other possible factors

Transformaciones del álgebra lineal para la generación de movimiento usando la interfaz gráfica de MATLAB

El presente proyecto de investigación tiene como propósito: Implementar transformaciones del Algebra lineal en Matlab que generen el movimiento de un conjunto de graficas básicas en una trayectoria de R2 Basados en Ejercicios Matemáticos de la Asignatura de Algebra Lineal de la Escuela Profesional de Ingeniería Industrial de la Facultad de Ingeniería de la Universidad San Pedro de Chimbote. La Investigación se realizará a través de un estudio descriptivo - prepositivo, desarrollado con un diseño de investigación no experimental, de corte transversal. La población de estudio estará constituida por un conjunto variado de figuras básicas en el plano, los cuales proporcionarán la base para extenderlos y aplicarlos en figuras de mayor complejidad. La Metodología a emplear se basará en el método inductivo. La presente investigación nos permitió: Implementar transformaciones del Álgebra lineal en Matlab que generan el movimiento de un conjunto de gráficas básicas en una trayectoria dada.Trabajo de investigació

Uso de internet y las habilidades sociales de estudiantes universitarios en zonas rurales de Chimbote

El presente proyecto de investigación tuvo como Objetivo principal, Relacionar el uso del Internet y las Habilidades Sociales, de Alumnos Universitarios de la Facultad de Ingeniería de la Universidad San Pedro, que viven en zonas rurales de la Provincia del Santa. El método que se utilizó es inductivo, ya que es un procedimiento mediante el cual a partir de hechos singulares se pasó a generalizaciones; estadístico porque contribuyó a determinar la muestra, a tabular los datos y establecer generalizaciones a partir de ellos y teórico ya que permitió profundizar en el conocimiento y cualidades esenciales de los fenómenos, a través de la utilización de una Escala de Habilidades Sociales y una encuesta para recopilar información sobre el uso de Internet en zonas rurales. Ambas herramientas poseen Validez y Confiabilidad. Como Resultado de éste Proyecto de Investigación, se logró encontrar una relación Directa, ya que asumimos que, cuando se hace mejor utilización del Internet, lograron mejorar sus Habilidades sociales, de los estudiantes universitarios de La Facultad de Ingeniería de la Universidad San Pedro de ChimboteTrabajo de investigació

Monitoring visual attention on a neurorehabilitation environment based on interactive video

The use of new technologies in neurorehabilitation has led to higher intensity rehabilitation processes, extending therapies in an economically sustainable way. Interactive Video (IV) technology allows therapists to work with virtual environments that reproduce real situations. In this way, patients deal with Activities of the Daily Living (ADL) immersed within enhanced environments [1]. These rehabilitation exercises, which focus in re-learning lost functions, will try to modulate the neural plasticity processes [2]. This research presents a system where a neurorehabilitation IV-based environment has been integrated with an eye-tracker device in order to monitor and to interact using visual attention. While patients are interacting with the neurorehabilitation environment, their visual behavior is closely related with their cognitive state, which in turn mirrors the brain damage condition suffered by them [3] [4]. Patients’ gaze data can provide knowledge on their attention focus and their cognitive state, as well as on the validity of the rehabilitation tasks proposed [5]

2D-Tasks for Cognitive Rehabilitation

Neuropsychological Rehabilitation is a complex clinic process which tries to restore or compensate cognitive and behavioral disorders in people suffering from a central nervous system injury. Information and Communication Technologies (ICTs) in Biomedical Engineering play an essential role in this field, allowing improvement and expansion of present rehabilitation programs. This paper presents a set of cognitive rehabilitation 2D-Tasks for patients with Acquired Brain Injury (ABI). These tasks allow a high degree of personalization and individualization in therapies, based on the opportunities offered by new technologies

Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset

Mitochondrial dysfunction has been implicated in the etiology of monogenic Parkinson’s disease (PD). Yet the role that mitochondrial processes play in the most common form of the disease; sporadic PD, is yet to be fully established. Here, we comprehensively assessed the role of mitochondrial function-associated genes in sporadic PD by leveraging improvements in the scale and analysis of PD GWAS data with recent advances in our understanding of the genetics of mitochondrial disease. We calculated a mitochondrial-specific polygenic risk score (PRS) and showed that cumulative small effect variants within both our primary and secondary gene lists are significantly associated with increased PD risk. We further reported that the PRS of the secondary mitochondrial gene list was significantly associated with later age at onset. Finally, to identify possible functional genomic associations we implemented Mendelian randomization, which showed that 14 of these mitochondrial functionassociated genes showed functional consequence associated with PD risk. Further analysis suggested that the 14 identified genes are not only involved in mitophagy, but implicate new mitochondrial processes. Our data suggests that therapeutics targeting mitochondrial bioenergetics and proteostasis pathways distinct from mitophagy could be beneficial to treating the early stage of PD

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability

Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with several brain-related and cell-type-specific genomic annotations to connect human genomic PD findings to specific brain cell types. We found that PD heritability attributable to common variation does not enrich in global and regional brain annotations or brain-related cell-type-specific annotations. Likewise, we found no enrichment of PD susceptibility genes in brain-related cell types. In contrast, we demonstrated a significant enrichment of PD heritability in a curated lysosomal gene set highly expressed in astrocytic, microglial, and oligodendrocyte subtypes, and in LoF-intolerant genes, which were found highly expressed in almost all tested cellular subtypes. Our results suggest that PD risk loci do not lie in specific cell types or individual brain regions, but rather in global cellular processes detectable across several cell types

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity