Increased responsiveness of murine eosinophils to MIPâ 1β (CCL4) and TCAâ 3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141970/1/jlb1019.pd

El ensayo Micro Deval. Sus características y ámbitos de aplicación

En este documento se presentan los aspectos más relevantes del proceso de implementación del ensayo Micro Deval, contemplado por la Norma ASTM D 6928, “Standard test method for resistance of coarse aggregate to degradation by abrasion in the Micro-Deval apparatus”, en los laboratorios de Suelos y Pavimentos del Centro de Estudios Geotécnicos de la Escuela Colombiana de Ingeniería. En el proceso de implementación se evaluaron las principales características, ventajas y limitaciones del ensayo, los factores que afectan sus resultados, las correlaciones con otros ensayos relacionados con la dureza y con la durabilidad de los agregados, en especial con el ensayo de Desgaste Los Ángeles, y las correlaciones del ensayo con el comportamiento en servicio de los pavimentos, obtenidas en diferentes ambientes por diversos autores. Estos aspectos se tratan en este documento y se dejan para otro documento los resultados encontrados, al aplicar el ensayo Micro Deval, sobre agregados provenientes principalmente de fuentes de la ciudad de Bogotá. Se concluye en general que el Ensayo Micro Deval tiene gran aceptación, es simple, consume poco tiempo, tiene buena repetibilidad, reproducibilidad y comprobada correlación con el comportamiento en servicio de los agregados, ya se usen para la conformación de capas granulares o para la elaboración de mezclas asfálticas.This report shows the most relevant aspects of the implementation of the Micro Deval test, according to ASTM D 6928, “Standard test method for resistance of coarse aggregate to degradation by abrasion in the Micro-Deval apparatus”, at the Escuela Colombiana de Ingeniería Soils and Pavements Laboratory. During the implementation process the main characteristics, advantages, weaknesses, limiting factors of the test were evaluated, as well as correlations with other tests related to hardness and durability of aggregates, particularly the Los Angeles test and correlations with pavements in-service performance in different environments according to different authors. It is concluded that the Micro-Deval test is a widely accepted test, simple, no time consuming, has good repeatability, reproducibility and shows good correlation with aggregates in-service performance, either for granular bases or asphalt mixes. As other studies have shown, the Micro-Deval results had no correlation with the Los Angeles and aggregates absorption results

Caracterización de agregados pétreos con el ensayo Micro Deval

En este documento se presentan los aspectos más relevantes del proceso de implementación del ensayo Micro Deval, contemplado por la Norma ASTM D 6928, “Standard test method for resistance of coarse aggregate to degradation by abrasion in the Micro-Deval apparatus”, en los laboratorios de Suelos y Pavimentos del Centro de Estudios Geotécnicos de la Escuela Colombiana de Ingeniería. En esta segunda parte se incluyen los resultados obtenidos de los ensayos Micro Deval y de Desgaste Los Ángeles y sus variantes (100 rev. y en húmedo 500 rev.) realizados sobre 15 muestras de agregados, utilizados en la ciudad de Bogotá principalmente para la elaboración de mezclas asfálticas. Igualmente, se incluye el análisis de estos resultados junto con unas conclusiones preliminares, así como algunas recomendaciones derivadas de este proceso. Como se ha mostrado en otros estudios, sobre los materiales analizados en el presente no se evidenció una adecuada correlación con el ensayo de Desgaste Los Ángeles, ni con la absorción de los agregados. Sin embargo, las líneas de tendencia muestran un incremento en las pérdidas medidas con el ensayo de Desgaste Los Ángeles y en la absorción con el aumento en las pérdidas en el Micro Deval. Del análisis de los resultados encontrados también se concluye que si se tienen en cuenta los requisitos del agregado grueso para mezclas asfálticas en caliente, fijados por el IDU en las Especificaciones ET-2005, para tránsitos pesados (tipo T4 –T5) y capas de rodadura, el ensayo de Desgate Los Ángeles resulta ser más conservador que el Ensayo Micro Deval. Se recomienda continuar evaluando fuentes de materiales para seguir ajustando las respectivas especificaciones a las condiciones imperantes en nuestro medio.This report shows the most relevant aspects of the implementation of the Micro Deval test, according to ASTM D 6928, “Standard test method for resistance of coarse aggregate to degradation by abrasion in the Micro-Deval apparatus”, at the Escuela Colombiana de Ingeniería Soils and Pavements Laboratory. Micro-Deval and Los Angeles tests results in 15 samples of aggregates used in Bogotá, principally for asphalt mixes, are shown as well as the analyses of these results along with preliminary conclusions and recommendations. As other studies have shown, the Micro-Deval results had no correlation with the Los Angeles and aggregates absorption results. The trend lines do, however, show increasing Los Angeles Abrasion and absorption results with the increasing Micro Deval results. From the analysis of the materials results used in this investigation, it can be concluded that the Los Angeles test is more conservative than Micro-Deval test, for coarse aggregate used in hot asphalt mixes under IDU high volume of traffic (types T4 – T5) and surface courses, according the Specifications IDU ET-2005. It is recommended to evaluate more aggregate sources to continue adjusting specifications to our particular conditions

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers.

Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known. Here multiple Saccharomyces cerevisiae GCR assays and query mutations were crossed into arrays of mutants to identify progeny with increased GCR rates. One hundred eighty two GIS genes were identified that suppressed GCR formation. Another 438 cooperatively acting GIS genes were identified that were not GIS genes, but suppressed the increased genome instability caused by individual query mutations. Analysis of TCGA data using the human genes predicted to act in GIS pathways revealed that a minimum of 93% of ovarian and 66% of colorectal cancer cases had defects affecting one or more predicted GIS gene. These defects included loss-of-function mutations, copy-number changes associated with reduced expression, and silencing. In contrast, acute myeloid leukaemia cases did not appear to have defects affecting the predicted GIS genes

Relaciones entre actuaciones pedagógico-didácticas e índices de retención de estudiantes en cátedras de primer año.

El abandono de los estudios en primer año del Nivel Superior Universitario constituye un problema dado las consecuencias negativas, económicas, sociales, psicológicas y familiares que provoca. Desde el plano institucional universitario, asistimos entonces a escenas y contextos globales que nos plantean la necesidad de repensar los procesos de formación y los modos en los que éstos nos interpelan. En dirección a dar respuesta a esta problemática, la presente comunicación da cuenta de un estudio que se desarrolla en la carrera de Medicina Veterinaria de la Universidad Nacional de Villa María, Córdoba, Argentina. Específicamente, se busca establecer relaciones entre las actuaciones pedagógico-didácticas puestas en marcha en cátedras de primer año e índices de retención de estudiantes. Esto, a los fines de contar con registros sistemáticos y disponer de datos fácilmente accesibles, que se constituyan en indicadores que posibiliten la orientación de cursos de acción a seguir y la consiguiente intervención. Cabe destacar que esta investigación propone una combinación de estrategias metodológicas cuantitativas y cualitativas, en pos de sostener un enfoque progresivo que requiere una articulación permanente entre el abordaje teórico y el trabajo de campo. Sumado a esto, una actitud de apertura y flexibilidad al uso de estrategias e instrumentos metodológicos; recaudos en la labor de descripción e interpretación y por último la necesaria triangulación teórica, metodológica y de sujetos implicados. Por otra parte, logra la conformación de redes de intercambio de experiencias de innovación educativa, como un dispositivo de transformación en las prácticas docentes. En torno a ello, se propone una manera de  investigar en la que la experiencia y la presencia del sujeto constituyan un núcleo de sentido en todo el proceso. Básicamente se trata de escuchar a los distintos actores institucionales intervinientes, teniendo en cuenta a la educación como una relación, como un espacio de encuentro con el “otro” muchas veces pensado de manera predeterminada, dejando de lado lo que tiene la experiencia de contingente y novedosa

Parabacteroides distasonis:intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health

Parabacteroides distasonis is the type strain for the genus Parabacteroides, a group of gram-negative anaerobic bacteria that commonly colonize the gastrointestinal tract of numerous species. First isolated in the 1930s from a clinical specimen as Bacteroides distasonis, the strain was re-classified to form the new genus Parabacteroides in 2006. Currently, the genus consists of 15 species, 10 of which are listed as 'validly named' (P. acidifaciens, P. chartae, P. chinchillae, P. chongii, P. distasonis, P. faecis, P. goldsteinii, P. gordonii, P. johnsonii, and P. merdae) and 5 'not validly named' (P. bouchesdurhonensis, P. massiliensis, P. pacaensis, P. provencensis, and P. timonensis) by the List of Prokaryotic names with Standing in Nomenclature. The Parabacteroides genus has been associated with reports of both beneficial and pathogenic effects in human health. Herein, we review the literature on the history, ecology, diseases, antimicrobial resistance, and genetics of this bacterium, illustrating the effects of P. distasonis on human and animal health

Short-term variability in euphotic zone biogeochemistry and primary productivity at Station ALOHA : a case study of summer 2012

Author Posting. © American Geophysical Union, 2015. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Global Biogeochemical Cycles 29 (2015): 1145–1164, doi:10.1002/2015GB005141.Time-series observations are critical to understand the structure, function, and dynamics of marine ecosystems. The Hawaii Ocean Time-series program has maintained near-monthly sampling at Station ALOHA (22°45′N, 158°00′W) in the oligotrophic North Pacific Subtropical Gyre (NPSG) since 1988 and has identified ecosystem variability over seasonal to interannual timescales. To further extend the temporal resolution of these near-monthly time-series observations, an extensive field campaign was conducted during July–September 2012 at Station ALOHA with near-daily sampling of upper water-column biogeochemistry, phytoplankton abundance, and activity. The resulting data set provided biogeochemical measurements at high temporal resolution and documents two important events at Station ALOHA: (1) a prolonged period of low productivity when net community production in the mixed layer shifted to a net heterotrophic state and (2) detection of a distinct sea-surface salinity minimum feature which was prominent in the upper water column (0–50 m) for a period of approximately 30 days. The shipboard observations during July–September 2012 were supplemented with in situ measurements provided by Seagliders, profiling floats, and remote satellite observations that together revealed the extent of the low productivity and the sea-surface salinity minimum feature in the NPSG.NOAA Climate Observation Division; National Science Foundation (NSF) Center for Microbial Oceanography: Research and Education (C-MORE) Grant Numbers: EF0424599, OCE-1153656, OCE-1260164; Gordon and Betty Moore Foundation Marine Microbiology Investigator2016-02-1

Assessing gastro-intestinal related quality of life in cystic fibrosis: Validation of PedsQL GI in children and their parents

Background: Most patients with cystic fibrosis (CF) suffer from pancreatic insufficiency, leading to fat malabsorption, malnutrition and abdominal discomfort. Until recently, no specific tool was available for assessing gastro-intestinal related quality of life (GI QOL) in patients with CF. As the Horizon2020 project MyCyFAPP aims to improve GI QOL by using a newly designed mobile application, a sensitive and reliable outcome measure was needed. We aimed to study the applicability of the existing child-specific Pediatric Quality of Life Inventory, Gastrointestinal Symptoms Scales and Module (PedsQL GI) in children with CF. Methods: A multicenter, prospective observational study was performed in 6 European centers to validate the PedsQL GI in children with CF during 3 months. Results: In total, 248 children and their parents were included. Within-patient variability of PedsQL GI was low (24.11), and there was reasonable agreement between children and parents (ICC 0.681). Nine of 14 subscales were informative (no ceiling effect). The PedsQL GI and the median scores for 4 subscales were significantly lower in patients compared to healthy controls. Positive associations were found between PedsQL GI and age (OR = 1.044, p = 0.004) and between PedsQL GI and BMI z-score (OR = 1.127, p = 0.036). PedsQL GI correlated with most CFQ-R subscales (r 0.268 to 0.623) and with a Visual Analogue Scale (r = 0.20). Conclusions: PedsQL GI is a valid and applicable instrument to assess GI QOL in children with CF. Future research efforts should examine the responsiveness of the CF PedsQL GI to change in the context of clinical interventions and trials

Search for New Physics with Jets and Missing Transverse Momentum in pp collisions at sqrt(s) = 7 TeV

A search for new physics is presented based on an event signature of at least three jets accompanied by large missing transverse momentum, using a data sample corresponding to an integrated luminosity of 36 inverse picobarns collected in proton--proton collisions at sqrt(s)=7 TeV with the CMS detector at the LHC. No excess of events is observed above the expected standard model backgrounds, which are all estimated from the data. Exclusion limits are presented for the constrained minimal supersymmetric extension of the standard model. Cross section limits are also presented using simplified models with new particles decaying to an undetected particle and one or two jets