A multidisciplinary study of a syntectonic pluton close to a major lithospheric-scale fault: relationships between the Montmarault granitic massif and the Sillon Houiller Fault in the Variscan French Massif Central. Part I: Geochronology, mineral fabrics and tectonic implications

International audienceDue to its location along one of the major faults, the Sillon Houiller Fault (SHF) of the French Massif Central (FMC), the Montmarault granitic pluton is well-suited to better understand the place of the late-orogenic magmatism in Variscan orogeny. Through a methodological approach, the close spatial association of the pluton with the lithospheric SHF is investigated in order to clarify the relationships between faulting and magmatic processes during the Late Carboniferous. Therefore, a multidisciplinary study has been carried out on the Montmarault massif. Combining geochronology, field and laboratory microstructural observations, Anisotropy of Magnetic Susceptibility (AMS) methods presented in Part I, and gravity and aeromagnetic modeling (Part II), as well as similar studies from other plutons in the FMC, allows us to draw the following conclusions: 1. The Montmarault pluton, dated by the chemical U-Th-Pb method on monazite at 321 ± 2 Ma, was emplaced in a NW-SE maximum stretching trend which is consistent with the regional extensional tectonic regime; 2. The Montmarault pluton is rooted in its eastern part along the SHF with a laccolite-like shape in its western part; 3. At ca 320 Ma, the “Proto-SHF” acted probably as a normal fault considered as the feeding channel for the magma emplacement, ; 4. Late Carboniferous NE-SW extensional tectonics reworked the Montmarault pluton in a brittle post-solidus stage

Pluton-dyke relationships in a Variscan granitic complex from AMS and gravity modelling. Inception of the extensional tectonics in the South Armorican Domain (France)

International audienceThe Carnac granitic Complex (South Armorican Domain, Western France) was emplaced during Late Carboniferous times in the deepest Variscan unit, roofed by two major extensional shear zones. Through the acquisition and interpretation of field data, Anisotropy of Magnetic Susceptibility and gravity data, emphasized by petrological and structural observations, we address the emplacement model and possible magmatic processes involved between dyking to massive plutonism in a synkinematic context. Gravity modelling highlights an overall eastward thinning of the pluton, and several deep zones in the western part of the complex, interpreted as the pluton feeder zones. The internal granitic fabric, developed in a sub-solidus state, shows marked planar-linear anisotropy, consistent with a vertical shortening in the WNW-ESE regional stretching regime and eastward magma spreading. This study documents the occurrence of numerous NNE-SSW trending dykes within the eastern part of the pluton, suggesting that this granitic Complex formed by the coalescence of dykes oriented perpendicular to the regional stretching direction, and thus interpreted as large-scale "tension gashes". The synkinematic character of the Carnac Complex intrusion, recently dated at ca. 319 ± 6 Ma, thus times the inception of the late-orogenic extensional deformation experienced in the whole South Armorican Domain

Emplacement in an extensional setting of the Mont Lozère-Borne granitic complex (SE France) inferred from comprehensive AMS, structural and gravity studies.

The emplacement mode and setting of the Late Hercynian Mont Lozère–Borne granitic complex (French Massif Central), which consists of several plutons, is investigated. Structural and anisotropy of magnetic susceptibility (AMS) studies have been carried out to characterize the internal fabrics of the granitic plutons. Throughout the Pont-de-Montvert–Borne pluton, an E–W-trending magnetic lineation is well developed. In the host rock and the thermal aureole, a conspicuous E–W-trending lineation is interpreted as an evidence of a late-orogenic extensional event. To the east of the pluton, the AMS fabric is characterized by values of anisotropy degree (P′) around 4–5% with a prolate ellipsoid and subsolidus structures, whereas, to the west, the P′ parameter is weaker with an oblate ellipsoid and purely magmatic microstructures. A gravity investigation allows determination of the 3D shape of the pluton. The western part of the granitic complex is thicker than the eastern one and is interpreted as the feeder zone. This suggests an eastward spreading of the magma. The consistency between regional stretching and directions of AMS lineations in the pluton and the shape of the complex deduced from gravity strongly argues that the emplacement mode of the complex was influenced by the regional extensional tectonic setting during the collapse of the Hercynian belt

3-D Magnetotelluric Investigations for geothermal exploration in Martinique (Lesser Antilles). Characteristic Deep Resistivity Structures, and Shallow Resistivity Distribution Matching Heliborne TEM Results

Within the framework of a global French program oriented towards the development of renewable energies, Martinique Island (Lesser Antilles, France) has been extensively investigated (from 2012 to 2013) through an integrated multi-methods approach, with the aim to define precisely the potential geothermal ressources, previously highlighted (Sanjuan et al., 2003). Amongst the common investigation methods deployed, we carried out three magnetotelluric (MT) surveys located above three of the most promising geothermal fields of Martinique, namely the Anses d'Arlet, the Montagne Pel{\'e}e and the Pitons du Carbet prospects. A total of about 100 MT stations were acquired showing single or multi-dimensional behaviors and static shift effects. After processing data with remote reference, 3-D MT inversions of the four complex elements of MT impedance tensor without pre-static-shift correction, have been performed for each sector, providing three 3-D resistivity models down to about 12 to 30 km depth. The sea coast effect has been taken into account in the 3-D inversion through generation of a 3-D resistivity model including the bathymetry around Martinique from the coast up to a distance of 200 km. The forward response of the model is used to calculate coast effect coefficients that are applied to the calculated MT response during the 3-D inversion process for comparison with the observed data. 3-D resistivity models of each sector, which are inherited from different geological history, show 3-D resistivity distribution and specificities related to its volcanological history. In particular, the geothermal field related to the Montagne Pel{\'e}e strato-volcano, is characterized by a quasi ubiquitous conductive layer and quite monotonic typical resistivity distribution making interpretation difficult in terms of geothermal targets. At the opposite, the resistivity distribution of Anse d'Arlet area is radically different and geothermal target is thought to be connected to a not so deep resistive intrusion elongated along a main structural axis. Beside these interesting deep structures, we demonstrate, after analyzing the results of the recent heliborne TEM survey covering the whole Martinique, that surface resistivity distribution obtained from 3-D inversion reproduce faithfully the resistivity distribution observed by TEM. In spite of a very different sampling scale, this comparison illustrates the ability of 3-D MT inversion to take into account and reproduce static shift effects in the sub-surface resistivity distribution.Comment: Wordl Geothermal Congress 2015, Apr 2015, Melbourne, Australi

3-D magnetotelluric inversion with coast effect modeling to assess the geothermal potential of Anses d'Arlet (Martinique, Lesser Antilles)

2pWithin the framework of a global French program towards development of renewable energies, Martinique Island (Lesser Antilles, France) has been extensively investigated (from 2012 to 2013) through an integrated multi-disciplinary approach, with the aim to identify precisely the potential geothermal resources previously highlighted (Gadalia et al., 2014). Among the investigation methods deployed (geological, geochemical and hydrogeological), we carried out three magnetotelluric (MT) surve ys at three of the four most promising areas of Martinique, namely the Anses d'Arlet, the Montagne Pelée and the Pitons du Carbet prospects. A total of 32 MT tensors were collected in the Anses d'Arlet area in the frequency range 1000 Hz to 10-2-10-3Hz togetherwith TEM soundings for potential static shift correction. A 3-D MT inversion of the full tensor was carried out including the coast effect. The 3-D resistivity model reveals a major resistive body elongated in the NNO -SSE direction, corresponding to the main structural volcanic axis of the area, and interpreted as a deep intrusion almost reaching the surface. Based on geological observations -an alteration zone located between Anses d'Arlet and Petite Anse-the shallow conductive layer identified eastward is interpreted as the remaining of an old cap-rock partly eroded that becomes thicker southwards. The latter could be related with the altered core of the Morne Larcher. Other studies allowed the reconstructing of the geothermal system evolution to its present and moderate apparent activi ty mainly located south of the resistive anomaly. This intrusion could act as heat source for the geothermal system. This sector is identified as the most interesting for further exploration wells. In order to better understand structures highlighted by the real data distribution and test the strategy to integrate correction coefficients for the coast effect (modeled separately) during the inversion, we designed a forward model using the s ame bathymetry, topography and MT sounding distribution of the survey. Impedance tensors were calculated for the 32 sites. The geometry of the 3-D structure has been designed quasi-independently of the data distribution to assess the impact of un-appropriate acquisition grid. The 3-D inversion was run with these synthetic data (Hautot et al, 2000, 2007). The results indicate that the general structure is recovered for the first 1000 m. Deeper, and southward, the absence of MT soundings surrounding the resistive body prevented a good lateral constraint, causing its disappearance. To the north, the conductive body "pseudo caprock" is well defined, especially on layer 5 (Figure 2), were the apex of a supposed geothermal reservoir could be identified (sites 3 and 6). Deeper the eastern border remains very well constrained by the eastern MT synthetic soundings

A multidisciplinary study of a syntectonic pluton close to a major lithospheric-scale fault: relationships between the Montmarault granitic massif and the Sillon Houiller Fault in the Variscan French Massif Central. Part II: Gravity, aeromagnetic investigations and 3D geologic modeling.

International audienceNew gravity and aeromagnetic investigations have been carried out to understand the emplacement mechanisms of a granitic pluton and the relationships with a nearby lithospheric-scale fault. This paper concerns the second part of a methodological multidisciplinary study and complements previous geochronologic and Anisotropy of Magnetic Susceptibility (AMS) studies on the same pluton. In the northern part of the Variscan French Massif Central (FMC), the Montmarault massif crops out along the Sillon Houiller Fault (SHF). Bouguer and aeromagnetic anomaly maps imply thickening of the pluton along the SHF and suggest laccolitic spreading northwestwards. Based on petrophysical measurements, direct 2D joint gravity and magnetic modeling has been performed along 10 cross-sections. In order to quantitatively constrain the 3D pluton geometry and its relationships with surrounding geologic units, these geophysical cross-sections, new structural information (field and AMS measurements) and petrophysical data have been integrated into a regional 3D geological and geophysical model. Altogether, the results obtained from geochronology, petro-magnetic fabrics (Part I), gravity and aeromagnetic investigations as well as 3D modeling (Part II), demonstrate that the Montmarault pluton was emplaced during the Namurian period along the SHF. Our results further show that, at that time, in response to a NW-SE regional extension, if the SHF existed, it behaved as a normal fault. Mylonites attesting for synmagmatic normal motion on the northeastern part of the Montmarault pluton strengthen this tectonic scheme. During the Late Carboniferous, the FMC experienced NE-SW extension along the SHF by 80 km of brittle left lateral wrench offset. This second tectonic event is well recorded in the Stephanian coal basins which were formed along NW- SE listric brittle faults and constrain the present-day shape of the Montmarault pluton

Structure of late Variscan Millevaches leucogranite massif in the French Massif Central: AMS and gravity modelling results

In the Limousin area, Variscan leucogranitic plutons are spatially associated with normal faults and major strike-slip shear zones that are a continuation of the South Armorican shear zone. Our study focuses on the large N-S-trending Millevaches granitic massif (Massif Central, France), and intends to highlight, through gravity modelling, structural and anisotropy of magnetic susceptibility (AMS), the massif structure at depth and to discuss the mode of emplacement of granites within a strike-slip tectonic context. The mica subfabric suggests that the magnetic foliations display a general NW-SE sub-horizontal pattern on both sides of the N-S Pradines dextral wrench fault zone that deforms the core of the massif on 5 km width. The magnetic lineation trend exhibits a sigmoïdal pattern, N-S in the Pradines fault zone and NW-SE on both sides of it, which are consistent with a dextral wrench component. The horizontal magnetic foliations and lineations are consistent with the thin granite laccolith model. There is no significant imprint of the extensional Variscan belt collapse on the internal fabric of Millevaches granites than the tectonic dextral transcurrent movement prevailing in this area. © 2005 Elsevier Ltd. All rights reserved

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)