Business consulting en procesos operacionales de la empresa Compresores del Perú S.A.C.

La empresa Compresores del Perú S.A.C. es una empresa dedicada a la comercialización de compresores, repuestos y atención de servicios multimarca con más de 15 años en el mercado peruano. Durante la pandemia COVID-19 la empresa continuó con sus operaciones sin necesidad de someter a algún tipo de suspensión perfecta de las actividades de su personal debido a que el rubro principal de la empresa es atender a la industria minera, lo cual permitió mantener el nivel de crecimiento sostenido. Sin embargo existe una preocupación de los dueños por la cantidad de reclamos mensuales, debido a la tercerización de procesos que impedía el control en cada etapa del proceso y la calidad del producto terminado. Es por ello que se plantea el Business Consulting para generar la propuesta de mejora de los problemas identificados: el incumplimiento en los tiempos de entrega, la falta de un sistema integrado automatizado de gestión, la escasez de proveedores, la inadecuada gestión de las importaciones, el bajo stock de productos y la falta de planificación de la demanda. Siendo el propósito de la tesis la identificación, análisis y el plantemiento de mejoras para hacer sostenible el crecimiento de la empresa de acuerdo a las metas y objetivos de Compresores del Perú S.A.C. los cuales fueron validados de acuerdo a información primaria de cada área operativa por medio de la aplicación de diferentes instrumentos y herramientas de gestión empresariales sobre la cual se planteó un modelo de simulación de mejora de procesos en diferentes escenarios siendo comprobada su eficacia, eficiencia y trazabilidad refrendado en la proyección de costos.Compresores del Perú S.A.C. is a company dedicated to the commercialization of compressors, superheating parts and multi-brand services with more than 15 years in the Peruvian market. During the COVID-19 pandemic, the company maintained its operations without the need to suspend the activities of its personnel, because the main activity of the company is to serve the mining industry, which allowed it to maintain a sustained level of growth. However, the owners are concerned about the number of minor claims, due to the outsourcing of processes that prevented the control in each phase of the process and the quality of the finished product. It is for this reason that Business Consulting proposes to develop a proposal to improve the problems identified: failure to meet delivery deadlines, lack of an automated integrated management system, shortage of suppliers, inadequate management of imports, low stock of products and lack of procurement planning. The objective of the thesis was to identify, analyze and propose improvements to make the company's growth sustainable according to the goals and objectives of Compresores del Perú S.A.C., which were validated according to the primary information of each operational area through the application of different instruments and tools of business management on which a simulation model was proposed

Business consulting en procesos operacionales de la empresa Compresores del Perú S.A.C.

La empresa Compresores del Perú S.A.C. es una empresa dedicada a la comercialización de compresores, repuestos y atención de servicios multimarca con más de 15 años en el mercado peruano. Durante la pandemia COVID-19 la empresa continuó con sus operaciones sin necesidad de someter a algún tipo de suspensión perfecta de las actividades de su personal debido a que el rubro principal de la empresa es atender a la industria minera, lo cual permitió mantener el nivel de crecimiento sostenido. Sin embargo existe una preocupación de los dueños por la cantidad de reclamos mensuales, debido a la tercerización de procesos que impedía el control en cada etapa del proceso y la calidad del producto terminado. Es por ello que se plantea el Business Consulting para generar la propuesta de mejora de los problemas identificados: el incumplimiento en los tiempos de entrega, la falta de un sistema integrado automatizado de gestión, la escasez de proveedores, la inadecuada gestión de las importaciones, el bajo stock de productos y la falta de planificación de la demanda. Siendo el propósito de la tesis la identificación, análisis y el plantemiento de mejoras para hacer sostenible el crecimiento de la empresa de acuerdo a las metas y objetivos de Compresores del Perú S.A.C. los cuales fueron validados de acuerdo a información primaria de cada área operativa por medio de la aplicación de diferentes instrumentos y herramientas de gestión empresariales sobre la cual se planteó un modelo de simulación de mejora de procesos en diferentes escenarios siendo comprobada su eficacia, eficiencia y trazabilidad refrendado en la proyección de costos.Compresores del Perú S.A.C. is a company dedicated to the commercialization of compressors, superheating parts and multi-brand services with more than 15 years in the Peruvian market. During the COVID-19 pandemic, the company maintained its operations without the need to suspend the activities of its personnel, because the main activity of the company is to serve the mining industry, which allowed it to maintain a sustained level of growth. However, the owners are concerned about the number of minor claims, due to the outsourcing of processes that prevented the control in each phase of the process and the quality of the finished product. It is for this reason that Business Consulting proposes to develop a proposal to improve the problems identified: failure to meet delivery deadlines, lack of an automated integrated management system, shortage of suppliers, inadequate management of imports, low stock of products and lack of procurement planning. The objective of the thesis was to identify, analyze and propose improvements to make the company's growth sustainable according to the goals and objectives of Compresores del Perú S.A.C., which were validated according to the primary information of each operational area through the application of different instruments and tools of business management on which a simulation model was proposed

Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis

Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a novel genetic risk factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) and three within IL1RL1 (rs2310173, rs13015714 and rs2058660), that also were previously associated with several inflammatory diseases, were genotyped in 380 Caucasian IgAV patients and 845 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when IL33 and IL1RL1 variants were analysed independently. Likewise, no statistically significant differences were found in IL33 or IL1RL1 genotype and allele frequencies when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when IL33 and IL1RL1 haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV.Acknowledgements: We are indebted to the patients and healthy controls for their essential collaboration to this study. We also thank the National DNA Bank Repository (Salamanca) for supplying part of the control samples. This study was supported by European Union FEDER funds and `Fondo de Investigaciones Sanitarias´ (Grant PI18/00042) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). DP-P is a recipient of a Río Hortega programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, `Investing in your future´) (Grant Number CM20/00006). SR-M is supported by funds of the RETICS Program (RD16/0012/0009) (ISCIII, cofunded by the European Regional Development Fund (ERDF)). VP-C is supported by a pre-doctoral grant from IDIVAL (PREVAL 18/01). BA-M is a recipient of a `López Albo´ Post-Residency Programme funded by Servicio Cántabro de Salud. LL-G is supported by funds from IDIVAL (INNVAL20/06). OG is staff personnel of Xunta de Galicia (Servizo Galego de Saude (SERGAS)) through a research-staff stabilization contract (ISCIII/SERGAS) and his work is funded by ISCIII and the European Union FEDER fund (Grant Numbers RD16/0012/0014 (RIER) and PI17/00409). He is beneficiary of project funds from the Research Executive Agency (REA) of the European Union in the framework of MSCA-RISE Action of the H2020 Programme, project 734899—Olive-Net. RL-M is a recipient of a Miguel Servet type I programme fellowship from the ISCIII, co-funded by ESF (`Investing in your future´) (Grant Number CP16/00033)

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

Peer reviewe

Measurements of the Electroweak Diboson Production Cross Sections in Proton-Proton Collisions at root s=5.02 TeV Using Leptonic Decays

The first measurements of diboson production cross sections in proton-proton interactions at a center-of-mass energy of 5.02 TeV are reported. They are based on data collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 302 pb(-1). Events with two, three, or four charged light leptons (electrons or muons) in the final state are analyzed. The WW, WZ, and ZZ total cross sections are measured as sigma(WW) = 37:0(-5.2)(+5.5) (stat)(-2.6)(+2.7) (syst) pb, sigma(WZ) = 6.4(-2.1)(+2.5) (stat)(-0.3)(+0.5)(syst) pb, and sigma(ZZ) = 5.3(-2.1)(+2.5)(stat)(-0.4)(+0.5) (syst) pb. All measurements are in good agreement with theoretical calculations at combined next-to-next-to-leading order quantum chromodynamics and next-to-leading order electroweak accuracy

Observation of tW production in the single-lepton channel in pp collisions at root s=13 TeV

A measurement of the cross section of the associated production of a single top quark and a W boson in final states with a muon or electron and jets in proton-proton collisions at root s = 13 TeV is presented. The data correspond to an integrated luminosity of 36 fb(-1) collected with the CMS detector at the CERN LHC in 2016. A boosted decision tree is used to separate the tW signal from the dominant t (t) over bar background, whilst the subleading W+jets and multijet backgrounds are constrained using data-based estimates. This result is the first observation of the tW process in final states containing a muon or electron and jets, with a significance exceeding 5 standard deviations. The cross section is determined to be 89 +/- 4 (stat) +/- 12 (syst) pb, consistent with the standard model.Peer reviewe

Measurement of the top quark mass using events with a single reconstructed top quark in pp collisions at root s=13 TeV

Abstract:A measurement of the top quark mass is performed using a data sample en-riched with single top quark events produced in thetchannel. The study is based on proton-proton collision data, corresponding to an integrated luminosity of 35.9 fb−1, recorded at√s= 13TeV by the CMS experiment at the LHC in 2016. Candidate events are selectedby requiring an isolated high-momentum lepton (muon or electron) and exactly two jets,of which one is identified as originating from a bottom quark. Multivariate discriminantsare designed to separate the signal from the background. Optimized thresholds are placedon the discriminant outputs to obtain an event sample with high signal purity. The topquark mass is found to be172.13+0.76−0.77GeV, where the uncertainty includes both the sta-tistical and systematic components, reaching sub-GeV precision for the first time in thisevent topology. The masses of the top quark and antiquark are also determined separatelyusing the lepton charge in the final state, from which the mass ratio and difference aredetermined to be0.9952+0.0079−0.0104and0.83+1.79−1.35GeV, respectively. The results are consistentwithCPTinvariance