Circular 59

This list of recommended annual flower varieties includes information on several hundred annual flower cultivars. The recommended varieties were selected from flowers grown in 1985 and 1986 at the Agricultural and Forestry Experiment Station Farm at the University of Alaska- Fairbanks. While this is by no means a complete listing of varieties suitable for Interior gardens, it does reflect many years of experience in annual flower production at the AFES farm. The methods used to evaluate the flowers and definitions for terms used in the listing can be found under Data Collection.Introduction -- Methods: Bedding Plant Production, Field Conditions, Weather Conditions, Data Collection -- List of Recommended Annual Flower Varieties -- Photo Section -- Appendix 1. Seeding Information -- Appendix 2. Flower Varieties by Color: Blue, Purple; Red, Pink; Red, Pink and White Mixes; White; Yellow, Orange, Gold; Mixed Colors; Foliage Only -- Appendix 3. Bloom Period: Early Season, All Season, Midseason, Late Season, Frost Resistant -- Appendix 4. Plant Heights: Short Varieties, Medium Varieties, Tall Varieties -- Appendix 5. Flowers for Special Purposes: Hanging Baskets, Light Shade, Walls, Rock Garden, Background -- Appendix 6. Seed Source

The nature of tragedy.

Thesis (Ed.M.)--Boston Universit

The Ursinus Weekly, February 22, 1973

USGA finally elects 1973-4 officers • Ursinus College Union opens quietly but successfully • S.F.A.R.C. discusses computer use, transcript cost, HH use, & Olevian stove • Tuition increase slated by Ursinus Board • Editorial: The Prisoners return; Looking back • Faculty portrait: Dr. John Wickersham • Afloat in the celluloid sea: The Getaway • Music review: Eric nemeyer\u27s 19 piece jazz band makes debut • ProTheatre plans several productions and a workshop for Spring semester • Wismer\u27s Mother Hubbard left with bare cupboard • 18 year old drinking age to be decided by courts • Letter to the editor: Praise for Chambers • Pi Nu notes active campus musicians • The Wyeth-McCoy-Hurds make painting a family affair • 1973 Bulletin has some adjustments, changes • New introductory religion course slated for Fall semester • Profile: Roger Blind • Matmen win two • Splish, splash! • Swarthmore nets Boydies • Two for three: Not badhttps://digitalcommons.ursinus.edu/weekly/1097/thumbnail.jp

Genetic Ancestry-Smoking Interactions and Lung Function in African Americans: A Cohort Study

Background: Smoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americans. We aimed to determine whether African ancestry modifies the association between smoking and lung function and its rate of decline in African Americans. Methodology/Principal Findings: We evaluated a prospective ongoing cohort of 1,281 African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study initiated in 1997. We also examined an ongoing prospective cohort initiated in 1985 of 1,223 African Americans in the Coronary Artery Disease in Young Adults (CARDIA) Study. Pulmonary function and tobacco smoking exposure were measured at baseline and repeatedly over the follow-up period. Individual genetic ancestry proportions were estimated using ancestry informative markers selected to distinguish European and West African ancestry. African Americans with a high proportion of African ancestry had lower baseline forced expiratory volume in one second (FEV1) per pack-year of smoking (-5.7 ml FEV1/ smoking pack-year) compared with smokers with lower African ancestry (-4.6 ml in FEV1/ smoking pack-year) (interaction P value = 0.17). Longitudinal analyses revealed a suggestive interaction between smoking, and African ancestry on the rate of FEV1 decline in Health ABC and independently replicated in CARDIA. Conclusions/Significance: African American individuals with a high proportion of African ancestry are at greater risk for losing lung function while smoking. © 2012 Aldrich et al

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Clinical and Radiologic Assessments to Predict Breast Cancer Pathologic Complete Response to Neoadjuvant Chemotherapy

To prospectively compare the ability of clinical examination, mammography, vascularity-sensitive ultrasound, and magnetic resonance imaging (MRI) to determine pathologic complete response (CR) in breast cancer patients undergoing neoadjuvant chemotherapy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44230/1/10549_2005_Article_2510.pd

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum

Phosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer’s disease (LOAD), based on recent genome wide association studies (GWAS). However, how it affects AD occurrence is still unknown. Brain reserve hypothesis highlights the tolerant capacities of brain as a passive means to fight against neurodegenerations. Here, we took the baseline volume and/or thickness of LOAD-associated brain regions as proxies of brain reserve capacities and investigated whether PICALM genetic variations can influence the baseline reserve capacities and the longitudinal atrophy rate of these specific regions using data from Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. In mixed population, we found that brain region significantly affected by PICALM genetic variations was majorly restricted to posterior cingulate. In sub-population analysis, we found that one PICALM variation (C allele of rs642949) was associated with larger baseline thickness of posterior cingulate in health. We found seven variations in health and two variations (rs543293 and rs592297) in individuals with mild cognitive impairment were associated with slower atrophy rate of posterior cingulate. Our study provided preliminary evidences supporting that PICALM variations render protections by facilitating reserve capacities of posterior cingulate in non-demented elderly