Regeneration of O Portiño's beach and urbanization of the area.

Por medio de este proyecto se trata de mejorar la playa de O Portiño en A Coruña, ubicada en la zona del puerto de San Pedro de Visma. Ésta se caracteriza por sus dimensiones reducidas tanto longitudinalmente como de playa seca, así como por una serie de deficiencias en instalaciones para el disfrute de los usuarios. Debido a esto se propone la ampliación de la playa tanto en playa seca, como en dimensión longitudinal. Para lo cual se realiza un estudio de alternativas para alcanzar una solución óptima acorde a los criterios de evaluación empleados: económico, funcional y ambiental. Así mismo, se plantea la habilitación de un área de descanso en la zona contigua a la playa, que actualmente presenta un estado de semi-abandono, dotándola de mesas, papeleras, fuentes,… logrando mediante ello un espacio acondicionado para el uso y disfrute de los usuarios. Esta actuación tiene un Presupuesto Base de Licitación que asciende a la cantidad de DOSCIENTOS SESENTA Y SIETE MIL OCHOCIENTOS CINCUENTA Y SIETE EUROS CON SETENTA Y CUATRO CÉNTIMOS. Este anteproyecto no incluye cálculos de abastecimiento, drenaje, iluminación ni estabilidad de perfiles de playaTraballo fin de grao (UDC.ETSECCP). Tecnoloxía da Enxeñaría Civil. Curso 2015/201

Relaciones interpersonales y desempeño laboral de los docentes de la Unidad Educativa San Pablo, Santa Elena, Ecuador, 2018

En la época, en que vivimos, en el ámbito mundial, nacional y local, se da una marcada inquietud al interior, de los establecimientos educativos en perfeccionar las relaciones de tipo interpersonal, las cuales beneficien al ejercicio laboral de su personal docente y favorezcan para conseguir los objetivos institucionales. Al interior, de la U.E “San Pablo”, como referencia a este estudio, los disímiles actores educativos exteriorizaban que las relaciones interpersonales eran defectuosas, lo cual afectaba al desempeño laboral. Este inconveniente dio lugar a la siguiente interrogante ¿Qué relación existe entre las relaciones interpersonales y el desempeño laboral de los profesores de la U.E “San Pablo”, Sta Elena – Ecuador, 2018? Para contestar esta interrogante, se estableció como directriz, determinar la relación existente entre las variables relaciones interpersonales y desempeño laboral de los profesores de la U.E “San Pablo”, Sta Elena - Ecuador, 2018. El estudio se efectuó por el método cuantitativo. El tipo de esta investigación fue correlacional, utilizando en diseño descriptivo – correlacional, se designó un muestreo censal a 30 profesores, debido que la población era muy pequeña. El instrumento para recoger la información fue el cuestionario, el primer cuestionario sobre relaciones interpersonales y el otro cuestionario sobre desempeño laboral, aplicados a los profesores de esta institución educativa, los mismos que se validaron mediante la matriz respectiva. Para analizar la información se utilizó las pruebas estadísticas r de Pearson y la t de student, las que ayudaron a determinar la relación entre ambas variables y comprobar las hipótesis. Los resultados mostraron un predominio del nivel de relaciones interpersonales favorable con un 53% y una prevalencia del nivel de desempeño laboral satisfactorio con el 93%. También determinaron que existe relación reveladora entre ambas variables. El índice de relación según el coeficiente r de Pearson fue de 0,544** (Sig.= 0.002 < 0.01) lo que indica una correlación moderada, directa y reveladora a nivel 0.01

Virtual reality and 21st century education

Virtual Reality (RV), is one of the technological tools of the 21st century applied in the field of education and has increased significantly the use of it, to achieve the expected learning in students, the present This article aimed to demonstrate that VR as an innovative tool in 21st-century education contributes significantly to the teaching-learning process of students and teachers. It has worked based on a descriptive methodology-documentary, applying the analysis and interpretation of content, was limited to the review of articles published in digital journals, located in different databases, among the results there is a challenge that education should Assume and actively incorporate virtual reality, such as the technology that is a fundamental part of the daily life of the new generations, as an educational paradigm focused on the student, where it is intended to be autonomous and independent in the generation of learning

Viral protein-based nanoparticles (part 2): Pharmaceutical applications

Viral protein nanoparticles (ViP NPs) such as virus-like particles and virosomes are structures halfway between viruses and synthetic nanoparticles. The biological nature of ViP NPs endows them with the biocompatibility, biodegradability, and functional properties that many synthetic nanoparticles lack. At the same time, the absence of a viral genome avoids the safety concerns of viruses. Such characteristics of ViP NPs offer a myriad of opportunities for theirapplication at several points across disease development: from prophylaxis to diagnosis and treatment. ViP NPs present remarkable immunostimulant properties, and thus the vaccination field has benefited the most from these platforms capable of overcoming the limitations of both traditional and subunit vaccines. This was reflected in the marketing authorization of several VLP- and virosome-based vaccines. Besides, ViP NPs inherit the ability of viruses to deliver their cargo to target cells. Because of that, ViP NPs are promising candidates as vectors for drug and gene delivery, and for diagnostic applications. In this review, we analyze the pharmaceutical applications of ViP NPs, describing the products that are commercially available or under clinical evaluation, but also the advances that scientists are making toward the implementation of ViP NPs in other areas of major pharmaceutical interestThis publication is part of the following grants: PID2021–124986OB-I00 (Project “IMMMA”) funded by MCIN/AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe”; AC21_2/00046 (Project “RAIN”) funded by Health Institute Carlos III/MCIN/AEI/ 10.13039/501100011033 and by “European Union NextGenerationEU/EURONANOMED 3; PID2021–126510NB-I00 funded by MCIN/AEI/10.13039/501100011033 and “ERDF A way of making Europe”; and ED431G 2019/02 grant funded by Xunta de Galicia. RMC is a recipient of a predoctoral grant from the Ministerio de Educación y Formación Profesional (FPU20/01525)S

Doble role of bathocuproine disulfonic acid as multi-walled carbon nanotubes dispersing agent and copper preconcentration ligand: Analytical applications for the development of hydrogen peroxide and glucose electrochemical sensors

We are reporting a new strategy for preparing carbon nanotubes (CNTs)-based hydrogen peroxide and glucose amperometric sensors by taking advantage of the dual role of bathocuproine disulfonic acid (BCS) as dispersing agent of multi-walled carbon nanotubes (MWCNTs) and as ligand for the preconcentration of Cu(II). The platform was obtained by casting glassy carbon electrodes (GCE) with the dispersion of MWCNTs in BCS (MWCNTs-BCS) followed by the preconcentration of Cu(II) by surface complex formation at open circuit potential (GCE/MWCNTs-BCS/Cu). The resulting electrode was used for the sensitive amperometric quantification of hydrogen peroxide at 0.400 V catalyzed by the preconcentrated copper, with a linear range between 5.0 × 10−7 and 7.4 × 10-6 M, a sensitivity of 24.3 mA.M-1, and a detection limit of 0.2 μM. The adsorption of GOx at GCE/MWCNTs-BCS/Cu followed by the immobilization of Nafion (Naf), allowed the construction of a sensitive and selective amperometric glucose biosensor with a linear range between 5.0 × 10-6 M and 4.9 × 10-4 M, a sensitivity of (477 ± 3) μA.M-1 and a detection limit of 2 μM. The proposed (bio)sensors were successfully used for the quantification of hydrogen peroxide in enriched milk samples and glucose in milk and commercial beverages without any pretreatment.Fil: Gallay, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Rodriguez, Marcela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Eguílaz Rubio, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentin

Modelagem Computacional da Convecção Forçada Laminar em Dutos com Temperatura Variável no Contorno

Anais do III Encontro de Iniciação Científica da Unila - Sessão de Engenharia de Energias Renováveis - 06/11/14 – 15h50 às 18h30 - Unila-PTI - Bloco 09 – Espaço 02 – Sala 02Dutos de seção transversal circular são comumente utilizados na indústria, no entanto, dutos de seção não circular vêm sendo cada vez mais pesquisados e utilizados, tanto no âmbito acadêmico quanto industrial. Como não há muitos estudos relacionados a influência da convecção forçada com temperatura variável no contorno das paredes de dutos. Neste projeto busca-se desenvolver um modelo computacional para análise da convecção forçada laminar em dutos de seção transversal circular e retangular, com temperatura variável prescrita no contorno das paredes do duto. As equações governantes utilizadas para obter o campo de velocidades e temperatura foram as equações da conservação de massa, quantidade de movimento e energia. Para isto, adotou-se as seguintes considerações: escoamento em regime laminar com perfil térmico e hidrodinamicamente desenvolvido, escoamento incompressível e propriedades constantes. Cabe ressaltar, que para obtenção do campo de temperatura do escoamento na seção transversal do duto em função das temperaturas prescritas no contorno, utilizou-se a metodologia da equação da energia adimensionalisada. Para resolver as equações diferencias empregou-se o Método de Diferenças Finitas (MDF). O modelo calcula em primeira instância o campo de velocidade, em seguida é resolvida a equação da energia, obtendo-se assim, o campo de temperatura do fluido para uma dada distribuição imposta no contorno, não necessariamente uniforme. Os resultados obtidos para o campo de velocidades e temperatura, assim como, os dois parâmetros importantes, desde o ponto de vista da engenharia: fator de atrito e o número de Nusselt foram comparados e validados com os resultados existentes publicados em literatura.Bolsista Pibic – FA ; Universidade Federal da Integração Latino-Americana (UNILA

"Alternanthera sessilis" (L.) R. Br. ex DC. (Amaranthaceae) en la Península Ibérica

Alternanthera sessilis (L.) R. Br. ex DC. (Amaranthaceae) in the Iberian PeninsulaPalabras clave. Alternanthera sessilis, Amaranthaceae, alóctona, Península Ibérica.Key Words. Alternanthera sessilis, Amaranthaceae, alien plant, Iberian Peninsula

Nanoarchitectures based on multi-walled carbon nanotubes non-covalently functionalized with Concanavalin A: A new building-block with supramolecular recognition properties for the development of electrochemical biosensors

We propose an innovative nanoarchitecture for the development of electrochemical biosensors based on the non-covalent functionalization of multi-walled carbon nanotubes (MWCNTs) with the lectin Concanavalin A (ConA) and the site-specific supramolecular binding of glycobiomolecules. As proof-of-concept, we propose the use of two glycoenzymes, glucose oxidase (GOx) and horseradish peroxidase (HRP), for building mono and bienzymatic glucose biosensors. The selected conditions for the preparation of the dispersion were 1.5 mg MWCNTs in 1.0 mL of 2.0 mg mL −1 ConA sonicated for 5.0 min with sonicator probe. The monoenzymatic glucose biosensor was prepared by casting GCE with the MWCNTs-ConA dispersion (GCE/MWCNTs-ConA) followed by the interaction with GOx (GCE/MWCNTs-ConA/GOx), while the bienzymatic one was obtained by interaction of GCE/MWCNTs-ConA with GOx + HRP (GCE/MWCNTs-ConA/GOx-HRP). The best analytical performance was obtained with the bienzymatic biosensor from the amperometric response at -0.050 V in the presence of 1.0 × 10 -4 M hydroquinone. The sensitivity was (2.22 ± 0.03) μA mM −1 (which was 5.2 times higher than the one obtained with the monoenzymatic biosensor) and a detection limit of 0.31 μM. The reproducibility was 5.4% and the biosensor was challenged with human blood serum showing an excellent correlation with the values reported by the laboratory.Fil: Ortiz, Elvis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Universidad Autónoma Metropolitana Iztapalapa; MéxicoFil: Gallay, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Galicia, Laura. Universidad Autónoma Metropolitana Iztapalapa; MéxicoFil: Eguílaz Rubio, Marcos. Universidad Autónoma Metropolitana Iztapalapa; MéxicoFil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentin

RhoA activation promotes transformation and loss of thyroid cell differentiation interfering with thyroid transcription factor-1 activity

12 pages, 8 figures, 1 table.Highly specialized cells, the thyrocytes, express a thyroid-specific set of genes for thyroglobulin (Tg), thyroperoxidase, and the transcription factors TTF-1, TTF-2, and Pax-8. The implication of the small GTPase RhoA in TSH-mediated proliferation of FRTL-5 rat thyroid cells has been previously demonstrated. To further analyze RhoA function in thyroid cell proliferation and differentiation patterns, we combined transient and stable transfection assays to express different mutant RhoA forms in FRTL-5 cells. Constitutively active RhoA (FRTL-5-RhoA QL cells) exhibited a fibroblast-like phenotype with organized actin fibers, whereas cells expressing the RhoA negative dominant phenotype (FRTL-5-RhoA N19 cells) present a rounded morphology and lose normal cytoskeletal architecture. In addition, expression of the constitutively active form of RhoA results in TSH-independent proliferation and anchorage-independent growth and induces tumors when inoculated in nude mice. Interestingly, FRTL-5-RhoA QL cells express less Tg and TTF-1 than wild-type FRTL-5 (FRTL-5- vector) or FRTL-5-RhoA N19, suggesting a loss at the differentiation stage. This effect is mediated, at least in part, by a decrease in TTF-1 activity, since transient or stable expression of RhoA QL results in a reduction in the activity of the wild-type Tg promoter as well as an artificial promoter the activation of which depends exclusively on TTF-1. The similarity between RhoA effects and thyroid transformation by Ras suggests that RhoA may act as a downstream effector of Ras; in fact, the dominant negative RhoA N19 abolished the down- regulatory effect of Ras V12 over the Tg promoter. Taken together, these results show for the first time that active RhoA is able to transform FRTL-5 cells and that this effect is coupled to a loss of thyroid differentiation due to impaired TTF-1 activity.This work was supported by DGICYT Grants PM97/0065 and BMC2001-2087, and CAM Grant 08.1/0025/99. D.L.M. and M.R. are recipients of a fellowship from the Spanish Ministerio de Educación y Cultura and Ciencia y Tecnología, respectively.Peer reviewe