Prevención de la adicción a videojuegos: eficacia de las técnicas de control de la impulsividad en el programa PrevTec 3.1

Participaron 1.1106 alumnos de Educación Primaria y Secundaria de 13 centros educativos de la ciudad de Valencia y su área metropolitana. Se aplicó un diseño mixto o de medidas parcialmente repetidas, con una variable intra-sujeto –momento de medida- y una variable entre-sujetos –un grupo recibió las sesiones del programa PrevTec 3.1 (tradicional), otro recibió el programa con técnicas de control de la impulsividad adicionales, y un tercer grupo conformó el grupo en lista de espera-. Las técnicas adicionales consistían en: 1. Antes de ponerse a usar los videojuegos, esperar cinco minutos y, 2. Ponerse una alarma que sonara cuando terminase el tiempo de juego y que sirviera como señal para parar. Los resultados más relevantes son los siguientes: • La evolución del grupo que permanece en lista de espera muestra que cuando no se realiza la intervención (programa de prevención en cualquiera de sus modalidades), los resultados no varían, es decir, se mantiene la misma frecuencia y tiempo de uso de los videojuegos • Las dos modalidades del módulo de videojuegos del programa PrevTec 3.1 –módulo tradicional y módulo con técnicas de control de la impulsividad adicionales- resultan útiles para lograr un descenso del patrón de uso de los videojuegos –así como la dependencia de los mismos-, en todas las edades (9 a 16 años), tanto en chicas como en chicos, y tanto en dependientes como en no dependientes. • Si bien las dos modalidades resultan eficaces, el programa con técnicas de control de la impulsividad adicionales logra una mayor magnitud del cambio del patrón de uso de los videojuegos. • Los resultados logrados tras la aplicación del programa se mantienen en el seguimiento en ambas modalidades o condiciones. En el módulo con técnicas de control de la impulsividad, el patrón de uso de los videojuegos continúa descendiendo una vez finalizadas las sesiones. • El módulo de videojuegos con técnicas de control de la impulsividad es especialmente eficaz –y superior al módulo de videojuegos tradicional- en no dependientes

Impacts of Early Holocene environmental dynamics on open-air occupation patterns in the Western Mediterranean: insights from El Arenal de la Virgen (Alicante, Spain)

Open-air sites represent a fundamental proxy of the Early Holocene adaptive systems in the Iberian Peninsula. However, its research potential for the study of human–environmental interactions has been minimally explored. In this work, we present the results of an integrated research programme focused on open-area excavations at the Mesolithic site of Arenal de la Virgen (Alicante, Spain). Novel multi-scalar geoarchaeological and archaeo-stratigraphic studies, coupled with featured-based palaeobotanical analysis, were used to design an extensive radiocarbon dating programme and produce different Bayesian chronological models. Our results distinguish two different Mesolithic occupation phases, dating to 9.3–9.1 and 8.6–8.3k cal a bp respectively, consisting of combustion features and lithic scatters. The comparison of occupational dynamics with the nearby palaeoecological records of Salines and Villena indicated that both Mesolithic phases occurred under relatively stable environmental conditions. The second Mesolithic phase, however, ended during the onset of the 8.2k cal a bp climatic event, when sedimentation processes shifted from soil formation to accretion of aeolian sands. We demonstrate that the end of the Mesolithic occupations at Arenal de la Virgen coincides with the cessation of radiocarbon-dated activity in other open-air Postglacial sites in the central Mediterranean region of Iberia.This research is primarily part of a project that has received funding from the European Research Council (ERC) under the Horizon 2020 research and innovation programme (Grant agreement No. 683018) to JFLdP. Additional analyses on the pollen data sets have been produced in the context of the research project HAR2017-88503-P supported by the Spanish Ministry of Science and Innovation. JFLdP is additionally supported by the Plan Gen-T programme (Ref.CIDEGENT-18/040) from the Generalitat Valenciana. JRR is currently supported by a Margarita Salas fellowship (ref. MARSALAS21-22) at the University of Alicante, and AP-D is holder of a María Zambrano fellowship at the University of the Basque Country (UPV/EHU) both funded by the European Union-Next Gene and the Ministry of Universities (Government of Spain)

El yacimiento de Colata (Montaverner, Valencia) y los 'poblados de silos' del IV milenio en las comarcas centro-meridionales del País Valenciano

Les estructures documentades al jaciment de Colata (Montaverner, València) mostren la parcialitat del registre que caracteritza aquest tipus de jaciment a l'aire lliure del IV mil·lenni aC, cosa que obliga a plantejar noves estratègies per a reinterpretar l¿evolució en les conductes d'emmagatzematge, consum i producció d'aliments, i en la organització social d'aquestes comunitats. Paraules'clau: Vall d'Albaida. Estructures excavades. Poblats de sitges. Patró d'assentament. Organització social

A funerary perspective on Bell Beaker period in the Western Mediterranean. Reading the social context of individual burials at La Vital (Gandía, Valencia)

The discussion about social dynamics in recent Pre- history is supported by the study of funerary practices. The presence and significance of individual and collec- tive burials in Final Neolithic/Chalcolithic societies in the southeast of the Iberian Peninsula provides new evi- dence for the debate concerning the emergence of social inequalities in this region. Our contribution is based on the recent discovery and excavation of several individual pit burials in domestic contexts at the site of La Vital (Gandía, Valencia). The particularities of the identified burials (different ritual episodes) and their content (Bell Beaker pottery, metal objects, animal offerings) together with an accurate chronometric database allow us to con- sider several issues in relation to settlement dynamics, social networks and relationships for the period from the end of the 4th to the middle of the 3rd millennium cal BC in the central area of the Mediterranean coast of the Iberian Peninsula. La reflexión sobre la dinámica de las relaciones sociales en la Prehistoria reciente encuentra un apoyo clave en el análisis de las prácticas funerarias. La presencia y significación de los enterramientos individuales y colectivos en las sociedades del Neolítico final/ Calcolítico en el sureste de la Península Ibérica proporciona una nueva evidencia al debate sobre la aparición de las desigualdades sociales en la región. Nuestra contribución se basa en el reciente descubrimiento y excavación de varias tumbas individuales en fosa, localizadas en contextos domésticos, en el yacimiento de La Vital (Gandía, Valencia). Las peculiaridades del continente (detección de episodios rituales particulares en las distintas tumbas) y del contenido (vasos campaniformes, objetos metálicos, ofrendas animales), unido a una ajustada cronometría, permiten plantear diversas alternativas relativas a la dinámica poblacional, las redes de circulación de información y las formas de reproducción social entre finales del IV y el desarrollo del III milenio cal BC en el área central del Mediterráneo en la Península Ibérica

Late Mesolithic burials at Casa Corona (Villena, Spain): direct radiocarbon and palaeodietary evidence of the last forager populations in Eastern Iberia

Current knowledge about the Mesolithic-Neolithic transition in the Central and Western Mediterranean European regions is deeply limited by the paucity of Late Mesolithic human osteological data and the presence of chronological gaps covering several centuries between the last foragers and the first archaeological evidence of farming peoples. In this work, we present new data to fill these gaps. We provide direct AMS radiocarbon dating and carbon (d13C) and nitrogen (d15N) stable isotope analysis were carried out on bone collagen samples of two single burials from the recently discovered open-air Late Mesolithic site of Casa Corona (Villena, Spain). The results shed new light on the chronology and subsistence patterns of the last Mesolithic communities in the Central Mediterranean region of the Iberian Peninsula. Radiocarbon results date the human remains and funerary activity of the site to 6059e5849 cal BC, statistically different from other Late Mesolithic sites and the earliest Neolithic contexts, and bridging the 500 yrs chronological gap of the Mesolithic-Neolithic transition from the area. Isotopic evidence shows that diet was based on terrestrial resources despite the proximity to the site of lagoon and marine ecosystems. This and previous isotope studies from the region suggest a lower reliance upon marine resources than for Atlantic and Cantabrian sites, although intra-regional patterns of neighbouring Mesolithic populations exhibit both fully terrestrial diets and diets with significant amounts of aquatic resources in them. We hypothesize that in the Central Mediterranean region of Spain the Late Mesolithic dietary adaptations imposed structural limits on demographic growth of the last foragers and favoured rapid assimilation by the earliest Neolithic populations

Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

Modern humans have populated Europe for more than 45,000 years. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe, but resembles that of preceding individuals associated with the Aurignacian culture. This ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean culture, and with the following Magdalenian culture that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers, who were also characterized by marked differences in phenotypically relevant variants.Open access funding provided by Max Planck Society. This project has received funding by the European Research Council under the European Union’s Horizon 2020 research and innovation programme under grant agreements no. 803147-RESOLUTION (to S.T.), no. 771234-PALEoRIDER (to W.H.), no. 864358 (to K.M.), no. 724703 and no. 101019659 (to K.H.). K.H. is also supported by the Deutsche Forschungsgemeinschaft (DFG FOR 2237). E.A. has received funding from the Van de Kamp fonds. PACEA co-authors of this research benefited from the scientific framework of the University of Bordeaux’s IdEx Investments for the Future programme/GPR Human Past. A.G.-O. is supported by a Ramón y Cajal fellowship (RYC-2017-22558). L. Sineo, M.L. and D.C. have received funding from the Italian Ministry of University and Research (MUR) PRIN 2017 grants 20177PJ9XF and 20174BTC4R_002. H. Rougier received support from the College of Social and Behavioral Sciences of CSUN and the CSUN Competition for RSCA Awards. C.L.S. and T. Saupe received support from the European Union through the European Regional Development Fund (project no. 2014-2020.4.01.16-0030) and C.L.S. received support from the Estonian Research Council grant PUT (PRG243). S. Shnaider received support from the Russian Science Foundation (no. 19-78-10053).Peer reviewe

Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

: Modern humans have populated Europe for more than 45,000 years1,2. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. This ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean culture, and with the following Magdalenian culture that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers, who were also characterized by marked differences in phenotypically relevant variants

Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

Publisher Copyright: © 2023, The Author(s).Modern humans have populated Europe for more than 45,000 years1,2. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. This ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean culture, and with the following Magdalenian culture that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers, who were also characterized by marked differences in phenotypically relevant variants.Peer reviewe

X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients

Rett syndrome (RTT) is a severe neurological disorder usually caused by mutations in the MECP2 gene. Since the MECP2 gene is located on the X chromosome, X chromosome inactivation (XCI) could play a role in the wide range of phenotypic variation of RTT patients; however, classical methylation-based protocols to evaluate XCI could not determine whether the preferentially inactivated X chromosome carried the mutant or the wild-type allele. Therefore, we developed an allele-specific methylation-based assay to evaluate methylation at the loci of several recurrent MECP2 mutations. We analyzed the XCI patterns in the blood of 174 RTT patients, but we did not find a clear correlation between XCI and the clinical presentation. We also compared XCI in blood and brain cortex samples of two patients and found differences between XCI patterns in these tissues. However, RTT mainly being a neurological disease complicates the establishment of a correlation between the XCI in blood and the clinical presentation of the patients. Furthermore, we analyzed MECP2 transcript levels and found differences from the expected levels according to XCI. Many factors other than XCI could affect the RTT phenotype, which in combination could influence the clinical presentation of RTT patients to a greater extent than slight variations in the XCI pattern