Gestaltningsförslag för utemiljön vid samfälligheten Fläderblomman

I det här examensarbetet undersöks hur utemiljön på samfällighetsområdet Hofterup- Fläderblomman kan bli grönare och mer varierad än vad den är idag. Frågeställningen som besvaras är om boendevärdet på Fläderblomman kan ge en bättre social hållbarhet genom att tillföra mer växtlighet samt vilka växter som är lämpliga för platsens ståndort. Syftet med arbetet har varit att ta fram ett övergripande gestaltningsförslag som ska förbättra boendevärdet med hjälp av växtmaterial samt belysa vikten av en varierad och grönskande närmiljö. Inledningsvis fokuserar arbetet på en litteraturstudie med tyngdpunkt på social hållbarhet och växters inverkan på denna. Vidare beskrivs faktorer som påverkar växtplatsen, det vill säga ståndorten. Avslutningsvis i litteraturstudien beskrivs CSR- modellen, vilken beskriver växters överlevnadsstrategier. I den undersökande delen av arbetet görs platsbesök, platsdokumentation och samtal med representanter från styrelsen på Fläderblomman. Platsanalysen görs med stöd av Catherine Dee´s sju rumsliga strukturer (Dee 2001) och vidare från denna sammanställs en behovslista som tas vidare in i gestaltningsprocessen. Undersökningen utmynnar i ett gestaltningsförslag i form av en illustrationsplan, skisser samt växtlista. Gestaltningens fokus ligger på fyra huvudområden på projektplatsen: Entréer & gångstråk, finrummet, mellanrummen samt sällskapsrummet & stig. Växterna har i första hand valts för att klara rådande ståndort men även för att bidra med årstidsvariation, vintergrönt, blomning från vår till sen höst och en del för att bidra med vinterstruktur. Resultatet av arbetet visar på att genom att arbeta med ståndortsanpassat växtmaterial kan mer långsiktigt hållbara planteringar skapas. Om intressanta områden gestaltas lockas de boende ut på området och på så sätt kan också spontana möten ske. Med utgångspunkt i de studier och teorier som tas upp i arbetet om hur människan påverkas av gröna miljöer kan social hållbarhet förbättras.In this thesis, it is investigated how the outdoor environment in the community area HofterupFläderblomman can become greener and more varied than it is today. The question that is answered is whether the housing value of Fläderblomman can provide better social sustainability by adding more vegetation and which plants are suitable for the site’s location. The purpose of the work has been to produce an overall design proposal that will improve the housing value with the help of plant material and highlight the importance of one varied and lush local environment. Initially, the work focuses on a literature study with an emphasis on social sustainability and the impact of plants on this. Furthermore, factors that affect the growing site are described. Finally, the literature study describes the CSR model, which describes the survival strategies of plants. In the investigative part of the work, site visits, site documentation and conversations with representatives from the board at Fläderblomman. The site analysis is done with the support of Catherine Dee´s seven spatial structures (Dee 2001) and further from this a list of needs is compiled which is taken further into the design process. The survey results in a design proposal in the form of a illustration plan, sketches and plant list. The design’s focus is on four main areas the project site: Entrances & walkways, the fine room, the spaces and the lounge & path. The plants have primarily been chosen to cope with the prevailing location but also to contribute with seasonal variation, winter green, flowering from spring to late autumn and some to contribute with winter structure. The result of the work shows that by working with site-adapted plant material, more long-term sustainable plantings can be created. If interesting areas are designed, the residents are attracted to the area and in this way spontaneous meetings can also take place. Based on the studies and theories discussed in work on how people are affected by green environments, social sustainability can be improved

Влияние рыбьего жира на активность АТФ-чувствительных калиевых каналов коронарных сосудов крыс, перенесших пренатальный стресс

РЫБИЙ ЖИРКАЛИЕВЫЕ КАНАЛЫКОРОНАРНЫЕ СОСУДЫКРЫСЫКАЛИЕВЫЕ КАНАЛЫАТФ-ЧУВСТВИТЕЛЬНЫЕ КАЛИЕВЫЕ КАНАЛЫБЕРЕМЕННОСТЬ ЖИВОТНЫХСТРЕС

Nordic Vets against AMR—An Initiative to Share and Promote Good Practices in the Nordic–Baltic Region

In the Nordic countries, antimicrobial use in animals and the prevalence of antimicrobial resistance are among the lowest in Europe. The network “Nordic Vets Against AMR” organized a meeting in 2021, with key actors including representatives from universities, veterinary authorities and veterinary organizations in Finland, Norway and Sweden. This paper reflects the most important discussions on education, research, policy and future perspectives, including the experiences of these countries. It concludes that Nordic veterinarians are well placed to lead the way in the fight against antimicrobial resistance and that the sharing of experiences can support colleagues in other countries. Veterinary education must go hand in hand with research activities and continuously updated guidelines and legislation. There is also a need for postgraduate training on antimicrobial resistance and prudent antimicrobial use. The veterinary profession must, by any means necessary, protect the efficiency of antimicrobials for the sake of animal health, animal welfare and productivity, as well as public health. While restrictive use of antimicrobials is crucial, the ability of veterinarians to use this medical tool is also important for the sake of animal welfare and global food security

Nordic Vets against AMR—An Initiative to Share and Promote Good Practices in the Nordic–Baltic Region

Peer reviewe

Exploring the genetics of irritable bowel syndrome: A GWA study in the general population and replication in multinational case-control cohorts

OBJECTIVE: IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies. DESIGN: We conducted a GWA study (GWAS) of IBS in a general population sample of 11\u2005326 Swedish twins. IBS cases (N=534) and asymptomatic controls (N=4932) were identified based on questionnaire data. Suggestive association signals were followed-up in 3511 individuals from six case-control cohorts. We sought genotype-gene expression correlations through single nucleotide polymorphism (SNP)-expression quantitative trait loci interactions testing, and performed in silico prediction of gene function. We compared candidate gene expression by real-time qPCR in rectal mucosal biopsies of patients with IBS and controls. RESULTS: One locus at 7p22.1, which includes the genes KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2) and GRID2IP (glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein), showed consistent IBS risk effects in the index GWAS and all replication cohorts and reached p=9.31 710(-6) in a meta-analysis of all datasets. Several SNPs in this region are associated with cis effects on KDELR2 expression, and a trend for increased mucosal KDLER2 mRNA expression was observed in IBS cases compared with controls. CONCLUSIONS: Our results demonstrate that general population-based studies combined with analyses of patient cohorts provide good opportunities for gene discovery in IBS. The 7p22.1 and other risk signals detected in this study constitute a good starting platform for hypothesis testing in future functional investigations. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

A. Palotie on työryhmän Schizophrenia Working Grp Psychiat jäsen.We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P = 1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P = 8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Peer reviewe

Organizational ethos in a multicultural society - a case study

This paper describes and analyzes the strategies and efforts of a public organization in order to establish organizational credibility in multicultural areas. The trust-building efforts by the organization, a local rescue services in the south of Sweden, are a response to several years of social unrest, communicative clashes and hostile treatment between operative firemen and residents in areas of the city. In this paper a rhetorical perspective is introduced to analyze the relationship-building activities launched by the rescue services in order to change the organizational image and to create a more hospitable relationship between operative firemen and residents. It is argued that the rhetorical concept of ethos (credibility, trust) is appropriate to discern different dimensions (competence, character and good-will) in the process of establishing organizational credibility. The study, mainly based on 33 qualitative interviews, shows that there has been a clear shift in the organizational ethos towards the dimension of good-will. Investing in the community and in social issues, thus clearly demonstrating good-will, are important parts of the ethos-building activities. Key-actors in this change are a group of link-workers with immigrant background who facilitate of the residents identifying with the organization. While the efforts seem to contribute to a changing organizational ethos, there are some difficulties on the way. The main challenge seems to be the internal opposition towards the strategic shift of the organization