703 research outputs found
The break up of heavy electrons at a quantum critical point
The point at absolute zero where matter becomes unstable to new forms of
order is called a quantum critical point (QCP). The quantum fluctuations
between order and disorder that develop at this point induce profound
transformations in the finite temperature electronic properties of the
material. Magnetic fields are ideal for tuning a material as close as possible
to a QCP, where the most intense effects of criticality can be studied. A
previous study on theheavy-electron material found that near a
field-induced quantum critical point electrons move ever more slowly and
scatter off one-another with ever increasing probability, as indicated by a
divergence to infinity of the electron effective mass and cross-section. These
studies could not shed light on whether these properties were an artifact of
the applied field, or a more general feature of field-free QCPs. Here we report
that when Germanium-doped is tuned away from a chemically induced
quantum critical point by magnetic fields there is a universal behavior in the
temperature dependence of the specific heat and resistivity: the characteristic
kinetic energy of electrons is directly proportional to the strength of the
applied field. We infer that all ballistic motion of electrons vanishes at a
QCP, forming a new class of conductor in which individual electrons decay into
collective current carrying motions of the electron fluid.Comment: Pdf files of article available at
http://www.physics.rutgers.edu/~coleman/online/breakup.pdf, pdf file of news
and views article available at
http://www.physics.rutgers.edu/~coleman/online/nvbreakup.pd
Cavity mode enhancement of terahertz emission from equilateral triangular microstrip antennas of the high- superconductor BiSrCaCuO
We study the transverse magnetic (TM) electromagnetic cavity mode wave functions for an ideal equilateral triangular microstrip antenna (MSA) exhibiting point group symmetry. When the operations are imposed upon the antenna, the TM() modes with wave vectors are much less dense than commonly thought. The operations restrict the integral and to satisfy = 3, where 0 and 1 for the modes even and odd under reflections about the three mirror planes, respectively. We calculate the forms of representative wave functions and the angular dependence of the output power when these modes are excited by the uniform and non-uniform ac Josephson current sources in thin, ideally equilateral triangular MSAs employing the intrinsic Josephson junctions in the high transition temperature superconductor BiSrCaCuO, and fit the emissions data from an earlier sample for which the symmetry was apparently broken.UCF RAMP program, JSPS Research Fellowship for young scientists, CREST-JST (Japan Science and Technology Agency), WPI (World Premier International Research Center Initiative)- MANA (Materials Nanoarchitectonics) project (NIMS
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Cavity mode enhancement of terahertz emission from equilateral triangular microstrip antennas of the high- superconductor BiSrCaCuO
We study the transverse magnetic (TM) electromagnetic cavity mode wave functions for an ideal equilateral triangular microstrip antenna (MSA) exhibiting point group symmetry. When the operations are imposed upon the antenna, the TM() modes with wave vectors are much less dense than commonly thought. The operations restrict the integral and to satisfy = 3, where 0 and 1 for the modes even and odd under reflections about the three mirror planes, respectively. We calculate the forms of representative wave functions and the angular dependence of the output power when these modes are excited by the uniform and non-uniform ac Josephson current sources in thin, ideally equilateral triangular MSAs employing the intrinsic Josephson junctions in the high transition temperature superconductor BiSrCaCuO, and fit the emissions data from an earlier sample for which the symmetry was apparently broken.UCF RAMP program, JSPS Research Fellowship for young scientists, CREST-JST (Japan Science and Technology Agency), WPI (World Premier International Research Center Initiative)- MANA (Materials Nanoarchitectonics) project (NIMS
Electronic excitations in BiSrCaCuO : Fermi surface, dispersion, and absence of bilayer splitting
From a detailed study, including polarization dependence, of the normal state
angle-resolved photoemission spectra for BiSrCaCuO, we find
only one CuO band related feature. All other spectral features can be
ascribed either to umklapps from the superlattice or to ``shadow bands''. Even
though the dispersion of the peaks looks like band theory, the lineshape is
anomalously broad and no evidence is found for bilayer splitting. We argue that
the ``dip feature'' in the spectrum below arises not from bilayer
splitting, but rather from many body effects.Comment: 4 pages, revtex, 3 uuencoded postscript figure
Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis
Activation of dendritic cells by different pathogens induces the secretion of proinflammatory mediators resulting in
local inflammation. Importantly, innate immunity must be properly controlled, as its continuous activation leads to the
development of chronic inflammatory diseases such as psoriasis. Lipopolysaccharide (LPS) or peptidoglycan (PGN)
induced tolerance, a phenomenon of transient unresponsiveness of cells to repeated or prolonged stimulation,
proved valuable model for the study of chronic inflammation. Thus, the aim of this study was the identification of the
transcriptional diversity of primary human immature dendritic cells (iDCs) upon PGN induced tolerance. Using SAGESeq
approach, a tag-based transcriptome sequencing method, we investigated gene expression changes of primary
human iDCs upon stimulation or restimulation with Staphylococcus aureus derived PGN, a widely used TLR2 ligand.
Based on the expression pattern of the altered genes, we identified non-tolerizeable and tolerizeable genes. Gene
Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (Kegg) analysis showed marked enrichment of
immune-, cell cycle- and apoptosis related genes. In parallel to the marked induction of proinflammatory mediators,
negative feedback regulators of innate immunity, such as TNFAIP3, TNFAIP8, Tyro3 and Mer are markedly
downregulated in tolerant cells. We also demonstrate, that the expression pattern of TNFAIP3 and TNFAIP8 is
altered in both lesional, and non-lesional skin of psoriatic patients. Finally, we show that pretreatment of immature
dendritic cells with anti-TNF-α inhibits the expression of IL-6 and CCL1 in tolerant iDCs and partially releases the
suppression of TNFAIP8. Our findings suggest that after PGN stimulation/restimulation the host cell utilizes different
mechanisms in order to maintain critical balance between inflammation and tolerance. Importantly, the transcriptome
sequencing of stimulated/restimulated iDCs identified numerous genes with altered expression to date not associated
with role in chronic inflammation, underlying the relevance of our in vitro model for further characterization of IFNprimed
iDCs
Large Anomalous Hall effect in a silicon-based magnetic semiconductor
Magnetic semiconductors are attracting high interest because of their
potential use for spintronics, a new technology which merges electronics and
manipulation of conduction electron spins. (GaMn)As and (GaMn)N have recently
emerged as the most popular materials for this new technology. While Curie
temperatures are rising towards room temperature, these materials can only be
fabricated in thin film form, are heavily defective, and are not obviously
compatible with Si. We show here that it is productive to consider transition
metal monosilicides as potential alternatives. In particular, we report the
discovery that the bulk metallic magnets derived from doping the narrow gap
insulator FeSi with Co share the very high anomalous Hall conductance of
(GaMn)As, while displaying Curie temperatures as high as 53 K. Our work opens
up a new arena for spintronics, involving a bulk material based only on
transition metals and Si, and which we have proven to display a variety of
large magnetic field effects on easily measured electrical properties.Comment: 19 pages with 5 figure
Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex
Compartmentalization of the plasma membrane in a cell is fundamental for its proper functions. In this study, we present evidence that mammalian Fat4 and Dachsous1 cadherins regulate the apical plasma membrane organization in the embryonic cerebral cortex. In neural progenitor cells of the cortex, Fat4 and Dachsous1 were concentrated together in a cell–cell contact area positioned more apically than the adherens junction (AJ). These molecules interacted in a heterophilic fashion, affecting their respective protein levels. We further found that Fat4 associated and colocalized with the Pals1 complex. Ultrastructurally, the apical junctions of the progenitor cells comprised the AJ and a stretch of plasma membrane apposition extending apically from the AJ, which positionally corresponded to the Fat4–Dachsous1-positive zone. Depletion of Fat4 or Pals1 abolished this membrane apposition. These results highlight the importance of the Fat4–Dachsous1–Pals1 complex in organizing the apical membrane architecture of neural progenitor cells
Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment
Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart
OBJECTIVE: Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of inflammation on cardiac metabolism is unknown. We investigated the effects of diet-induced obesity on cardiac inflammation and glucose metabolism in mice.
RESEARCH DESIGN AND METHODS: Male C57BL/6 mice were fed a high-fat diet (HFD) for 6 weeks, and heart samples were taken to measure insulin sensitivity, glucose metabolism, and inflammation. Heart samples were also examined following acute interleukin (IL)-6 or lipid infusion in C57BL/6 mice and in IL-6 knockout mice following an HFD.
RESULTS: Diet-induced obesity reduced cardiac glucose metabolism, GLUT, and AMP-activated protein kinase (AMPK) levels, and this was associated with increased levels of macrophages, toll-like receptor 4, suppressor of cytokine signaling 3 (SOCS3), and cytokines in heart. Acute physiological elevation of IL-6 suppressed glucose metabolism and caused insulin resistance by increasing SOCS3 and via SOCS3-mediated inhibition of insulin receptor substrate (IRS)-1 and possibly AMPK in heart. Diet-induced inflammation and defects in glucose metabolism were attenuated in IL-6 knockout mice, implicating the role of IL-6 in obesity-associated cardiac inflammation. Acute lipid infusion caused inflammation and raised local levels of macrophages, C-C motif chemokine receptor 2, SOCS3, and cytokines in heart. Lipid-induced cardiac inflammation suppressed AMPK, suggesting the role of lipid as a nutrient stress triggering inflammation.
CONCLUSIONS: Our findings that nutrient stress activates cardiac inflammation and that IL-6 suppresses myocardial glucose metabolism via inhibition of AMPK and IRS-1 underscore the important role of inflammation in the pathogenesis of diabetic heart
Quantum Criticality in Heavy Fermion Metals
Quantum criticality describes the collective fluctuations of matter
undergoing a second-order phase transition at zero temperature. Heavy fermion
metals have in recent years emerged as prototypical systems to study quantum
critical points. There have been considerable efforts, both experimental and
theoretical, which use these magnetic systems to address problems that are
central to the broad understanding of strongly correlated quantum matter. Here,
we summarize some of the basic issues, including i) the extent to which the
quantum criticality in heavy fermion metals goes beyond the standard theory of
order-parameter fluctuations, ii) the nature of the Kondo effect in the quantum
critical regime, iii) the non-Fermi liquid phenomena that accompany quantum
criticality, and iv) the interplay between quantum criticality and
unconventional superconductivity.Comment: (v2) 39 pages, 8 figures; shortened per the editorial mandate; to
appear in Nature Physics. (v1) 43 pages, 8 figures; Non-technical review
article, intended for general readers; the discussion part contains more
specialized topic
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