8 research outputs found
Analysis of routine blood markers for predicting amputation/reâamputation risk in diabetic foot
No full textA multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity
No full textInsights into the anthropogenic load and occupational health risk of heavy metals in floor dust of selected workplaces in an industrial city of Iran
No full textSERS spectroscopy using Au-Ag nanoshuttles and hydrophobic paper-based Au nanoflower substrate for simultaneous detection of dual cervical cancerâassociated serum biomarkers
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Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity
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The biology of vascular calcification
No full textVascular calcification (VC), characterized by different mineral deposits (i.e., carbonate apatite, whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a relevant pathological process for the aging population and a life-threatening complication in acquired and in genetic diseases. Similarly to bone remodeling, VC is an actively regulated process in which many cells and molecules play a pivotal role. This review aims at: (i) describing the role of resident and circulating cells, of the extracellular environment and of positive and negative factors in driving the mineralization process; (ii) detailing the types of VC (i.e., intimal, medial and cardiac valve calcification); (iii) analyzing rare genetic diseases underlining the importance of altered pyrophosphate-dependent regulatory mechanisms; (iv) providing therapeutic options and perspectives
