Prácticas de autocuidado en adultos mayores: un estudio cualitativo en población mexicana

Background: Older adults perform self-care activities based on common knowledge, which should be valued by the nursing team. Objectives: To describe and analyze the self-care behaviors of older adults in a Mexican population. Methodology: Qualitative ethnographic study, using Leininger’s qualitative research method. Results: Seventeen older adults were interviewed. Te analysis resulted in 4 explanatory patterns: 1) I keep my peace of mind through what I think, feel, and believe; 2) I watch my diet and pay attention not only to what I eat but also how I eat it; 3) Staying busy is what keeps me going; 4) and Seeking help and helping myself. Te following risk behaviors were identifed: Postponing medical care; Self-medication; and Food-related beliefs. Conclusion: Identifying older adults’ reported behaviors would contribute to the planning of culturally-sensitive nursing interventions.Marco contextual: Los adultos mayores realizan prácticas de autocuidado con base en sus saberes populares, estas de- ben ser valoradas por el personal de enfermería. Objetivos: Describir y analizar las prácticas de autocuidado que llevan a cabo adultos mayores de una población mexicana. Metodología: Investigación cualitativa etnográfica, en la que se utilizó el método de análisis cualitativo de Leininger. Resultados: Se entrevistó a 17 adultos mayores. El análisis originó 4 patrones explicativos: 1) Conservo mi tranquilidad a través de lo que pienso, siento y creo; 2) Cuido mi alimentación porque no solo es lo que se come, sino cómo se come; 3) Mantenerme ocupado es lo que me tiene en pie; 4) Pidiendo ayuda y ayudándose uno mismo. Las prácticas de riesgo son posponer la atención médica, automedicarse y las creencias en la alimentación. Conclusión: La identificación de las prácticas expresadas por los adultos mayores aportaría una plusvalía en la planificación de las intervenciones de enfermería en el ámbito de los cuidados culturalmente sensibles

Enhancing competitive island cooperative neuro - evolution through backpropagation for pattern classification

Cooperative coevolution is a promising method for training neural networks which is also known as cooperative neuro-evolution. Cooperative neuro-evolution has been used for pattern classification, time series prediction and global optimisation problems. In the past, competitive island based cooperative coevolution has been proposed that employed different instances of problem decomposition methods for competition. Neuro-evolution has limitations in terms of training time although they are known as global search methods. Backpropagation algorithm employs gradient descent which helps in faster convergence which is needed for neuro-evolution. Backpropagation suffers from premature convergence and its combination with neuro-evolution can help eliminate the weakness of both the approaches. In this paper, we propose a competitive island cooperative neuro-evolutionary method that takes advantage of the strengths of gradient descent and neuro-evolution. We use feedforward neural networks on benchmark pattern classification problems to evaluate the performance of the proposed algorithm. The results show improved performance when compared to related methods

Ruling out four-neutrino oscillation interpretations of the LSND anomaly?

Prompted by recent solar and atmospheric data, we re-analyze the four-neutrino description of current global neutrino oscillation data, including the LSND evidence for oscillations. The higher degree of rejection for non-active solar and atmospheric oscillation solutions implied by the SNO neutral current result as well as by the latest 1489-day Super-K atmospheric neutrino data allows us to rule out (2+2) oscillation schemes proposed to reconcile LSND with the rest of current neutrino oscillation data. Using an improved goodness of fit (gof) method especially sensitive to the combination of data sets we obtain a gof of only 1.6 times 10^{-6} for (2+2) schemes. Further, we re-evaluate the status of (3+1) oscillations using two different analyses of the LSND data sample. We find that also (3+1) schemes are strongly disfavoured by the data. Depending on the LSND analysis we obtain a gof of 5.6 times 10^{-3} or 7.6 times 10^{-5}. This leads to the conclusion that all four-neutrino descriptions of the LSND anomaly, both in (2+2) as well as (3+1) realizations, are highly disfavoured. Our analysis brings the LSND hint to a more puzzling status.Comment: 21 pages, 7 figure

Cornering (3+1) sterile neutrino schemes

Using the most recent atmospheric neutrino data, as well as short-baseline, long-baseline and tritium $\beta$-decay data we show that the joint interpretation of the LSND, solar and atmospheric neutrino anomalies in (3+1) sterile neutrino schemes is severely disfavored, in contrast to the theoretically favored (2+2) schemes.Comment: 14 pages, 4 figures, v3: extended tritium decay analysis, small corrections in Fig. 2 and Eq.(4), version accepted for publication in Phys. Lett.

The Spanish HIV BioBank: a model of cooperative HIV research

<p>Abstract</p> <p>Background</p> <p>The collection of samples from HIV-infected patients is the beginning of the chain of translational research. To carry out quality research that could eventually end in a personalized treatment for HIV, it is essential to guarantee the availability, quality and traceability of samples, under a strict system of quality management.</p> <p>Methods</p> <p>The Spanish HIV BioBank was created with the objectives of processing, storing and providing distinct samples from HIV/AIDS patients, categorized according to strictly defined characteristics, free of charge to research projects. Strict compliance to ethical norms is always guaranteed.</p> <p>Results</p> <p>At the moment, the HIV BioBank possesses nearly 50,000 vials containing different prospective longitudinal study sample types. More than 1,700 of these samples are now used in 19 national and international research projects.</p> <p>Conclusion</p> <p>The HIV BioBank represents a novel approach to HIV research that might be of general interest not only for basic and clinical research teams working on HIV, but also for those groups trying to establish large networks focused on research on specific clinical problems. It also represents a model to stimulate cooperative research among large numbers of research groups working as a network on specific clinical problems. The main objective of this article is to show the structure and function of the HIV BioBank that allow it to very efficiently release samples to different research project not only in Spain but also in other countries.</p

MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models

Targeting the DNA damage response (DDR) in tumors with defective DNA repair is a clinically successful strategy. The RAS/RAF/MEK/ERK signalling pathway is frequently deregulated in human cancers. In this study, we explored the effects of MEK inhibition on the homologous recombination pathway and explored the potential for combination therapy of MEK inhibitors with DDR inhibitors and a hypoxia-activated prodrug. We studied effects of combining pimasertib, a selective allosteric inhibitor of MEK1/2, with olaparib, a small molecule inhibitor of poly (adenosine diphosphate [ADP]-ribose) polymerases (PARP), and with the hypoxia-activated prodrug evofosfamide in ovarian and pancreatic cancer cell lines. Apoptosis was assessed by Caspase 3/7 assay and protein expression was detected by immunoblotting. DNA damage response was monitored with γH2AX and RAD51 immunofluorescence staining. In vivo antitumor activity of pimasertib with evofosfamide were assessed in pancreatic cancer xenografts. We found that BRCA2 protein expression was downregulated following pimasertib treatment under hypoxic conditions. This translated into reduced homologous recombination repair demonstrated by levels of RAD51 foci. MEK inhibition was sufficient to induce formation of γH2AX foci, suggesting that inhibition of this pathway would impair DNA repair. When combined with olaparib or evofosfamide, pimasertib treatment enhanced DNA damage and increased apoptosis. The combination of pimasertib with evofosfamide demonstrated increased anti-tumor activity in BRCA wild-type Mia-PaCa-2 xenograft model, but not in the BRCA mutated BxPC3 model. Our data suggest that targeted MEK inhibition leads to impaired homologous recombination DNA damage repair and increased PARP inhibition sensitivity in BRCA- 2 proficient cancers

Active-active and active-sterile neutrino oscillation solutions to the atmospheric neutrino anomaly

We perform a fit to the full data set corresponding to 33.3 kt-yr of data of the Super-Kamiokande experiment as well as to all other experiments in order to compare the two most likely solutions to the atmospheric neutrino anomaly in terms of oscillations in the $\nu_\mu \to \nu_\tau$ and $\nu_\mu \to \nu_s$ channels. Using state-of-the-art atmospheric neutrino fluxes we have determined the allowed regions of oscillation parameters for both channels. We find that the $\Delta m^2$ values for the active-sterile oscillations (both for positive and negative $\Delta m^2$) are higher than for the $\nu_\mu \to \nu_\tau$ case, and that the increased Super-Kamiokande sample slightly favours $\nu_\mu \to \nu_\tau$ oscillations over oscillations into a sterile species $\nu_s$, $\nu_\mu \to \nu_s$, and disfavours $\nu_\mu \to \nu_e$. We also give the zenith angle distributions predicted for the best fit points in each of the possible oscillation channels. Finally we compare our determinations of the atmospheric neutrino oscillation parameters with the expected sensitivities of future long-baseline experiments K2K, MINOS, ICARUS, OPERA and NOE.Comment: Updated to 535 days of Super-Kamiokande and corresponding modifications in the discussion and figures. Some References adde

Immune microenvironment dysfunctions enable malignification at the onset of myelodysplastic syndromes

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