NN Scattering: Chiral Predictions for Asymptotic Observables

We assume that the nuclear potential for distances larger than 2.5 fm is given just by the exchanges of one and two pions and, for the latter, we adopt a model based on chiral symmetry and subthreshold pion-nucleon amplitudes, which contains no free parameters. The predictions produced by this model for nucleon-nucleon observables are calculated and shown to agree well with both experiment and those due to phenomenological potentials.Comment: 16 pages, 12 PS figures included, to appear in Physical Review

Dynamic Ordering and Transverse Depinning of a Driven Elastic String in a Disordered Media

We examine the dynamics of an elastic string interacting with quenched disorder driven perpendicular and parallel to the string. We show that the string is the most disordered at the depinning transition but with increasing drive partial ordering is regained. For low drives the noise power is high and we observe a 1/f^2 noise signature crossing over to a white noise character with low power at higher drives. For the parallel driven moving string there is a finite transverse critical depinning force with the depinning transition occuring by the formation of running kinks.Comment: 4 pages, 4 postscript figure

Quark Condensate in the Deuteron

We study the changes produced by the deuteron on the QCD quark condensate by means the Feynman-Hellmann theorem and find that the pion mass dependence of the pion-nucleon coupling could play an important role. We also discuss the relation between the many body effect of the condensate and the meson exchange currents, as seen by photons and pions. For pion probes, the many-body term in the physical amplitude differs significantly from that of soft pions, the one linked to the condensate. Thus no information about the many-body term of the condensate can be extracted from the pion-deuteron scattering length. On the other hand, in the Compton amplitude, the relationship with the condensate is a more direct one.Comment: to appear in Physics Review C (19 pages, 3 figures

CHIRAL BACKGROUND FOR THE TWO PION EXCHANGE NUCLEAR POTENTIAL: A PARAMETRIZED VERSION

We argue that the minimal chiral background for the two-pion exchange nucleon-nucleon interaction has nowadays a rather firm conceptual basis, which entitles it to become a standard ingredient of any modern potential. In order to facilitate applications, we present a parametrized version of a configuration space potential derived previously. We then use it to assess the phenomenological contents of some existing NN potentials.Comment: REVTEX style, 16 pages, 5 PostScript figures compressed, tarred and uuencode

Updating temperature and salinity mean values and trends in the Western Mediterranean: the RADMED project

Postprin

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy

Phenotype and genotype of 87 patients with Mowat–Wilson syndrome and recommendations for care

Purpose: Mowat–Wilson syndrome (MWS) is a rare intellectual disability/multiple congenital anomalies syndrome caused by heterozygous mutation of the ZEB2 gene. It is generally underestimated because its rarity and phenotypic variability sometimes make it difficult to recognize. Here, we aimed to better delineate the phenotype, natural history, and genotype–phenotype correlations of MWS. Methods: In a collaborative study, we analyzed clinical data for 87 patients with molecularly confirmed diagnosis. We described the prevalence of all clinical aspects, including attainment of neurodevelopmental milestones, and compared the data with the various types of underlying ZEB2 pathogenic variations. Results: All anthropometric, somatic, and behavioral features reported here outline a variable but highly consistent phenotype. By presenting the most comprehensive evaluati