755 research outputs found
rac-5-Acetyl-6-hyÂdroxy-3,6-dimethyl-4-phenyl-4,5,6,7-tetraÂhydro-2H-indazole
The title compound, C17H20N2O2, is chiral but crystallizes in a centrosymmetric space group as a racemate, the relative configuration at the stereogenic centres being 2S*,3R*,4S*. The cycloÂhexane ring adopts a half-chair conformation while the pyrazole ring has an envelope conformation. The crystal packing displays interÂmolecular OâHâŻN and NâHâŻO hydrogen bonding
CONSERVATIVE FLUIDS AND LUBRICANTS BASED ON TURBINE OIL, NITRO, AMIDO AND PARAFFIN WAX
To create conservation fluids and lubricants based on the oil acids and polyethylene polyamine (PEPA) synthesized amidoamines, and based on ñ-olefins (C12, C14 and C16-C18) and the nitric acids-nitro compounds. Using of amido, nitro and solid n-paraffins in the turbine oil T-30 (Standard 32-74) formulated lubricants and conservation fluid which are tested under different conditions. It is shown that in comparison with the preservative fluid, the preservative lubrication more effective
Early experience with the ARTISENTIALÂź articulated instruments in laparoscopic low anterior resection with TME
Background: The notion of articulation in surgery has been largely synonymous with robotics. The ARTISENTIALÂź instruments aim at bringing advanced articulation to laparoscopy to overcome challenges in narrow anatomical spaces. In this paper, we present first single-center results of a series of low anterior resections, performed with ARTISENTIALÂź. Methods: Between September 2020 and August 2021, at the Department of Surgery, St. Marienkrankenhaus Siegen, Siegen, Germany, patients with cancer of the mid- and low rectum were prospectively enrolled in a pilot feasibility study to evaluate the ARTISENTIALÂź articulated instruments in performing a laparoscopic low anterior resection. Perioperative and short-term postoperative data were analyzed. Results: Seventeen patients (10 males/7 females) were enrolled in this study. The patients had a median age of 66Â years (range 47â80Â years) and a median body mass index of 28Â kg/m2 (range 23â33Â kg/m2). The median time to rectal transection was 155Â min (range 118â280Â min) and the median total operative time was 276Â min (range 192â458Â min). The median estimated blood loss was 30Â ml (range 5â70Â ml) and there were no conversions to laparotomy. The median number of harvested lymph nodes was 15 (range 12â28). Total mesorectal excision (TME) quality was âgoodâ in all patients with no cases of circumferential resection margin involvement (R0 = 100%). The median length of stay was 9Â days (range 7â14Â days). There were no anastomotic leaks and the overall complication rate was 17.6%. There was one unrelated readmission with no mortality. Conclusions: Low anterior resection with ARTISENTIALÂź is feasible and safe. All patients had a successful TME procedure with a good oncological outcome. We will now seek to evaluate the benefits of ARTISENTIALÂź in comparison with standard laparoscopic instruments through a larger study
THE COMPLETE PATHOMORPHOLOGICAL RESPONSE TO NEOADJUVANT THERAPY AND ITS ROLE IN THE TREATMENT STRATEGY FOR RECTAL CANCER
The therapeutic strategy in rectal cancer has substantially changed in the past decade. Total mesorectumectomy has been widely used. Many specialized health facilities have accepted radio/chemoradiotherapy for locally advanced rectal cancer as a standard. At the same time as high as one quarter of the patients receiving neoadjuvant therapy demonstrate a complete pathomorphological regression of a tumor. In this connection, the current literature discusses whether medical treatment is permissible in this group of patients
Extractive Dearomatization of Naphthalane Oil Fraction with Ionic Liquid and -N-Methyl-2-Pyrrolidone
In the article are given an analysis of the results of researches carried out for the purpose of selective treatment of the Naphthalane oil fraction boiling at 260-3400C with ionic liquid (IL) -morfolinphormiate synthesized on the basis formic acid + morpholine and - N-methyl-2-pyrrolidon (N-MP) andĂÂ as an extractant. The aim is to remove poisonous components -ĂÂ sulfur compounds and toxic carcinogenic polynuclear aromatic hydrocarbons in order to improve therapeutic properties of Naphthalane oil cut. For this purpose we have used extraction method. On the basis of the conducted researches the role of -N-methyl-2-pyrrolidone and IL-morpholinephormiatee in extraction conditions have been determined in selective treatment of Nafthalan oil, according to the results of spectral analysis residual amount of aromatic hydrocarbons decreased from 18.5% wt accordance to 2%, 1.5%. As well as the amount of sulphur decreased from 0.0354% to 0.010%,ĂÂ 0.011% and 0.019%.In the next stage the treated raffinates with N-methyl-2-pyrrolidone has been purified on silica. In a result amount of aromatic hydrocarbons drastically decrease to be 0.07% and 0.02%. As a result we aquire transparency and at the same time the percentage amount of aromatic hydrocarbons drastically decreased from 2% to 0,07%, 1.5%, to 0.02%. Raffinates obtained in a 2-4 stage dearomatization with N-MP and IL. Raffinate are measured on NMR, UV and IR spectral analysis
ĐĐĐĐĐ«Đ ĐĐĐąĐĐĐРЀĐĐĐĐĐЧĐĐĄĐĐĐ ĐĐąĐĐĐą ĐĐ ĐĐĐĐĐĐȘĐźĐĐĐĐąĐĐŁĐź ĐąĐĐ ĐĐĐĐź Đ ĐĐĐ Đ ĐĐĐŹ РХйРĐĐąĐĐĐĐ ĐĐЧĐĐĐĐŻ Đ ĐĐĐ ĐĐ ĐŻĐĐĐ ĐĐĐšĐĐ
The therapeutic strategy in rectal cancer has substantially changed in the past decade. Total mesorectumectomy has been widely used. Many specialized health facilities have accepted radio/chemoradiotherapy for locally advanced rectal cancer as a standard. At the same time as high as one quarter of the patients receiving neoadjuvant therapy demonstrate a complete pathomorphological regression of a tumor. In this connection, the current literature discusses whether medical treatment is permissible in this group of patients.Đ ĐżĐŸŃĐ»Đ”ĐŽĐœĐžĐ” ĐŽĐ”ŃŃŃОлДŃĐžŃ Đ»Đ”ŃĐ”Đ±ĐœĐ°Ń ŃŃŃĐ°ŃĐ”ĐłĐžŃ ĐČ ĐŸŃĐœĐŸŃĐ”ĐœĐžĐž ŃĐ°ĐșĐ° ĐżŃŃĐŒĐŸĐč ĐșĐžŃĐșĐž (Đ ĐĐ) ŃŃŃĐ”ŃŃĐČĐ”ĐœĐœĐŸ ĐžĐ·ĐŒĐ”ĐœĐžĐ»Đ°ŃŃ. ĐĐŸĐČŃĐ”ĐŒĐ”ŃŃĐœĐŸĐ” ŃĐ°ŃĐżŃĐŸŃŃŃĐ°ĐœĐ”ĐœĐžĐ” ĐżĐŸĐ»ŃŃОла ŃĐŸŃĐ°Đ»ŃĐœĐ°Ń ĐŒĐ”Đ·ĐŸŃĐ”ĐșŃŃĐŒŃĐșŃĐŸĐŒĐžŃ. ĐŃŃĐ”ĐČĐ°Ń/Ń
ĐžĐŒĐžĐŸĐ»ŃŃĐ”ĐČĐ°Ń ŃĐ”ŃĐ°ĐżĐžŃ ĐŒĐ”ŃŃĐœĐŸ-ŃĐ°ŃĐżŃĐŸŃŃŃĐ°ĐœĐ”ĐœĐœĐŸĐłĐŸ Đ ĐĐ ĐżŃĐžĐœŃŃĐ° ĐČ ĐșĐ°ŃĐ”ŃŃĐČĐ” ŃŃĐ°ĐœĐŽĐ°ŃŃĐ° ĐŒĐœĐŸĐłĐžĐŒĐž ŃпДŃОалОзОŃĐŸĐČĐ°ĐœĐœŃĐŒĐž лДŃĐ”Đ±ĐœŃĐŒĐž ŃŃŃĐ”Đ¶ĐŽĐ”ĐœĐžŃĐŒĐž. ĐŃĐž ŃŃĐŸĐŒ ĐŽĐŸ ŃĐ”ŃĐČĐ”ŃŃĐž паŃĐžĐ”ĐœŃĐŸĐČ, ĐżĐŸĐ»ŃŃĐžĐČŃĐžŃ
ĐœĐ”ĐŸĐ°ĐŽŃŃĐČĐ°ĐœŃĐœŃŃ ŃĐ”ŃапОŃ, ĐŽĐ”ĐŒĐŸĐœŃŃŃĐžŃŃŃŃ ĐżĐŸĐ»ĐœŃĐč паŃĐŸĐŒĐŸŃŃĐŸĐ»ĐŸĐłĐžŃĐ”ŃĐșĐžĐč ŃДгŃĐ”ŃŃ ĐŸĐżŃŃ
ĐŸĐ»Đž. Đ ŃĐČŃĐ·Đž Ń ŃŃĐžĐŒ ĐČ ŃĐŸĐČŃĐ”ĐŒĐ”ĐœĐœĐŸĐč лОŃĐ”ŃĐ°ŃŃŃĐ” ĐŸĐ±ŃŃжЎаДŃŃŃ ĐČĐŸĐżŃĐŸŃ ĐŸ ĐŽĐŸĐżŃŃŃĐžĐŒĐŸŃŃĐž ĐșĐŸĐœŃĐ”ŃĐČĐ°ŃĐžĐČĐœĐŸĐč ŃĐ°ĐșŃĐžĐșĐž ĐČ ĐŸŃĐœĐŸŃĐ”ĐœĐžĐž ŃĐșĐ°Đ·Đ°ĐœĐœĐŸĐč ĐșĐ°ŃĐ”ĐłĐŸŃОО Đ±ĐŸĐ»ŃĐœŃŃ
Technological Aspects of Introduction Crocus Alatavicus According to GACP Requirements
According to the forecasts of the World Health Organization, the share of herbal medicines in the global pharmaceutical market is more than 40%. The pronounced growth trend of phytopreparations can lead to depletion of stocks of medicinal plants and the introduction of medicinal plants into the culture is a suitable solution to the problem. In order to ensure the quality of medicinal plants, in 2003 the World Health Organization (WHO) issued guidelines on Good cultivation and harvesting practices (GACP) medicinal plants. This article presents the results of the introduction of the Crocus alatavicus plant by seeds. The aim of the study is to develop a technology for the introduction of Crocus alatavicus by the method of seed propagation according to the principles of GACP. The development of the introduction technology according to the principles of GACP guarantees the provision of domestic pharmaceutical production with high-quality plant raw materials. The introduction was carried out at the pilot production plantation of "Phytoleum" LLP. The results of the study showed that during seed propagation, autumn sowing of Crocus alatavicus seeds is preferable. The introduction of organic fertilizer of vermicompost before sowing seeds has a positive effect on the germination of seeds and the survival of seedlings. The plant in the fourth year of vegetation goes into the generative period and the fruit will form. The results of the introduction of Crocus alatavicus by seeds in the period from 2018 to 2022 showed good seed germination and high survival of seedlings, which makes it possible to recommend the plant for introduction into culture. It is important to emphasize that the ability to cultivate C. alatavicus from seeds creates new opportunities for use as domestic raw materials for the purpose of further rational use in scientific and practical medicine, preserving this species in culture
Costs and Benefits of Labour Mobility between the EU and the Eastern Partnership Partner Countries - Country Report: Azerbaijan
Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC
The uncertainty on the calorimeter energy response to jets of particles is
derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the
calorimeter response to single isolated charged hadrons is measured and
compared to the Monte Carlo simulation using proton-proton collisions at
centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009
and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter
response to specific types of particles (positively and negatively charged
pions, protons, and anti-protons) is measured and compared to the Monte Carlo
predictions. Finally, the jet energy scale uncertainty is determined by
propagating the response uncertainty for single charged and neutral particles
to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3%
for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table,
submitted to European Physical Journal
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