Efecto de la temperatura de termotratamiento en el comportamiento eléctrico de la madera de pino radiata

Se analiza el efecto de la temperatura del termotratamiento sobre la conductividad eléctrica de la madera de pino radiata. Sobre probetas de madera de pino radiata de procedencia País Vasco (España), termotratada a 190ºC y 210ºC por el método Thermowood así como sobre piezas testigo de la misma especie, procedencia y dimensiones, acondicionadas todas ellas hasta masa constante a 20ºC/40%HR, 20ºC/65%HR y 20ºC/90%HR se evaluó la resistencia eléctrica (longitudinal y transversal) y, posteriormente, se ajustó el modelo Samuelson para modelizar en cada tipo de material la relación humedad de la madera-resistencia eléctrica. Se concluye que la temperatura empleada en el tratamiento térmico de la madera afecta no sólo a la humedad de equilibrio sino, también, a su conductividad eléctrica, siendo máximo este efecto en el tratamiento efectuado a 210ºC

Correlated Anisotropies in the Cosmic Far-Infrared Background Detected by MIPS/Spitzer: Constraint on the Bias

We report the detection of correlated anisotropies in the Cosmic Far-Infrared Background at 160 microns. We measure the power spectrum in the Spitzer/SWIRE Lockman Hole field. It reveals unambiguously a strong excess above cirrus and Poisson contributions, at spatial scales between 5 and 30 arcminutes, interpreted as the signature of infrared galaxy clustering. Using our model of infrared galaxy evolution we derive a linear bias b=1.74 \pm 0.16. It is a factor 2 higher than the bias measured for the local IRAS galaxies. Our model indicates that galaxies dominating the 160 microns correlated anisotropies are at z~1. This implies that infrared galaxies at high redshifts are biased tracers of mass, unlike in the local Universe.Comment: ApJ Letters, in pres

Determinación de curvas para la estimación del contenido de humedad de diez maderas de frondosas mediante medidas de resistencia eléctrica

Accuracy in moisture content measurement is of great importance in the assurance of wood product quality and isnecessary to meet administrative and normative requirements. Improving the accuracy of resistance-type moisture meters,and meeting the normative demands of their annual calibration, requires the use of optimised curves relating electricalresistance to moisture content for the most commercially important wood types. The Samuelsson model, adjusted bylinear regression techniques, was used to describe the relationship between the electrical resistance and moisture contentof seven boreal and three tropical hardwoods available on the Spanish market. The curves produced can be used to predictthe moisture contents of these hardwoods via the measurement of their electrical resistance with an error of just ± 1.0%.These curves should also prove of great use in the calibration of wood resistance-type moisture meters.La precisión en la medida del contenido de humedad juega un papel fundamental no solo en el aseguramiento de lacalidad de los productos de la madera sino, también, en el cumplimiento de las exigencias normativas y administrativasque gravitan sobre los productos. Para ser capaces de mejorar la precisión de la medida tomada por los xilohigrómetrosde resistencia y cumplir con las exigencias normativas de calibración anual de los equipos, es necesario obtener curvasoptimizadas que relacionen la resistencia eléctrica con la humedad en las maderas de mayor importancia comercial.El modelo de Samuelsson, Log[Log(R) + 1] = a.h + b, ajustado mediante técnicas de regresión lineal, fue usado paradescribir la relación existente entre la resistencia eléctrica de la madera (R) y el contenido de humedad (h) de sietemaderas de frondosas boreales y tres de frondosas tropicales comercialmente disponibles en el mercado español. Lascurvas obtenidas pueden ser usadas para la predicción del contenido de humedad de dichas maderas, con un errormáximo de ± 1.0%, mediante la medición de su resistencia eléctrica. Estas curvas serían también de interés para lacalibración de medidores de humedad de madera por resistencia eléctrica

Short-term effectiveness of a mobile phone app for increasing physical activity and adherence to the mediterranean diet in primary care: A randomized controlled trial (EVIDENT II study)

Background: The use of mobile phone apps for improving lifestyles has become generalized in the population, although little is still known about their effectiveness in improving health. Objective: We evaluate the effect of adding an app to standard counseling on increased physical activity (PA) and adherence to the Mediterranean diet, 3 months after implementation. Methods: A randomized, multicenter clinical trial was carried out. A total of 833 participants were recruited in six primary care centers in Spain through random sampling: 415 in the app+counseling group and 418 in the counseling only group. Counseling on PA and the Mediterranean diet was given to both groups. The app+counseling participants additionally received training in the use of an app designed to promote PA and the Mediterranean diet over a 3-month period. PA was measured with the 7-day Physical Activity Recall (PAR) questionnaire and an accelerometer; adherence to the Mediterranean diet was assessed using the Mediterranean Diet Adherence Screener questionnaire. Results: Participants were predominantly female in both the app+counseling (249/415, 60.0%) and counseling only (268/418, 64.1%) groups, with a mean age of 51.4 (SD 12.1) and 52.3 (SD 12.0) years, respectively. Leisure-time moderate-to-vigorous physical activity (MVPA) by 7-day PAR increased in the app+counseling (mean 29, 95% CI 5-53 min/week; P=.02) but not in the counseling only group (mean 17.4, 95% CI ''18 to 53 min/week; P=.38). No differences in increase of activity were found between the two groups. The accelerometer recorded a decrease in PA after 3 months in both groups: MVPA mean ''55.3 (95% CI ''75.8 to ''34.9) min/week in app+counseling group and mean ''30.1 (95% CI ''51.8 to ''8.4) min/week in counseling only group. Adherence to the Mediterranean diet increased in both groups (8.4% in app+counseling and 10.4% in counseling only group), with an increase in score of 0.42 and 0.53 points, respectively (P<.001), but no difference between groups (P=.86). Conclusions: Leisure-time MVPA increased more in the app+counseling than counseling only group, although no difference was found when comparing the increase between the two groups. Counseling accompanied by printed materials appears to be effective in improving adherence to the Mediterranean diet, although the app does not increase adherence

JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

BACKGROUND: Microsomal transfer protein inhibitors (MTPi) have the potential to be used as a drug to lower plasma lipids, mainly plasma triglycerides (TG). However, studies with animal models have indicated that MTPi treatment results in the accumulation of hepatic TG. The purpose of this study was to evaluate whether JTT-130, a unique MTPi, targeted to the intestine, would effectively reduce plasma lipids without inducing a fatty liver. METHODS: Male guinea pigs (n = 10 per group) were used for this experiment. Initially all guinea pigs were fed a hypercholesterolemic diet containing 0.08 g/100 g dietary cholesterol for 3 wk. After this period, animals were randomly assigned to diets containing 0 (control), 0.0005 or 0.0015 g/100 g of MTPi for 4 wk. A diet containing 0.05 g/100 g of atorvastatin, an HMG-CoA reductase inhibitor was used as the positive control. At the end of the 7(th )week, guinea pigs were sacrificed to assess drug effects on plasma and hepatic lipids, composition of LDL and VLDL, hepatic cholesterol and lipoprotein metabolism. RESULTS: Plasma LDL cholesterol and TG were 25 and 30% lower in guinea pigs treated with MTPi compared to controls (P < 0.05). Atorvastatin had the most pronounced hypolipidemic effects with a 35% reduction in LDL cholesterol and 40% reduction in TG. JTT-130 did not induce hepatic lipid accumulation compared to controls. Cholesteryl ester transfer protein (CETP) activity was reduced in a dose dependent manner by increasing doses of MTPi and guinea pigs treated with atorvastatin had the lowest CETP activity (P < 0.01). In addition the number of molecules of cholesteryl ester in LDL and LDL diameter were lower in guinea pigs treated with atorvastatin. In contrast, hepatic enzymes involved in maintaining cholesterol homeostasis were not affected by drug treatment. CONCLUSION: These results suggest that JTT-130 could have potential clinical applications due to its plasma lipid lowering effects with no alterations in hepatic lipid concentrations

Modeling the evolution of infrared galaxies: A Parametric backwards evolution model

We aim at modeling the infrared galaxy evolution in an as simple as possible way and reproduce statistical properties among which the number counts between 15 microns and 1.1 mm, the luminosity functions, and the redshift distributions. We then aim at using this model to interpret the recent observations (Spitzer, Akari, BLAST, LABOCA, AzTEC, SPT and Herschel), and make predictions for future experiments like CCAT or SPICA. This model uses an evolution in density and luminosity of the luminosity function with two breaks at redshift ~0.9 and 2 and contains the two populations of the Lagache et al. (2004) model: normal and starburst galaxies. We also take into account the effect of the strong lensing of high-redshift sub-millimeter galaxies. It has 13 free parameters and 8 additional calibration parameters. We fit the parameters to the IRAS, Spitzer, Herschel and AzTEC measurements with a Monte-Carlo Markov chain. The model ajusted on deep counts at key wavelengths reproduces the counts from the mid-infrared to the millimeter wavelengths, as well as the mid-infrared luminosity functions. We discuss the contribution to the cosmic infrared background (CIB) and to the infrared luminosity density of the different populations. We also estimate the effect of the lensing on the number counts, and discuss the recent discovery by the South Pole Telescope (SPT) of a very bright population lying at high-redshift. We predict confusion level for future missions using a P(D) formalism, and the Universe opacity to TeV photons due to the CIB.Comment: 25 pages, 10 tables, 18 figures, accepted for publication in A&

Effectiveness and safety of obeticholic acid in a Southern European multicenter cohort of patients with primary biliary cholangitis and suboptimal response to ursodeoxycholic acid

Background Obeticholic acid (OCA) was recently approved as the only on-label alternative for patients with primary biliary cholangitis (PBC) with intolerance or suboptimal response to ursodeoxycholic acid (UDCA). However, few data are available outside clinical trials. Aim To assess the effectiveness and safety of OCA in a real-world cohort of patients with non-effective UDCA therapy. Methods Open-label, prospective, real-world, multicentre study, enrolling consecutive patients who did not meet Paris II criteria, from 18 institutions in Spain and Portugal. Effectiveness was assessed by the changes in GLOBE and UK-PBC scores from baseline. POISE and Paris II criteria were evaluated after 12 months of OCA . Liver fibrosis was evaluated by FIB-4 and AST to platelet ratio index (APRI). Results One hundred and twenty patients were eligible, median time since PBC diagnosis 9.3 (4.0-13.8) years, 21.7% had cirrhosis, and 26.7% received had previous or concomitant treatment with fibrates. Seventy-eight patients completed at least 1 year of OCA. The Globe-PBC score decreased to 0.17 (95% CI 0.05 to 0.28; P = 0.005) and the UK-PBC score decreased to 0.81 (95% CI -0.19 to 1.80; P = 0.11). There was a significant decrease in alkaline phosphatase of 81.3 U/L (95% CI 42.5 to 120; P < 0.001), ALT 22.1 U/L (95% CI 10.4 to 33.8; P < 0.001) and bilirubin 0.12 mg/dL (95% CI 0 to 0.24; P = 0.044). FIB-4 and APRI remained stable. According to the POISE criteria, 29.5% (23 out of 78) achieved response. The adverse events rate was 35%; 11.67% discontinued (8.3% due to pruritus). Conclusions This study supports data from phase III trials with significant improvement of PBC-Globe continuous prognostic marker score among OCA-treated patients with good tolerability

The Cosmic Far-Infrared Background Buildup Since Redshift 2 at 70 and 160 microns in the COSMOS and GOODS fields

The Cosmic Far-Infrared Background (CIB) at wavelengths around 160 {\mu}m corresponds to the peak intensity of the whole Extragalactic Background Light, which is being measured with increasing accuracy. However, the build up of the CIB emission as a function of redshift, is still not well known. Our goal is to measure the CIB history at 70 {\mu}m and 160 {\mu}m at different redshifts, and provide constraints for infrared galaxy evolution models. We use complete deep Spitzer 24 {\mu}m catalogs down to about 80 {\mu}Jy, with spectroscopic and photometric redshifts identifications, from the GOODS and COSMOS deep infrared surveys covering 2 square degrees total. After cleaning the Spitzer/MIPS 70 {\mu}m and 160 {\mu}m maps from detected sources, we stacked the far-IR images at the positions of the 24 {\mu}m sources in different redshift bins. We measured the contribution of each stacked source to the total 70 and 160 {\mu}m light, and compare with model predictions and recent far-IR measurements made with Herschel/PACS on smaller fields. We have detected components of the 70 and 160 {\mu}m backgrounds in different redshift bins up to z ~ 2. The contribution to the CIB is maximum at 0.3 <= z <= 0.9 at 160{\mu}m (and z <= 0.5 at 70 {\mu}m). A total of 81% (74%) of the 70 (160) {\mu}m background was emitted at z < 1. We estimate that the AGN relative contribution to the far-IR CIB is less than about 10% at z < 1.5. We provide a comprehensive view of the CIB buildup at 24, 70, 100, 160 {\mu}m. IR galaxy models predicting a major contribution to the CIB at z < 1 are in agreement with our measurements, while our results discard other models that predict a peak of the background at higher redshifts. Our results are available online http://www.ias.u-psud.fr/irgalaxies/ .Comment: Accepted in Astronomy & Astrophysic

Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients

OBJECTIVE: To examine the role of Tie2 signalling in macrophage activation within the context of the inflammatory synovial microenvironment present in patients with RA and PsA. METHODS: Clinical responses and macrophage function were examined in wild-type and Tie2-overexpressing (Tie2-TG) mice in the K/BxN serum transfer model of arthritis. Macrophages derived from peripheral blood monocytes from healthy donors, RA and PsA patients, and RA and PsA synovial tissue explants were stimulated with TNF (10 ng/ml), angiopoietin (Ang)-1 or Ang-2 (200 ng/ml), or incubated with an anti-Ang2 neutralizing antibody. mRNA and protein expression of inflammatory mediators was analysed by quantitative PCR, ELISA and Luminex. RESULTS: Tie2-TG mice displayed more clinically severe arthritis than wild-type mice, accompanied by enhanced joint expression of IL6, IL12B, NOS2, CCL2 and CXCL10, and activation of bone marrow-derived macrophages in response to Ang-2 stimulation. Ang-1 and Ang-2 significantly enhanced TNF-induced expression of pro-inflammatory cytokines and chemokines in macrophages from healthy donors differentiated with RA and PsA SF and peripheral blood-derived macrophages from RA and PsA patients. Both Ang-1 and Ang-2 induced the production of IL-6, IL-12p40, IL-8 and CCL-3 in synovial tissue explants of RA and PsA patients, and Ang-2 neutralization suppressed the production of IL-6 and IL-8 in the synovial tissue of RA patients. CONCLUSION: Tie2 signalling enhances TNF-dependent activation of macrophages within the context of ongoing synovial inflammation in RA and PsA, and neutralization of Tie2 ligands might be a promising therapeutic target in the treatment of these diseases

The ISW-tSZ cross correlation: ISW extraction out of pure CMB data

If Dark Energy introduces an acceleration in the universal expansion then large scale gravitational potential wells should be shrinking, causing a blueshift in the CMB photons that cross such structures (Integrated Sachs-Wolfe effect, [ISW]). Galaxy clusters are known to probe those potential wells. In these objects, CMB photons also experience inverse Compton scattering off the hot electrons of the intra-cluster medium, and this results in a distortion with a characteristic spectral signature of the CMB spectrum (the so-called thermal Sunyaev-Zel'dovich effect, [tSZ]). Since both the ISW and the tSZ effects take place in the same potential wells, they must be spatially correlated. We present how this cross ISW-tSZ signal can be detected in a CMB-data contained way by using the frequency dependence of the tSZ effect in multi frequency CMB experiments like {\it Planck}, {\em without} requiring the use of external large scale structure tracers data. We find that by masking low redshift clusters, the shot noise level decreases significantly, boosting the signal to noise ratio of the ISW--tSZ cross correlation. We also find that galactic and extragalactic dust residuals must be kept at or below the level of ~0.04 muK^2 at l=10, a limit that is a factor of a few below {\it Planck}'s expectations for foreground subtraction. If this is achieved, CMB observations of the ISW-tSZ cross correlation should also provide an independent probe for the existence of Dark Energy and the amplitude of density perturbations.Comment: submitted to MNRA