Polar cap index (PC) as a proxy for ionospheric electric field in the near‐pole region

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95640/1/grl13514.pd

Формирование личностного образовательного пространства преподавателя в условиях развивающего обучения в системе повышения квалификации

The paper makes an attempt to analyze the nature and stages of personal educational space of a teacher involved in vocational training. The article explores the interaction between personal educational space and open social educational environment which is represented as communicative informational potential of further training and satisfying the needs in education and self-realization. The author considers personal educational space as a process, activity and phenomenon provided by education. At the same time, the education of a person performs as a certain part of educational space. When being personalized this part is fixed as “own one” in the founded educational space “for me” which contributes to personal development. The authors raise the problem of integration of new educational technologies that have particular features related to the fact that software and computers are one of the main means in education, upbringing and management of personal self-fulfillment. This is explained by significant change in relations among the main subjects of educational process. The article demonstrates target-oriented and methodological further training revealed in seminars, workshops and demo lessons as the educational space aimed at application of modern information systems. This reveals the particular features of efficient teachers training to applying IT-technologies in every day work. Considering that the technologies are innovative and change the individual work of a person, the authors note that these technologies extend the information and personal educational space of a teacher. The programmes implemented in the open educational space of further training at Industrial-Economic Faculty of Vocational Training under Sholom-Aleikhem Amur State University are aimed at getting deep and developed new knowledge, skills and competencies of teachers. These programmes assume grasping information-communicative technologies and contribute to the development of personal educational space of a teacher.В статье предпринята попытка проанализировать сущность и этапы становления личностного образовательного пространства преподавателя СПО как его взаимодействие с открытой социальной образовательной средой, представленной коммуникативно-информационным потенциалом повышения квалификации в контексте удовлетворения его образовательных потребностей и самореализации. Авторы рассматривают образовательное пространство личности в ее собственном сущностном представлении об образовании как форме бытия (взаимодействия) в ней и как процесс, деятельность, явление, обусловленное образованием. В то же время образовательная деятельность личности - это определенная часть образовательного пространства, которая, персонализируясь, фиксируется как «собственная» в создаваемом образовательном пространстве «для меня», что и обеспечивает личностный рост. В связи с этим возникает проблема интеграции новых образовательных технологий, имеющих ряд принципиальных особенностей, обусловленных тем, что в современных условиях компьютерное сопровождение является одним из главных средств в системе обучения, воспитания, управления самореализацией личности. Эта ситуация объясняется тем, что с развитием информационного общества произошло существенное изменение отношений между основными субъектами образовательного процесса. В статье представлено целенаправленное и методически организованное повышение квалификации в рамках семинаров, мастер-классов, открытых уроков как открытое образовательное пространство, ориентированное на применение современных информационных систем, что раскрывает особенности целесообразного обеспечения подготовки преподавателей к использованию в ежедневной работе информационно-коммуникационных технологий. Поскольку эти технологии являются инновационными и качественно меняют уровень самостоятельной работы личности, расширяя объем учебной информации, это позволяет расширить личностное образовательное пространство преподавателя. Программы, реализуемые в открытом образовательном пространстве повышения квалификации промышленно-экономического факультета программ среднего профессионального образования ФГОБУ ВПО «Приамурский государственный университет имени Шолом-Алейхема», направлены на углубление, расширение и обновление профессиональных знаний и умений преподавателей. Анализ этих программ показывает, что они, в частности, предусматривают овладение преподавателями информационно-коммуникационными технологиями, способствуя формированию личностного образовательного пространства преподавателя

Improved Cellular Specificity of Plasmonic Nanobubbles versus Nanoparticles in Heterogeneous Cell Systems

The limited specificity of nanoparticle (NP) uptake by target cells associated with a disease is one of the principal challenges of nanomedicine. Using the threshold mechanism of plasmonic nanobubble (PNB) generation and enhanced accumulation and clustering of gold nanoparticles in target cells, we increased the specificity of PNB generation and detection in target versus non-target cells by more than one order of magnitude compared to the specificity of NP uptake by the same cells. This improved cellular specificity of PNBs was demonstrated in six different cell models representing diverse molecular targets such as epidermal growth factor receptor, CD3 receptor, prostate specific membrane antigen and mucin molecule MUC1. Thus PNBs may be a universal method and nano-agent that overcome the problem of non-specific uptake of NPs by non-target cells and improve the specificity of NP-based diagnostics, therapeutics and theranostics at the cell level

Биоэтическая проблема менеджмента коммуникативного пространства

The communication space as self-organization semiotic system was studied. This study was based on the information- synergetic approach model (I.V. Melik-Haikazjan). The limits of different communication models ordering were revealed, what al- lowed defining the structure of the communication space and the methods of its management.На основании модели информационно-синергетического подхода (И.В. Мелик-Гайказян) исследуются условия управ- ления коммуникативным пространством как самоорганизующейся информационной семиотической системой. Установ- ленные границы встраивания различных моделей коммуникации позволили выявить структуру коммуникативного про- странства и определить механизмы управления им

Nonlinear thermo-optical properties of two-layered spherical system of gold nanoparticle core and water vapor shell during initial stage of shell expansion

Nonlinear thermo-optical properties of two-layered spherical system of gold nanoparticle core and water vapor shell, created under laser heating of nanoparticle in water, were theoretically investigated. Vapor shell expansion leads to decreasing up to one to two orders of magnitude in comparison with initial values of scattering and extinction of the radiation with wavelengths 532 and 633 nm by system while shell radius is increased up to value of about two radii of nanoparticle. Subsequent increasing of shell radius more than two radii of nanoparticle leads to rise of scattering and extinction properties of system over initial values. The significant decrease of radiation scattering and extinction by system of nanoparticle-vapor shell can be used for experimental detection of the energy threshold of vapor shell formation and investigation of the first stages of its expansion

The Solar Cycle: A new prediction technique based on logarithmic values

A new prediction technique based on logarithmic values is proposed to predict the maximum amplitude (Rm) of a solar cycle from the preceding minimum aa geomagnetic index (aamin). The correlation between lnRm and lnaamin (r = 0.92) is slightly stronger than that between Rm and aamin (r = 0.90). From this method, cycle 24 is predicted to have a peak size of Rm (24) = 81.7(1\pm13.2%). If the suggested error in aa (3 nT) before 1957 is corrected, the correlation coefficient between Rm and aamin (r = 0.94) will be slightly higher, and the peak of cycle 24 is predicted much lower, Rm(24) = 52.5\pm13.1. Therefore, the prediction of Rm based on the relationship between Rm and aamin depends greatly on the accurate measurement of aa.Comment: 6 pages, 3 figures, Accepted for publication in Astrophysics & Space Scienc

Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: Cellular model of pathology

The neurodegenerative disease Friedreich's ataxia (FRDA) is the most common autosomal-recessively inherited ataxia and is caused by a GAA triplet repeat expansion in the first intron of the frataxin gene. In this disease, transcription of frataxin, a mitochondrial protein involved in iron homeostasis, is impaired, resulting in a significant reduction in mRNA and protein levels. Global gene expression analysis was performed in peripheral blood samples from FRDA patients as compared to controls, which suggested altered expression patterns pertaining to genotoxic stress. We then confirmed the presence of genotoxic DNA damage by using a gene-specific quantitative PCR assay and discovered an increase in both mitochondrial and nuclear DNA damage in the blood of these patients (p<0.0001, respectively). Additionally, frataxin mRNA levels correlated with age of onset of disease and displayed unique sets of gene alterations involved in immune response, oxidative phosphorylation, and protein synthesis. Many of the key pathways observed by transcription profiling were downregulated, and we believe these data suggest that patients with prolonged frataxin deficiency undergo a systemic survival response to chronic genotoxic stress and consequent DNA damage detectable in blood. In conclusion, our results yield insight into the nature and progression of FRDA, as well as possible therapeutic approaches. Furthermore, the identification of potential biomarkers, including the DNA damage found in peripheral blood, may have predictive value in future clinical trials

DNA helicase and helicase–nuclease enzymes with a conserved iron–sulfur cluster

Conserved Iron–Sulfur (Fe–S) clusters are found in a growing family of metalloproteins that are implicated in prokaryotic and eukaryotic DNA replication and repair. Among these are DNA helicase and helicase–nuclease enzymes that preserve chromosomal stability and are genetically linked to diseases characterized by DNA repair defects and/or a poor response to replication stress. Insight to the structural and functional importance of the conserved Fe–S domain in DNA helicases has been gleaned from structural studies of the purified proteins and characterization of Fe–S cluster site-directed mutants. In this review, we will provide a current perspective of what is known about the Fe–S cluster helicases, with an emphasis on how the conserved redox active domain may facilitate mechanistic aspects of helicase function. We will discuss testable models for how the conserved Fe–S cluster might operate in helicase and helicase–nuclease enzymes to conduct their specialized functions that help to preserve the integrity of the genome