1,533 research outputs found

    Reading Muscles: Preparation for Standardized Testing in High School Students

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    As educators, it is our responsibility to help students in their journey to academic growth and discovery. Being such, many teachers find themselves struggling for that perfect balance between making students more comfortable and pushing them outside of their comfort zones. Many Language Arts teachers, if asked, would likely state that when they hold test preparation activities, the class is run in a relatively similar manner as it might be on any other given day. Yes, the reading material and subsequent questions might have been acquired from a test preparation booklet appropriate to the students’ grade level, but most other circumstances remain stable, unchanged. Students are often only expected to complete one reading and one coinciding set of questions with minimal limitations on where and from whom they might attain assistance when a problem occurs. The material is test preparation-worthy but the situation is not

    A review of migration and fertility theory through the lens of African immigrant fertility in France

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    This paper evaluates fertility and migration theory in order to further understand the impact of migration on fertility. I first analyze the fertility and migration literature separately and then look at the burgeoning literature on the impact of migration on fertility. As a result, I propose an integrated framework for analyzing the migration-fertility nexus. Within the fertility context, I use Bongaarts and Watkins concept of social interaction, whereas within the migration context, I draw on Massey’s capitalist transition theory, and Pessar and Mahler’s ‘gendered geometries of power’. This integrated framework considers three major factors: the sending country, the global context of migration systems, and the receiving country. Gender is the key to understanding fertility decisions within all three levels. Migration from Africa to France is considered in order to exemplify these processes. Bozon’s typology of African demographic patterns shows how and why the sending country matters for future childbearing decisions post-migration. To further explore this facet, four countries are used to evaluate the impact of migrating from specific types of countries on fertility post-migration: Senegal, Mali, Cameroon, and Rwanda. The global context of migration is constantly changing, both encouraging and restraining men and women in particular ways, which also affects fertility choices. Finally, the receiving country interacts with migrants in various ways—immigration policies, the economy, and social institutions—playing important roles in fertility outcomes.Africa, France, fertility, migration

    Mechanisms for DNA Charge Transport

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    DNA charge transport (CT) chemistry has received considerable attention by scientific researchers over the past 15 years since our first provocative publication on long range CT in a DNA assembly.1,2 This interest, shared by physicists, chemists and biologists, reflects the potential of DNA CT to provide a sensitive route for signaling, whether in the construction of nanoscale biosensors or as an enzymatic tool to detect damage in the genome. Research into DNA CT chemistry began as a quest to determine whether the DNA double helix, a macromolecular assembly in solution with π-stacked base pairs, might share conductive characteristics with π-stacked solids. Physicists carried out sophisticated experiments to measure the conductivity of DNA samples, but the means to connect discrete DNA assemblies into the devices to gauge conductivity varied, as did the conditions under which conductivities were determined. Chemists constructed DNA assemblies to measure hole and electron transport in solution using a variety of hole and electron donors. Here, too, DNA CT was seen to depend upon the connections, or coupling, between donors and the DNA base pair stack. Importantly, these experiments have resolved the debate over whether DNA CT is possible. Moreover these studies have shown that DNA CT, irrespective of the oxidant or reductant used to initiate the chemistry, can occur over long molecular distances but can be exquisitely sensitive to perturbations in the base pair stack. Here we review some of the critical characteristics of DNA charge transport chemistry, taking examples from a range of systems, and consider these characteristics in the context of their mechanistic implications. This review is not intended to be exhaustive but instead to be illustrative. For instance, we describe studies involving measurements in solution using pendant photooxidants to inject holes, conductivity studies with covalently modified assemblies, and electrochemical studies on DNA-modified electrodes. We do not focus in detail on the differences amongst these constructs but instead on their similarities. It is the similarity among these various systems that allows us to consider different mechanisms to describe DNA CT. Thus we review also the various mechanisms for DNA CT that have been put forth and attempt to reconcile these mechanistic proposals with the many disparate measurements of DNA CT. Certainly the debate among researchers has shifted from "is DNA CT possible?" to "how does it work?". This review intends to explore this latter question in detail

    Single-Step Charge Transport through DNA over Long Distances

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    Quantum yields for charge transport across adenine tracts of increasing length have been measured by monitoring hole transport in synthetic oligonucleotides between photoexcited 2-aminopurine, a fluorescent analogue of adenine, and N_2-cyclopropyl guanine. Using fluorescence quenching, a measure of hole injection, and hole trapping by the cyclopropyl guanine derivative, we separate the individual contributions of single- and multistep channels to DNA charge transport and find that with 7 or 8 intervening adenines the charge transport is a coherent, single-step process. Moreover, a transition occurs from multistep to single-step charge transport with increasing donor/acceptor separation, opposite to that generally observed in molecular wires. These results establish that coherent transport through DNA occurs preferentially across 10 base pairs, favored by delocalization over a full turn of the helix

    Teaching Listening For Prominence In Combination With Reading To Help Students Determine New Information

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    The purpose of this study was to assess whether teaching adult English Language Learners (ELLs) to listen for new information spoken with prominence on the target new information increased their ability to make inferences about meaning. Data collected included: a pre and post-test to assess students’ learning during the intervention; an uptake sheet to solicit students’ self-perception of their learning about pronunciation and placement of new information; and a Likert scale to elicit participants’ self-assessment of their ability to identify and use prominence. While results of the post-test on selecting the correct inference were inconclusive, quantitative and qualitative data indicated gains in hearing prominence

    This Will Be My Legacy

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    This Will Be My Legacy is a short fiction film following Martha, a lonely and directionless young woman who is a contestant in a competition promising to send the winners to colonize Mars. The contestants must accept that, should they embark on the mission, they will likely die on Mars due to there being no available technology that would allow for their return. Despite this, Martha connects to the companys self-help inspired rhetoric of humanitys progress and personal greatness

    Using free teaching resources from HHMI BioInteractive to map out the richness of the scientific process

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    In this workshop, you will experience as a learner the free online interactive tool How Science Works. You will use it to investigate the richness of the scientific process (including, but not limited to, the scientific method). After that, you will consider with peers other ways in which you might use the tool, including ways to guide learners in designing their own scientific inquiry. This is suitable for educators at all levels and in all scientific disciplines. How Science Works is part of a suite of roughly 600 free, online tools available to educators from HHMI BioInteractive. Bring your internet-enabled device to access the tool during the workshop

    Statistical inference of transmission fidelity of DNA methylation patterns over somatic cell divisions in mammals

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    We develop Bayesian inference methods for a recently-emerging type of epigenetic data to study the transmission fidelity of DNA methylation patterns over cell divisions. The data consist of parent-daughter double-stranded DNA methylation patterns with each pattern coming from a single cell and represented as an unordered pair of binary strings. The data are technically difficult and time-consuming to collect, putting a premium on an efficient inference method. Our aim is to estimate rates for the maintenance and de novo methylation events that gave rise to the observed patterns, while accounting for measurement error. We model data at multiple sites jointly, thus using whole-strand information, and considerably reduce confounding between parameters. We also adopt a hierarchical structure that allows for variation in rates across sites without an explosion in the effective number of parameters. Our context-specific priors capture the expected stationarity, or near-stationarity, of the stochastic process that generated the data analyzed here. This expected stationarity is shown to greatly increase the precision of the estimation. Applying our model to a data set collected at the human FMR1 locus, we find that measurement errors, generally ignored in similar studies, occur at a nontrivial rate (inappropriate bisulfite conversion error: 1.6% with 80% CI: 0.9--2.3%). Accounting for these errors has a substantial impact on estimates of key biological parameters. The estimated average failure of maintenance rate and daughter de novo rate decline from 0.04 to 0.024 and from 0.14 to 0.07, respectively, when errors are accounted for. Our results also provide evidence that de novo events may occur on both parent and daughter strands: the median parent and daughter de novo rates are 0.08 (80% CI: 0.04--0.13) and 0.07 (80% CI: 0.04--0.11), respectively.Comment: Published in at http://dx.doi.org/10.1214/09-AOAS297 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org
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