Efecto de micorrizas nativas y fósforo en los rendimientos del maíz en Guárico, Venezuela

This study evaluated the efficiency of 4 native species of fungi mycorrhizal and mixing Scutellospora pellucida, Scutellospora calospora, Glomus leptotichum and Acaulospora mellea in absortion N and P and its effect on crop yields of hybrid corn HIMECA 3005 with 4 doses of P (0, 27, 54 and 80 kg ha-1 of P2O5). The study took place in soils of sabanna of Guarico state – Venezuela. Fungi were seeded at 0,9 between rows and 0,4 m between plants, sampling was done in the opposite leaf the corn cob in flowering stage. Quantification of P and N leaf was made by Murphy - Riley and distillation Kjeldalh respectively, whereas yields were evaluated in the three central rows of each plot. A randomized block design with factorial arrangement was used, the ANAVA, It was performed with Statistic 8.0. Findings revealed that doses of P and evaluated morphotypes influenced the decision-N and P in the corn plant, 54 kg ha-1 of P2O5 and consortium of inoculants those of better efficiency for the taking of N; while the dose of 54 kg ha-1 de P2O5 and Scutellospora pellucida formaking of P. It was concluded that these two inoculants can decrease the dose of P to 25% and increase maize yields by up to 100% based on the production of the area (2000 kg ha-1 ).  En suelos de sabana del estado Guárico – Venezuela, se evaluó la eficiencia de cuatro especies de hongos formadores de micorrizas nativa y su mezcla: Scutellospora pellucida, Scutellospora calospora, Glomus leptotichum y Acaulospora mellea en la toma de N y P, y su efecto en los rendimientos del cultivo de maíz hibrido HIMECA 3005 con 4 dosis de P (0, 27, 54 y 80 kg ha-1 de P2O5). Se sembró a 0,9 m entre hileras y 0,4 m entre plantas, la cuantificación del P y N foliar se hizo muestreando la hoja opuesta a la mazorca, por los métodos de Murphy – Riley y destilación con Kjeldalh; los redimientos se evaluaron en los tres surcos centrales de cada parcela. Se utilizó un diseño de bloques al azar con arregló factorial. Encontrándose que las dosis de P y los morfotipos evaluados influyeron en la toma de N y P, siendo 54 kg ha-1 de P2O5 y la mezcla de inóculos los de mejor eficiencia para la toma de N; mientras que la dosis de 54 kg ha-1 de P2O5 más Scutellospora pellucida para la toma de P. Se concluyó que estos inóculos pueden disminuir la aplicacion de P en un 25% e incrementar los rendimientos del maíz hasta en un 100% (de 2 a 4 t ha-1 ) con base en la producción de la zona. Palabras clave: Micorrizas, suelos de sabana, absorción de nutrientes

Preparación de canales curvos y calcificados

La preparación durante el tratamiento endodóntico consiste en la correcta limpieza y conformación del sistema de conductos radiculares, y que conserve siempre su forma original. Al finalizar la preparación, se debe obtener un conducto con conicidad uniforme y con un tope apical, que permita un selle hermético al momento de la obturación. Se debe tener en cuenta la dificultad para lograr resultados satisfactorios sobre todo en conductos curvos y calcificados debido a la complejidad de éstos. Las técnicas implementadas y el instrumental adecuado para la preparación de conductos, han sido muchos con el fin de minimizar los errores durante la preparación. No obstante, ninguna técnica ni instrumental por sí solo resulta ideal en la prevención de estos errores; es necesario el cumplimiento de algunos principios básicos durante la preparación de estos conductos, tales como la correcta preparación coronal, el uso continuo de irrigantes y agentes quelantes, el mantenimiento de la permeabilidad, el limado anticurvatura y la doble conicidad. La incorrección de estos principios conlleva a errores, los cuales dificultan el éxito del tratamiento endodóntico. Los avances de la ciencia y el advenimiento de los instrumentos de níquel-titanio, han logrado facilitar el tratamiento de endodoncia, tanto que ya no es considerado como anteriormente se le atribuía que era un procedimiento difícil, lo importante predecir la orientación y anatomía del conducto antes de emplear técnicas o instrumentales, ya que un error en ellas nos llevará al fracaso del tratamiento. (DUAZARY 2011, 66 - 73

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic lowgrade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders

From customer-oriented strategy to perceived organizational financial performance: the role of human resource management and customer-linking capability

Drawing on the organizational capabilities literature, we developed and tested a model of how supportive human resource management (HRM) improved firms’ financial performance perceived by marketing managers through fostering the implementation of a customer-oriented strategy. Customer-linking capability, which is the capability in managing close customer relationships, indicated the implementation of the customer-oriented strategy. Data collected from two emerging economies–China and Hungary–established that supportive HRM partially mediated the relationship between customer-oriented strategy and customer-linking capability. Customer-linking capability further explained how supportive HRM contributed to perceived financial performance. This study explicates the implication of customer-oriented strategy for HRM and reveals the importance of HRM in strategy implementation. It also sheds some light on the “black-box” between HRM and performance. While making important contributions to the field of strategy, HRM and marketing, this study also offers useful practical implications

RRx-001, A novel dinitroazetidine radiosensitizer

The ‘holy grail’ in radiation oncology is to improve the outcome of radiation therapy (RT) with a radiosensitizer—a systemic chemical/biochemical agent that additively or synergistically sensitizes tumor cells to radiation in the absence of significant toxicity. Similar to the oxygen effect, in which DNA bases modified by reactive oxygen species prevent repair of the cellular radiation damage, these compounds in general magnify free radical formation, leading to the permanent “fixation” of the resultant chemical change in the DNA structure. The purpose of this review is to present the origin story of the radiosensitizer, RRx-001, which emerged from the aerospace industry. The activity of RRx-001 as a chemosensitizer in multiple tumor types and disease states including malaria, hemorrhagic shock and sickle cell anemia, are the subject of future reviews

Recovery of dialysis patients with COVID-19 : health outcomes 3 months after diagnosis in ERACODA

Background. Coronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients 3 months after their COVID-19 diagnosis. Methods. We analyzed data on dialysis patients diagnosed with COVID-19 from 1 February 2020 to 31 March 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes studied were patient survival, residence and functional and mental health status (estimated by their treating physician) 3 months after COVID-19 diagnosis. Complete follow-up data were available for 854 surviving patients. Patient characteristics associated with recovery were analyzed using logistic regression. Results. In 2449 hemodialysis patients (mean ± SD age 67.5 ± 14.4 years, 62% male), survival probabilities at 3 months after COVID-19 diagnosis were 90% for nonhospitalized patients (n = 1087), 73% for patients admitted to the hospital but not to an intensive care unit (ICU) (n = 1165) and 40% for those admitted to an ICU (n = 197). Patient survival hardly decreased between 28 days and 3 months after COVID-19 diagnosis. At 3 months, 87% functioned at their pre-existent functional and 94% at their pre-existent mental level. Only few of the surviving patients were still admitted to the hospital (0.8-6.3%) or a nursing home (∼5%). A higher age and frailty score at presentation and ICU admission were associated with worse functional outcome. Conclusions. Mortality between 28 days and 3 months after COVID-19 diagnosis was low and the majority of patients who survived COVID-19 recovered to their pre-existent functional and mental health level at 3 months after diagnosis

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Preparación de canales curvos y calcificados

La preparación durante el tratamiento endodóntico consiste en la correcta limpieza y conformación del sistema de conductos radiculares, y que conserve siempre su forma original. Al finalizar la preparación, se debe obtener un conducto con conicidad uniforme y con un tope apical, que permita un selle hermético al momento de la obturación.Se debe tener en cuenta la dificultad para lograr resultados satisfactorios sobre todo en conductos curvos y calcificados debido a la complejidad de éstos. Las técnicas implementadas y el instrumental adecuado para la preparación de conductos, han sido muchos con el fin de minimizar los errores durante la preparación.No obstante, ninguna técnica ni instrumental por sí solo resulta ideal en la prevención de estos errores; es necesarioel cumplimiento de algunos principios básicos durante la preparación de estos conductos, tales como la correctapreparación coronal, el uso continuo de irrigantes y agentes quelantes, el mantenimiento de la permeabilidad, el limado anticurvatura y la doble conicidad. La incorrección de estos principios conlleva a errores, los cuales dificultan el éxito del tratamiento endodóntico.Los avances de la ciencia y el advenimiento de los instrumentos de níquel-titanio, han logrado facilitar el tratamiento de endodoncia, tanto que ya no es considerado como anteriormente se le atribuía que era un procedimiento difícil, lo importante predecir la orientación y anatomía del conducto antes de emplear técnicas o instrumentales, ya que un error en ellas nos llevará al fracaso del tratamiento