26 research outputs found
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
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- Alhroob M
- Alimonti G
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- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
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- Aamir A
- Abbas J
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- Abuhussein N
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
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- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
A saturated map of common genetic variants associated with human height
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- Lehtimaki T
- Leonard HL
- Lettre G
- Li HX
- Li LM
- Li SCA
- Li XH
- Li XY
- Liang JJ
- Lieb W
- Lin HH
- Lin K
- Lin SY
- Lin X
- Lind L
- Lindgren CM
- Linneberg A
- Liu CT
- Liu J
- Liu JJ
- Liu XP
- Lo KS
- Locke AE
- Loeffler M
- Loh PR
- London B
- Long JR
- Loos RJF
- Lores-Motta L
- Luan JA
- Lubitz SA
- Lull K
- Lye SJ
- Lyssenko V
- Lyytikainen LP
- Machado M
- Mackey DA
- Magi R
- Magnusson PKE
- Mahajan A
- Malden DE
- Mamakou V
- Mangino M
- Manichaikul A
- Marcus GM
- Marouli E
- Marten J
- Martin NG
- Marz W
- Matsuda F
- Mattheisen M
- Mavarani L
- McCarthy MI
- McDaid AF
- McGarrah RW
- McGue M
- McKnight AJ
- Medina-Gomez C
- Medland SE
- Meidtner K
- Melendez TL
- Mellstrom D
- Mercader JM
- Metspalu A
- Miao JK
- Milaneschi Y
- Miller JE
- Millwood IY
- Mishra PP
- Mitchell BD
- Mitchell P
- Mitchell RE
- Mohlke KL
- Mollehave LT
- Mook-Kanamori DO
- Moore A
- Morgan A
- Morris AD
- Mucci LA
- Mucha S
- Mukamel RE
- Munroe PB
- Munz M
- Nakatochi M
- Nalls MA
- Nazarian S
- Nelson AE
- Nelson CP
- Nethander M
- Neville MJ
- Newton-Cheh C
- Ng MCY
- Nho CW
- Nielsen AA
- Nielsen CS
- Nolte IM
- Nongmaithem SS
- Noordam R
- North KE
- Nothen MM
- Ntalla I
- Nutile T
- O'Donnell CJ
- Ohlsson C
- Okada Y
- Oldehinkel AJ
- Orozco L
- Pahkala K
- Pajukanta P
- Palmer CNA
- Pandit A
- Parna K
- Parra EJ
- Pattaro C
- Pauper M
- Pedersen O
- Pennell CE
- Penninx BWJH
- Perusse L
- Peters A
- Petersen ERB
- Petersen LV
- Peyser PA
- Pitkanen N
- Polasek O
- Porteous DJ
- Posthuma D
- Poveda A
- Power C
- Pramstaller PP
- Preuss MH
- Province MA
- Pyarajan S
- Qi QB
- Qu J
- Rader DJ
- Raffield LM
- Raghavan S
- Raitakari OT
- Rakugi H
- Ralhan S
- Rallidis LS
- Ramirez J
- Rao DC
- Rasheed A
- Raven D
- Rayner NW
- Redline S
- Reilly DF
- Reiner AP
- Rhee SY
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- Rutters F
- Ryan KA
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- Sabater-Lleal M
- Sakaue S
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- Salomaa V
- Samani NJ
- Sanghera DK
- Sattar N
- Saxena R
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- Scholz M
- Schulze MB
- Schunkert H
- Scott LJ
- Scott RJ
- Sendamarai A
- Sever P
- Shen BT
- Shi JCZ
- Shin JH
- Shiroma EJ
- Shoemaker MB
- Shu XO
- Sidore C
- Sidorenko J
- Sim X
- Simonsick EM
- Sims M
- Singh JR
- Singleton AB
- Sinner MF
- Sitlani CM
- Slieker RKC
- Smit RAJ
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- Smyth LJ
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- Southam LE
- Spector TD
- Spracklen CN
- Stampfer MJ
- Stark KJ
- Stefansson K
- Steinthorsdottir V
- Strachan DP
- Sun L
- Sun YV
- Tabara Y
- Tai ES
- Takeuchi F
- Tallapragada D
- Tang H
- Tardif JC
- Taylor KD
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- Terzikhan N
- Tesolin P
- Teumer A
- Thanaraj TA
- Theusch E
- Thompson DJ
- Thorleifsson G
- Thorsteinsdottir U
- Timmers PRHJ
- Timpson NJ
- Tonjes A
- Tremblay A
- Trompet S
- Tuomi T
- Tuomilehto J
- Turman C
- Tusie-Luna MT
- Uitterlinden AG
- Vaccargiu S
- van Dam RM
- van der Harst P
- van der Laan SW
- van der Most PJ
- Van der Velde N
- van Duijn CM
- van Klinken JB
- van Schoor NM
- van Setten J
- Vedantam S
- Verma SS
- Verweij N
- Veturi Y
- Vidal PM
- Visscher PM
- Vitart V
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- Volzke H
- Vrieze S
- Wacher-Rodarte NH
- Walker M
- Walters RG
- Wang CA
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- Wang Z
- Wareham NJ
- Warren HR
- Watanabe RM
- Watkins H
- Wei WB
- Weir DR
- Werge TM
- Wickremasinghe AR
- Widen E
- Wielscher M
- Wiggins KL
- Wilkens LR
- Willemsen G
- Willer CJ
- Willett WC
- Wilson JF
- Winkler TW
- Winsvold BS
- Wong A
- Wong TY
- Woo JT
- Wood AR
- Wright AF
- Wu JY
- Wu Y
- Wuttke M
- Xia R
- Xie T
- Xu HC
- Yajnik CS
- Yamamoto K
- Yang J
- Yang JY
- Yao J
- Yengo L
- Yin XY
- Yokota M
- Young H
- Young KL
- Yousri NA
- Yu L
- Yuan JM
- Zeggini E
- Zemel BS
- Zeng LY
- Zhang WH
- Zhang XY
- Zhao JH
- Zhao W
- Zheng W
- Zhou W
- Zhu XF
- Zimmermann ME
- Zmuda JM
- Zoledziewska M
- Zonderman AB
- Zwart JA
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/11/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes(1). Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel(2)) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants
A saturated map of common genetic variants associated with human height.
- Author
- 't Hart LM
- 23andMe Research Team
- Abecasis GR
- Adair LS
- Adams HHH
- Aguilar-Salinas CA
- Ahluwalia TS
- Akiyama M
- Al-Mulla F
- Allison MA
- Alvarez M
- Andersen MK
- Ani A
- Appadurai V
- Arbeeva L
- Arias JD
- Arnett DK
- Asselbergs FW
- Assimes TL
- Attia J
- Auton A
- Banas B
- Bandinelli S
- Bartell E
- Bennett DA
- Bergler T
- Berndt SI
- Bharadwaj D
- Bhaskar S
- Bielak LF
- Biino G
- Bin Wei W
- Bisgaard H
- Boehnke M
- Boerwinkle E
- Bollepalli S
- Bonnycastle LL
- Boomsma DI
- Borja JB
- Bork-Jensen J
- Bouchard C
- Bowden DW
- Bradfield JP
- Bradford Y
- Brandslund I
- Braund PS
- Brody JA
- Brumpton B
- Burgdorf KS
- Buring JE
- Böger CA
- Bønnelykke K
- Børglum AD
- Cade BE
- Cai H
- Cai Q
- Campbell A
- Catamo E
- Caulfield MJ
- Cañadas-Garre M
- Chai J-F
- Chai X
- Chambers JC
- Chandak GR
- Chang L-C
- Chang Y-C
- Chanock SJ
- Chasman DI
- Chaturvedi N
- Chen C-H
- Chen S-H
- Chen Y-DI
- Chen Z
- Cheng C-Y
- Chesi A
- Cho YS
- Choi SH
- Christofidou P
- Christophersen IE
- Chung R-H
- Ciullo M
- Cocca M
- Cole JW
- Collins FS
- Concas MP
- Cooper RS
- Couture C
- Cruz M
- Cucca F
- Cuellar-Partida G
- Cupples LA
- Cutler MJ
- Damrauer SM
- Danning R
- Dantoft TM
- Daw EW
- de Borst GJ
- de Groot LCPGM
- De Jager PL
- de Kleijn DPV
- Dedoussis GV
- Degenhard F
- Delgado GE
- Delitala A
- Deloukas P
- Demirkan A
- den Hollander AI
- Deng X
- Devineni P
- Dietl A
- Dimitriou M
- Dimitrov L
- DiscovEHR (DiscovEHR and MyCode Community Health Initiative)
- Dorajoo R
- Du S
- Easton DF
- Ekici AB
- Elders PJM
- Eliasen AU
- Eliassen AH
- Ellinor PT
- Elmståhl S
- eMERGE (Electronic Medical Records and Genomics Network)
- Engmann JE
- Erdmann J
- Esko T
- Evans MK
- Fairhurst-Hunter Z
- Farmaki A-E
- Fatkin D
- Faul JD
- Feenstra B
- Feitosa MF
- Fernandez-Lopez J-C
- Ferreira T
- Ferrucci L
- Ford I
- Forer L
- Fornage M
- Francescatto M
- Franke A
- Franks PW
- Frayling TM
- Freedman BI
- Freitag-Wolf S
- Fuchsberger C
- Galesloot TE
- Gao Y
- Gao Z
- Gasparini P
- Geller F
- Giannakopoulou O
- Gieger C
- Girotto G
- Giulianini F
- Gjesing AP
- Goddard ME
- Goel A
- Golightly YM
- Gonzalez-Villalpando C
- Gordon SD
- Gordon-Larsen P
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- Graff M
- Graham SE
- Grallert H
- Grant SFA
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- Griffiths L
- Grove J
- Gudnason V
- Guo X
- Gustafsson S
- Haessler J
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- Hansen T
- Hansen TF
- Hartman CA
- Hattersley AT
- Havulinna AS
- Haworth SJ
- Hayward C
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- Hebbar P
- Heckbert SR
- Heid IM
- Heng C-K
- Hengstenberg C
- Hewitt AW
- Highland HH
- Hindy G
- Hirschhorn JN
- Hishigaki H
- Ho Y-LA
- Hofer E
- Holliday E
- Horn K
- Hornsby WE
- Hottenga J-J
- Hoyng CB
- Huang H
- Huang J
- Huang PL
- Huang W
- Huerta-Chagoya A
- Huffman JE
- Hung Y-J
- Hunt SC
- Huo S
- Hveem K
- Hwang MY
- Hyppönen E
- Iacono WG
- Ichihara S
- Iha H
- Ikeda DD
- Ikram MA
- Isasi CR
- Isono M
- Jackson AU
- Jackson RD
- Janaka de Silva H
- Jansen IE
- Jarvelin M-R
- Ji Y
- Jiang Y
- Jin Z-B
- Johansson I
- Jonas JB
- Jonsson A
- Joshi PK
- Jousilahti P
- Jukema JW
- Justice AE
- Jäger S
- Jöckel K-H
- Jørgensen T
- Kalafati I-P
- Kamatani Y
- Kanai M
- Kang KD
- Kanoni S
- Kaprio J
- Karaderi T
- Kardia SLR
- Karpe F
- Kasturiratne A
- Kato N
- Katsuya T
- Kawaguchi T
- Kee F
- Kember RL
- Kentistou KA
- Kessler T
- Khera AV
- Khor CC
- Kiemeney LALM
- Kim B-J
- Kim EK
- Kim H-L
- Kim H-N
- Kim YJ
- Kirchhof P
- Kivimaki M
- Kleber ME
- Knol MJ
- Koh W-P
- Koistinen HA
- Kolovou GD
- Kooner JS
- Kooperberg C
- Kovacs P
- Kraaijeveld A
- Kraft P
- Krauss RM
- Kumari M
- Kurbasic A
- Kutalik Z
- Kähönen M
- Kårhus LL
- Köttgen A
- Laakso M
- Lange LA
- Langenberg C
- Launer LJ
- Lauzon M
- Le Marchand L
- Le P
- Lea R
- Lee H
- Lee J-Y
- Lee NR
- Lehtimäki T
- Leonard HL
- Lettre G
- Li H
- Li L
- Li SA
- Li X
- Li X
- Liang J
- Lieb W
- Lifelines Cohort Study
- Lin H
- Lin K
- Lin S-Y
- Lin X
- Lind L
- Lindgren CM
- Linneberg A
- Liu C-T
- Liu J
- Liu J
- Liu X
- Lo KS
- Locke AE
- Loeffler M
- Loh P-R
- London B
- Long J
- Loos RJF
- Lores-Motta L
- Luan J
- Lubitz SA
- Lye SJ
- Lyssenko V
- Lyytikäinen L-P
- Lüll K
- Machado M
- Mackey DA
- Magnusson PKE
- Mahajan A
- Malden DE
- Mamakou V
- Mangino M
- Manichaikul A
- Marcus GM
- Marouli E
- Marten J
- Martin NG
- Matsuda F
- Mattheisen M
- Mavarani L
- McCarthy MI
- McDaid AF
- McGarrah RW
- McGue M
- McKnight AJ
- Medina-Gomez C
- Medland SE
- Meidtner K
- Melendez TL
- Mellström D
- Mercader JM
- Metspalu A
- Miao J
- Milaneschi Y
- Miller JE
- Millwood IY
- Mishra PP
- Mitchell BD
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- Mohlke KL
- Mook-Kanamori DO
- Moore A
- Morgan A
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- Mucci LA
- Mucha S
- Mukamel RE
- Munroe PB
- Munz M
- Mägi R
- März W
- Møllehave LT
- Nakatochi M
- Nalls MA
- Nazarian S
- Nelson AE
- Nelson CP
- Nethander M
- Neville MJ
- Newton-Cheh C
- Ng MCY
- Nho CW
- Nielsen AA
- Nielsen CS
- Nolte IM
- Nongmaithem SS
- Noordam R
- North KE
- Ntalla I
- Nutile T
- Nöthen MM
- O'Donnell CJ
- Ohlsson C
- Okada Y
- Oldehinkel AJ
- Orozco L
- Pahkala K
- Pajukanta P
- Palmer CNA
- Pandit A
- Parra EJ
- Pattaro C
- Pauper M
- Pedersen O
- Pennell CE
- Penninx BWJH
- Perusse L
- Peters A
- Petersen ERB
- Petersen LV
- Peyser PA
- Pitkänen N
- Polašek O
- Porteous DJ
- Posthuma D
- Poveda A
- Power C
- PRACTICAL Consortium
- Pramstaller PP
- Preuss MH
- Province MA
- Pyarajan S
- Pärna K
- Qi Q
- Qu J
- Rader DJ
- Raffield LM
- Raghavan S
- Raitakari OT
- Rakugi H
- Ralhan S
- Rallidis LS
- Ramirez J
- Rao DC
- Rasheed A
- Raven D
- Rayner NW
- Redline S
- Reilly DF
- Reiner AP
- Rhee SY
- Ridker PM
- Rienstra M
- Ripatti S
- Ritchie MD
- Rivadeneira F
- Riveros C
- Roden DM
- Rohde R
- Rosendaal FR
- Rotter JI
- Rudan I
- Ruggiero D
- Ruotsalainen SE
- Rutters F
- Ryan KA
- Rüeger S
- Sabanayagam C
- Sabater-Lleal M
- Sakaue S
- Saleheen D
- Salomaa V
- Samani NJ
- Sanghera DK
- Sattar N
- Saxena R
- Schmidt B
- Schmidt H
- Schmidt R
- Scholz M
- Schulze MB
- Schunkert H
- Scott LJ
- Scott RJ
- Sendamarai A
- Sever P
- Shen B
- Shi J
- Shin JH
- Shiroma EJ
- Shoemaker MB
- Shu X-O
- Sidore C
- Sidorenko J
- Sim X
- Simonsick EM
- Sims M
- Singh JR
- Singleton AB
- Sinner MF
- Sitlani CM
- Slieker RC
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- Spracklen CN
- Stampfer MJ
- Stark KJ
- Stefansson K
- Steinthorsdottir V
- Strachan DP
- Sun L
- Sun YV
- Tabara Y
- Tai ES
- Takeuchi F
- Tallapragada DSP
- Tang H
- Tardif J-C
- Taylor KD
- Tayo BO
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- Terzikhan N
- Tesolin P
- Teumer A
- Thanaraj TA
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- Thompson DJ
- Thorleifsson G
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- Timmers PRHJ
- Timpson NJ
- Tremblay A
- Trompet S
- Tuomi T
- Tuomilehto J
- Turman C
- Tusié-Luna M-T
- Tönjes A
- Uitterlinden AG
- Understanding Society Scientific Group
- VA Million Veteran Program
- Vaccargiu S
- van Dam RM
- van der Harst P
- van der Laan SW
- van der Most PJ
- Van der Velde N
- van Duijn CM
- van Klinken JB
- van Schoor NM
- van Setten J
- Vedantam S
- Verma SS
- Verweij N
- Veturi Y
- Vidal PM
- Visscher PM
- Vitart V
- Vollenweider P
- Vrieze S
- Völker U
- Völzke H
- Wacher-Rodarte NH
- Walker M
- Walters RG
- Wang C
- Wang CA
- Wang L
- Wang YX
- Wang Z
- Wareham NJ
- Warren HR
- Watanabe RM
- Watkins H
- Weir DR
- Werge TM
- Wickremasinghe AR
- Widen E
- Wielscher M
- Wiggins KL
- Wilkens LR
- Willemsen G
- Willer CJ
- Willett WC
- Wilson JF
- Winkler TW
- Winsvold BS
- Wong A
- Wong T-Y
- Woo J-T
- Wood AR
- Wright AF
- Wu J-Y
- Wu Y
- Wuttke M
- Xia R
- Xie T
- Xu H
- Yajnik CS
- Yamamoto K
- Yang J
- Yang J
- Yao J
- Yengo L
- Yin X
- Yokota M
- Young H
- Young KL
- Yousri NA
- Yu L
- Yuan J-M
- Zeggini E
- Zemel BS
- Zeng L
- Zhang W
- Zhang X
- Zhao J-H
- Zhao W
- Zheng W
- Zhou W
- Zhu X
- Zimmermann ME
- Zmuda JM
- Zoledziewska M
- Zonderman AB
- Zwart J-A
- Åsvold BO
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 12/10/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
Measurements of spin correlation in top-antitop quark events from proton-proton collisions at √s=7 TeV using the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Almond J
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Amidei D
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Angelozzi I
- Anger P
- Angerami A
- Anghinolfi F
- Anh TV
- Anisenkov AV
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- Antonov A
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- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans RC
- Armbruster AJ
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- Arnal V
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- Bagiacchi P
- Bagnaia P
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- Bain T
- Baines JT
- Baker OK
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- Balli F
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- Banerjee S
- Bannoura AAE
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Barnovska Z
- Baroncelli A
- Barone G
- Barr AJ
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- Usai G
- Usanova A
- Vacavant L
- Vacek V
- Vachon B
- Valencic N
- Valentinetti S
- Valero A
- Valery L
- Valkar S
- Vallecorsa S
- Van den Wollenberg W
- Van der Deijl PC
- van der Geer R
- van der Graaf H
- Van der Leeuw R
- van der Ster D
- van Eldik N
- van Gemmeren P
- van Huysduynen LH
- Van Nieuwkoop J
- van Vulpen I
- van Woerden MC
- Vanadia M
- Vandelli W
- Vanguri R
- Vaniachine A
- Vankov P
- Vannucci F
- Vaque FV
- Vardanyan G
- Vari R
- Varnes EW
- Varol T
- Varouchas D
- Vartapetian A
- Varvell KE
- Vazeille F
- Vazquez JGP
- Veatch J
- Veloso F
- Veneziano S
- Ventura A
- Ventura D
- Venturi M
- Venturi N
- Venturini A
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen JC
- Verzini MJA
- Vest A
- Vetterli MC
- Viazlo O
- Vichou I
- Vickey T
- Viehhauser GHA
- Viel S
- Vigne R
- Villa M
- Vilucchi E
- Vincter MG
- Vinogradov VB
- Virzi J
- Vivarelli I
- Vlachos S
- Vladoiu D
- Vlasak M
- Vogel A
- Vogel M
- Vokac P
- Volpi G
- Volpi M
- von der Schmitt H
- von Radziewski H
- von Toerne E
- Vorobel V
- Vorobev K
- Vos M
- Voss R
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Vykydal Z
- Wagner P
- Wagner W
- Wahlberg H
- Wahrmund S
- Wakabayashi J
- Walder J
- Walker R
- Walkowiak W
- Wall R
- Waller P
- Walls FMG
- Walsh B
- Wang C
- Wang C
- Wang F
- Wang H
- Wang H
- Wang J
- Wang J
- Wang K
- Wang R
- Wang SM
- Wang T
- Wang X
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Warsinsky M
- Washbrook A
- Wasicki C
- Watkins PM
- Watson AT
- Watson IJ
- Watson MF
- Watts G
- Watts S
- Waugh BM
- Webb S
- Weber MS
- Weber SW
- Webster JS
- Weidberg AR
- Weigell P
- Weinert B
- Weingarten J
- Weiser C
- Weits H
- Wells PS
- Wemans ADV
- Wenaus T
- Wendland D
- Weng Z
- Wengler T
- Wenig S
- Wermes N
- Werner M
- Werner P
- Wessels M
- Wetter J
- Whalen K
- White A
- White MJ
- White R
- White S
- Whiteson D
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilkens HG
- Will JZ
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wilson A
- Wilson JA
- Wingerter-Seez I
- Winklmeier F
- Winter BT
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong KHY
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wright M
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yamada M
- Yamaguchi H
- Yamaguchi Y
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yanush S
- Yao L
- Yao W-M
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 16/09/2013
- Field of study
Measurements of spin correlation in top quark pair production are presented using data collected with the ATLAS detector at the LHC with proton-proton collisions at a center-of-mass energy of 7 TeV, corresponding to an integrated luminosity of 4.6 fb−1. Events are selected in final states with two charged leptons and at least two jets and in final states with one charged lepton and at least four jets. Four different observables sensitive to different properties of the top quark pair production mechanism are used to extract the correlation between the top and antitop quark spins. Some of these observables are measured for the first time. The measurements are in good agreement with the Standard Model prediction at next-to-leading-order accuracy
A Cyclodextrin-Based Photoresponsive Molecular Gate that Functions Independently of Either Solvent or Potentially Competitive Guests
- Publication venue
- 'Wiley'
- Publication date
- 01/08/2021
- Field of study
The photoinduced interconversion between cinnamido-substituted cyclodextrins constitutes a gating switch through which the substituent moves to open or block access to the cyclodextrin cavity. Most unusually for a cyclodextrin-based device, the operation of this gate is solvent-independent and unaffected by potentially competitive guests. It occurs in MeOH and DMSO, as well as in water. This contrasts with other cyclodextrin inclusion phenomena that are usually driven by hydrophobic effects and limited to aqueous media
Investigating the bona fide differentiation capacity of human pluripotent stem cells
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
10.1038/cr.2011.142Cell Research2216-
Age-Related Changes in the Cardiometabolic Profiles in Singapore Resident Adult Population: Findings from the National Health Survey 2010
- Author
- A Menke
- AS Levey
- BW Schalk
- Chin Meng Khoo
- CJ Newschaffer
- Derrick Heng
- E Szoke
- E Upmeier
- F Amati
- G Conte
- Giuseppe Danilo Norata
- J Kronborg
- J Liu
- JH Kim
- JW Tukey
- KA Matthews
- M Akahoshi
- M Coylewright
- M Walter
- M Yamada
- MP Weijenberg
- N Dubowitz
- RD Abbott
- RJ Glassock
- S Jiang
- SG Chrysant
- SS Franklin
- SS Franklin
- Stefan Ma
- TP Loh
- Tze Ping Loh
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Hydrogels for Stem Cell Fate Control and Delivery in Regenerative Medicine
- Author
- A Al-Abboodi
- A Chenite
- A Stolzing
- AI Caplan
- AJ Engler
- AJ Rufaihah
- AJ Rufaihah
- AK Ho
- AM Mackay
- AS Hoffman
- B Heng
- B Jeong
- B Jeong
- B Jeong
- B Jeong
- B Jeong
- B Jeong
- B Jeong
- B Yan
- BA Jones
- BC Heng
- BC Heng
- BC Heng
- BC Heng
- BJ Tarasevich
- BM Gillette
- D Park
- DA Young
- DC Hay
- DE Discher
- DJ Macaya
- DR Albrecht
- E Figallo
- E Fuchs
- E Woo
- E Ye
- EH Kim
- EY Kang
- F Chowdhury
- FK Kidwai
- FY McWhorter
- G Bhakta
- G Sun
- H Chang
- H Liu
- H Qi
- H Song
- HJ Lee
- HS Abandansari
- J Cleary
- J Fan
- J Folkman
- J Lee
- J Li
- J Lii
- J Su
- J Zhang
- JA Thomson
- JJ Roberts
- JJ Roberts
- JM Gimble
- JS Miller
- JS Park
- JW Nichol
- K Takahashi
- KA Mosiewicz
- KA Payne
- L Bian
- L Jeng
- L-S Wang
- L-S Wang
- LA Boyer
- LH Nguyen
- LM Bellan
- LS Nair
- M Guvendiren
- M Yamada
- MA Ouimet
- MAJ Mazumder
- Meirelles L Silva da
- MF Brizzi
- MF Pittenger
- MJ Hwang
- MJ Hwang
- MJ Sawkins
- MK Joo
- MO Guloglu
- MP Lutolf
- MP Lutolf
- N Bhattarai
- N Tuleuova
- NA Silva
- ND Leipzig
- O Sarig-Nadir
- OZ Fisher
- P Schexnailder
- PM Gilbert
- Q Lian
- Q Lian
- Q Lu
- R Gauvin
- RG Wylie
- S Gerecht
- S Khetan
- S Natesan
- S Trkov
- S Wang
- S-C Zhang
- S-H Lee
- SA Arvidson
- SB Anderson
- SE Skrabalak
- SE Skrabalak
- SJ Bae
- SJ Bae
- SJ Bryant
- SR Sershen
- ST Lee
- ST Lee
- STB Ho
- SW Choi
- T Cao
- T Hoare
- T Vazin
- TC Lim
- TC Lim
- TM Hsieh
- TM Liu
- TT Lau
- TT Lau
- UP Shinde
- V Tabar
- VL Tsang
- VP Shastri
- VPN Nguyen
- VW Wong
- WG Liu
- WS Toh
- WS Toh
- WS Toh
- WS Toh
- WS Toh
- WS Toh
- WS Toh
- WS Toh
- WS Toh
- X Fu
- X Fu
- XJ Loh
- XJ Loh
- XJ Loh
- XJ Loh
- XJ Loh
- XJ Loh
- XJ Loh
- XJ Loh
- XJ Loh
- Y Jeong
- Y Ji
- Y Kitazawa
- Y Ling
- Y Peng
- Y Shiba
- Y Song
- Y-C Chen
- Y-H Cheng
- Y-S Hwang
- YD Park
- YJ Choi
- YM Chung
- YX Cao
- Z Li
- Z Zhang
- ZQ Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Neutron Star Extreme Matter Observatory: A kilohertz-band gravitational-wave detector in the global network
- Author
- Ackley K
- Adya Vaishali
- Agrawal P.
- Altin Paul
- Ashton G.
- Bailes Matthew
- Baltinas E.
- Barbuio A.
- Beniwal D.
- Blair Carl
- Blair David
- Bolingbroke G.N
- Chang Seo-Won
- Chow Jong
- Eichholz Johannes
- Forsyth Perry
- Gozzard David
- Grace Benjamin
- Holland Nathan
- Kapasi Disha
- Kijbunchoo Nutsinee
- Loh Ka-Heng
- McClelland David
- McKenzie Kirk
- McManus David
- McRae Terry
- Roberts Lyle
- Sarre Lauren
- Scott Susan M.
- Shaddock Daniel
- Sibley Paul
- Slagmolen Bram
- Spollard James
- Toyra Daniel
- Wade Andrew
- Ward Katie
- Ward Robert
- Wette Karl
- Wolf Christian
- Yap Min Jet
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 28/11/2021
- Field of study
Gravitational waves from coalescing neutron stars encode information about nuclear matter at extreme densities, inaccessible by laboratory experiments. The late inspiral is influenced by the presence of tides, which depend on the neutron star equation of state. Neutron star mergers are expected to often produce rapidly-rotating remnant neutron stars that emit gravitational waves. These will provide clues to the extremely hot post-merger environment. This signature of nuclear matter in gravitational waves contains most information in the 2-4 kHz frequency band, which is outside of the most sensitive band of current detectors. We present the design concept and science case for a neutron star extreme matter observatory (NEMO): a gravitational-wave interferometer optimized to study nuclear physics with merging neutron stars. The concept uses high circulating laser power, quantum squeezing and a detector topology specifically designed to achieve the high-frequency sensitivity necessary to probe nuclear matter using gravitational waves. Above one kHz, the proposed strain sensitivity is comparable to full third-generation detectors at a fraction of the cost. Such sensitivity changes expected event rates for detection of post-merger remnants from approximately one per few decades with two A+ detectors to a few per year, and potentially allows for the first gravitational-wave observations of supernovae, isolated neutron stars, and other exotica.We are grateful to Matt Evans and the anonymous
referee for valuable comments on the manuscript. This work was supported through Australian Research Council (ARC) Centre of Excellence
CE170100004, ARC Future Fellowships FT150100281, FT160100112, and
FT190100574, ARC Discovery Project DP180103155, and the Direct Grant,
Project 4053406, from the Research Committee of the Chinese University of
Hong Kong