Experience in the implementation of the dual trainingsystem in Russia in the course of the project «The future of white metallurgy»

Статья посвящена теме дуального обучения в колледже, актуальной в настоящее время. Представлены суть и отличительные особенности данной модели обучения. Представлен один из передовых проектов с элементами дуального обучения «Будущее Белой металлургии» реализуемый ОАО «Первоуральский новотрубный завод» и ГАПОУ СО «Первоуральский металлургический колледж»The article is devoted to the topic of the dual education at the College relevant to the present time. The essence of the distinctive features of this training model. Presents one of the best projects with elements of dual training «The Future of White metallurgy» JSC «Pervouralsk new Pipe plant» and GAPO WITH «Pervouralsk metallurgical College» implemente

The experience of rating the students of the corporate educational program of the group chelyabinsk tuberolling plants «The future of white metallurgy»

The article deals with the experience of rating system implementation for students studying at Pervouralsk Metallurgical College on the basis of «The Future of White Metallurgy» corporate educational program. Basic prerequisites for creating rating system and results of carrying out two stages of assessment are consideredРассматривается опыт реализации системы рейтингования студентов корпоративной образовательной программы «Будущее Белой металлургии», обучающихся в Первоуральском металлургическом колледже. Представлены основные предпосылки для создания системы рейтингования и результаты проведения двух этапов оценк

Long-Term Seizure Suppression and Optogenetic Analyses of Synaptic Connectivity in Epileptic Mice with Hippocampal Grafts of GABAergic Interneurons

Studies in rodent epilepsy models suggest that GABAergic interneuron progenitor grafts can reduce hyperexcitability and seizures in temporal lobe epilepsy (TLE). Although integration of the transplanted cells has been proposed as the underlying mechanism for these disease-modifying effects, prior studies have not explicitly examined cell types and synaptic mechanisms for long-term seizure suppression. To address this gap, we transplanted medial ganglionic eminence (MGE) cells from embryonic day 13.5 VGAT-Venus or VGAT-ChR2-EYFP transgenic embryos into the dentate gyrus (DG) of adult mice 2 weeks after induction of TLE with pilocarpine. Beginning 3–4 weeks after status epilepticus, we conducted continuous video-electroencephalographic recording until 90–100 d. TLE mice with bilateral MGE cell grafts in the DG had significantly fewer and milder electrographic seizures, compared with TLE controls. Immunohistochemical studies showed that the transplants contained multiple neuropeptide or calcium-binding protein-expressing interneuron types and these cells established dense terminal arborizations onto the somas, apical dendrites, and axon initial segments of dentate granule cells (GCs). A majority of the synaptic terminals formed by the transplanted cells were apposed to large postsynaptic clusters of gephyrin, indicative of mature inhibitory synaptic complexes. Functionality of these new inhibitory synapses was demonstrated by optogenetically activating VGAT-ChR2-EYFP-expressing transplanted neurons, which generated robust hyperpolarizations in GCs. These findings suggest that fetal GABAergic interneuron grafts may suppress pharmacoresistant seizures by enhancing synaptic inhibition in DG neural circuits

BRAIN Initiative: Cutting-Edge Tools and Resources for the Community.

The overarching goal of the NIH BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative is to advance the understanding of healthy and diseased brain circuit function through technological innovation. Core principles for this goal include the validation and dissemination of the myriad innovative technologies, tools, methods, and resources emerging from BRAIN-funded research. Innovators, BRAIN funding agencies, and non-Federal partners are working together to develop strategies for making these products usable, available, and accessible to the scientific community. Here, we describe several early strategies for supporting the dissemination of BRAIN technologies. We aim to invigorate a dialogue with the neuroscience research and funding community, interdisciplinary collaborators, and trainees about the existing and future opportunities for cultivating groundbreaking research products into mature, integrated, and adaptable research systems. Along with the accompanying Society for Neuroscience 2019 Mini-Symposium, "BRAIN Initiative: Cutting-Edge Tools and Resources for the Community," we spotlight the work of several BRAIN investigator teams who are making progress toward providing tools, technologies, and services for the neuroscience community. These tools access neural circuits at multiple levels of analysis, from subcellular composition to brain-wide network connectivity, including the following: integrated systems for EM- and florescence-based connectomics, advances in immunolabeling capabilities, and resources for recording and analyzing functional connectivity. Investigators describe how the resources they provide to the community will contribute to achieving the goals of the NIH BRAIN Initiative. Finally, in addition to celebrating the contributions of these BRAIN-funded investigators, the Mini-Symposium will illustrate the broader diversity of BRAIN Initiative investments in cutting-edge technologies and resources

Влияние инокуляции клубней картофеля бактериями рода Bacillus на популяцию ризосферных микроорганизмов

Estimation of the effectiveness and potential mechanism of action of biological agents on various soil profiles and crops allows more accurate recommendations for their application, and ultimately leads to an increase in crop yields. In the article is researched the composition and structure of the soil microbial community during pre-planting inoculation of potato tubers of the Tuleevsky variety with strains of the g. Bacillus: B. thuringiensis ssp. morrisoni; B. thuringiensis sp. dacota; B. subtilis; B. liheniformis during 2019-2020 in the Novosibirsk region, Novosibirsk, Educational and Production Facility «Sad Michurintsev» of the Novosibirsk State Agrarian University. The most effective strain was B. thuringiensis vs. dacota, which has a multilateral positive effect on soil microflora. The strongest effect on ammonifying bacteria was shown by B. thuringiensis vs. morrisoni. All bacterial strains inhibited the development of Fusarium and Penicillium fungi. Bacteria those assimilate the mineral nitrogen developed most actively during application of B. thuringiensis vs. dacota in 2019, and B. thuringiensis vs. morrisoni in 2020. Most of the strains had a positive effect on the group of cellulose-destroying and nitrogen-fixing bacteria, but B. thuringiensis vs. dacota showed the highest stimulation of bacterial growth, while B. subtilis oppressed this group. Bacillus liheniformis strain showed antagonistic features against phytopatogens, which also represents a great potential interest for its use in crop production.Понимание эффективности и потенциального механизма действия биологических агентов на различных почвенных профилях и культурах позволяет дать более точные рекомендации по их применению и в конечном итоге приводит к увеличению урожайности сельскохозяйственных культур. В работе исследованы состав и структура микробного сообщества почвы при предпосадочной инокуляции клубней картофеля сорта Тулеевский штаммами рода Bacillus: B. thuringiensis ssp. morrisoni, B. thuringiensis ssp. dacota, B. subtilis, B. liheniformis в 2019–2020 гг. в Новосибирской области, УПХ «Сад мичуринцев» Новосибирского ГАУ. Наиболее эффективным штаммом оказался B. thuringiensis vs. dacota, оказывающий многостороннее положительное влияние на почвенную микрофлору. Наиболее сильный эффект на бактерии-аммонификаторы оказал штамм B. thuringiensis vs. morrisoni. Все бактериальные штаммы угнетали развитие грибов родов Fusarium и Penicillium. Бактерии, усваивающие минеральный азот, развивались активнее всего при применении B. thuringiensis vs. dacota в 2019 г., а B. thuringiensis vs. morrisoni – в 2020 г. На группу целлюлозоразрушающих и азотфиксирующих бактерий большинство штаммов оказали положительное действие, но самую высокую стимуляцию роста бактерий показал B. thuringiensis vs. dacota, а B. subtilis угнетал данную группу. Штамм Bacillus liheniformis проявил антагонистические свойства в отношении фитопатогенов, что также представляет большой потенциальный интерес для его использования в растениеводстве

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Resistant inability for health reasons as basis for the early powers termination of the President of the Russian Federation

This article describes the procedure for early termination of powers of the President of the Russian Federation on the basis of persistent inability for health reasons. The analysis of the various points of view on the procedure and the problems that arise in its implementation, including the judges of the Constitutional Court of the Russian Federation N. V. Vitruk. It is made an attempt to define the concept of “persistent inability for health reasons”. It is analyzed each ground for early termination of powers of the President of the Russian Federation in terms of subjective and objective nature of the occurrence. We consider the Russian President's integrity and its relationship with the public interest of the country. “Limiting” the mystery of private life of the Russian President, in view of his increased public importance, we offer not to recognize his exclusive right to the secrecy of data on diseases which can make him unable to carry out assigned powers. It is necessary to appoint the systematic estimation of the physical and mental state of health of the President by specially created body of health care. Moreover, this article offers some proposals to inform the public about the health of senior government officials