968 research outputs found
A noncomplementation screen for quantitative trait alleles in Saccharomyces cerevisiae
- Publication venue
- Digital Commons@Becker
- Publication date
- 01/01/2012
- Field of study
Both linkage and linkage disequilibrium mapping provide well-defined approaches to mapping quantitative trait alleles. However, alleles of small effect are particularly difficult to refine to individual genes and causative mutations. Quantitative noncomplementation provides a means of directly testing individual genes for quantitative trait alleles in a fixed genetic background. Here, we implement a genome-wide noncomplementation screen for quantitative trait alleles that affect colony color or size by using the yeast deletion collection. As proof of principle, we find a previously known allele of CYS4 that affects colony color and a novel allele of CTT1 that affects resistance to hydrogen peroxide. To screen nearly 4700 genes in nine diverse yeast strains, we developed a high-throughput robotic plating assay to quantify colony color and size. Although we found hundreds of candidate alleles, reciprocal hemizygosity analysis of a select subset revealed that many of the candidates were false positives, in part the result of background-dependent haploinsufficiency or second-site mutations within the yeast deletion collection. Our results highlight the difficulty of identifying small-effect alleles but support the use of noncomplementation as a rapid means of identifying quantitative trait alleles of large effect
Design and feasibility testing of a novel group intervention for young women who binge drink in groups
- Author
- A O'Donnell
- AC Leon
- AE Anderson
- AL Graham
- Ambrose J. Melson
- B Borsari
- B Harkin
- C Neighbors
- CH Dupree
- D Bardsley
- D Huh
- D Raistrick
- DA Southern
- DE Jonas
- DJ Bowen
- EA Locke
- EF Kaner
- EF Kaner
- Elena D. Dimova
- ER Schoenfeld
- Ethan Moitra
- G Moore
- GA Lancaster
- I Ajzen
- I Nazareth
- I Szmigin
- Iain K. Crombie
- J Previte
- J Ritchie
- J Ritchie
- J Skagerstrom
- JE Lange
- JE Lange
- JE Samson
- JH Foster
- JM Townshend
- JW LaBrie
- JW LaBrie
- JW LaBrie
- KB Carey
- KL Johnston
- L Ross
- L Sobell
- L Thabane
- L Twigg
- LC Sobell
- Linda Irvine
- MK Ethen
- MS Hagger
- N Bertholet
- P Craig
- P MacNeela
- P Niland
- P Seaman
- Peter M. Rice
- R Engineer
- R Hingson
- R Schwarzer
- Rosaline Barbour
- S MacLean
- S Michie
- SC Tough
- Sheila Allan
- SJ UyBico
- TH Bien
- Tracey M. Fraser
- VC Brueton
- Vivien Swanson
- WR Miller
- WR Miller
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2018
- Field of study
BackgroundYoung women frequently drink alcohol in groups and binge drinking within these natural drinking groups is common. This study describes the design of a theoretically and empirically based group intervention to reduce binge drinking among young women. It also evaluates their engagement with the intervention and the acceptability of the study methods.MethodsFriendship groups of women aged 18â35 years, who had two or more episodes of binge drinking (>6 UK units on one occasion; 48g of alcohol) in the previous 30 days, were recruited from the community. A face-to-face group intervention, based on the Health Action Process Approach, was delivered over three sessions. Components of the intervention were woven around fun activities, such as making alcohol free cocktails. Women were followed up four months after the intervention was delivered. Results The target of 24 groups (comprising 97 women) was recruited. The common pattern of drinking was infrequent, heavy drinking (mean consumption on the heaviest drinking day was UK 18.1 units). Process evaluation revealed that the intervention was delivered with high fidelity and acceptability of the study methods was high. The women engaged positively with intervention components and made group decisions about cutting down. Twenty two groups set goals to reduce their drinking, and these were translated into action plans. Retention of individuals at follow up was 87%.ConclusionsThis study successfully recruited groups of young women whose patterns of drinking place them at high risk of acute harm. This novel approach to delivering an alcohol intervention has potential to reduce binge drinking among young women. The high levels of engagement with key steps in the behavior change process suggests that the group intervention should be tested in a full randomised controlled trial
A stable aberrant immunophenotype characterizes nearly all cases of cutaneous T-cell lymphoma in blood and can be used to monitor response to therapy
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/12/2002
- Field of study
BACKGROUND: Abnormal variations in the expression level of some commonly expressed T-cell antigens are a feature of many T-cell malignancies. METHODS: We sought to assess the frequency of such abnormal antigen expression by flow cytometry in peripheral blood (PB) samples from patients with mycosis fungoides (MF) and SĂ©zary syndrome (SS). We correlated presence of morphologically identifiable tumor cells on PB smear with the frequency of abnormalities in the level of expression of CD3, CD4, CD7, CD8 and CD26. We also examined the degree of stability of these abnormal findings in tumor cells over the course of disease. The flow cytometric findings in 100 PB samples from 44 patients, including 38 who had multiple sequential PB samples (2â8 samples each), were assessed. RESULTS: Abnormalities were seen in the expression level of one or more T-cell markers in 41 cases (93%) including CD3 in 34% of patients, CD4 in 54%, CD26 in 86% and CD 45 in 40% (10 cases tested). In all but 2 cases, the abnormal T-cell immunophenotype remained similar over the course of treatment and correlated with the relative numbers of tumor cells counted on PB smear. CONCLUSIONS: Using a standard T-cell panel, stable phenotypically aberrant T-cell populations representing the tumor are detected in the vast majority of involved PB samples in MF/SS and can be used to monitor response to therapy
An Immune Basis for Lung Parenchymal Destruction in Chronic Obstructive Pulmonary Disease and Emphysema
- Author
- Anthonisen
- Baggiolini
- Baggiolini
- Barnes
- Barnes
- Cawston
- Churg
- Cole
- Corry
- Corry
- Cosio
- D'Ambrosio
- David B Corry
- Del Prete
- Di Stefano
- Dorothy E Lewis
- Fahy
- Farrah Kheradmand
- Fiocchi
- Goodacre
- Gronski
- Grunig
- Hautamaki
- He
- Hogg
- Joan Hacken
- Joseph Huh
- Kamogawa
- Kang
- Kay
- Kim
- Klier
- Li-Zhen Song
- Linda Green
- Ling Song
- Liu
- Loetscher
- Loetscher
- Luster
- Luther
- Madani
- Muller
- Padrid
- Panina-Bordignon
- Pauwels
- Peter J Barnes
- Rafael Espada
- Remzi Bag
- Renauld
- Saetta
- Saetta
- Sallusto
- Sandra Grumelli
- Satoh
- Senior
- Sternlicht
- Sternlicht
- Turato
- Upham
- Uppaluri
- Wakugawa
- Xie
- Zheng
- Zlotnik
- Publication venue
- Public Library of Science
- Publication date
- 01/10/2004
- Field of study
BACKGROUND: Chronic obstructive pulmonary disease and emphysema are a frequent result of long-term smoking, but the exact mechanisms, specifically which types of cells are associated with the lung destruction, are unclear. METHODS AND FINDINGS: We studied different subsets of lymphocytes taken from portions of human lungs removed surgically to find out which lymphocytes were the most frequent, which cell-surface markers these lymphocytes expressed, and whether the lymphocytes secreted any specific factors that could be associated with disease. We found that loss of lung function in patients with chronic obstructive pulmonary disease and emphysema was associated with a high percentage of CD4(+) and CD8(+) T lymphocytes that expressed chemokine receptors CCR5 and CXCR3 (both markers of T helper 1 cells), but not CCR3 or CCR4 (markers of T helper 2 cells). Lung lymphocytes in patients with chronic obstructive pulmonary disease and emphysema secrete more interferon gammaâoften associated with T helper 1 cellsâand interferon-inducible protein 10 and monokine induced by interferon, both of which bind to CXCR3 and are involved in attracting T helper 1 cells. In response to interferon-inducible protein 10 and monokine induced by interferon, but not interferon gamma, lung macrophages secreted macrophage metalloelastase (matrix metalloproteinase-12), a potent elastin-degrading enzyme that causes tissue destruction and which has been linked to emphysema. CONCLUSIONS: These data suggest that Th1 lymphoctytes in the lungs of people with smoking-related damage drive progression of emphysema through CXCR3 ligands, interferon-inducible protein 10, and monokine induced by interferon
Catalytic and Non-Catalytic Roles for the Mono-ADP-Ribosyltransferase Arr in the Mycobacterial DNA Damage Response
- Author
- A Goldfarb
- AK Ojha
- B Tiemann
- C Gong
- C Tribuddharat
- Christina L. Stallings
- CL Stallings
- CM Sassetti
- D Avarbock
- D Chatterji
- D Eastman
- D Lautier
- EA Campbell
- ER Dabbs
- ET Houang
- G Arlet
- GS Stent
- H Nanamiya
- HI Boshoff
- HI Boshoff
- I Smith
- J Baysarowich
- J Parker
- J Shima
- Janine Santos
- JD Friesen
- JD Wang
- JL Dahl
- JL Dahl
- JW Huh
- K Kasai
- K Ochi
- K Ochi
- K Ochi
- K Ochi
- K Ochi
- K Wilkens
- KH Darwin
- KM Krueger
- KM Sinha
- KM Sinha
- KP Holbourn
- L Krasny
- L Rand
- Linda Chu
- LU Magnusson
- Lucy X. Li
- MH Serres
- Michael S. Glickman
- MJ Pallen
- MR Faraone-Mennella
- MS Glickman
- N Sommer
- NA Buchmeier
- NC Stephanou
- P Sander
- R Block
- R Depping
- RM Jenvert
- RS Pitcher
- S Kawamoto
- S Quan
- S Quan
- SP Haugen
- SP Yates
- T Koch
- T Koch
- T Naas
- TM Wendrich
- TP Primm
- V Schreiber
- X Yang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Recent evidence indicates that the mycobacterial response to DNA double strand breaks (DSBs) differs substantially from previously characterized bacteria. These differences include the use of three DSB repair pathways (HR, NHEJ, SSA), and the CarD pathway, which integrates DNA damage with transcription. Here we identify a role for the mono-ADP-ribosyltransferase Arr in the mycobacterial DNA damage response. Arr is transcriptionally induced following DNA damage and cellular stress. Although Arr is not required for induction of a core set of DNA repair genes, Arr is necessary for suppression of a set of ribosomal protein genes and rRNA during DNA damage, placing Arr in a similar pathway as CarD. Surprisingly, the catalytic activity of Arr is not required for this function, as catalytically inactive Arr was still able to suppress ribosomal protein and rRNA expression during DNA damage. In contrast, Arr substrate binding and catalytic activities were required for regulation of a small subset of other DNA damage responsive genes, indicating that Arr has both catalytic and noncatalytic roles in the DNA damage response. Our findings establish an endogenous cellular function for a mono-ADP-ribosyltransferase apart from its role in mediating Rifampin resistance
Highlights From the Annual Meeting of the American Epilepsy Society 2022
- Author
- Alexander Allyson L
- Andrade Danielle M
- Arevalo-Astrada Miguel
- Auer Nancy
- Bainbridge Jacquelyn L
- Bartolomei Fabrice
- Baxendale Sallie A
- Becker Danielle A
- Berg Anne T
- Bernasconi Andrea
- Bernasconi Neda
- Bernhardt Boris
- Bhatnagar Shivani
- Bluemcke Ingmar
- Blumenfeld Hal
- Buchanan Gordon F
- Burdette David E
- Burneo Jorge G
- Busch Robyn M
- Chauvel Patrick
- Chin Jeannie
- Clifford Lisa
- Conner Kelly R
- Conway Jeannine
- Cook Mark J
- Diaz-Arastia Ramon
- Drees Cornelia
- French Jacqueline A
- Ganguly Taneeta Mindy
- Gelfand Michael A
- Glauser Tracy A
- Gleichgerrcht Ezequiel
- Goldman Alica M
- Gonzalez-Martinez Jorge
- Gotman Jean
- Grinspan Zachary
- Guilfoyle Shanna
- Gupta Gita
- Hammer Michael
- Hartman Adam L
- Hentges Katie
- Hogan R Edward
- Huh Linda
- Hyslop Ann
- Jobst Barbara
- Jobst Barbara
- Josephson Colin B
- Kelley Sarah A
- Knupp Kelly
- Koepp Matthias
- Kothare Sanjeev
- Krook-Magnuson Esther
- Kwasa Jasmine
- La Vega-Talbott Maite
- Lam Alice D
- Lee Jong Woo
- Lowenstein Daniel H
- Maturu Sarita
- Mayor Luis Carlos
- McDonald Carrie
- McKee Heather R
- McKhann Guy M
- Meador Kimford J
- Mefford Heather C
- Michael Elizabeth H
- Mikati Mohamad A
- Millichap John J
- Mitchell James W
- Myers Leah S
- Naritoku Dean
- Neville Kerri L
- Noebels Jeffrey
- O'Brien Terence J
- Oluigbo Chima O
- Patel Anup D
- Pavlova Milena K
- Paz Jeanne T
- Pennell Page B
- Perry M Scott
- Perucca Piero
- Pitkaenen Asla
- Plueger Madona
- Pugh Mary Jo
- Quigg Mark
- Reddy Shilpa B
- Reynolds Tamara S
- Rubinos Clio
- Ryan Christopher
- Sajatovic Martha
- Santana-Gomez Cesar
- Schommer Linsday
- Schuele Stephan
- Shellhaas Renee A
- Shrey Daniel W
- Singh Rani K
- Sperling Michael R
- Suleman Saher
- Templer Jessica W
- Thom Maria
- Trinka Eugen
- Valencia Ignacio
- Varadkar Sophia M
- Velez-Ruiz Naymee
- Veliskova Jana
- Voskobiynyk Yuliya
- Wagner Janelle L
- Wagnon Jacy L
- Waller Claire
- Waller Jill
- Wang Zhong Irene
- Welborn Michelle W
- Wirrell Elaine
- Publication venue
- SAGE PUBLICATIONS INC
- Publication date
- 16/08/2023
- Field of study
With more than 6000 attendees between in-person and virtual offerings, the American Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever-growing number of physicians, scientists, and allied health professionals gathered to learn a variety of topics about epilepsy. The program was carefully tailored to meet the needs of professionals with different interests and career stages. This article summarizes the different symposia presented at the meeting. Basic science lectures addressed the primary elements of seizure generation and pathophysiology of epilepsy in different disease states. Scientists congregated to learn about anti-seizure medications, mechanisms of action, and new tools to treat epilepsy including surgery and neurostimulation. Some symposia were also dedicated to discuss epilepsy comorbidities and practical issues regarding epilepsy care. An increasing number of patient advocates discussing their stories were intertwined within scientific activities. Many smaller group sessions targeted more specific topics to encourage member participation, including Special Interest Groups, Investigator, and Skills Workshops. Special lectures included the renown Hoyer and Lombroso, an ILAE/IBE joint session, a spotlight on the impact of Dobbs v. Jackson on reproductive health in epilepsy, and a joint session with the NAEC on coding and reimbursement policies. The hot topics symposium was focused on traumatic brain injury and post-traumatic epilepsy. A balanced collaboration with the industry allowed presentations of the latest pharmaceutical and engineering advances in satellite symposia
Diagnostic Yield and Treatment Impact of Targeted Exome Sequencing in Early-Onset Epilepsy
- Author
- Anita Datta
- Aspasia Michoulas
- Bruce H. Bjornson
- Clara D. M. van Karnebeek
- Clara D. M. van Karnebeek
- Conrado DeGuzman
- Corneliu Bolbocean
- Corneliu Bolbocean
- Cyrus Boelman
- Daniel M. Evans
- Elena Lopez-Rangel
- Eric B. Toyota
- Erin Slade
- Gabriella Horvath
- Ilaria Guella
- Kathryn Selby
- Linda L. Huh
- Margot I. Van Allen
- Marna B. McKenzie
- Mary B. Connolly
- Matthew J. Farrer
- Michelle Demos
- Patrice Eydoux
- Patrice Eydoux
- Ramona Salvarinova
- Sarah E. Buerki
- Sarah E. Buerki
- Shelin Adam
- Tanya N. Nelson
- Tanya N. Nelson
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/01/2019
- Field of study
Targeted whole-exome sequencing (WES) is a powerful diagnostic tool for a broad spectrum of heterogeneous neurological disorders. Here, we aim to examine the impact on diagnosis, treatment and cost with early use of targeted WES in early-onset epilepsy. WES was performed on 180 patients with early-onset epilepsy (â€5 years) of unknown cause. Patients were classified as Retrospective (epilepsy diagnosis >6 months) or Prospective (epilepsy diagnosis <6 months). WES was performed on an Ion Protonâą and variant reporting was restricted to the sequences of 620 known epilepsy genes. Diagnostic yield and time to diagnosis were calculated. An analysis of cost and impact on treatment was also performed. A molecular diagnoses (pathogenic/likely pathogenic variants) was achieved in 59/180 patients (33%). Clinical management changed following WES findings in 23 of 59 diagnosed patients (39%) or 13% of all patients. A possible diagnosis was identified in 21 additional patients (12%) for whom supporting evidence is pending. Time from epilepsy onset to a genetic diagnosis was faster when WES was performed early in the diagnostic process (mean: 145 days Prospective vs. 2,882 days Retrospective). Costs of prior negative tests averaged 8,344perpatientintheRetrospectivegroup,suggestingsavingsof5,110 per patient using WES. These results highlight the diagnostic yield, clinical utility and potential cost-effectiveness of using targeted WES early in the diagnostic workup of patients with unexplained early-onset epilepsy. The costs and clinical benefits are likely to continue to improve. Advances in precision medicine and further studies regarding impact on long-term clinical outcome will be important
MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abercrombie Daniel
- Acharya Himal
- Acosta Darin
- Acosta John Gabriel
- Adam Wolfgang
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Adloff Catherine
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Aggleton Robin
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Albajar Carmen
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- AldĂĄ JĂșnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Allen Brandon
- Almond John
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrogi Federico
- Amendola Chiara
- Amin Nick
- Amram Oz
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yu.
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Antchev Georgy
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Araujo Mariana
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Aruta Caterina
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asenov Patrick
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Asmuss Paul
- Atakisi Ismail Okan
- Atanasov Ivan
- Ather Mohsan Waseem
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
- Auzinger Georg
- Avati Valentina
- Avery Paul
- Avila Carlos
- Awan Muhammad Imran Malik
- Ayala Edy
- Aydogmus Sen Fatma
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzurri Paolo
- Baarmand Marc M
- Babaev Anton
- Babounikau Illia
- Bacchetta Nicola
- Bachiller Irene
- Bachtis Michail
- Backhaus Malte
- Baden A.
- Baden Drew
- Baechler Joachim
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakas Georgios
- Bakhshiansohi Hamed
- Baldenegro Barrera Cristian
- Ball Austin
- Ban Yong
- Band Reyer
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Bargassa Pedrame
- Baringer Philip
- Barnes Virgil E
- Barney David
- Baron Owen
- Barrio Luna Mar
- Bartek Rachel
- Bartosik Nazar
- BartĂłk MĂĄrton
- Baselga Marta
- Bastos Diogo
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar AT
- Baur Sebastian
- Baxter Samuel
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Becerril Gonzalez Hugo
- Bechtel Janek
- Beghin Diego
- Behera Prafulla Kumar
- Behera Subash Chandra
- Behnke Olaf
- Bein Samuel
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Bellora Andrea
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benecke Anna
- Benelli Gabriele
- Beni Noemi
- Benitez Jose F
- Benussi Luigi
- Beretvas Andrew
- Bergauer Thomas
- Berger Pirmin
- Berger Thomas
- Beri Suman Bala
- BermĂșdez MartĂnez Armando
- Bernardes Cesar Augusto
- Bernet Colin
- Berry Douglas
- Berryhill Jeffrey
- Bertacchi Valerio
- Besancon Marc
- Beschi Andrea
- Bhal Eshwen
- Bhardwaj Ashutosh
- Bharti Monika
- Bhat Muzamil Ahmad
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhattacharya Soham
- Bheesette Srinidhi
- Bhowmik Debabrata
- Bhowmik Sandeep
- Bhyun Ji Hwan
- Bi Ran
- Bialkowska Helena
- Bianchini Lorenzo
- Bianco Michele
- Bianco Stefano
- Biasini Maurizio
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bin Anuar Afiq Aizuddin
- Bisello Dario
- Black Kevin
- Blekman Freya
- Blinov Vladimir
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Boccali Tommaso
- Bocci Andrea
- Bodek Arie
- Boimska Bozena
- Boletti Alessio
- Bologna Simone
- Bols Emil SĂžrensen
- Bonacorsi Daniele
- Bonanomi Matteo
- Bonchev Miroslav
- Bonomally Shameena
- Boos Edouard
- Boran Fatma
- Borchsh Vladislav
- Borg Johan
- Borgonovi Lisa
- Bornheim Adolf
- Borras Kerstin
- Bortignon Pierluigi
- Bose Tulika
- Bossini Edoardo
- Botta Cristina
- Botta Valeria
- Boudoul Gaelle
- Bouhali Othmane
- Bourgatte Guillaume
- Bourilkov Dimitri
- Bozzo Marco
- Bragagnolo Alberto
- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Brainerd Christopher
- BRANDAO MALBOUISSON Helena
- Brandt Stephanie
- Branson James G
- Breedon Richard
- Breeze Shane
- Brew Christopher
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brivio Francesco
- Brochero Cifuentes Javier Andres
- Brom Jean-Marie
- Brondolin Erica
- Brooke James John
- Brown Robert M
- Brunner David
- Bruno Giacomo
- Brzhechko Danyyl
- BrĂŒcken Erik
- Bucci Rachael
- Buccilli Andrew
- Buchanan James
- Buchmuller Oliver
- Buchot Perraguin Axel
- Bueghly James
- Bundock Aaron
- Bunichev Viacheslav
- Bunin Pavel
- Bunkowski Karol
- Buontempo Salvatore
- Burkett Kevin
- Burkle Bjorn
- Burt Kira
- Bury Florian Joel J
- Busson Philippe
- Busza Wit
- Butalla Stephen
- Butler Joel Nathan
- Butler Philip H
- Butz Erik
- Bychkova Oksana
- Bylinkin Alexander
- Bylsma Ben
- Byszuk Adrian
- Cabrera Andrés
- Cabrillo Iban Jose
- Cadamuro Luca
- Caillol CĂ©cile
- Cakir Altan
- Calandri Alessandro
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Call Kenneth
- Calligaris Luigi
- Calzaferri Simone
- Camen Camille
- Caminada Lea
- Campagnari Claudio
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Canepa Anadi
- Cankocak Kerem
- Capiluppi Paolo
- Cappati Alessandra
- Caputo Claudio
- Caraway Bryan
- Cardini Andrea
- Cardwell Bryan
- Carle Aurélien
- Carlin Roberto
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Cartiglia Nicolo
- Carvalho Antunes De Oliveira Alexandra
- Carvalho Wagner
- Casarsa Massimo
- Caspart René
- Cassese Antonio
- Castaldi Rino
- Castaneda Hernandez Alfredo
- Castilla-Valdez Heriberto
- Castro Andrea
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Ceccarelli Rudy
- Cepaitis Vilius
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerminara Gianluca
- Cerrada Marcos
- Cerri Olmo
- Cetorelli Flavia
- Chabert Eric Christian
- Chahal Gurpreet Singh
- Chang Paoti
- Chang Philip
- Chanon Nicolas
- Chao Yuan
- Chapon Emilien
- Charaf Otman
- Charlot Claude
- Chatterjee Rajdeep Mohan
- Chatterjee Suman
- Chauhan Shubhanshu
- Chauhan Sushil
- Chawla Ridhi
- Chazin Quero Barbara
- Checchia Paolo
- Chekhovsky Vladimir
- Chen Cheng
- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
- Chen Mingshui
- Chen Po-Hsun
- Chen Xuan
- Chen Yi
- Chen Yuan
- Chen Ziheng
- Chenarani Shirin
- Cheng Tongguang
- Cheng Yangyang
- Cherepanov Vladimir
- Chernyavskaya Nadezda
- Chertok Maxwell
- Cheung H. W. K.
- Chhibra Simranjit Singh
- Chiarito Brandon
- Chinellato Jose
- Chistov Ruslan
- Chlebana Frank
- Cho Sungwoong
- Choi Junho
- Choi Suyong
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Chu Jennifer
- Chudasama Ruchi
- Chwalek Thorsten
- Ciangottini Diego
- Ciocca Claudia
- Ciocci Maria Agnese
- Cipriani Marco
- Ciriolo Vincenzo
- Cirkovic Predrag
- Citron Matthew
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
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- Wickramarathna DDC.
- Wiedenbeck Sebastian
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- Winterbottom Daniel
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- Wissing Christoph
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- Wong Wing Yan
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- Woodard Anna
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- Wu Zhenbin
- Wuchterl Sebastian
- Wulz Claudia-Elisabeth
- Wuyckens Sophie
- Wyslouch Bolek
- WĂŒrthwein Frank
- Xia Fan
- Xiao Jie
- Xiao Meng
- Xiao Rui
- Xie Si
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- Yagil Avraham
- Yalvac Metin
- Yan Furong
- Yang Unki
- Yang Yu Chul
- Yao Yao
- YARAR Hevjin
- Yates Brent
- Yazgan Efe
- Yetkin Elif Asli
- Yi Kai
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Inseok
- You Zhengyun
- Yu David
- Yu Geum Bong
- Yu Intae
- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabi Alexandre
- Zacharopoulou Anna
- Zahid Sema
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zecchinelli Angelo Giacomo
- Zenaiev Oleksandr
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Sijing
- Zhang Wenyu
- Zhang Yi
- Zhang Zhicai
- Zhao Jingzhou
- Zhokin Alexander
- Zhu De Hua
- Zhu Ren-Yuan
- Ziemons Tim
- Zientek Margaret
- Zlebcik Radek
- Zobec Joze
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Ălvarez FernĂĄndez Adrian
- Ăzçelik Ăzlem
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe
Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abercrombie Daniel
- Abreu A.
- Acharya Himal
- Acosta Darin
- Adam Wolfgang
- Adamidis K.
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Aggleton Robin
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Ahuja Sudha
- Aime` Chiara
- Aimeâ C.
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Albergo Sebastiano
- Albert Andreas
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- AldĂĄ JĂșnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Almond John
- Alpana Km
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gallo Pereira Miguel
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrozas Marijus
- Amendola Chiara
- Amin Nick
- Amram Oz
- Amsler Claude
- An Sitong
- An Ying
- Anagnostou Georgios
- Andrea Jeremy
- Andreassi Guido
- Andreev Vladimir
- Andreev Yu.
- Andreev Yuri
- Andrejkovic Janik Walter
- Andrews Michael Benjamin
- Androsov Konstantin
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- Norberg Scarlet
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- Rathjens Denis
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- Re Valerio
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- Smirnov Igor
- Smirnov Vitaly
- Smith Caleb
- Smith Nicholas
- Smith Vincent J
- Smith Wesley H
- Snigirev Alexander
- Snoeys Walter
- Snow Gregory R
- Snyder Christina
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- Spalding William J
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- Stickland David
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- Zarucki Mateusz
- Zecchinelli Angelo Giacomo
- Zeinali Maryam
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Liuyao
- Zhang Wenyu
- Zhang Yi
- Zhang Yousen
- Zhang Zhicai
- Zhao Jingzhou
- Zhizhin Ilia
- Zhokin Alexander
- Zhu De Hua
- Zhu Ren-Yuan
- Ziemons Tim
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zotz Alexander
- Zou David
- Zou Rui
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Ălvarez FernĂĄndez Adrian
- Ăzçelik Ăzlem
- Publication venue
- Publication date
- 01/01/2021
- Field of study
A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe
Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abercrombie Daniel
- Abu Zeid Shimaa
- Acharya Himal
- Acosta Darin
- Acosta John Gabriel
- Adam Wolfgang
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Adloff Catherine
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Aggleton Robin
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Albajar Carmen
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- AldĂĄ JĂșnior Walter Luiz
- Aleksandrov Aleksandar
- Alexakhin Vadim
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Allen Brandon
- Almond John
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrogi Federico
- Amendola Chiara
- Amin Nick
- Amram Oz
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yu.
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Antchev Georgy
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Araujo Mariana
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Aruta Caterina
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asenov Patrick
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Asmuss Paul
- Atakisi Ismail Okan
- Atanasov Ivan
- Ather Mohsan Waseem
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
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- Avery Paul
- Avila Carlos
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- Aziz Tariq
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- Azzurri Paolo
- Baarmand Marc M
- Babaev Anton
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- Backhaus Malte
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- Yetkin Elif Asli
- Yi Kai
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- Zacharopoulou Anna
- Zahid Sema
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- Zalewski Piotr
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- Zarucki Mateusz
- Zecchinelli Angelo Giacomo
- Zenaiev Oleksandr
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Aobo
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Sijing
- Zhang Wenyu
- Zhang Yi
- Zhang Zhicai
- Zhao Jingzhou
- Zhokin Alexander
- Zhu De Hua
- Zhu Ren-Yuan
- Ziemons Tim
- Zientek Margaret
- Zlebcik Radek
- Zobec Joze
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zucchetta Alberto
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Ălvarez FernĂĄndez Adrian
- Ăzçelik Ăzlem
- Publication venue
- Publication date
- 01/01/2020
- Field of study
The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe
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