Observation of Landau level-like quantizations at 77 K along a strained-induced graphene ridge

Recent studies show that the electronic structures of graphene can be modified by strain and it was predicted that strain in graphene can induce peaks in the local density of states (LDOS) mimicking Landau levels (LLs) generated in the presence of a large magnetic field. Here we report scanning tunnelling spectroscopy (STS) observation of nine strain-induced peaks in LDOS at 77 K along a graphene ridge created when the graphene layer was cleaved from a sample of highly oriented pyrolytic graphite (HOPG). The energies of these peaks follow the progression of LLs of massless 'Dirac fermions' (DFs) in a magnetic field of 230 T. The results presented here suggest a possible route to realize zero-field quantum Hall-like effects at 77 K

The One-Way Communication Complexity of Dynamic Time Warping Distance

We resolve the randomized one-way communication complexity of Dynamic Time Warping (DTW) distance. We show that there is an efficient one-way communication protocol using O~(n/alpha) bits for the problem of computing an alpha-approximation for DTW between strings x and y of length n, and we prove a lower bound of Omega(n / alpha) bits for the same problem. Our communication protocol works for strings over an arbitrary metric of polynomial size and aspect ratio, and we optimize the logarithmic factors depending on properties of the underlying metric, such as when the points are low-dimensional integer vectors equipped with various metrics or have bounded doubling dimension. We also consider linear sketches of DTW, showing that such sketches must have size Omega(n)

Relationship heterogeneity in Taiwanese maritime logistics service supply chains

Purpose With the diverse, heterogeneous nature of relationships being a key characteristic of service supply chains, their management is an important area for consideration. This is particularly true in the maritime logistics industry, yet the factors that lead to this heterogeneity are less well understood. This paper aims to explore the structure of relationships within the maritime logistics network and determine why they vary. Design/methodology/approach Interviews were carried out with 41 practitioners involved in the Taiwanese maritime logistics network. The data from these interviews were analyzed using thematic analysis and quasi-quantification. Findings The interviews identify that structural holes exist within this maritime logistics network, and that these particularly influence the relationships within this sector with ports being significantly affected. However, five factors are particularly identified that can further impact the strength of these relationships. Often, weak links between ports and both cargo owners and freight forwarders emerge as value-added services are provided by the network. Research limitations/implications The findings are framed in a Taiwanese context, where cultural and political norms may give different results to other geographical regions. The research also limits consideration to containerized flows. Practical implications By providing detailed insights into relationship structures within the maritime logistics network, managers can take steps to develop appropriate links with other members of the network, reflecting upon the factors that lead to heterogeneity. Originality/value This paper expands knowledge on logistics service supply chains, identifying the importance of relationships in a derived demand environment. For maritime researchers, specific factors leading to relationship heterogeneity in the network are detailed, to inform future research

Simulation of an optically induced asymmetric deformation of a liquid-liquid interface

Deformations of liquid interfaces by the optical radiation pressure of a focused laser wave were generally expected to display similar behavior, whatever the direction of propagation of the incident beam. Recent experiments showed that the invariance of interface deformations with respect to the direction of propagation of the incident wave is broken at high laser intensities. In the case of a beam propagating from the liquid of smaller refractive index to that of larger one, the interface remains stable, forming a nipple-like shape, while for the opposite direction of propagation, an instability occurs, leading to a long needle-like deformation emitting micro-droplets. While an analytical model successfully predicts the equilibrium shape of weakly deformed interface, very few work has been accomplished in the regime of large interface deformations. In this work, we use the Boundary Integral Element Method (BIEM) to compute the evolution of the shape of a fluid-fluid interface under the effect of a continuous laser wave, and we compare our numerical simulations to experimental data in the regime of large deformations for both upward and downward beam propagation. We confirm the invariance breakdown observed experimentally and find good agreement between predicted and experimental interface hump heights below the instability threshold

Total Synthesis of Kingianins A, D, and F

A synthesis fit for a king: The total synthesis of (±)-kingianinsA, D, and F has been achieved in ten steps. Key features include the gram-scale synthesis and partial reduction of a conjugated tetrayne to a (Z,Z,Z,Z)-tetraene, the domino 8π-6π electro

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) initiates and progresses in the bone marrow, and as such, the marrow microenvironment is a critical regulatory component in development of this cancer. However, ALL studies were conducted mainly on flat plastic substrates, which do not recapitulate the characteristics of marrow microenvironments. To study ALL in a model of in vivo relevance, we have engineered a 3-D microfluidic cell culture platform. Biologically relevant populations of primary human bone marrow stromal cells, osteoblasts and human leukemic cells representative of an aggressive phenotype were encapsulated in 3-D collagen matrix as the minimal constituents and cultured in a microfluidic platform. The matrix stiffness and fluidic shear stress were controlled in a physiological range. The 3-D microfluidic as well as 3-D static models demonstrated coordinated cell-cell interactions between these cell types compared to the compaction of the 2-D static model. Tumor cell viability in response to an antimetabolite chemotherapeutic agent, cytarabine in tumor cells alone and tri-culture models for 2-D static, 3-D static and 3-D microfluidic models were compared. The present study showed decreased chemotherapeutic drug sensitivity of leukemic cells in 3-D tri-culture models from the 2-D models. The results indicate that the bone marrow microenvironment plays a protective role in tumor cell survival during drug treatment. The engineered 3-D microfluidic tri-culture model enables systematic investigation of effects of cell-cell and cell-matrix interactions on cancer progression and therapeutic intervention in a controllable manner, thus improving our limited comprehension of the role of microenvironmental signals in cancer biology

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) initiates and progresses in the bone marrow, and as such, the marrow microenvironment is a critical regulatory component in development of this cancer. However, ALL studies were conducted mainly on flat plastic substrates, which do not recapitulate the characteristics of marrow microenvironments. To study ALL in a model of in vivo relevance, we have engineered a 3-D microfluidic cell culture platform. Biologically relevant populations of primary human bone marrow stromal cells, osteoblasts and human leukemic cells representative of an aggressive phenotype were encapsulated in 3-D collagen matrix as the minimal constituents and cultured in a microfluidic platform. The matrix stiffness and fluidic shear stress were controlled in a physiological range. The 3-D microfluidic as well as 3-D static models demonstrated coordinated cell-cell interactions between these cell types compared to the compaction of the 2-D static model. Tumor cell viability in response to an antimetabolite chemotherapeutic agent, cytarabine in tumor cells alone and tri-culture models for 2-D static, 3-D static and 3-D microfluidic models were compared. The present study showed decreased chemotherapeutic drug sensitivity of leukemic cells in 3-D tri-culture models from the 2-D models. The results indicate that the bone marrow microenvironment plays a protective role in tumor cell survival during drug treatment. The engineered 3-D microfluidic tri-culture model enables systematic investigation of effects of cell-cell and cell-matrix interactions on cancer progression and therapeutic intervention in a controllable manner, thus improving our limited comprehension of the role of microenvironmental signals in cancer biology

Nucleosome-mediated cooperativity between transcription factors

Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes. The classical model of cooperativity requires direct interactions between TFs, thus constraining the arrangement of TFs sites in a CRR. On the contrary, genomic and functional studies demonstrate a great deal of flexibility in such arrangements with variable distances, numbers of sites, and identities of the involved TFs. Such flexibility is inconsistent with the cooperativity by direct interactions between TFs. Here we demonstrate that strong cooperativity among non-interacting TFs can be achieved by their competition with nucleosomes. We find that the mechanism of nucleosome-mediated cooperativity is mathematically identical to the Monod-Wyman-Changeux (MWC) model of cooperativity in hemoglobin. This surprising parallel provides deep insights, with parallels between heterotropic regulation of hemoglobin (e.g. Bohr effect) and roles of nucleosome-positioning sequences and chromatin modifications in gene regulation. Characterized mechanism is consistent with numerous experimental results, allows substantial flexibility in and modularity of CRRs, and provides a rationale for a broad range of genomic and evolutionary observations. Striking parallels between cooperativity in hemoglobin and in transcription regulation point at a new design principle that may be used in range of biological systems

Micro-events in the active and quiet solar corona

The content of hot material in the corona is not constant. Soft X-ray and high-temperature EUV line observations show that new material, apparently heated and evaporated from the chromosphere, is frequently injected into the corona both in active and quiet regions. Active regions are found to exhibit transient brightenings, termed here microflares, due to such enhancements in emission measure. They appear at a rate of up to 10 per hour in RHESSI observations of 3--15 keV X-rays, occurring even during the periods of lowest solar activity so far in the mission. The RHESSI observations combined with measurements at other wavelengths yield estimates of the energy input into the corona. These observations suggest that the models for coronal heating must be complemented with respect to continuous replenishing the lower corona by chromospheric material heated to coronal temperatures. The observed micro-events are secondary phenomena and do not represent the primary energy release, nor its total amount. Nevertheless, they are an interesting source of information on the heating process(es) of the corona. The micro-events are compared to events in quiet regions, termed here nanoflares, which seem to be a different population, well separated in temperature and emission measure from microflares.Comment: COSPAR meeting Houston 2002, PASP proceedings, in pres