196 research outputs found
Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy
Aim: Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because of serious hepatotoxicity. We estimated the risk of acute and serious liver injury associated with the use of nimesulide and other NSAIDs, with a prevalence of use greater than or equal to 5%.
Methods: This is a multicentre case–control study carried out in nine Italian hospitals from October 2010 to January 2014. Cases were adults, with a diagnosis of acute liver injury. Controls presented acute clinical disorders not related to chronic conditions, not involving the liver. Adjusted odds ratio (ORs) with 95% confidence interval (CI) were calculated initially with a bivariate and then multivariate analysis.
Results: We included 179 cases matched to 1770 controls. Adjusted OR for acute serious liver injury associated with all NSAIDs was 1.69, 95% CI 1.21–2.37. Thirty cases were exposed to nimesulide (adjusted OR 2.10, 95% CI 1.28–3.47); the risk increased according to the length of exposure (OR > 30 days: 12.55, 95% CI 1.73–90.88) and to higher doses (OR 10.69, 95% CI 4.02–28.44). Risk of hepatotoxicity was increased also for ibuprofen, used both at recommended dosages (OR 1.92, 95% CI 1.13–3.26) and at higher doses (OR 3.73, 95% CI 1.11–12.46) and for ketoprofen ≥ 150 mg (OR 4.65, 95% CI 1.33–10.00).
Conclusion: Among all NSAIDs, nimesulide is associated with the higher risk, ibuprofen and high doses of ketoprofen are also associated with a modestly increased risk of hepatotoxicity
Observation of the rare decay K_S -> pi^0mu^+mu^-
A search for the decay K_S -> pi^0mu^+mu^- has been made by the NA48/1
Collaboration at the CERN SPS accelerator. The data were collected during 2002
with a high-intensity K_S beam. Six events were found with a background
expectation of 0.22^+0.18_-0.11 event. Using a vector matrix element and unit
form factor, the measured branching ratio is B(K_S ->
pi^0mu^+mu^-)=[2.9^+1.5_-1.2(stat)+/-0.2(syst)]x10^{-9}.Comment: 19 pages, 8 figures, 4 tables. To be published in Physics Letters
First Observation and Measurement of the Decay K+- -> pi+- e+ e- gamma
Using the full data set of the NA48/2 experiment, the decay K+- -> pi+- e+ e-
gamma is observed for the first time, selecting 120 candidates with 7.3 +- 1.7
estimated background events. With K+- -> pi+- pi0D as normalisation channel,
the branching ratio is determined in a model-independent way to be Br(K+- ->
pi+- e+ e- gamma, m_eegamma > 260 MeV/c^2) = (1.19 +- 0.12_stat +- 0.04_syst) x
10^-8. This measured value and the spectrum of the e+ e- gamma invariant mass
allow a comparison with predictions of Chiral Perturbation Theory.Comment: 13 pages, 3 figures. Accepted for publication in Phys.Lett.
First observation and branching fraction and decay parameter measurements of the weak radiative decay Xi0 --> Lambda e+e-
The weak radiative decay Xi0 --> Lambda e+e- has been detected for the first
time. We find 412 candidates in the signal region, with an estimated background
of 15 +/- 5 events. We determine the branching fraction B(Xi0 --> Lambda e+e-)
= [7.6 +/- 0.4(stat) +/- 0.4(syst) +/- 0.2(norm)] x 10^{-6}, consistent with an
internal bremsstrahlung process, and the decay asymmetry parameter
alpha_{XiLambdaee} = -0.8 +/- 0.2, consistent with that of Xi0 --> Lambda
gamma. The charge conjugate reaction Xi0_bar --> Lambda_bar e+e- has also been
observed.Comment: 20 pages, 5 figures, 4 tables; revised: 19 pages, 4 figures, 4
tables, after reviewers' comments: 1 figure removed, 1 figure corrected,
minor editorial changes; to be published in Phys. Lett.
Empirical parameterization of the K+- -> pi+- pi0 pi0 decay Dalitz plot
As first observed by the NA48/2 experiment at the CERN SPS, the \p0p0
invariant mass (M00) distribution from \kcnn decay shows a cusp-like anomaly
at M00=2m+, where m+ is the charged pion mass. An analysis to extract the pi pi
scattering lengths in the isospin I=0 and I=2 states, a0 and a2, respectively,
has been recently reported. In the present work the Dalitz plot of this decay
is fitted to a new empirical parameterization suitable for practical purposes,
such as Monte Carlo simulations of K+- -> pi+- pi0 pi0 decays.Comment: 9 pages, 3 figures
Search for direct CP-violation in K+- --> pi+-pi0pi0 decays
A search for direct CP-violation in K+- --> pi+-pi0pi0 decays based on 47.14
million events has been performed by the NA48/2 experiment at the CERN SPS. The
asymmetry in the Dalitz plot linear slopes A_g=(g^+ - g^-)/(g^+ + g^-) is
measured to be A_g=(1.8 +- 2.6).10^{-4}. The design of the experiment and the
method of analysis provide good control of instrumental charge asymmetries in
this measurement. The precision of the result is limited by statistics and is
almost one order of magnitude better than that of previous measurements by
other experiments.Comment: 14 page
New Precise Measurements of the \xilamgam and \xisiggam Decay Asymmetries
The decay asymmetries of the weak radiative Hyperon decays Xi0 \to Lambda
gamma and Xi0 \to Sigma0 gamma have been measured with high precision using
data of the NA48/1 experiment at CERN. From about 52000 Xi0 \to Lambda gamma
and 15000 Xi0 \to Sigma0 gamma decays, we obtain for the decay asymmetries
alpha(Xi0 \to Lambda gamma) = -0.704 +/- 0.019(stat) +/- 0.064(syst) and
alpha(Xi0 \to Sigma0 gamma) = -0.729 +/- 0.030(stat) +/- 0.076(syst),
respectively. These results are in good agreement with previous experiments,
but more precise.Comment: 14 pages, 4 figures, accepted for publication in PL
New measurement of the charged kaon semileptonic (Ke4) decay Branching Ratio and Hadronic Form Factors
A sample of more than one million Ke4 decay candidates with less than one
percent background contamination has been collected by the NA48/2 experiment at
the CERN SPS in 2003-2004, allowing a detailed study of the decay properties.
The branching ratio, inclusive of radiative Ke4gamma decays, is measured to be
BR(Ke4) = (4.257 +/- 0.016_exp +/- 0.031_ext) x 10-5 with a total relative
error of 0.8%. This measurement complements the study of S- and P-wave hadronic
form factors by assigning absolute values to the relative hadronic form factors
obtained earlier in a simultaneous analysis of the pion-pion scattering lengths
conducted on the same data sample. The overall form factor normalization f_s =
5.705 +/- 0.017_exp +/- 0.031_ext is obtained with a total relative precision
of 0.6%.Comment: 21 pages, 5 figures, 5 tables, submitted to Phys. Lett.
Measurement of the Dalitz plot slope parameters of the decay
The distribution of the decays in the Dalitz plot
has been measured by the NA48/2 experiment at the CERN SPS with a sample of
fully reconstructed events. With the standard Particle Data
Group parameterization the following values of the slope parameters were
obtained: , ,
. The quality and statistical accuracy of the data have
allowed an improvement in precision by more than an order of magnitude, and are
such as to warrant a more elaborate theoretical treatment, including pion-pion
rescattering, which is in preparation.Comment: 14 pages, 5 figures. Version submitted to Phys. Lett. B. Slightly
improved analysis and bibliography
First observation and study of the K± → π±π0e+e− decay
The NA48/2 experiment at CERN reports the first observation of the K±→π±π0e+e− decay from an exposure of 1.7×1011 charged kaon decays recorded in 2003-2004. A sample of 4919 candidates with 4.9% background contamination allows the determination of the branching ratio in the full kinematic region, BR(K±→π±π0e+e−)=(4.24±0.14)×10−6. The study of the kinematic space shows evidence for a structure dependent contribution in agreement with predictions based on chiral perturbation theory. Several P- and CP-violating asymmetries are also evaluated
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