Circles of coastal sustainability: a framework for coastal management

© 2020 by the authors. The coastal zone is a space where many social, economic, and political activities intersect with natural processes. In this paper, we present an adaptation of the method of ‘Circles of Sustainability’, used to provide a visual assessment of indicators that define sustainability profiles for cities. It is used as a basis for a ‘Circles of Coastal Sustainability’ (CCS) framework that can be used at multiple spatial scales to assess indicators of critical processes that facilitate/constrain sustainability of the world’s coastal zones. The development of such a framework can support management by identifying key features that influence environmental sustainability and human well-being. CCS presents a holistic assessment of four interdependent boundary domains: Environment and Ecology, Social and Cultural, Economics, and Governance and Policy. This approach improves its utility and usability for decision-makers and researchers. CCS adds to existing assessment frameworks that are often focused on particular themes and/or domains that confine their utility to the context of sustainable development and the UN Agenda 2030 Sustainable Development Goals, which demand an inherently holistic and integrated evaluation. CCS is a holistic framework designed to assess the boundaries to sustainability for socio-ecological systems at multiple scales for the world’s coasts.Erasmus Mundus programme Water and Coastal Managemen

Critical thermodynamics of three-dimensional chiral model for N > 3

The critical behavior of the three-dimensional $N$-vector chiral model is studied for arbitrary $N$. The known six-loop renormalization-group (RG) expansions are resummed using the Borel transformation combined with the conformal mapping and Pad\'e approximant techniques. Analyzing the fixed point location and the structure of RG flows, it is found that two marginal values of $N$ exist which separate domains of continuous chiral phase transitions $N > N_{c1}$ and $N N > N_{c2}$ where such transitions are first-order. Our calculations yield $N_{c1} = 6.4(4)$ and $N_{c2} = 5.7(3)$. For $N > N_{c1}$ the structure of RG flows is identical to that given by the $\epsilon$ and 1/N expansions with the chiral fixed point being a stable node. For $N < N_{c2}$ the chiral fixed point turns out to be a focus having no generic relation to the stable fixed point seen at small $\epsilon$ and large $N$. In this domain, containing the physical values $N = 2$ and $N = 3$, phase trajectories approach the fixed point in a spiral-like manner giving rise to unusual crossover regimes which may imitate varying (scattered) critical exponents seen in numerous physical and computer experiments.Comment: 12 pages, 3 figure

Chiral phase transitions: focus driven critical behavior in systems with planar and vector ordering

The fixed point that governs the critical behavior of magnets described by the $N$-vector chiral model under the physical values of $N$ ($N =2, 3$) is shown to be a stable focus both in two and three dimensions. Robust evidence in favor of this conclusion is obtained within the five-loop and six-loop renormalization-group analysis in fixed dimension. The spiral-like approach of the chiral fixed point results in unusual crossover and near-critical regimes that may imitate varying critical exponents seen in physical and computer experiments.Comment: 4 pages, 5 figures. Discussion enlarge

Partial loss of function of the GHRH Receptor leads to mild Growth Hormone Deficiency

OBJECTIVE: Recessive mutations in GHRHR are associated with severe isolated growth hormone deficiency (IGHD), with a final height in untreated patients of 130 cm ± 10 cm (-7.2 ± 1.6 SDS; males) and 114 ± 0.7 cm (-8.3 ± 0.1 SDS; females). DESIGN: We hypothesized that a consanguineous Pakistani family with IGHD in three siblings (two males, one female) would have mutations in GH1 or GHRHR. RESULTS: Two novel homozygous missense variants [c.11G>A (p.R4Q), c.236C>T (p.P79L)] at conserved residues were identified in all three siblings. Both were absent from control databases, aside from pR4Q appearing once in heterozygous form in the Exome Aggregation Consortium Browser. The brothers were diagnosed with GH deficiency at 9.8 and 6.0 years (height SDS: -2.24 and -1.23, respectively), with a peak GH of 2.9 μg/liter with low IGF-1/IGF binding protein 3. Their sister presented at 16 years with classic GH deficiency (peak GH <0.1 μg/liter, IGF-1 <3.3 mmol/liter) and attained an untreated near-adult height of 144 cm (-3.0 SDS); the tallest untreated patient with GHRHR mutations reported. An unrelated Pakistani female IGHD patient was also compound homozygous. All patients had a small anterior pituitary on magnetic resonance imaging. Functional analysis revealed a 50% reduction in maximal cAMP response to stimulation with GHRH by the p.R4Q/p.P79L double mutant receptor, with a 100-fold increase in EC50. CONCLUSION: We report the first coexistence of two novel compound homozygous GHRHR variants in two unrelated pedigrees associated with a partial loss of function. Surprisingly, the patients have a relatively mild IGHD phenotype. Analysis revealed that the pP79L mutation is associated with the compromise in function, with the residual partial activity explaining the mild phenotype

Anterior pituitary cell networks

Both endocrine and non-endocrine cells of the pituitary gland are organized into structural and functional networks which are formed during embryonic development but which may be modified throughout life. Structural mapping of the various endocrine cell types has highlighted the existence of distinct network motifs and relationships with the vasculature which may relate to temporal differences in their output. Functional characterization of the network activity of growth hormone and prolactin cells has revealed a role for cell organization in gene regulation, the plasticity of pituitary hormone output and remarkably the ability to memorize altered demand. As such, the description of these endocrine cell networks alters the concept of the pituitary from a gland which simply responds to external regulation to that of an oscillator which may memorize information and constantly adapt its coordinated networks’ responses to the flow of hypothalamic inputs

Metabolism regulates exposure of pancreatic islets to circulating molecules in vivo.

International audiencePancreatic β-cells modulate insulin secretion through rapid sensing of blood glucose and integration of gut-derived signals. Increased insulin demand during pregnancy and obesity alters islet function and mass and leads to gestational diabetes mellitus and type 2 diabetes in predisposed individuals. However, it is unclear how blood-borne factors dynamically access the islets of Langerhans. Thus, understanding the changes in circulating molecule distribution that accompany compensatory β-cell expansion may be key to developing novel antidiabetic therapies. Here, using two-photon microscopy in vivo in mice, we demonstrate that islets are almost instantly exposed to peaks of circulating molecules, which rapidly pervade the tissue before clearance. In addition, both gestation and short-term high-fat-diet feeding decrease molecule extravasation and uptake rates in vivo in islets, independently of β-cell expansion or islet blood flow velocity. Together, these data support a role for islet vascular permeability in shaping β-cell adaptive responses to metabolic demand by modulating the access and sensing of circulating molecules

Imaging and manipulating pituitary function in the awake mouse

International audienceExtensive efforts have been made to explore how the activities of multiple brain cells combine to alter physiology through imaging and cell-specific manipulation in different animal models. However, the temporal regulation of peripheral organs by the neuroendocrine factors released by the brain is poorly understood. We have established a suite of adaptable methodologies to interrogate in vivo the relationship of hypothalamic regulation with the secretory output of the pituitary gland, which has complex functional networks of multiple cell types intermingled with the vasculature. These allow imaging and optogenetic manipulation of cell activities in the pituitary gland in awake mouse models, in which both neuronal regulatory activity and hormonal output are preserved. These methodologies are now readily applicable for longitudinal studies of short-lived events (e.g., calcium signals controlling hormone exocytosis) and slowly evolving processes such as tissue remodeling in health and disease over a period of days to weeks

A splitting approach for the fully nonlinear and weakly dispersive Green-Naghdi model

The fully nonlinear and weakly dispersive Green-Naghdi model for shallow water waves of large amplitude is studied. The original model is first recast under a new formulation more suitable for numerical resolution. An hybrid finite volume and finite difference splitting approach is then proposed. The hyperbolic part of the equations is handled with a high-order finite volume scheme allowing for breaking waves and dry areas. The dispersive part is treated with a classical finite difference approach. Extensive numerical validations are then performed in one horizontal dimension, relying both on analytical solutions and experimental data. The results show that our approach gives a good account of all the processes of wave transformation in coastal areas: shoaling, wave breaking and run-up

Land–ocean interactions in the coastal zone: past, present & future

The Land–ocean Interactions in the Coastal Zone (LOICZ) project was established in 1993 as a core project of the International Geosphere–Biosphere Programme (IGBP) to provide the science knowledge to answer "How will changes in land use, sea level and climate alter coastal systems, and what are the wider consequences?" In its first phase of operation (1993–2003) LOICZ began a fundamental investigation focused on biophysical dimensions, including seminal assessments of coastal seas as net sources or sinks of atmospheric CO2, river discharge to the oceans, and biogeochemical modelling. In the second generation of LOICZ (2004–2014), increased attention was paid to the human dimensions of the coast, involving the inclusion of cross-cutting themes such as coastal governance, social-ecological systems, ecological economics and activities around capacity building and the promotion of early career scientists. This paper provides a synthesis of this work and looks forward to the future challenges for the project. With the transition to Future Earth, there is a paradigm shift emerging. The new vision is to support transformation to a sustainable and resilient future for society and nature on the coast, by facilitating innovative, integrated and solutions-oriented science. Realising this vision takes LOICZ into a third generation: to be at the forefront of co-designing, co-producing and co-implementing knowledge for coastal resilience and sustainability. LOICZ as Future Earth Coasts will continue to address 'hotspots' of coastal vulnerability, focusing on themes of dynamic coasts, human development and the coast, and pathways to global coastal sustainability and constraints thereof

Discrete bands of petroleum hydrocarbons and molecular organic markers identified within massive coral skeletons

The tissues of corals deposit an aragonite exoskeleton beneath their outer living film at a rate dependent on growth and hence on environmental conditions. This typically results in annual (seasonal) bands being formed within colonies. By analysing molecular organic markers within these bands, our research suggests that coral skeletons record contamination from oil and potentially could be used to investigate other anthropogenic and biogenic organic inputs. Our analyses of sections from within corals (Porites lutea) sampled from the Gulf coasts of Kuwait and Saudi Arabia demonstrate discrete bands of oil contamination which, using selected terpenoid biomarkers, can be source-indexed to specific oil fields (i.e. Kuwait, Iranian or Arabian crude oils). Together with dating using microscopic and X-ray inspection, this offers the potential to investigate contamination during recent years. Further research is, however, necessary to elucidate degradation mechanisms during, and following, the occlusion process of organics within coral skeletons