COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.

We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients

Yield scaling, size hierarchy and fluctuations of observables in fragmentation of excited heavy nuclei

Multifragmentation properties measured with INDRA are studied for single sources produced in Xe+Sn reactions in the incident energy range 32-50 A MeV and quasiprojectiles from Au+Au collisions at 80 A MeV. A comparison for both types of sources is presented concerning Fisher scaling, Zipf law, fragment size and fluctuation observables. A Fisher scaling is observed for all the data. The pseudo-critical energies extracted from the Fisher scaling are consistent between Xe+Sn central collisions and Au quasi-projectiles. In the latter case it also corresponds to the energy region at which fluctuations are maximal. The critical energies deduced from the Zipf analysis are higher than those from the Fisher analysis.Comment: 30 pages, accepted for publication in Nuclear Physics A, references correcte

Fragment properties of fragmenting heavy nuclei produced in central and semi-peripheral collisions

Fragment properties of hot fragmenting sources of similar sizes produced in central and semi-peripheral collisions are compared in the excitation energy range 5-10 AMeV. For semi-peripheral collisions a method for selecting compact quasi-projectiles sources in velocity space similar to those of fused systems (central collisions) is proposed. The two major results are related to collective energy. The weak radial collective energy observed for quasi-projectile sources is shown to originate from thermal pressure only. The larger fragment multiplicity observed for fused systems and their more symmetric fragmentation are related to the extra radial collective energy due to expansion following a compression phase during central collisions. A first attempt to locate where the different sources break in the phase diagram is proposed.Comment: 23 pages submitted to NP

Bimodality: a possible experimental signature of the liquid-gas phase transition of nuclear matter

We have observed a bimodal behaviour of the distribution of the asymmetry between the charges of the two heaviest products resulting from the decay of the quasi-projectile released in binary Xe+Sn and Au+Au collisions from 60 to 100 MeV/u. Event sorting has been achieved through the transverse energy of light charged particles emitted on the quasi-target side, thus avoiding artificial correlations between the bimodality signal and the sorting variable. Bimodality is observed for intermediate impact parameters for which the quasi-projectile is identified. A simulation shows that the deexcitation step rather than the geometry of the collision appears responsible for the bimodal behaviour. The influence of mid-rapidity emission has been verified. The two bumps of the bimodal distribution correspond to different excitation energies and similar temperatures. It is also shown that it is possible to correlate the bimodality signal with a change in the distribution of the heaviest fragment charge and a peak in potential energy fluctuations. All together, this set of data is coherent with what would be expected in a finite system if the corresponding system in the thermodynamic limit exhibits a first order phase transition.Comment: 30 pages, 31 figure

Multifragmentation and phase transition for hot nuclei

5 pages, Proceedings of NN2009, August 17-21, Beijing (China)Recent important progress on the knowledge of multifragmentation and phase transition for hot nuclei, thanks to the high detection quality of the INDRA array, is reported. It concerns i) the radial collective energies involved in hot fragmenting nuclei/sources produced in central and semi- peripheral collisions and their influence on the observed fragment partitions, ii) a better knowledge of freeze-out properties obtained by means of a simulation based on all the available experimental information and iii) the quantitative study of the bimodal behaviour of the heaviest fragment distribution for fragmenting hot heavy quasi-projectiles which allows the extraction, for the first time, of an estimate of the latent heat of the phase transition

Multifragmentation threshold in ^{93}Nb+{nat}Mg collisions at 30 MeV/nucleon

We analyzed the $^{93}Nb$ on $^{nat}Mg$ reaction at 30 MeV/nucleon in the aim of disentangling binary sequential decay and multifragmentation decay close to the energy threshold, i.e. $\simeq 3$ MeV/nucleon. Using the backtracing technique applied to the statistical models GEMINI and SMM we reconstruct simulated charge, mass and excitation energy distributions and compare them to the experimental ones. We show that data are better described by SMM than by GEMINI in agreement with the fact that multifragmentation is responsible for fragment production at excitation energies around 3 MeV/nucleon.Comment: 16 pages, 12 figures, 5 tables Soumis \`a Nuclear Physics

Multifragmentation process for different mass asymmetry in the entrance channel around the Fermi energy

The influence of the entrance channel asymmetry upon the fragmentation process is addressed by studying heavy-ion induced reactions around the Fermi energy. The data have been recorded with the INDRA 4pi array. An event selection method called the Principal Component Analysis is presented and discussed. It is applied for the selection of central events and furthermore to multifragmentation of single source events. The selected subsets of data are compared to the Statistical Multifragmentation Model (SMM) to check the equilibrium hypothesis and get the source characteristics. Experimental comparisons show the evidence of a decoupling between thermal and compresional (radial flow) degrees of freedom in such nuclear systems.Comment: 28 pages, 15 figures, article sumitted to Nuclear Physics

Decay of excited nuclei produced in the 78;82Kr+40Ca reactions at 5.5 MeV/nucleon

International audienc

Multi-particle correlation function to study short-lived nuclei

Unstable 10C nuclei are produced as quasi-projectiles in 12C+24Mg collisions at E/A = 53 and 95 MeV. The decay of their short-lived states is studied with the INDRA multidetector array via multi-particle correlation functions. The obtained results show that heavy-ion collisions can be used as a tool to access spectroscopic information of unbound states in exotic nuclei, such as their energies and the relative importance of different sequential decay widths.Comment: 8 figures, accepted for publication in Nuclear Physics

Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events

The $B^0$-$\bar B^0$ oscillation frequency has been measured with a sample of 23 million \B\bar B pairs collected with the BABAR detector at the PEP-II asymmetric B Factory at SLAC. In this sample, we select events in which both B mesons decay semileptonically and use the charge of the leptons to identify the flavor of each B meson. A simultaneous fit to the decay time difference distributions for opposite- and same-sign dilepton events gives $\Delta m_d = 0.493 \pm 0.012{(stat)}\pm 0.009{(syst)}$ ps$^{-1}$.Comment: 7 pages, 1 figure, submitted to Physical Review Letter