Lowland river responses to intraplate tectonism and climate forcing quantified with luminescence and cosmogenic 10Be

Intraplate tectonism has produced large-scale folding that steers regional drainage systems, such as the 1600 km-long Cooper Ck, en route to Australia’s continental depocentre at Lake Eyre. We apply cosmogenic 10Be exposure dating in bedrock, and luminescence dating in sediment, to quantify the erosional and depositional response of Cooper Ck where it incises the rising Innamincka Dome. The detachment of bedrock joint-blocks during extreme floods governs the minimum rate of incision (17.4±6.5 mm/ky) estimated using a numerical model of episodic erosion calibrated with our 10Be measurements. The last big-flood phase occurred no earlier than ~112–121ka. Upstream of the Innamincka Dome long-term rates of alluvial deposition, partly reflecting synclinal-basin subsidence, are estimated from 47 luminescence dates in sediments accumulated since ~270 ka. Sequestration of sediment in subsiding basins such as these may account for the lack of Quaternary accumulation in Lake Eyre, and moreover suggests that notions of a single primary depocentre at base-level may poorly represent lowland, arid-zone rivers. Over the period ~75–55 ka Cooper Ck changed from a bedload- dominant, laterally-active meandering river to a muddy anabranching channel network up to 60 km wide. We propose that this shift in river pattern was a product of base-level rise linked with the slowly deforming syncline–anticline structure, coupled with a climate-forced reduction in discharge. The uniform valley slope along this subsiding alluvial and rising bedrock system represents an adjustment between the relative rates of deformation and the ability of greatly enhanced flows at times during the Quaternary to incise the rising anticline. Hence, tectonic and climate controls are balanced in the long term

MDC1 maintains active elongation complexes of RNA polymerase II

The role of MDC1 in the DNA damage response has been extensively studied; however, its impact on other cellular processes is not well understood. Here, we describe the role of MDC1 in transcription as a regulator of RNA polymerase II (RNAPII). Depletion of MDC1 causes a genome-wide reduction in the abundance of actively engaged RNAPII elongation complexes throughout the gene body of protein-encoding genes under unperturbed conditions. Decreased engaged RNAPII subsequently alters the assembly of the spliceosome complex on chromatin, leading to changes in pre-mRNA splicing. Mechanistically, the S/TQ domain of MDC1 modulates RNAPII-mediated transcription. Upon genotoxic stress, MDC1 promotes the abundance of engaged RNAPII complexes at DNA breaks, thereby stimulating nascent transcription at the damaged sites. Of clinical relevance, cancer cells lacking MDC1 display hypersensitivity to RNAPII inhibitors. Overall, we unveil a role of MDC1 in RNAPII-mediated transcription with potential implications for cancer treatment

Production of Mesons and Baryons at High Rapidity and High Pt in Proton-Proton Collisions at s\sqrt{s} = 200 GeV

We present particle spectra for charged hadrons $\pi^\pm, K^\pm, p$ and $\bar{p}$ from pp collisions at $\sqrt{s}$=200$GeV measured for the first time at forward rapidities (2.95 and 3.3). The kinematics of these measurements are skewed in a way that probes the small momentum fraction in one of the protons and large fractions in the other. Large proton to pion ratios are observed at values of transverse momentum that extend up to 4 GeV/c, where protons have momenta up to 35 GeV. Next-to-leading order perturbative QCD calculations describe the production of pions and kaons well at these rapidities, but fail to account for the large proton yields and small$\bar{p}/p$ ratios associated with baryon transport

Suppression of charged particle production at large transverse momentum in central Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}} = 2.76 TeV

Inclusive transverse momentum spectra of primary charged particles in Pb-Pb collisions at $\sqrt{s_{_{\rm NN}}}$ = 2.76 TeV have been measured by the ALICE Collaboration at the LHC. The data are presented for central and peripheral collisions, corresponding to 0-5% and 70-80% of the hadronic Pb-Pb cross section. The measured charged particle spectra in $|\eta|<0.8$ and $0.3 < p_T < 20$ GeV/$c$ are compared to the expectation in pp collisions at the same $\sqrt{s_{\rm NN}}$, scaled by the number of underlying nucleon-nucleon collisions. The comparison is expressed in terms of the nuclear modification factor $R_{\rm AA}$. The result indicates only weak medium effects ($R_{\rm AA} \approx$ 0.7) in peripheral collisions. In central collisions, $R_{\rm AA}$ reaches a minimum of about 0.14 at $p_{\rm T}=6$-7GeV/$c$ and increases significantly at larger $p_{\rm T}$. The measured suppression of high-$p_{\rm T}$ particles is stronger than that observed at lower collision energies, indicating that a very dense medium is formed in central Pb-Pb collisions at the LHC.Comment: 15 pages, 5 captioned figures, 3 tables, authors from page 10, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/98

Nuclear stopping and rapidity loss in Au+Au collisions at sqrt{s_{NN}}=62.4 GeV

Transverse momentum spectra of protons and anti-protons measured in the rapidity range 0<y<3.1 from 0-10% central Au+Au collisions at sqrt{s_{NN}}=62.4 GeV are presented. The rapidity densities, dN/dy, of protons, anti-protons and net-protons N()p-N(pbar) have been deduced from the spectra over a rapidity range wide enough to observe the expected maximum net-baryon density. From mid-rapidity to y=1 the net-proton yield is roughly constant (dN/dy ~ 10),but rises to dN/dy ~25 at 2.3<y<3.1. The mean rapidity loss is 2.01 +-0.16 units from beam rapidity. The measured rapidity distributions are compared to model predictions. Systematics of net-baryon distributions and rapidity loss vs. collision energy are discussed.Comment: 5 pages, 5 figures. Submitted Phys.Lett.

Kaon and Pion Production in Central Au+Au Collisions at \sqrt{s_{NN}}=62.4 GeV

Invariant pT spectra and rapidity densities covering a large rapidity range(-0.1 < y < 3.5) are presented for $\pi^{\pm}$ and $K^{\pm}$ mesons from central Au+Au collisions at $\sqrt{s_{NN}}$ = 62.4 GeV. The mid-rapidity yields of meson particles relative to their anti-particles are found to be close to unity ($\pi^-/\pi^+ \sim 1$, $K^-/K^+ \sim 0.85$) while the anti-proton to proton ratio is $\bar{p}/p \sim 0.49$. The rapidity dependence of the $\pi^-/\pi^+$ ratio is consistent with a small increase towards forward rapidities while the $K^-/K^+$ and $\bar{p}/p$ ratios show a steep decrease to $\sim$ 0.3 for kaons and 0.022 for protons at $y\sim 3$. It is observed that the kaon production relative to its own anti-particle as well as to pion production in wide rapidity and energy ranges shows an apparent universal behavior consistent with the baryo-chemical potential, as deduced from the $\bar{p}/p$ ratio, being the driving parameter.Comment: Submitted to PLB, 6 journal pages, 7 figure

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P < 5 × 10-8) three novel loci associated with HDL-C near CD163-APOBEC1 (P = 7.4 × 10-9), NCOA2 (P = 1.6 × 10-8), and NID2-PTGDR (P = 4.2 × 10-8), and one novel locus associated with TG near WDR11-FGFR2 (P = 2.7 × 10-10). Conditional analyses identified a second signal near CD163-APOBEC1. We then combined results from the East Asian meta-analysis with association results from up to 187,365 European individuals from the Global Lipids Genetics Consortium in a trans-ancestry meta-analysis. This analysis identified (log10Bayes Factor ≥6.1) eight additional novel lipid loci. Among the twelve total loci identified, the index variants at eight loci have demonstrated at least nominal significance with other metabolic traits in prior studies, and two loci exhibited coincident eQTLs (P < 1 × 10-5) in subcutaneous adipose tissue for BPTF and PDGFC. Taken together, these analyses identified multiple novel lipid loci, providing new potential therapeutic targets

Customer emotions in service failure and recovery encounters

Emotions play a significant role in the workplace, and considerable attention has been given to the study of employee emotions. Customers also play a central function in organizations, but much less is known about customer emotions. This chapter reviews the growing literature on customer emotions in employee–customer interfaces with a focus on service failure and recovery encounters, where emotions are heightened. It highlights emerging themes and key findings, addresses the measurement, modeling, and management of customer emotions, and identifies future research streams. Attention is given to emotional contagion, relationships between affective and cognitive processes, customer anger, customer rage, and individual differences