21 research outputs found
The influence of driver’s mood on car following and glance behaviour: Using cognitive load as an intervention
Driving safety relies on a driver’s ability to maintain their attentional focus and that mood is one of the factors which influences this ability. This driving simulator study used mind wandering theory to understand the changes in car following behaviour and driver glance patterns when affected by neutral, happy, sad and angry moods during car following. Two types of cognitive load were used to investigate ways of disengaging drivers from the mind wandering state. The moods were induced via music and mental imagery and assessed via self-reports and physiological measures. The results show that mood valence and arousal have different effects on driving safety, with negative moods resulting in the most dangerous driving, regardless of arousal. The cognitive load, in some cases, disengaged drivers from mood-related mind wandering. However, more detailed research is needed to understand the amount of load necessary for this disengagement in different moods. The importance of using driving-related measures together with glance patterns in mood research was highlighted to overcome ambiguities resulting from conclusions based on single measurements
Syndromes paranéoplasiques en ophtalmologie
International audienceParaneoplastic syndromes involving the visual system are a heterogeneous group of disorders occurring in the setting of systemic malignancy. Although these syndromes are rare, the clinical manifestations can herald an unsuspected, underlying malignancy. The associated antibodies and histopathology of each syndrome are presented to help in the understanding of these autoimmune phenomena. Outlined in this review article are diagnostic features useful in differentiating cancer-associated retinopathy, melanoma-associated retinopathy, paraneoplastic polymorphous vitelliform maculopathy, bilateral diffuse uveal melanocytic proliferation and paraneoplastic neurologic syndromes such as optic neuropathy, opsoclonus-myoclonus, Lambert-Eaton myasthenia and paraneoplastic cerebellar degeneration
Immune-related Encephalitis in Two Patients Treated With Immune Checkpoint Inhibitor
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Preoperative brain metabolism and quality of life after subthalamic nucleus stimulation in Parkinson's disease
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Allogeneic stem cell transplantation for relapsed primary central nervous system lymphoma: Is it feasible?
Improving the antitumor activity of R-CHOP with NGR-hTNF in primary CNS lymphoma: final results of a phase 2 trial
STAT3 Activation Is Associated with Interleukin-10 Expression and Survival in Primary Central Nervous System Lymphoma
PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma
Primary CNS lymphoma at first relapse/progression: characteristics, management, and outcome of 256 patients from the French LOC network
International audienceBackground - Treatment of relapsed/refractory (R/R) primary CNS lymphoma (PCNSL) is poorly defined, because randomized trials and large studies are lacking. The aim of this study was to analyze the characteristics, management, and outcome of R/R PCNSL patients after first-line therapy in a nationwide cohort.Methods - We analyzed R/R PCNSL patients following first-line treatment who had been prospectively registered in the database of the French network for oculocerebral lymphoma (LOC) between 2011 and 2014.Results - Among 563 PCNSL patients treated with first-line therapy, we identified 256 with relapsed (n = 93, 16.5%) or refractory (n = 163, 29.0%) disease. Patients who were asymptomatic at relapse/progression (25.5%), mostly diagnosed on routine follow-up neuroimaging, tended to have a better outcome. Patients who received salvage therapy followed by consolidation (mostly intensive chemotherapy plus autologous hematopoietic stem cell transplantation [ICT + AHSCT]) experienced prolonged survival compared with those who did not receive salvage or consolidation therapy. Independent prognostic factors at first relapse/progression were: KPS ≥ 70 vs KPS Conclusions - About a third of PCNSL patients are primary refractory to first line treatment. We identified several independent prognostic factors that can guide the management of R/R PCNSL patients.<br