The first record of \u3cem\u3eScorpiops bhutanensis\u3c/em\u3e Tikader & Bastawade, 1983 from China, with the first report of its female (Scorpiones: Scorpiopidae)

The first record of Scorpiops bhutanensis Tikader & Bastawade, 1983 from China (Xizang). An emended diagnosis, detailed redescription, and illustrations of the species are provided. Its female is reported here for the first time

Recognizing human actions from low-resolution videos by region-based mixture models

© 2016 IEEE. Recognizing human action from low-resolution (LR) videos is essential for many applications including large-scale video surveillance, sports video analysis and intelligent aerial vehicles. Currently, state-of-the-art performance in action recognition is achieved by the use of dense trajectories which are extracted by optical flow algorithms. However, the optical flow algorithms are far from perfect in LR videos. In addition, the spatial and temporal layout of features is a powerful cue for action discrimination. While, most existing methods encode the layout by previously segmenting body parts which is not feasible in LR videos. Addressing the problems, we adopt the Layered Elastic Motion Tracking (LEMT) method to extract a set of long-term motion trajectories and a long-term common shape from each video sequence, where the extracted trajectories are much denser than those of sparse interest points(SIPs); then we present a hybrid feature representation to integrate both of the shape and motion features; and finally we propose a Region-based Mixture Model (RMM) to be utilized for action classification. The RMM models the spatial layout of features without any needs of body parts segmentation. Experiments are conducted on two publicly available LR human action datasets. Among which, the UT-Tower dataset is very challenging because the average height of human figures is only about 20 pixels. The proposed approach attains near-perfect accuracy on both of the datasets

A High-Performance Liquid Chromatography:Chemiluminescence Method for Potential Determination of Vardenafil in Dietary Supplement

A flow method of high-performance liquid chromatography (HPLC) seperation and chemiluminescence (CL) detection for sensitive vardenafil analysis in dietary supplements was developed. The vardenafil separation was achieved on a C18 column at 30°C using ethanol-H3PO4 and ethylenediaminetetraacetic acid disodium salt (Na2EDTA) aqueous solution (25 : 75, v/v%) as mobile phase. The followed continuous CL detection was conducted based on the strong CL enhancement by the presence of vardenafil to luminol-K3Fe(CN)6 reaction in alkaline medium. At the flow rate of 0.8 mL/min, the vardenafil retention time (tR) was 6.4 min. Factors that affected the HPLC resolution and CL detection were studied and optimized. The calibration curve obtained for vardenafil standard was linear in concentration range of 8.0 × 10−7 ~ 1.0 × 10−4 mol/L. The relative standard deviations (RSD) of intraday and interday precision were less than 3.5%. The proposed method was applied to the vardenafil determination in oral liquid, wine, and capsule samples

Abrupt Motion Tracking via Nearest Neighbor Field Driven Stochastic Sampling

Stochastic sampling based trackers have shown good performance for abrupt motion tracking so that they have gained popularity in recent years. However, conventional methods tend to use a two-stage sampling paradigm, in which the search space needs to be uniformly explored with an inefficient preliminary sampling phase. In this paper, we propose a novel sampling-based method in the Bayesian filtering framework to address the problem. Within the framework, nearest neighbor field estimation is utilized to compute the importance proposal probabilities, which guide the Markov chain search towards promising regions and thus enhance the sampling efficiency; given the motion priors, a smoothing stochastic sampling Monte Carlo algorithm is proposed to approximate the posterior distribution through a smoothing weight-updating scheme. Moreover, to track the abrupt and the smooth motions simultaneously, we develop an abrupt-motion detection scheme which can discover the presence of abrupt motions during online tracking. Extensive experiments on challenging image sequences demonstrate the effectiveness and the robustness of our algorithm in handling the abrupt motions.Comment: submitted to Elsevier Neurocomputin

Activation of PI3K/AKT and ERK MAPK signal pathways is required for the induction of lytic cycle replication of Kaposi's Sarcoma-associated herpesvirus by herpes simplex virus type 1

<p>Abstract</p> <p>Background</p> <p>Kaposi's sarcoma-associated herpesvirus (KSHV) is causally linked to several acquired immunodeficiency syndrome-related malignancies, including Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease. Regulation of viral lytic replication is critical to the initiation and progression of KS. Recently, we reported that herpes simplex virus type 1 (HSV-1) was an important cofactor that activated lytic cycle replication of KSHV. Here, we further investigated the possible signal pathways involved in HSV-1-induced reactivation of KSHV.</p> <p>Results</p> <p>By transfecting a series of dominant negative mutants and protein expressing constructs and using pharmacologic inhibitors, we found that either Janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) or JAK1/STAT6 signaling failed to regulate HSV-1-induced KSHV replication. However, HSV-1 infection of BCBL-1 cells activated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB, also called AKT) pathway and inactivated phosphatase and tensin homologue deleted on chromosome ten (PTEN) and glycogen synthase kinase-3β (GSK-3β). PTEN/PI3K/AKT/GSK-3β pathway was found to be involved in HSV-1-induced KSHV reactivation. Additionally, extracellular signal-regulated protein kinase (ERK) mitogen-activated protein kinase (MAPK) pathway also partially contributed to HSV-1-induced KSHV replication.</p> <p>Conclusions</p> <p>HSV-1 infection stimulated PI3K/AKT and ERK MAPK signaling pathways that in turn contributed to KSHV reactivation, which provided further insights into the molecular mechanism controlling KSHV lytic replication, particularly in the context of HSV-1 and KSHV co-infection.</p

Diclofenac transdermal patch versus the sustained release tablet: A randomized clinical trial in rheumatoid arthritic patients

Purpose: To prepare and characterize transdermal films of diclofenac diethanolamine as a safer and more effective alternative than the sustained release (SR) tablet equivalent for prolonged relief from pain and inflammation in arthritis.Methods: Transdermal films of diclofenac were prepared using sodium carboxymethyl cellulose and polyvinyl pyrrolidone K30, with turpentine oil and sesame oil as penetration enhancers. The films were characterized for  physicochemical properties and for ex vivo permeation in a randomized clinical trial(RCT) for analgesic activities in arthritic patients.Results: The transdermal films were uniform in weight and thickness, flat, with high drug content (94.40 ± 1.04 to 98.62 ± 1.08 %) and with high folding endurance (149 ± 9.09 to 192 ± 10.12). Drug permeation through excised rat abdominal skin was prolonged. Films containing penetration enhancers showed higher ex vivo drug permeation than those without the enhancer; furthermore, drug permeation increased with increase in the concentration of enhancer. The films were  non-irritating to the skin. In RCT, F3 (containing turpentine oil, 1 %v/w) decreased the pain score from 9.87 ± 1.14 to 4.94 ± 0.78 units, compared with the SR tablet (once daily) which decreased pain from 9.59 ± 0.42 to 6.49 ± 1.20 units, 48 h post-administration. Turpentine oil showed better permeation enhancement than sesame oil in the transdermal films.Conclusion: Transdermal films of diclofenac, formulated with permeation enhancers, may have greater therapeutic advantages over conventional oral tablets in terms of prolonged release and improvement of patient compliance in rheumatoid arthritis.Keywords: Analgesic activity, Diclofenac, Permeation enhancer, Rheumatoid arthritis, Transdermal film