Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition

Disturbed functional brain networks and neurocognitive function in low-grade glioma patients: a graph theoretical analysis of resting-state MEG

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Correction: How Long Is Too Long in Contemporary Peer Review? Perspectives from Authors Publishing in Conservation Biology Journals.

<p>Correction: How Long Is Too Long in Contemporary Peer Review? Perspectives from Authors Publishing in Conservation Biology Journals</p

The TEEBAgriFood theory of change: from information to action

KEY MESSAGES • Information alone often fails to motivate change. Manipulation of data has led consumers to doubt scientific results, serving special interests at the expense of public benefit. Information overload implies the need for synthesis to enable better access and impact. • Rationalizations against the need for change include: fatalism, arguing that business is already changing of its own accord, that cheap food is more important than good food, and that the marketplace will adjust for externalities. • These views do not address the long-term systemic consequences of the global corporate model of food systems in a society that derives calories from corn syrup and protein from hamburger resulting in obesity and disease. • Free market, neoliberal policies are incapable of resolving externalities that affect public goods such as ecosystem services. Faith in the infallibility of the market is a shortcoming of mainstream economics. • Path dependency is a key barrier to change in food systems, causing inertia, but may also lock-in positive systemic change. A science of intentional systemic change is arising, grounded in better understanding of human economic behavior as the basis for collective action. • We espouse not one theory but rather a range of actor-relevant theories of change. • Consumer advocacy can bring businesses to assume greater responsibility for the effects of their actions. This theory of change has found expression in the threat of boycotts and reputational risk. • Certification has led to improvement in production practice within market niches but its true success begins when it pressures change in policy and practice throughout supply chains. • Governance of intentional transformation in food systems requires knowledge of political pressure points, and systematic efforts to shape narratives of principal actors, to redirect financial resources and to promote institutional and societal learning and adaptation. • We address the potential of multilateral organizations and agreements, national governments, the financial industry, agribusiness, producers and consumer groups to respond to the need for change. The roles of different actors are interlocking: there is no single point of entry for a theory of change. • The roles of principal actors are drawn along a continuum of change, suggesting specific roles and types of actions to be addressed in evaluation and intervention. Given societal concern, agents for change may persevere within government, agribusiness or civil society organizations; their ability to bring change is dynamic and opportunistic, and driven by strategic alliances. As levers of agrifood system transformation, it is crucial to engage influential governmental actors as change agents. • Actors’ respective ability to adopt the results of TEEBAgriFood studies as a tool to direct change will depend on how well those results are communicated and adopted as narratives by influential actors and as entry points for education and consumer consciousness

Omental and pleural milky spots: different reactivity patterns in mice infected with Schistosoma mansoni reveals coelomic compartmentalisation

In vertebrate animals, pleural and peritoneal cavities are repositories of milky spots (MS), which constitute an organised coelom-associated lymphomyeloid tissue that is intensively activated by Schistosoma mansoni infection. This study compared the reactive patterns of peritoneal MS to pleural MS and concluded from histological analysis that they represent independent responsive compartments. Whole omentum, lungs and the entire mediastinum of 54 S. mansoni-infected mice were studied morphologically. The omental MS of infected animals were highly activated, modulating from myeloid-lymphocytic (60 days of infection) to lymphomyeloid (90 days of infection) and lymphocytic or lymphoplasmacytic (160 days of infection) types. The non-lymphoid component predominated in the acute phase of infection and was expressed by monocytopoietic, eosinopoietic and neutropoietic foci, with isolated megakaryocytes and small foci of late normoblasts and mast cells. Nevertheless, pleural or thoracic MS of infected mice were monotonous, consisting of small and medium lymphocytes with few mast and plasma cells and no myeloid component. Our data indicate that compartmentalisation of the MS response is dependent on the lymphatic vascularisation of each coelomic cavity, limiting the effects or consequences of any stimulating or aggressive agents, as is the case with S. mansoni infection

Aquatic connectivity: challenges and solutions in a changing climate

AbstractThe challenge of managing aquatic connectivity in a changing climate is exacerbated in the presence of additional anthropogenic stressors, social factors, and economic drivers. Here we discuss these issues in the context of structural and functional connectivity for aquatic biodiversity, specifically fish, in both the freshwater and marine realms. We posit that adaptive management strategies that consider shifting baselines and the socio‐ecological implications of climate change will be required to achieve management objectives. The role of renewable energy expansion, particularly hydropower, is critically examined for its impact on connectivity. We advocate for strategic spatial planning that incorporates nature‐positive solutions, ensuring climate mitigation efforts are harmonized with biodiversity conservation. We underscore the urgency of integrating robust scientific modelling with stakeholder values to define clear, adaptive management objectives. Finally, we call for innovative monitoring and predictive decision‐making tools to navigate the uncertainties inherent in a changing climate, with the goal of ensuring the resilience and sustainability of aquatic ecosystems.</jats:p