Vacuum replicas in two-dimensional QCD

Two-dimensional QCD is studied from the point of view of existence of multiple chirally noninvariant solutions to the mass-gap equation. The ground-state solution is reproduced and an infinite set of replica solutions is discovered for this equation using the WKB quantisation procedure.Comment: LaTeX2e, 9 pages, 1 Postscript figure, uses epsfig.sty, to appear in Phys.Lett.

Inflation with Non-minimal Gravitational Couplings and Supergravity

We explore in the supergravity context the possibility that a Higgs scalar may drive inflation via a non-minimal coupling to gravity characterised by a large dimensionless coupling constant. We find that this scenario is not compatible with the MSSM, but that adding a singlet field (NMSSM, or a variant thereof) can very naturally give rise to slow-roll inflation. The inflaton is necessarily contained in the doublet Higgs sector and occurs in the D-flat direction of the two Higgs doublets.Comment: 13 pages, 1 figur

The thermal coupling constant and the gap equation in the λϕD4\lambda\phi^{4}_{D} model

By the concurrent use of two different resummation methods, the composite operator formalism and the Dyson-Schwinger equation, we re-examinate the behavior at finite temperature of the O(N)-symmetric $\lambda\phi^{4}$ model in a generic D-dimensional Euclidean space. In the cases D=3 and D=4, an analysis of the thermal behavior of the renormalized squared mass and coupling constant are done for all temperatures. It results that the thermal renormalized squared mass is positive and increases monotonically with the temperature. The behavior of the thermal coupling constant is quite different in odd or even dimensional space. In D=3, the thermal coupling constant decreases up to a minimum value diferent from zero and then grows up monotonically as the temperature increases. In the case D=4, it is found that the thermal renormalized coupling constant tends in the high temperature limit to a constant asymptotic value. Also for general D-dimensional Euclidean space, we are able to obtain a formula for the critical temperature of the second order phase transition. This formula agrees with previous known values at D=3 and D=4.Comment: 23 pages, 4 figure

Heavy Quark Expansion and Preasymptotic Corrections to Decay Widths in the 't Hooft Model

We address nonperturbative power corrections to inclusive decay widths of heavy flavor hadrons in the context of the 't Hooft model (two-dimensional QCD at N_c->oo), with the emphasis on the spectator-dependent effects sensitive to the flavor of the spectator. The summation of exclusive widths is performed analytically using the `t Hooft equation. We show that the 1/m_Q expansion of both the Weak Annihilation and Pauli Interference widths coincides with the OPE predictions, to the computed orders. Violation of local duality in the inclusive widths is quantified, and the new example is identified where the OPE prediction and the actual effect are completely saturated by a single final state. The qualitative aspects of quark hadronization emerging from the analysis in the 't Hooft model are discussed. Certain aspects of summation of spectator-independent hadronic weak decay widths are given in more detail, which were not spelled out previously. We also give some useful details of the 1/m_Q expansion in the 't~Hooft model.Comment: 54 pages, 8 figures in the text. Version to be published in Phys. Rev. D. A number of typos are corrected and relevant references added. Clarifications in Conclusions, Appendices 2.1 and 3 are adde

The Conformal Sector of F-theory GUTs

D3-brane probes of exceptional Yukawa points in F-theory GUTs are natural hidden sectors for particle phenomenology. We find that coupling the probe to the MSSM yields a new class of N = 1 conformal fixed points with computable infrared R-charges. Quite surprisingly, we find that the MSSM only weakly mixes with the strongly coupled sector in the sense that the MSSM fields pick up small exactly computable anomalous dimensions. Additionally, we find that although the states of the probe sector transform as complete GUT multiplets, their coupling to Standard Model fields leads to a calculable threshold correction to the running of the visible sector gauge couplings which improves precision unification. We also briefly consider scenarios in which SUSY is broken in the hidden sector. This leads to a gauge mediated spectrum for the gauginos and first two superpartner generations, with additional contributions to the third generation superpartners and Higgs sector.Comment: v2: 51 pages, 2 figures, remark added, typos correcte

Bethe-Salpeter Approach for Unitarized Chiral Perturbation Theory

The Bethe-Salpeter equation restores exact elastic unitarity in the $s-$ channel by summing up an infinite set of chiral loops. We use this equation to show how a chiral expansion can be undertaken in the two particle irreducible amplitude and the propagators accomplishing exact elastic unitarity at any step. Renormalizability of the amplitudes can be achieved by allowing for an infinite set of counter-terms as it is the case in ordinary Chiral Perturbation Theory. Crossing constraints can be imposed on the parameters to a given order. Within this framework, we calculate the leading and next-to-leading contributions to the elastic $\pi \pi$ scattering amplitudes, for all isospin channels, and to the vector and scalar pion form factors in several renormalization schemes. A satisfactory description of amplitudes and form factors is obtained. In this latter case, Watson's theorem is automatically satisfied. From such studies we obtain a quite accurate determination of some of the ChPT $SU(2)-$low energy parameters ({\bar l}_1 - {\bar l}_2 = -6.1\er{0.1}{0.3} and ${\bar l}_6= 19.14 \pm 0.19$). We also compare the two loop piece of our amplitudes to recent two--loop calculations.Comment: 63 pages, 9 figures. Some discussions on off-shell ambiguities and convergence of the expansion adde

Cisplatin neurotoxicity in the treatment of metastatic germ cell tumour: time course and prognosis

In order to ascertain the incidence and prognosis of cisplatin-induced neurotoxicity in testis cancer patients undergoing combination chemotherapy, 29 patients with metastatic disease were studied prospectively. Assessments included enquiry into neurological symptoms, measurement of sural nerve sensory action potential and conduction velocity, and vibration threshold in the left big toe. At the end of chemotherapy (3 to 4 cycles) only 3 out of 26 (11%) patients had paraesthesiae, but 3 months later the proportion rose to 65%. Resolution occurred in the majority over the ensuing 12 months so that only 17% had persistent symptoms. None of the 11 patients treated with 3 cycles of chemotherapy had persisting symptoms. Vibration thresholds showed a significant deterioration during chemotherapy (P = 0.032), further deterioration in the 3 months following chemotherapy (P = 0.009) and significant improvement between 3 and 12 months after chemotherapy (P = 0.038). Sural nerve sensory action potentials and conduction velocities were unhelpful.© 2001 Cancer Research Campaignhttp://www.bjcancer.co

MSSM in view of PAMELA and Fermi-LAT

We take the MSSM as a complete theory of low energy phenomena, including neutrino masses and mixings. This immediately implies that the gravitino is the only possible dark matter candidate. We study the implications of the astrophysical experiments such as PAMELA and Fermi-LAT, on this scenario. The theory can account for both the realistic neutrino masses and mixings, and the PAMELA data as long as the slepton masses lie in the $500-10^6$TeV range. The squarks can be either light or heavy, depending on their contribution to radiative neutrino masses. On the other hand, the Fermi-LAT data imply heavy superpartners, all out of LHC reach, simply on the grounds of the energy scale involved, for the gravitino must weigh more than 2 TeV. The perturbativity of the theory also implies an upper bound on its mass, approximately $6-7$TeV.Comment: Published version, figures update

Placental transfer of anti-group B Streptococcus immunoglobulin G antibody subclasses from HIV-infected and uninfected women to their uninfected infants.

OBJECTIVES: Placental antibody transfer is impaired in the context of HIV infection, which may render HIV-exposed, uninfected infants vulnerable to group B Streptococcus (GBS) disease. The GBS antibody response predominately consists of immunoglobulin G2 (IgG2) antibody. Thus we determined whether concentration and placental transfer of anti-GBS antibody subclasses was altered in HIV-infected compared with HIV-uninfected mothers. DESIGN: A retrospective analysis of anti-GBS antibody subclasses in 38 HIV-infected and 33 HIV-uninfected mothers and their uninfected infants. METHODS: Sera were analysed using a novel flow cytometric assay that quantified binding of IgG1, IgG2, IgG3 and IgG4 to serotype (ST)Ia, STIII and STV GBS bacteria. RESULTS: IgG2 binding to GBS STIa and V was lower in HIV-infected women compared with HIV-uninfected women. Moreover, IgG2 binding to GBS STIa was also lower in HIV-exposed, uninfected infants compared with unexposed infants. However, there were no statistically significant differences in the transplacental transfer ratio of IgG2 for any GBS serotype. The transplacental transfer of total IgG was reduced for GBS STIII and V and IgG1 subclass for STIII; placental transfer of all other subclasses was comparable in HIV-affected and HIV-unaffected pregnancies. CONCLUSION: Anti-GBS IgG2 placental transfer is not affected by HIV infection. This is important for functional antibody against the capsular polysaccharide of GBS and provides confidence that maternal GBS vaccination may result in functional activity in HIV-infected and uninfected women

Absence of microsatellite instability and BRAF (V600E) mutation in testicular germ cell tumors

Testicular germ cell tumors (TGCT) are the most common malignant neoplasm in young men. DNA mismatch repair deficiency can lead to microsatellite instability (MSI), an important mechanism of genetic instability. A mutation of the BRAF gene has been implicated in the pathogenesis of several solid tumors and has recently become an important therapeutic target. The role of MSI and BRAF gene mutation in TGCT, particularly in refractory disease, is poorly understood and reported findings are controversial. In this study, we aimed to determine the frequency and clinical impact of MSI status and BRAF mutations in TGCT. DNA was isolated from formalin-fixed paraffin embedded (FFPE) tissue from 150 TGCT cases. The MSI phenotype was evaluated using multiplex PCR for five quasimonomorphic mononucleotide repeat markers. Exon 15 of the BRAF oncogene (V600E) was analyzed by PCR, followed by direct sequencing. Sixteen percent of cases were considered to have refractory disease. In a small subset of cases (17 for MSI and 18 for BRAF), the quantity and quality of DNA recovery were poor and therefore, were unable to be analyzed. The remaining 133 TGCT cases showed a complete absence of MSI. Of the 132 cases successfully evaluated for BRAF mutations, all were V600E wild-type. In conclusion, despite a distinct response of testicular germ cell tumors to therapy, microsatellite instability, and the BRAF V600E mutation were absent in all testicular germ cell tumors tested in this study.This project was financially supported by Barretos Cancer Hospital internal research funds (PAIP). The authors acknowledge Dr. Laura Musselwhite for her critical review of the manuscript