CORE
πΊπ¦Β
Β make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Cisplatin neurotoxicity in the treatment of metastatic germ cell tumour: time course and prognosis
Authors
Ashraf M
Berger T
+27Β more
Bokemeyer C
C J Fowler
Cavaletti G
Cavaletti G
Daugaard GK
de Wit R
di Benedetto M
Einhorn LH
Einhorn LH
Einhorn LH
Foster-Nora JA
Gerritsen van der Hoop R
Grunberg SM
Hardaker WT
Hilkens PH
Hilkens PHE
Kaye SB
Kedar A
Le Quesne PM
M von Schlippe
Mollman JE
Nielsen VK
Planting AS
Riggs JE
S J Harland
Steiness IB
Steiness IB
Publication date
Publisher
Nature Publishing Group
Doi
Cite
View
on
PubMed
Abstract
In order to ascertain the incidence and prognosis of cisplatin-induced neurotoxicity in testis cancer patients undergoing combination chemotherapy, 29 patients with metastatic disease were studied prospectively. Assessments included enquiry into neurological symptoms, measurement of sural nerve sensory action potential and conduction velocity, and vibration threshold in the left big toe. At the end of chemotherapy (3 to 4 cycles) only 3 out of 26 (11%) patients had paraesthesiae, but 3 months later the proportion rose to 65%. Resolution occurred in the majority over the ensuing 12 months so that only 17% had persistent symptoms. None of the 11 patients treated with 3 cycles of chemotherapy had persisting symptoms. Vibration thresholds showed a significant deterioration during chemotherapy (P = 0.032), further deterioration in the 3 months following chemotherapy (P = 0.009) and significant improvement between 3 and 12 months after chemotherapy (P = 0.038). Sural nerve sensory action potentials and conduction velocities were unhelpful.Β© 2001 Cancer Research Campaignhttp://www.bjcancer.co
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Crossref
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 01/04/2019