63 research outputs found
Nucleic acid amplification tests in the diagnosis of tuberculous pleuritis: a systematic review and meta-analysis
- Author
- A al-Quorain
- A de Lassence
- A Verma
- AF Seibert
- AMC Rose
- American Thoracic Society
- B Littenberg
- BS Nagesh
- CC Pao
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- CK Liam
- CM Chan
- Cochrane Methods Group on Systematic Review of Screening and Diagnostic Tests
- D de Wit
- D de Wit
- E Perez-Rodriguez
- EC Bueno
- F Artiles
- F Gamboa
- F Gamboa
- F Song
- F Vlaspolder
- G Kaltwasser
- G Mangiapan
- GE Pfyffer
- GL Woods
- GT Noordhoek
- HMC Gracia
- HW Berger
- J Almeda
- J Lau
- JA Knottnerus
- JAMA Tan
- JB Mehta
- JD van Embden
- JG Lijmer
- JJ Deeks
- JJ Palacios
- JM Querol
- K Aoe
- K Rantakokko-Jalava
- L Dar
- L Portillo-Gomez
- L Valdes
- L Valdes
- L Valdes
- LC Martins
- M Egger
- M Pai
- MD Frye
- MF Tan
- MV Villegas
- N Markowitz
- NS Morcillo
- OL Sarmiento
- P Gunisha
- R Laniado-Laborin
- RF D'Amato
- RW Light
- S Ehlers
- S Greco
- S Mitarai
- S Shah
- SMH Abanto
- U Reischl
- V Parandaman
- V Villena
- W Reechaipichitkul
- WL Deville
- Y Miyazaki
- Publication venue
- BioMed Central
- Publication date
- 01/01/2004
- Field of study
BACKGROUND: Conventional tests for tuberculous pleuritis have several limitations. A variety of new, rapid tests such as nucleic acid amplification tests – including polymerase chain reaction – have been evaluated in recent times. We conducted a systematic review to determine the accuracy of nucleic acid amplification (NAA) tests in the diagnosis of tuberculous pleuritis. METHODS: A systematic review and meta-analysis of 38 English and Spanish articles (with 40 studies), identified via searches of six electronic databases, hand searching of selected journals, and contact with authors, experts, and test manufacturers. Sensitivity, specificity, and other measures of accuracy were pooled using random effects models. Summary receiver operating characteristic curves were used to summarize overall test performance. Heterogeneity in study results was formally explored using subgroup analyses. RESULTS: Of the 40 studies included, 26 used in-house ("home-brew") tests, and 14 used commercial tests. Commercial tests had a low overall sensitivity (0.62; 95% confidence interval [CI] 0.43, 0.77), and high specificity (0.98; 95% CI 0.96, 0.98). The positive and negative likelihood ratios for commercial tests were 25.4 (95% CI 16.2, 40.0) and 0.40 (95% CI 0.24, 0.67), respectively. All commercial tests had consistently high specificity estimates; the sensitivity estimates, however, were heterogeneous across studies. With the in-house tests, both sensitivity and specificity estimates were significantly heterogeneous. Clinically meaningful summary estimates could not be determined for in-house tests. CONCLUSIONS: Our results suggest that commercial NAA tests may have a potential role in confirming (ruling in) tuberculous pleuritis. However, these tests have low and variable sensitivity and, therefore, may not be useful in excluding (ruling out) the disease. NAA test results, therefore, cannot replace conventional tests; they need to be interpreted in parallel with clinical findings and results of conventional tests. The accuracy of in-house nucleic acid amplification tests is poorly defined because of heterogeneity in study results. The clinical applicability of in-house NAA tests remains unclear
Neurocisticercose no estado do Rio Grande do Norte: relato de oito casos
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Pathogens and host immunity in the ancient human oral cavity.
- Author
- A Amano
- A Coxon
- A Linossier
- A Sharma
- AC Tanner
- AG Henry
- Anita Radini
- B Liu
- BL Pihlstrom
- Camilla Speller
- Cecil M Lewis
- Christian D Kelstrup
- Christian Trachsel
- Christian von Mering
- Christina Warinner
- CJ Adler
- CL Munro
- CM Kusminski
- CP De La Fuente
- D Knights
- D McDonald
- D Szklarczyk
- D Willner
- DH Huson
- Domingo C Salazar-García
- DR Zerbino
- E Cappellini
- Elisabeth Eppler
- Enrico Cappellini
- EP Nawrocki
- Eske Willerslev
- F Meyer
- FE Dewhirst
- Frank Rühli
- G Stelzer
- G Xie
- H Bocherens
- H Schutkowski
- Hans Ulrich Luder
- J Wang
- JA Leonard
- JA Vizcaíno
- Jesper V Olsen
- Jessica Hendy
- JJ Gillespie
- Jonas Grossmann
- José Alfredo Samaniego Castruita
- João F Matias Rodrigues
- JR Cole
- JW Wood
- K Hardy
- K Nakano
- K Shay
- Kai Yik Teoh
- Lars H Hansen
- LC Kuo
- M Emonts
- M Goker
- M Gracia-Arnaiz
- M Thomas P Gilbert
- Matthew J Collins
- MI Ryder
- MM Savitski
- MN Price
- MO Sommer
- MP Richards
- N Fierer
- N Shimotahira
- Natallia Shved
- NF Alikhan
- NM O'Brien-Simpson
- P Hujoel
- Paolo Nanni
- PD Marsh
- PR Marri
- R Frei
- R Furugen
- Raul Y Tito
- RC Edgar
- RJ Palmer
- Roger Seiler
- Rounak Vyas
- S Mitra
- SA Palmer
- Sarah Fiddyment
- Simon Barkow-Oesterreicher
- SJ Leishman
- Sophy Charlton
- SS Socransky
- SU Gorr
- SW Lee
- T Chen
- T Deguchi
- Toshihisa Kawai
- V Brinkmann
- V Zijnge
- VM D'Costa
- VM Oelze
- VM Oelze
- Y Hancock
- Y Jin
- Publication venue
- Nat Genet
- Publication date
- 01/01/2014
- Field of study
Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human-associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, 'red complex' pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
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- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- Balcázar LC
- Balcázar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
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- Basile-Filho A
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- Bates D
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- Beane A
- Beduneau G
- Beduneau G
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- Beeharry SD
- Beerepoot M
- Begzjav T
- Beishuizen A
- Bell C
- Belletti A
- Bellissimo-Rodrigues F
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- Bellomo R
- Bellver BQ
- Belmonte R
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- Bendel S
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- Berg R
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- Bernal FF
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- Berrutti D
- Berthelsen RE
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- Besevli SG
- Bestle MH
- Bettex D
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- Beunders R
- Bhasin D
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- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
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- Bucknall T
- Buddi S
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- Buitinck SH
- Buranavanich P
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- CAPCRI Study
- Capellier G
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- Cardellino S
- Cardenas CL
- Cariou A
- Cariou A
- Carlesso E
- Carmona AF
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- Carpio D
- Carratalá A
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- Carreño ER
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- Carvalho JP
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- Casals XN
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- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
- Catalán RM
- Catena E
- Catena E
- Cauwenberghs H
- Cavalcanti D
- Cavalheiro AM
- Cavalier E
- Cavicchi FZ
- Cavicchi FZ
- Cengiz M
- Ceriani R
- Cermelli S
- Cerović O
- Cha YS
- Chabanne R
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- Champigneulle B
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- Chaouat M
- Charitidou E
- Charpentier C
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- Chaudhari HK
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- Chemam S
- Chen CM
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- Chen YS
- Chen YS
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
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- Chiappa C
- Chiou KR
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- Cinnella G
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- Combes A
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- ENVIN-HELICS Study Group
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- FINNRESUSCI Study Group
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- Frithiof R
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- FROG ICU Investigators
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- Gayat E
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- Gemmell LK
- Genc D
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- Georgopoulos D
- Geri G
- GETGAG Working Group
- GETGAG/SEMICYUC
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- Ghazal S
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- Giannopoulos A
- Giesinger RE
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- Guitard PG
- Guitard PG
- Guitard PG
- Gul F
- Gupta A
- Gupta D
- Gupta O
- Gustad LT
- Gutierrez LA
- Gutiérrez-Pizarraya A
- Guérin C
- Guérin C
- Guérin C
- Gálvez V
- Géri G
- Gómez LC
- Gómez-Jiménez C
- Gómez-Jiménez C
- Güven G
- Ha JK
- Hadley JS
- Haghbin S
- Haines R
- Hala P
- Hall D
- Hallows G
- Hallows G
- Hamilton A
- Han HS
- Han SH
- Han SH
- Handler E
- Hanekom S
- Haniffa R
- Hanna AA
- Haritydi T
- Harm S
- Harridge SD
- Harrison D
- Harrison M
- Hart N
- Hart R
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- Hashimoto Y
- Hassanin H
- Hatakeyama J
- Hatib F
- Hawkins K
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- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayashi K
- He X
- Healey AJ
- Hebert P
- Hegazy S
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- Helmy TA
- Helyar S
- Helyar S
- Hempel D
- Henderson MA
- Hendra H
- Henschel B
- Heras G
- Hernandis V
- Hernández A
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández G
- Hernández-Tejedor A
- Herpain A
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herruzo-Aviles A
- Heunks LM
- Hewitt H
- Heyne T
- Hickey S
- Hidalgo C
- Hikasa Y
- Hillier SD
- Himmel Y
- Himpe D
- Hinojosa-Perez R
- Hirata A
- Hirayama T
- Hirohata S
- Hodgson LE
- Hodgson LE
- Hofmeijer J
- Hollands S
- Hom H
- Hopkins PA
- Hopkins PA
- Hoppu S
- Hoppu S
- Horkan CM
- Horstmann C
- Horton A
- Horvat A
- Hou DS
- Houzé S
- Houzé S
- Howes D
- Hozhabri K
- Hrachovina M
- Hraiech S
- Hravnak M
- Hu HC
- Hua Y
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Huang CH
- Huang WC
- Huang WC
- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
- Hung WT
- Hung WT
- Hung WT
- Hung WT
- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
- Irazabal JM
- Ishimatsu S
- Itenov TS
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- Izawa M
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- Jaber S
- Jacky A
- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
- Jeong IY
- Jeong WY
- Jeong WY
- Jian Z
- Jiao LR
- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
- Kang PL
- Kang PL
- Kang PL
- Kang Y
- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
- Katabami K
- Katabami K
- Katabami K
- Katira BH
- Kavanagh BP
- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
- Ke MW
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- Keep J
- Keller E
- Kellner F
- Kelly JM
- Kenardy J
- Keough E
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- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
- Kim DJ
- Kim HJ
- Kim JM
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- Kim KS
- Kim KS
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- Kim MH
- Kim MH
- Kim W
- Kimmoun A
- King HS
- Kinnear J
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- Kirakli C
- Kirca H
- Kirman M
- Kirwan CJ
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- Klaus DA
- Kleinpell R
- Kluge S
- Knafelj R
- Knight LD
- Ko JI
- Ko SB
- Kobayashi A
- Koco E
- Kodate A
- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
- Kouatchet A
- Kovacikova L
- Kox M
- Kraegpoeth A
- Krenn CG
- Krishna B
- Kristof J
- Kruger A
- Kruger A
- Krüger A
- Ku NS
- Ku NS
- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
- Kurtz P
- Kwon HM
- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
- Kye YC
- Kyle UG
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
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- Lake K
- Lan SK
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- Lapteva K
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- Latini R
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- Latini R
- Latorre J
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- Lattuada M
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- Laurent A
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- Laureys S
- Lavrentieva A
- Lawrence N
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- Lee S
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- Lee YJ
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- Leitao AL
- Leite RT
- Leonard H
- Leone M
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- Lerma FA
- Lesmes SP
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- Lesmes SP
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- Lheureux O
- Lheureux O
- Lheureux O
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- Li SH
- Liao X
- Lichtenstein D
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- Limuti R
- Lin KC
- Lin KC
- Lin KC
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- Lin KL
- Lin PH
- Lin SC
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- Lin WC
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- Lischinsky A
- Lissonde F
- Lissonde F
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- Liu CP
- Liu CP
- Liu CP
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- Liu D
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- Llorente B
- Llorente MÁ
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- Lobo-Civico A
- Loizou C
- Lombardo MD
- Londoño JG
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- Lopez R
- Lopez-Caler C
- Lopez-Gude MJ
- Lorini L
- Lortat-Jacob B
- Lortat-Jacob B
- Lotay R
- Loudet CI
- Louf-Durier A
- Louf-Durier A
- Louis B
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- Lozano JA
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- Lukaszewicz AC
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- MacKay A
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- Maghsoudi B
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- Martín-Loeches I
- Martínez F
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- Mengelle C
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- Mergulhão PJ
- Merino-Vega D
- Messenger D
- Mezidi M
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- Midwinter MJ
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- Miguelena PR
- Mihara Y
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- Okamoto H
- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
- Olavarria E
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- Olivares F
- Olkkola KT
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- Preau S
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- Putzu A
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- Romero I
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- Rood PJ
- Ros Martínez J
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- Rossini P
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- Rota L
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- Ruiz A
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- Santiago AI
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- Santos F
- Sanui M
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
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- Savi C
- Savin I
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- Sawamura A
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- St George’s University of London
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- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
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- Suchomel P
- Suh GJ
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- Tokyo Womens Medical University
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- WIND study group
- WIND study group
- WIND study group
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- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
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- Ahmad N
- Ahmad T
- Ahmad T
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- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
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- Alherz F
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- Almeida W
- Alonso E
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- Alves MJ
- Amador JCB
- Ameer Y
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- Anillo V
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- Arustei M
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- Asimakos A
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- Athanasakis E
- Atiku M
- Attrill E
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- Avidan M
- Avila Sanchez FJ
- Avila EJD
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- Wittmann M
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- Woon YL
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- Wright S
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- Wu C
- Wu J
- Wu J
- Wu Q
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- Wyffels P
- Wylie K
- Xia J
- Xia Y
- Xia Z-Y
- Xiao W
- Xiao W
- Xie G
- Xie J
- Xie J
- Xie K
- Xifara A
- Xiong X
- Xiong Y
- Xouplidis K
- Xu G-J
- Xu L
- Xu L
- Xu Q
- Xu S
- Xue R
- Yagnik A
- Yan Y
- Yang J
- Yang L
- Yang Q
- Yang S
- Yang T
- Yang Y
- Yao S
- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
- Yuan F
- Yuan J
- Yuan J
- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
- Zhang H
- Zhang J
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- Zhang L
- Zhang M
- Zhang M
- Zhang Q
- Zhang R
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
CARBONO ORGÂNICO TOTAL E AGREGAÇÃO DO SOLO EM SISTEMA DE PLANTIO DIRETO AGROECOLÓGICO E CONVENCIONAL DE CEBOLA
- Author
- Alex Basso
- Angers DA
- Arcângelo Loss
- Bezerra RPM
- Boddey R
- Bolinder MA
- Bronick CJ
- Bruno Salvador Oliveira
- Calegari A
- Casali CA
- Claudinei Kurtz
- Coelho AM
- Costa Jr. C
- Coutinho FS
- Denef K
- Doneda A
- Gatiboni LC
- Giacomini SJ
- Golchin A
- Gracia RA
- Guedes Filho O
- Gustavo Brunetto
- Herlihy M
- Hermawan B
- Hoorman JJ
- Jucinei José Comin
- Leôncio de Paula Koucher
- Lima Filho OF
- Liu A
- Llerme NV
- Loss A
- Loss A
- Loss A
- Loss A
- Madari BE
- Mendes IC
- Monegat C
- Nascimento JT
- Oades JM
- Panachuki E
- Paulo Emílio Lovato
- Perin A
- Pierre Curmi
- Portugal AF
- Rilling MC
- Rodolfo Assis de Oliveira
- Rosa CM
- Salton JC
- Sisti CPJ
- Six J
- Six J
- Souza M
- Tedesco MJ
- Tivet F
- Urquiaga S
- Vezzani FM
- Vilanova CC
- Yeomans JC
- Yoder RE
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Educational strategies for the prevention of diabetes, hypertension, and obesity
- Author
- Aatola H
- Al Mamun A
- Alexandre Paulo Machado
- Barbosa RB
- Beets MW
- Bell AC
- Bruno Muniz Lima
- Caballero B
- Cahill LE
- Cha SH
- Cook DJ
- Cortés DE
- Daniels LA
- De-La-Torre-Ugarte-Guanilo MC
- DiSantis KI
- Domingos Jácomo Neto
- Drake KM
- Eliziana Ferreira D'Artibale
- Farrow CV
- Farshchi HR
- Ferreira VA
- Foster GD
- Giel KE
- Giovanna Pereira Tardin
- Goldhaber-Fiebert JD
- Gordon C
- Gracia-Marco L
- Gubbels JS
- Habib-Mourad C
- Hoey H
- James J
- Joyce Sammara Santos
- Kim HS
- King H
- Kovács E
- Kruk J
- Lackland DT
- Lavie CJ
- Levy MD
- Lima-Costa MF
- Low WY
- Manchikanti L
- Martínez-Valverde S
- Milton K
- Monique Guilharducci Laureano
- Moore LC
- Moore TJ
- Neumark-Sztainer D
- Oza-Frank R
- Park S
- Paulo Silva Reis
- Pedro Henrique Bauth Silva
- Pereira AL
- Phelan S
- Porterfield DS
- Robinson TN
- Rodin D
- Sahota P
- Slack T
- Spence AC
- Sundquist K
- Tam CL
- Torres HC
- Toscano CM
- Trogdon JG
- van der Weijden T
- Veras RP
- Vialle-Valentin CE
- Wikström K
- Yusuf S
- Zapka J
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery.
- Author
- Abad-Gurumeta A
- Abad-Motos A
- Abbott T
- Abdel-Nabi H
- Abu Khudair H
- Abu Kwiak S
- Abukhudair H
- Agarwal N
- Ahmad N
- Al Masri M
- Alarcon MM
- Aldecoa C
- Aldecoa C
- Alfonso SM
- Allcock C
- Amaral VDS
- Anumakonda V
- Ayach N
- Azi LMTDA
- Balasinorwala T
- Barberis L
- Bastos FA
- Baulch S
- Beattie S
- Bekele S
- Ben MRT
- Benedetti RH
- Berdunov V
- Blanco RP
- Blunt M
- Bolger C
- Brage SM
- Brandt S
- Buckley A
- Burnish R
- Buron FD
- Caldera-Alvarez MV
- Camara L
- Campbell D
- Campbell R
- Carlon VA
- Carroll J
- Cashman J
- Castro AMG
- Chowdary R
- Clark P
- Clark S
- Clarke H
- Claxton G
- Codere-Maruyama T
- Cole A
- Collings N
- Conde MJP
- Corcoran P
- Craven D
- Da Prat IC
- da Silva RJC
- Davila AS
- Dawson H
- de Almeida JP
- de Godoy EP
- de Nadal M
- de Pablo EL
- Dias P
- Diers A
- Diez AF
- dos Santos WF
- Duncan D
- Dunkley S
- Duran MV
- Edinger F
- Edwards M
- Edwards MR
- Ehrentraut H
- Ertmer M
- Evered L
- Evered L
- Falcao LF
- Farhoud E
- Feijoo JR
- Fernandes CR
- Fernandez M
- Fernandez-Francos S
- Fidler K
- Filipe H
- Fingerhut M-L
- Fitzgerald E
- Fleischer A
- Forbes G
- Fortier LP
- Fowler A
- Fowler S
- Funk D
- Galan P
- Galas FRBG
- Gardner W
- Gata A
- Ghidan A
- Gidda R
- Gillies MA
- Girling L
- Gleeson Y
- Gobert Q
- Godin N
- Gomes MDA
- Gonzalez AP
- Gracia E
- Gray K
- Griffiths B
- Grigoras I
- Grigoras I
- Grocott MPW
- Grote T
- Guerra Y
- Guha A
- Guimaraes GN
- Gunter U
- Gutierrez A
- Guttenthaler V
- Habig L
- Haines R
- Hajjar LA
- Hajjar LA
- Harris S
- Hatzakorzian R
- Heringlake M
- Herrero A
- Hodgson A
- Hodgson R
- Hodkinson G
- Hofer C
- Hofer CK
- Horan A
- Hudson C
- Ivermee C
- Jaeger M
- Januszewska M
- Jerath A
- Jitaru I
- Joaquim EHG
- Jonas M
- Jones T
- Kahan BC
- Kanapeckaite L
- Kelleher M
- Klintworth S
- Koch C
- Kowalski S
- Ladha K
- Lang A
- Lattermann R
- Lineburger E
- Lipka A
- MacDonald N
- MacDonald N
- Malbouisson LMS
- Manole M
- Manou V
- Marcolino I
- Mariotti S
- Markmann M
- Martin T
- Martinez-Hurtado E
- May S
- Mayo G
- McCluskey S
- McCluskey SA
- McGrane T
- McGregor A
- McQuaide S
- McSkeane A
- Meineri M
- Mihaylova B
- Mohamed M
- Monterola M
- Moore A
- Mugarra A
- Murat L
- Mythen MG
- Nannen L
- Navarro L
- Neumann C
- Niebrzegowska E
- Nozal-Mateo B
- Oliveira M
- Olsson S
- Ortola CF
- Pabel S
- Pakats M-L
- Pakou G
- Parada PD
- Pardal CB
- Parotto M
- Pates K
- Pawa N
- Pazmino-Canizares J
- Pearse RM
- Peral C
- Peral EC
- Perez A
- Perz LV
- Peyton P
- Phan TD
- Poonawala H
- Pozo N
- Prado RG
- Prentice S
- Price T
- Raj A
- Ratnam V
- Rea N
- Reay M
- Richebe P
- Ripolles-Melchor J
- Ripolles-Melchor J
- Ristescu I
- Rivas MC
- Romero E
- Rosbergen M
- Ruhrmann S
- Rusu D
- Salgado M
- Salles LC
- Salvachua-Fernandez R
- Sanchez CGM
- Sancho JM
- Sander M
- Sander M
- Sato H
- Sato T
- Saunders Z
- Sayan A
- Schemke S
- Schmidt C
- Schneck E
- Schricker T
- Schulte D
- Sellers D
- Shelley J
- Shore DD
- Sidiropolous S
- Simoes C
- Singer R
- Smee E
- Smith T
- Soares SD
- Soro M
- Stefani LC
- Stephens T
- Suarez SG
- Svensson M-L
- Szakmany T
- Szczeklik W
- Thankachen M
- Thompson R
- Thomson A
- Tilley A
- Tindall M
- Torres MB
- Trauzeddel R-F
- Treskatsch S
- Tuong P
- Turnbo T
- Una-Orejon R
- van Vlymen J
- Verdonck O
- Villafane AP
- Visauta EC
- Walker S
- Wasowicz M
- Watts A
- Weinstein M
- Weyland A
- Whalley J
- Wijeysundera D
- Wijeysundera DN
- Wilson T
- Winkler A
- Winter A
- Wittenberg M
- Wittmann M
- Yang G
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2019
- Field of study
INTRODUCTION: Postoperative morbidity and mortality in older patients with comorbidities undergoing gastrointestinal surgery are a major burden on healthcare systems. Infections after surgery are common in such patients, prolonging hospitalisation and reducing postoperative short-term and long-term survival. Optimal management of perioperative intravenous fluids and inotropic drugs may reduce infection rates and improve outcomes from surgery. Previous small trials of cardiac-output-guided haemodynamic therapy algorithms suggested a modest reduction in postoperative morbidity. A large definitive trial is needed to confirm or refute this and inform widespread clinical practice. METHODS: The Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial is a multicentre, international, parallel group, open, randomised controlled trial. 2502 high-risk patients undergoing major elective gastrointestinal surgery will be randomly allocated in a 1:1 ratio using minimisation to minimally invasive cardiac output monitoring to guide protocolised administration of intravenous fluid combined with low-dose inotrope infusion, or usual care. The trial intervention will be carried out during and for 4 hours after surgery. The primary outcome is postoperative infection of Clavien-Dindo grade II or higher within 30 days of randomisation. Participants and those delivering the intervention will not be blinded to treatment allocation; however, outcome assessors will be blinded when feasible. Participant recruitment started in January 2017 and is scheduled to last 3 years, within 50 hospitals worldwide. ETHICS/DISSEMINATION: The OPTIMISE II trial has been approved by the UK National Research Ethics Service and has been approved by responsible ethics committees in all participating countries. The findings will be disseminated through publication in a widely accessible peer-reviewed scientific journal. TRIAL REGISTRATION NUMBER: ISRCTN39653756.The OPTIMISE II trial is supported by Edwards Lifesciences (Irvine, CA) and the UK National Institute for Health Research through RMP’s NIHR Professorship
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
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- Adams Re
- Adegbola So
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- Adimonye A
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- Andolfi E
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- Angelieri D
- Angelini M
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- Badii B
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- Bagga R
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- Bailey S
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- Bailon-Cuadrado M
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- Balasubramaniam A
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- Ball A
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- Ball A.
- Ballabio M
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- Bandyopadhyay Sk
- Banks A
- Bansal H
- Baraghini M
- Barbosa L
- Barker T
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- Barnieh W
- Baronio G
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- Barrie A
- Barter Ca
- Bartoli A
- Bascuas-Rodrigo B
- Baseggio M
- Bastianpillai J
- Bawa S
- Baz-Figueroa C
- Bazán-Hinojo Mc
- Bazán-Hinojo Mc
- Beasley Wd
- Bedoya S
- Beggs A
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- Beltran-De-Heredia J
- Beltran-De-Heredia J
- Belvedere A
- Benevento A
- Bennett Jm
- Beral D
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- Bernal-Sprekelsen Jc
- Berry B
- Berti S
- Bevan Ke
- Bevan V
- Beverstock A
- Bhanderi S
- Bhanderi S
- Bhanderi S
- Bhanderi S
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- Bhangu A. Nepogodiev D
- Bhangu A
- Bhangu A
- Bhangu A
- Bhangu A
- Bhargava A
- Biancafarina A
- Biancafarina A
- Bianchi Cl
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- Bianco A
- Bilku D
- Birindelli A
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- Blackford Od
- Blackwell J
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- Blazeby Jm
- Blencowe N. S.
- Blencowe Ns
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- Bolton W
- Bolzon S
- Bond S
- Bond-Smith G
- Bondurri A
- Bonfante P
- Bonomo M
- Borg Cm
- Borges Fc
- Borghi F
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- Boshier Pr
- Botelho P
- Bowen J
- Bowerman H
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- Bowman Cr
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- Boyd-Carson H
- Boza K
- Bradshaw Cj
- Branagan G
- Bravo-Gutiérrez Af
- Bravo-Gutiérrez Af
- Brennan S
- Brett M
- Brewer H
- Brewer Hk
- Brewer Hk
- Brews R
- Brien Jo
- Bronder C
- Brown A
- Brown Ag
- Brown Ce
- Brown Ce
- Brown Ce
- Brown M
- Brown M
- Brown Od
- Brown R
- Bruce Js
- Brunelli Db
- Bryan Es
- Buckley-Jones S
- Bukhari W
- Bull C
- Bullivant Jk
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- Burns Km
- Burnside D
- Busuttil A
- Byrne Be
- Byrnes Ck
- Caballero A
- Caldeira Ab
- Caldwell M
- Callan R
- Calussi M
- Calvo H
- Calvo M
- Cameron Fc
- Campagnaro T
- Campagnaro T
- Campbell U
- Campbell Um
- Campbell W
- Cannata G
- Cannavò M
- Cantafio S
- Capelli P
- Carcoforo P
- Carden Ca
- Carder C
- Cardona R
- Cardoso D
- Carlucci M
- Carney K
- Caro A
- Carral-Freire M
- Carrano Fm
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- Cartwright H
- Carvalho Lc
- Carvalho N
- Casimiro C
- Castagnoli G
- Castagnoli G
- Caula C
- Caula C
- Cavallo D
- Cavero A
- Cay P
- Ceccarelli G
- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cervellera M
- Cesari Mc
- Chalk A
- Chambers B
- Chan D
- Chan T
- Chan Wh
- Chandler Sb
- Chandratreya N
- Chandratreya N
- Chapman J
- Chapman Sj
- Chapple Ks
- Charalabopoulos A
- Charalambous Mp
- Chasty B
- Chatzikonstantinou M
- Chatzikonstantinou M
- Chauhan P
- Chauhan P
- Chauhan P.
- Cheah Wl
- Chean Cs
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- Checcacci P
- Cheng Sa
- Cheruvu M
- Chessa A
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- Chetta G
- Chetta N
- Chianese G
- Chillitupa Cz
- Chimetto A
- Chin My
- Chishti Ia
- Chitsabesan P
- Chng S
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- Chok Sm
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- Chong B
- Choolani-Bhojwani E
- Choong Jh
- Choong Jh
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- Chowdhary M
- Chowdhury F
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- Christian L
- Christides A
- Christopoulos P
- Chudek D
- Chui K
- Cianchi F
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- Cillara N
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- Cirillo B
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- Clements B
- Clements C
- Clements J
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- Clements Ja
- Clements Jd
- Clements Jm
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- Clerici F
- Clingan R
- Cloney L
- Clough E
- Coccolini F
- Coccolini F
- Cocorullo G
- Coe Po
- Cohen Ja
- Colangelo E
- Coletta D
- Coletta D
- Coletti M
- Collado-Roura F
- Collier-Wakefield O
- Colombo F
- Colombo F
- Colvin Da
- Colvin Da
- Compagnoni B
- Conci S
- Connelly Tm
- Connor Kl
- Connor Kl
- Connor Mj
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- Conti D
- Contine Ac
- Contreras Rg
- Contreras-Saiz E
- Cook V
- Cooke F
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- Cormenzana Ob
- Correia D
- Correia J
- Cortés Gv
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- Cossu F
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- Costamagna D
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- Cynthia G
- Cánovas-Moreno G
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- D'Amico Fe
- D'Amico Fe
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- D'Auria M
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- D'Souza N
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- Dalmia S
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- Daniels I
- Danquah-Boateng D
- Dar Fa
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- Daureeawoo R
- Davidson Jr
- Davidson S
- Davies Pl
- Davis S
- De Andres U
- De Burgos Cb
- De Chaves-Rodríguez Pg
- De Freitas S
- De Luca E
- De Marchi F
- De Marco P
- De Nardi P
- De Nardi P
- De Nisco C
- De Padua C
- De Prizio M
- De-La-Herranz-Guerrero P
- De-Manzoni-Garberini A
- De-Manzoni-Garberini A
- De-Manzoni-Garberini A
- De-Marchi Ja
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- De-Soto-Cardenal B
- Dean Ea
- Dean S
- Del Basso C
- Del Pozo E
- Del-Valle-Ruiz Sr
- Delgado-Plasencia Lj
- Delimpalta C
- Delimpalta C
- Delogu D
- Denley S
- Dennison G
- Depalma N
- Deserra A
- Desiderio J
- Devezas V
- Devine Aa
- Dhar M
- Dharamavaram S
- Dhari Aa
- Dhesi S
- Di Cintio A
- Di Franco F
- Di Gioia P
- Di Saverio S
- Di Zitti L
- Diaz A
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- Divekar Ga
- Dixon F
- Dobbs S
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- Docherty Ja
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- Donaldson G
- Donaldson G
- Donohoe No
- Donohoe No
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- Drye N
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- Duran-Muñoz-Cruzado Vm.
- Durbacz M
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- Eardley Nj
- Earnshaw L
- Easdon S
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- Eguaras I
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- Eiben P
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- Elia M
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- English Wj
- Ercolani G
- Erdas E
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- Eretta Co
- Escoll-Rufino J
- Escuder J
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- Espin-Basany E
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- Espina B
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- Falaschi F
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- Fareleira A
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- Farina V
- Faris Ar
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- Farrow Ez
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- Faulkner G
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- Feleppa C
- Feliu F
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- Fernandes C
- Fernández Ec
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- Fernández-Candela A
- Fernández-Martínez D
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- Fernández-Martínez D
- Feroci F
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- Ferrer-Vilela I
- Fijo Lm
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- Forouzanfar A
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- García V
- García-Carrero M
- García-Catalá L
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- García-Granero A
- García-Granero A
- García-Gutierrez C
- García-Novoa A
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- Hraishawi I
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- Hussain A
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- Hutchinson B
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- Ibrahim Y
- Ikram S
- Ilozue T
- Imperatore M
- Inama M
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- Infante H
- Iosif E
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- Krishnamoorthy A
- Krivan S
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- Papandrea M
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- Pareja-Ciuró F
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- Pascual-Miguelañez I
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- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F.
- Pata G
- Pata G
- Pata G
- Patel As
- Patel By
- Patel By
- Patel C
- Patel H
- Patel Mm
- Patel N
- Patel Pk
- Patel Rt
- Patil Sd
- Patti S
- Pau R
- Payne Cj
- Payne Re
- Payá-Llorente C
- Payá-Llorente C
- Peacock M
- Pearce J
- Pearce J
- Pearce L
- Pearce L
- Pearson R
- Pedder A
- Peirce Cb
- Peiris Gb
- Peixoto R
- Peleki A
- Peleki A
- Pellegrino L
- Pellicanò Ga
- Pellicer-Franco E
- Pellino G
- Pento V
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- Peponis C
- Peprah D
- Pereira A
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- Pereira J
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- Perera Mi
- Perez-Calvo J
- Perin A
- Pertile D
- Pertile D
- Peña-Barturen C
- Phelan L
- Photiou D
- Pierre R
- Pietrabissa A
- Pigem A
- Pila U
- Pilkington Jp
- Pineño-Flores C
- Pinillos-Somalo A
- Pinkney Td
- Pinkney Td
- Pinkney Td
- Pinna E
- Pino-Perez O
- Pirari Pf
- Pisanu A
- Piu F
- Planellas P
- Plua-Muniz Kt
- Poacher A
- Podda F
- Podda M
- Podda M
- Podda M
- Poillucci G
- Pollard H
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- Popova D
- Poudevigne M
- Prats Ma
- Prideaux A
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- Primo Jc
- Pronin S
- Provenza G
- Puerta E
- Pulighe F
- Pullabatla-Venkata Up
- Punj S
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- Quinn Em
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- Rabie M
- Rabie Ma
- Rabie Mr
- Radwan Rw
- Radwan Rw
- Rahim A
- Rahman M
- Rahmani Ls
- Rajagopal S
- Rajaram R
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- Rajjoub Y
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- Ramos Xh
- Ramos-Bernado Mi
- Ramírez-Faraco M
- Ranathunga S
- Rangarajan K
- Rao M
- Rao V
- Raofi A
- Rashid M
- Rate A
- Ravindran R
- Raymond M
- Raza Ss
- Recreo Ac
- Reddy A
- Reddy A
- Redmond Ae
- Redondo E
- Redondo E
- Redondo-Calvo Fj
- Reese G
- Regina G
- Rehman S
- Rehman S
- Rekhraj S
- Ren Kz
- Renshaw S
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- Renzi Cr
- Resende Fm
- Rezacova M
- Rezvani S
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- Ribaudo M
- Ribeiro B
- Rich Je
- Richardson Td
- Ridaura N
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- Robb Hd
- Robertson C
- Robinson A
- Robinson A
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- Rodger V
- Rodicio-Miravalles Jl
- Rodriguez L
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodríguez Ec
- Rojo Ja
- Roldán-Ortiz S
- Rolph R
- Romano J
- Romano R
- Romario Uf
- Romoli L
- Roncero Ls
- Ronda Rn
- Roomi S
- Rosa Mj
- Rosat A
- Roscio F
- Roscio F
- Roscio F
- Rossi C
- Rossi D
- Rossi Gm
- Roth N
- Rothnie K
- Roxburgh C
- Roy C
- Ruano A
- Rubbini M
- Rudland I
- Ruffolo C
- Rufo E
- Ruggiu Gv
- Ruiz-Marín M
- Ruiz-Marín M
- Rupani S
- Rupasinghe Sn
- Rupasinghe Sn
- Rutherford Dg
- Ruzvidzo F
- Ruzzenente A
- Saad M
- Saad M
- Saavedra-Chacón M
- Saba A
- Sabia D
- Sacco R
- Sacks R
- Sadek S
- Saghir N
- Sagnotta A
- Sagnotta A
- Saha A
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- Sahnan K
- Sahnan K
- Sainz B
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- Salama Y
- Salamone G
- Salamone G
- Salamone G
- Salamone G
- Salandini Mc
- Salem A
- Salim S
- Salva Ab
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- Samuel M
- Sana S
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- Sanchez-Garcia S
- Sanchez-Guillen L
- Sanchez-Guillen L
- Sanchez-Martinez A
- Sancho-Muriel J
- Sandu L
- Sanna S
- Santamaria C
- Santamaría Pc
- Santarrufina-Martínez S
- Santos Sc
- Santurro L
- Sanz-Navarro S
- Sarmah P
- Sarmah P
- Sarmah P
- Sarveswaran J
- Sasia D
- Sasia D
- Saunders S
- Savill A
- Savino G
- Savino G
- Savioli F
- Scabini S
- Scabini S
- Scabini S
- Scandroglio Is
- Scanlon K
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- Scialandrone G
- Scricciolo M
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- Sebastián-Tomás Jc
- Seddon Tc
- Segalini E
- Segura-Sampedro Jj
- Sena G
- Sena-Ruiz F
- Seneviratne N
- Sepe C
- Serventi F
- Serventi F
- Seth M
- Setshwaelo T
- Sezen E
- Sgardelis P
- Sgrò A
- Sgrò A
- Sgrò A
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- Shah K
- Shah Sm
- Shah Sm
- Shaikh Ia
- Shakoor Z
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- Shanmugarajah K
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- Siaw O
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- Siddiqui Mn
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- Simmonds L
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- Singh J
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- Skalamera I
- Skerritt C
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- Smart Cj
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- Soares As
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- Sooriyamoorthy T
- Soria-Aledo V
- Soria-Aledo V
- Soriano Jt
- Sorrentino L
- Sousa Hs
- Souter J
- Sparta C
- Spaziani A
- Speake D
- Speake D
- Springate El
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- Staderini F
- Stecca T
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- Stephens Gf
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- Stevenson R
- Stewart Dj
- Stoica I
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- Strachan E
- Strange Ja
- Stubbs Bm
- Stupalkowska W
- Stupalkowska W
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- Swords C
- Symons N
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- Szucs A
- Szucs A
- Sánchez-Cifuentes A
- Sánchez-Fuentes Mn
- Sánchez-Rubio M
- Tabain V
- Taglietti L
- Tague Le
- Tahir W
- Tailor K
- Tallon-Aguilar L
- Tallon-Aguilar L
- Tamayo-López Mj
- Tamborska A
- Tamini N
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- Tapiolas I
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- Tayeh S
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- Tudyka V
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- Vescio G
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- Vigorita V
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- Zaborowski A
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- Zelazek M
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- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Efficient fatigue assessment of the upper and lower hopper knuckle connections of an oil tanker
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
- …