CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies

Primary cutaneous CD30-positive T-cell lymphoproliferative disorders are the second most common subgroup of cutaneous T-cell lymphomas. They include two clinically different entities with some overlapping features and borderline cases: lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma. Molecular studies of primary cutaneous anaplastic large cell lymphoma reveal an increasing level of heterogeneity that is associated with histological and immunophenotypic features of the cases and their response to specific therapies. Here, we review the most significant genetic, epigenetic and molecular alterations described to date in primary cutaneous CD30-positive T-cell lymphoproliferative disorders, and their potential as therapeutic targets

Necrobiosis lipoidica developing within a surgical scar in a non-diabetic patient: Type III Koebner phenomenon (isomorphic response), Wolf's isotopic response or Ruocco's immunocompromised cutaneous district?

Sir, Necrobiosis lipoidica is a chronic granulomatous disease typically associated with diabetes mellitus. We report a case of necrobiosis lipoidica occurring in a surgical scar in a non-diabetic patient. We found only nine previous reports of necrobiosis lipoidica appearing after trauma or in surgical scars, as a manifestation of Type III Koebner phenomenon. Most of these were in diabetic patients..

Mosca de los cuernos, Haematobia irritans irritans (Linnaeus 1758) (Diptera: Muscidae). Contribuciones para su conocimiento en la Argentina. III. Aspectos morfológicos básicos de los estados preadultos. Ciclo biológico

Fil: Abrahamovich, Alberto H.. Laboratorio de Apidología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Cicchino, Armando Conrado. División Entomología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Prieto, Olegario H.. Cátedra de Parasitología y enfermedades parasitarias de la Facultad de Ciencias Veterinarias. UBA; ArgentinaFil: Torres, Pablo R.. Área de Parasitología y enfermedades parasitarias de la Facultad de Ciencias Veterinarias. UBA; ArgentinaFil: Nuñez, Jorge L.. Cátedra de Parasitología y enfermedades parasitarias de la Facultad de Ciencias Veterinarias. UBA; Argentin

Mosca de los cuernos, Haematobia irritans irritans (Linnaeus 1758) (Diptera: Muscidae). Contribuciones para su conocimiento en la Argentina. II. Estado adulto: dimorfismo sexual y diferenciación con otros múscidos hallados sobre el pelaje de los bovinos

Fil: Cicchino, Armando Conrado. División Entomología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Abrahamovich, Alberto H.. Laboratorio de Apidología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Torres, Pablo R.. Área de Parasitología y enfermedades parasitarias de la Facultad de Ciencias Veterinarias. UBA; ArgentinaFil: Nuñez, Jorge L.. Cátedra de Parasitología y enfermedades parasitarias de la Facultad de Ciencias Veterinarias. UBA; ArgentinaFil: Prieto, Olegario H.. Cátedra de Parasitología y enfermedades parasitarias de la Facultad de Ciencias Veterinarias. UBA; Argentin

Los enemigos naturales de Haematobia irritans irritans (Diptera; Muscidae) en dos áreas ganaderas de la Argentina

Fil: Torres, Pablo R.. Área de Parasitología y enfermedades parasitarias de la Facultad de Ciencias Veterinarias. UBA; ArgentinaFil: Cicchino, Armando Conrado. División Entomología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Abrahamovich, Alberto H.. Laboratorio de Apidología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Núñez, Jorge L.. Área de Parasitología y enfermedades parasitarias de la Facultad de Ciencias Veterinarias. UBA; ArgentinaFil: Prieto, Olegario H.. Cátedra de Parasitología y enfermedades parasitarias de la Facultad de Ciencias Veterinarias. UBA; Argentin

S4N: A Spectroscopic Survey of Stars in the Solar Neighborhood

[ABRIDGED] We report the results of a high-resolution spectroscopic survey of all the stars more luminous than Mv = 6.5 mag within 14.5 pc from the Sun. We derive stellar parameters and perform a preliminary abundance and kinematic analysis of the F-G-K stars in the sample. The inferred metallicity ([Fe/H]) distribution is centered at about -0.1 dex, and shows a standard deviation of 0.2 dex. We identify a number of metal-rich K-type stars which appear to be very old, confirming the claims for the existence of such stars in the solar neighborhood. With atmospheric effective temperatures and gravities derived independently of the spectra, we find that our classical LTE model-atmosphere analysis of metal-rich (and mainly K-type) stars provides discrepant abundances from neutral and ionized lines of several metals. Based on transitions of majority species, we discuss abundances of 16 chemical elements. In agreement with earlier studies we find that the abundance ratios to iron of Si, Sc, Ti, Co, and Zn become smaller as the iron abundance increases until approaching the solar values, but the trends reverse for higher iron abundances. At any given metallicity, stars with a `low' galactic rotational velocity tend to have high abundances of Mg, Si, Ca, Sc, Ti, Co, Zn, and Eu, but low abundances of Ba, Ce, and Nd. The Sun appears deficient by roughly 0.1 dex in O, Si, Ca, Sc, Ti, Y, Ce, Nd, and Eu, compared to its immediate neighbors with similar iron abundances.Comment: 24 pages, 19 figures, to appear in A&A; data can be accessed from http://hebe.as.utexas.edu/s4n/ or http://www.astro.uu.se/~s4n

Prospection and identification of traditional-heritage Peruvian grapevine cultivars (Vitis vinifera L.) from Ica and Cañete valleys

Interest in ancient and autochthonous cultivars has increased in recent years since they are directly related to the historical and cultural values of a region. Ica and Cañete valleys (Peru) have a long history of grapevine cultivation and the aim of this study was to identify phenotypes corresponding to the most used varieties for the local production of Pisco and wine. The 29 samples were collected in 17 vineyards in the Ica and Cañete valleys, and were analyzed using 20 molecular markers and 5 morphological descriptors according to the OIV. Results showed that the 29 collected samples corresponded to 11 genotypes: seven traditional cultivars and four unknown genotypes not registered previously. The known cultivars were 'Muscat of Alexandria', 'Listán Prieto', 'Quebranta', 'Moscatel Rosado', 'Pedro Giménez', 'Muscat Hamburg' and 'Palomino Fino'. The four not registered genotypes are locally known as 'Mollar de Ica', 'Moscatel Rosada de Cañete', 'Prieta Mollar' and 'Torontel'. All of them correspond to offspring of traditional-heritage Peruvian cultivars. We also found a phenotypic variation of 'Listán Prieto' with muscat flavor and identified phenotypic berry color variations in 'Quebranta'. This study increases the knowledge of traditional Peruvian grape varieties and highlight the genetic variability preserved in the traditional vineyards of local producers

High-oxygen-barrier multilayer films based on polyhydroxyalkanoates and cellulose nanocrystals

This study reports on the development and characterization of organic recyclable high-oxygen-barrier multilayer films based on different commercial polyhydroxyalkanoate (PHA) materials, including a blend with commercial poly(butylene adipate-co-terephthalate) (PBAT), which contained an inner layer of cellulose nanocrystals (CNCs) and an electrospun hot-tack adhesive layer of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) derived from cheese whey (CW). As a result, the full multilayer structures were made from bio-based and/or compostable materials. A characterization of the produced films was carried out in terms of morphological, optical, mechanical, and barrier properties with respect to water vapor, limonene, and oxygen. Results indicate that the multilayer films exhibited a good interlayer adhesion and contact transparency. The stiffness of the multilayers was generally improved upon incorporation of the CNC interlayer, whereas the enhanced elasticity of the blend was reduced to some extent in the multilayer with CNCs, but this was still much higher than for the neat PHAs. In terms of barrier properties, it was found that 1 µm of the CNC interlayer was able to reduce the oxygen permeance between 71% and 86%, while retaining the moisture and aroma barrier of the control materials.This research work was funded by the H2020 EU project YPACK (reference number 773872) and by the Spanish Ministry of Science and Innovation (MICI) project RTI2018-097249-B-C21.Beatriz Melendez-Rodriguez would like to acknowledge the MICI for her FPI fellowship (BES-2016-077972) and Sergio Torres-Giner for his MICI Juan de la Cierva–Incorporación contract (IJCI-2016-29675). The authors would also like to acknowledge the Unidad Asociada in Polymer Technology, joint unit IATA(CSIC)-UJI

Transformed but not normal hepatocytes express UCP2

Uncoupling protein 2 (UCP2) expression in liver is restricted to non-parenchymal cells. By means of differential display screening between normal rat liver and H4IIE hepatoma cells we have isolated a cDNA clone encompassing part of UCP2 cDNA. Northern blot analysis revealed that UCP2 is expressed in some hepatocarcinoma cell lines, while it is absent in adult hepatocytes. UCP2 mRNA in H4IIE cells was downregulated when cells were cultured for 36 h in 0.1% serum and its expression was restored upon addition of 10% serum or phorbol esters. Hypomethylation of UCP2 was observed in transformed UCP2 expressing cells. Our results indicate that UCP2 is expressed in some hepatocarcinoma cell lines and that serum components may participate in maintaining elevated UCP2 levels